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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PTPRU-EPB41

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PTPRU-EPB41
FusionPDB ID: 70570
FusionGDB2.0 ID: 70570
HgeneTgene
Gene symbol

PTPRU

EPB41

Gene ID

10076

2035

Gene nameprotein tyrosine phosphatase receptor type Uerythrocyte membrane protein band 4.1
SynonymsFMI|PCP-2|PTP|PTP-J|PTP-PI|PTP-RO|PTPPSI|PTPRO|PTPU2|R-PTP-PSI|R-PTP-U|hPTP-J4.1R|EL1|HE
Cytomap

1p35.3

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionreceptor-type tyrosine-protein phosphatase UPTP piReceptor protein tyrosine phosphatase hPTP-Jpancreatic carcinoma phosphatase 2pi R-PTP-Psiprotein-tyrosine phosphatase Jprotein-tyrosine phosphatase piprotein-tyrosine phosphatase receptor omicronrprotein 4.1EPB4.1P4.1band 4.1elliptocytosis 1, RH-linkederythrocyte surface protein band 4.1
Modification date2020031320200320
UniProtAcc.

Q9HCM4

Ensembl transtripts involved in fusion geneENST idsENST00000323874, ENST00000345512, 
ENST00000356870, ENST00000373779, 
ENST00000428026, ENST00000460170, 
ENST00000415600, 		ENST00000460378, 
ENST00000343067, ENST00000347529, 
ENST00000349460, ENST00000356093, 
ENST00000373797, ENST00000373798, 
ENST00000373800, ENST00000398863, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 6 X 7=33613 X 13 X 6=1014
# samples 1015
** MAII scorelog2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1014*10)=-2.75702324650746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PTPRU [Title/Abstract] AND EPB41 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PTPRU(29563229)-EPB41(29356911), # samples:1
PTPRU(29563229)-EPB41(29356912), # samples:1
PTPRU(29602268)-EPB41(29379616), # samples:1
Anticipated loss of major functional domain due to fusion event.PTPRU-EPB41 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRU-EPB41 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRU-EPB41 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRU-EPB41 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PTPRU-EPB41 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PTPRU-EPB41 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTPRU-EPB41 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
PTPRU-EPB41 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PTPRU-EPB41 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePTPRU

GO:0006470

protein dephosphorylation

12501215

HgenePTPRU

GO:0008285

negative regulation of cell proliferation

16574648

HgenePTPRU

GO:0030336

negative regulation of cell migration

12501215|16574648

HgenePTPRU

GO:0034394

protein localization to cell surface

16574648

HgenePTPRU

GO:0090090

negative regulation of canonical Wnt signaling pathway

16574648

HgenePTPRU

GO:2000049

positive regulation of cell-cell adhesion mediated by cadherin

16574648

TgeneEPB41

GO:0032092

positive regulation of protein binding

3693401


check buttonFusion gene breakpoints across PTPRU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EPB41 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0X1-01APTPRUchr1

29563229

+EPB41chr1

29356912

+
ChimerDB4BRCATCGA-B6-A0X1PTPRUchr1

29563229

+EPB41chr1

29356911

+
ChimerDB4BRCATCGA-BH-A0B9-01APTPRUchr1

29602268

+EPB41chr1

29379616

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000345512PTPRUchr129602268+ENST00000356093EPB41chr129379616+565015821292441770
ENST00000345512PTPRUchr129602268+ENST00000398863EPB41chr129379616+545815821292249706
ENST00000345512PTPRUchr129602268+ENST00000343067EPB41chr129379616+574915821292540803
ENST00000345512PTPRUchr129602268+ENST00000349460EPB41chr129379616+280115821292498789
ENST00000345512PTPRUchr129602268+ENST00000373800EPB41chr129379616+264215821292339736
ENST00000345512PTPRUchr129602268+ENST00000347529EPB41chr129379616+268115821292378749
ENST00000345512PTPRUchr129602268+ENST00000373798EPB41chr129379616+577015821292540803
ENST00000345512PTPRUchr129602268+ENST00000373797EPB41chr129379616+215115821292108659
ENST00000373779PTPRUchr129602268+ENST00000356093EPB41chr129379616+565015821292441770
ENST00000373779PTPRUchr129602268+ENST00000398863EPB41chr129379616+545815821292249706
ENST00000373779PTPRUchr129602268+ENST00000343067EPB41chr129379616+574915821292540803
ENST00000373779PTPRUchr129602268+ENST00000349460EPB41chr129379616+280115821292498789
ENST00000373779PTPRUchr129602268+ENST00000373800EPB41chr129379616+264215821292339736
ENST00000373779PTPRUchr129602268+ENST00000347529EPB41chr129379616+268115821292378749
ENST00000373779PTPRUchr129602268+ENST00000373798EPB41chr129379616+577015821292540803
ENST00000373779PTPRUchr129602268+ENST00000373797EPB41chr129379616+215115821292108659
ENST00000356870PTPRUchr129602268+ENST00000356093EPB41chr129379616+563115631102422770
ENST00000356870PTPRUchr129602268+ENST00000398863EPB41chr129379616+543915631102230706
ENST00000356870PTPRUchr129602268+ENST00000343067EPB41chr129379616+573015631102521803
ENST00000356870PTPRUchr129602268+ENST00000349460EPB41chr129379616+278215631102479789
ENST00000356870PTPRUchr129602268+ENST00000373800EPB41chr129379616+262315631102320736
ENST00000356870PTPRUchr129602268+ENST00000347529EPB41chr129379616+266215631102359749
ENST00000356870PTPRUchr129602268+ENST00000373798EPB41chr129379616+575115631102521803
ENST00000356870PTPRUchr129602268+ENST00000373797EPB41chr129379616+213215631102089659
ENST00000323874PTPRUchr129602268+ENST00000356093EPB41chr129379616+563115631102422770
ENST00000323874PTPRUchr129602268+ENST00000398863EPB41chr129379616+543915631102230706
ENST00000323874PTPRUchr129602268+ENST00000343067EPB41chr129379616+573015631102521803
ENST00000323874PTPRUchr129602268+ENST00000349460EPB41chr129379616+278215631102479789
ENST00000323874PTPRUchr129602268+ENST00000373800EPB41chr129379616+262315631102320736
ENST00000323874PTPRUchr129602268+ENST00000347529EPB41chr129379616+266215631102359749
ENST00000323874PTPRUchr129602268+ENST00000373798EPB41chr129379616+575115631102521803
ENST00000323874PTPRUchr129602268+ENST00000373797EPB41chr129379616+213215631102089659
ENST00000428026PTPRUchr129602268+ENST00000356093EPB41chr129379616+56171549962408770
ENST00000428026PTPRUchr129602268+ENST00000398863EPB41chr129379616+54251549962216706
ENST00000428026PTPRUchr129602268+ENST00000343067EPB41chr129379616+57161549962507803
ENST00000428026PTPRUchr129602268+ENST00000349460EPB41chr129379616+27681549962465789
ENST00000428026PTPRUchr129602268+ENST00000373800EPB41chr129379616+26091549962306736
ENST00000428026PTPRUchr129602268+ENST00000347529EPB41chr129379616+26481549962345749
ENST00000428026PTPRUchr129602268+ENST00000373798EPB41chr129379616+57371549962507803
ENST00000428026PTPRUchr129602268+ENST00000373797EPB41chr129379616+21181549962075659
ENST00000460170PTPRUchr129602268+ENST00000356093EPB41chr129379616+5527145962318770
ENST00000460170PTPRUchr129602268+ENST00000398863EPB41chr129379616+5335145962126706
ENST00000460170PTPRUchr129602268+ENST00000343067EPB41chr129379616+5626145962417803
ENST00000460170PTPRUchr129602268+ENST00000349460EPB41chr129379616+2678145962375789
ENST00000460170PTPRUchr129602268+ENST00000373800EPB41chr129379616+2519145962216736
ENST00000460170PTPRUchr129602268+ENST00000347529EPB41chr129379616+2558145962255749
ENST00000460170PTPRUchr129602268+ENST00000373798EPB41chr129379616+5647145962417803
ENST00000460170PTPRUchr129602268+ENST00000373797EPB41chr129379616+2028145961985659

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000345512ENST00000356093PTPRUchr129602268+EPB41chr129379616+0.002296310.99770373
ENST00000345512ENST00000398863PTPRUchr129602268+EPB41chr129379616+0.0030536730.9969463
ENST00000345512ENST00000343067PTPRUchr129602268+EPB41chr129379616+0.0017195520.9982805
ENST00000345512ENST00000349460PTPRUchr129602268+EPB41chr129379616+0.0055553640.99444467
ENST00000345512ENST00000373800PTPRUchr129602268+EPB41chr129379616+0.0082134960.99178654
ENST00000345512ENST00000347529PTPRUchr129602268+EPB41chr129379616+0.0090422790.99095774
ENST00000345512ENST00000373798PTPRUchr129602268+EPB41chr129379616+0.0017305040.99826944
ENST00000345512ENST00000373797PTPRUchr129602268+EPB41chr129379616+0.0126123480.9873877
ENST00000373779ENST00000356093PTPRUchr129602268+EPB41chr129379616+0.002296310.99770373
ENST00000373779ENST00000398863PTPRUchr129602268+EPB41chr129379616+0.0030536730.9969463
ENST00000373779ENST00000343067PTPRUchr129602268+EPB41chr129379616+0.0017195520.9982805
ENST00000373779ENST00000349460PTPRUchr129602268+EPB41chr129379616+0.0055553640.99444467
ENST00000373779ENST00000373800PTPRUchr129602268+EPB41chr129379616+0.0082134960.99178654
ENST00000373779ENST00000347529PTPRUchr129602268+EPB41chr129379616+0.0090422790.99095774
ENST00000373779ENST00000373798PTPRUchr129602268+EPB41chr129379616+0.0017305040.99826944
ENST00000373779ENST00000373797PTPRUchr129602268+EPB41chr129379616+0.0126123480.9873877
ENST00000356870ENST00000356093PTPRUchr129602268+EPB41chr129379616+0.0023081860.99769187
ENST00000356870ENST00000398863PTPRUchr129602268+EPB41chr129379616+0.003079320.9969207
ENST00000356870ENST00000343067PTPRUchr129602268+EPB41chr129379616+0.0017313160.9982686
ENST00000356870ENST00000349460PTPRUchr129602268+EPB41chr129379616+0.0056863440.9943137
ENST00000356870ENST00000373800PTPRUchr129602268+EPB41chr129379616+0.0084330460.99156696
ENST00000356870ENST00000347529PTPRUchr129602268+EPB41chr129379616+0.0092834240.9907165
ENST00000356870ENST00000373798PTPRUchr129602268+EPB41chr129379616+0.0017401060.99825984
ENST00000356870ENST00000373797PTPRUchr129602268+EPB41chr129379616+0.0131447060.9868553
ENST00000323874ENST00000356093PTPRUchr129602268+EPB41chr129379616+0.0023081860.99769187
ENST00000323874ENST00000398863PTPRUchr129602268+EPB41chr129379616+0.003079320.9969207
ENST00000323874ENST00000343067PTPRUchr129602268+EPB41chr129379616+0.0017313160.9982686
ENST00000323874ENST00000349460PTPRUchr129602268+EPB41chr129379616+0.0056863440.9943137
ENST00000323874ENST00000373800PTPRUchr129602268+EPB41chr129379616+0.0084330460.99156696
ENST00000323874ENST00000347529PTPRUchr129602268+EPB41chr129379616+0.0092834240.9907165
ENST00000323874ENST00000373798PTPRUchr129602268+EPB41chr129379616+0.0017401060.99825984
ENST00000323874ENST00000373797PTPRUchr129602268+EPB41chr129379616+0.0131447060.9868553
ENST00000428026ENST00000356093PTPRUchr129602268+EPB41chr129379616+0.0022766870.9977233
ENST00000428026ENST00000398863PTPRUchr129602268+EPB41chr129379616+0.0030445090.9969555
ENST00000428026ENST00000343067PTPRUchr129602268+EPB41chr129379616+0.0017032860.9982967
ENST00000428026ENST00000349460PTPRUchr129602268+EPB41chr129379616+0.005561350.99443865
ENST00000428026ENST00000373800PTPRUchr129602268+EPB41chr129379616+0.0082746460.9917253
ENST00000428026ENST00000347529PTPRUchr129602268+EPB41chr129379616+0.009111850.9908881
ENST00000428026ENST00000373798PTPRUchr129602268+EPB41chr129379616+0.0017132910.99828666
ENST00000428026ENST00000373797PTPRUchr129602268+EPB41chr129379616+0.0129497950.9870502
ENST00000460170ENST00000356093PTPRUchr129602268+EPB41chr129379616+0.0021373980.99786264
ENST00000460170ENST00000398863PTPRUchr129602268+EPB41chr129379616+0.0028531050.9971469
ENST00000460170ENST00000343067PTPRUchr129602268+EPB41chr129379616+0.0015888040.9984112
ENST00000460170ENST00000349460PTPRUchr129602268+EPB41chr129379616+0.0050949580.9949051
ENST00000460170ENST00000373800PTPRUchr129602268+EPB41chr129379616+0.0075966610.9924034
ENST00000460170ENST00000347529PTPRUchr129602268+EPB41chr129379616+0.0085112780.9914887
ENST00000460170ENST00000373798PTPRUchr129602268+EPB41chr129379616+0.0015874920.9984125
ENST00000460170ENST00000373797PTPRUchr129602268+EPB41chr129379616+0.0116334980.9883664

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70570_70570_1_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000323874_EPB41_chr1_29379616_ENST00000343067_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_2_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000323874_EPB41_chr1_29379616_ENST00000347529_length(amino acids)=749AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANA
VKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLV

--------------------------------------------------------------

>70570_70570_3_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000323874_EPB41_chr1_29379616_ENST00000349460_length(amino acids)=789AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD
KRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETP

--------------------------------------------------------------

>70570_70570_4_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000323874_EPB41_chr1_29379616_ENST00000356093_length(amino acids)=770AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISET

--------------------------------------------------------------

>70570_70570_5_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000323874_EPB41_chr1_29379616_ENST00000373797_length(amino acids)=659AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD

--------------------------------------------------------------

>70570_70570_6_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000323874_EPB41_chr1_29379616_ENST00000373798_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_7_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000323874_EPB41_chr1_29379616_ENST00000373800_length(amino acids)=736AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDM

--------------------------------------------------------------

>70570_70570_8_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000323874_EPB41_chr1_29379616_ENST00000398863_length(amino acids)=706AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGTDDNSGDLDPGVLLTAQ

--------------------------------------------------------------

>70570_70570_9_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000345512_EPB41_chr1_29379616_ENST00000343067_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_10_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000345512_EPB41_chr1_29379616_ENST00000347529_length(amino acids)=749AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANA
VKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLV

--------------------------------------------------------------

>70570_70570_11_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000345512_EPB41_chr1_29379616_ENST00000349460_length(amino acids)=789AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD
KRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETP

--------------------------------------------------------------

>70570_70570_12_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000345512_EPB41_chr1_29379616_ENST00000356093_length(amino acids)=770AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISET

--------------------------------------------------------------

>70570_70570_13_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000345512_EPB41_chr1_29379616_ENST00000373797_length(amino acids)=659AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD

--------------------------------------------------------------

>70570_70570_14_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000345512_EPB41_chr1_29379616_ENST00000373798_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_15_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000345512_EPB41_chr1_29379616_ENST00000373800_length(amino acids)=736AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDM

--------------------------------------------------------------

>70570_70570_16_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000345512_EPB41_chr1_29379616_ENST00000398863_length(amino acids)=706AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGTDDNSGDLDPGVLLTAQ

--------------------------------------------------------------

>70570_70570_17_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000356870_EPB41_chr1_29379616_ENST00000343067_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_18_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000356870_EPB41_chr1_29379616_ENST00000347529_length(amino acids)=749AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANA
VKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLV

--------------------------------------------------------------

>70570_70570_19_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000356870_EPB41_chr1_29379616_ENST00000349460_length(amino acids)=789AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD
KRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETP

--------------------------------------------------------------

>70570_70570_20_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000356870_EPB41_chr1_29379616_ENST00000356093_length(amino acids)=770AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISET

--------------------------------------------------------------

>70570_70570_21_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000356870_EPB41_chr1_29379616_ENST00000373797_length(amino acids)=659AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD

--------------------------------------------------------------

>70570_70570_22_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000356870_EPB41_chr1_29379616_ENST00000373798_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_23_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000356870_EPB41_chr1_29379616_ENST00000373800_length(amino acids)=736AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDM

--------------------------------------------------------------

>70570_70570_24_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000356870_EPB41_chr1_29379616_ENST00000398863_length(amino acids)=706AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGTDDNSGDLDPGVLLTAQ

--------------------------------------------------------------

>70570_70570_25_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000373779_EPB41_chr1_29379616_ENST00000343067_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_26_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000373779_EPB41_chr1_29379616_ENST00000347529_length(amino acids)=749AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANA
VKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLV

--------------------------------------------------------------

>70570_70570_27_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000373779_EPB41_chr1_29379616_ENST00000349460_length(amino acids)=789AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD
KRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETP

--------------------------------------------------------------

>70570_70570_28_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000373779_EPB41_chr1_29379616_ENST00000356093_length(amino acids)=770AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISET

--------------------------------------------------------------

>70570_70570_29_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000373779_EPB41_chr1_29379616_ENST00000373797_length(amino acids)=659AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD

--------------------------------------------------------------

>70570_70570_30_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000373779_EPB41_chr1_29379616_ENST00000373798_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_31_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000373779_EPB41_chr1_29379616_ENST00000373800_length(amino acids)=736AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDM

--------------------------------------------------------------

>70570_70570_32_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000373779_EPB41_chr1_29379616_ENST00000398863_length(amino acids)=706AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGTDDNSGDLDPGVLLTAQ

--------------------------------------------------------------

>70570_70570_33_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000428026_EPB41_chr1_29379616_ENST00000343067_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_34_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000428026_EPB41_chr1_29379616_ENST00000347529_length(amino acids)=749AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANA
VKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLV

--------------------------------------------------------------

>70570_70570_35_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000428026_EPB41_chr1_29379616_ENST00000349460_length(amino acids)=789AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD
KRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETP

--------------------------------------------------------------

>70570_70570_36_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000428026_EPB41_chr1_29379616_ENST00000356093_length(amino acids)=770AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISET

--------------------------------------------------------------

>70570_70570_37_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000428026_EPB41_chr1_29379616_ENST00000373797_length(amino acids)=659AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD

--------------------------------------------------------------

>70570_70570_38_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000428026_EPB41_chr1_29379616_ENST00000373798_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_39_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000428026_EPB41_chr1_29379616_ENST00000373800_length(amino acids)=736AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDM

--------------------------------------------------------------

>70570_70570_40_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000428026_EPB41_chr1_29379616_ENST00000398863_length(amino acids)=706AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGTDDNSGDLDPGVLLTAQ

--------------------------------------------------------------

>70570_70570_41_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000460170_EPB41_chr1_29379616_ENST00000343067_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_42_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000460170_EPB41_chr1_29379616_ENST00000347529_length(amino acids)=749AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANA
VKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLV

--------------------------------------------------------------

>70570_70570_43_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000460170_EPB41_chr1_29379616_ENST00000349460_length(amino acids)=789AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD
KRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETP

--------------------------------------------------------------

>70570_70570_44_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000460170_EPB41_chr1_29379616_ENST00000356093_length(amino acids)=770AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISET

--------------------------------------------------------------

>70570_70570_45_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000460170_EPB41_chr1_29379616_ENST00000373797_length(amino acids)=659AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWD

--------------------------------------------------------------

>70570_70570_46_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000460170_EPB41_chr1_29379616_ENST00000373798_length(amino acids)=803AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKN
FMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDP

--------------------------------------------------------------

>70570_70570_47_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000460170_EPB41_chr1_29379616_ENST00000373800_length(amino acids)=736AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIP
TGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDM

--------------------------------------------------------------

>70570_70570_48_PTPRU-EPB41_PTPRU_chr1_29602268_ENST00000460170_EPB41_chr1_29379616_ENST00000398863_length(amino acids)=706AA_BP=484
MARAQALVLALTFQLCAPETETPAAGCTFEEASDPAVPCEYSQAQYDDFQWEQVRIHPGTRAPADLPHGSYLMVNTSQHAPGQRAHVIFQ
SLSENDTHCVQFSYFLYSRDGHSPGTLGVYVRVNGGPLGSAVWNMTGSHGRQWHQAELAVSTFWPNEYQVLFEALISPDRRGYMGLDDIL
LLSYPCAKAPHFSRLGDVEVNAGQNASFQCMAAGRAAEAERFLLQRQSGALVPAAGVRHISHRRFLATFPLAAVSRAEQDLYRCVSQAPR
GAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLT
RPGDGGTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTI
KNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDEDAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDE
PPEQAEPEPTEAWKDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGTDDNSGDLDPGVLLTAQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:29563229/chr1:29356911)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EPB41

Q9HCM4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. {ECO:0000269|PubMed:17920587}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+831190_275484.33333333333331447.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+83125_188484.33333333333331447.0DomainMAM
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+831288_383484.33333333333331447.0DomainFibronectin type-III 1
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+831386_484484.33333333333331447.0DomainFibronectin type-III 2
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+830190_275484.33333333333331437.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+83025_188484.33333333333331437.0DomainMAM
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+830288_383484.33333333333331437.0DomainFibronectin type-III 1
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+830386_484484.33333333333331437.0DomainFibronectin type-III 2
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+830190_275484.33333333333331434.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+83025_188484.33333333333331434.0DomainMAM
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+830288_383484.33333333333331434.0DomainFibronectin type-III 1
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+830386_484484.33333333333331434.0DomainFibronectin type-III 2
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+831190_275484.33333333333331441.0DomainNote=Ig-like C2-type
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+83125_188484.33333333333331441.0DomainMAM
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+831288_383484.33333333333331441.0DomainFibronectin type-III 1
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+831386_484484.33333333333331441.0DomainFibronectin type-III 2
TgeneEPB41chr1:29602268chr1:29379616ENST000003430671021615_713545.33333333333341892.3333333333333RegionNote=Spectrin--actin-binding
TgeneEPB41chr1:29602268chr1:29379616ENST000003430671021714_864545.33333333333341892.3333333333333RegionNote=C-terminal (CTD)
TgeneEPB41chr1:29602268chr1:29379616ENST00000347529917615_713510.3333333333333861.6666666666666RegionNote=Spectrin--actin-binding
TgeneEPB41chr1:29602268chr1:29379616ENST00000347529917714_864510.3333333333333861.6666666666666RegionNote=C-terminal (CTD)
TgeneEPB41chr1:29602268chr1:29379616ENST000003494601121494_614336.3333333333333711.6666666666666RegionNote=Hydrophilic
TgeneEPB41chr1:29602268chr1:29379616ENST000003494601121615_713336.3333333333333711.6666666666666RegionNote=Spectrin--actin-binding
TgeneEPB41chr1:29602268chr1:29379616ENST000003494601121714_864336.3333333333333711.6666666666666RegionNote=C-terminal (CTD)
TgeneEPB41chr1:29602268chr1:29379616ENST000003560931019615_713545.33333333333341859.3333333333333RegionNote=Spectrin--actin-binding
TgeneEPB41chr1:29602268chr1:29379616ENST000003560931019714_864545.33333333333341859.3333333333333RegionNote=C-terminal (CTD)
TgeneEPB41chr1:29602268chr1:29379616ENST000003737971015615_713545.3333333333334721.0RegionNote=Spectrin--actin-binding
TgeneEPB41chr1:29602268chr1:29379616ENST000003737971015714_864545.3333333333334721.0RegionNote=C-terminal (CTD)
TgeneEPB41chr1:29602268chr1:29379616ENST000003737981021615_713545.33333333333341907.0RegionNote=Spectrin--actin-binding
TgeneEPB41chr1:29602268chr1:29379616ENST000003737981021714_864545.33333333333341907.0RegionNote=C-terminal (CTD)
TgeneEPB41chr1:29602268chr1:29379616ENST000003738001119494_614336.3333333333333658.6666666666666RegionNote=Hydrophilic
TgeneEPB41chr1:29602268chr1:29379616ENST000003738001119615_713336.3333333333333658.6666666666666RegionNote=Spectrin--actin-binding
TgeneEPB41chr1:29602268chr1:29379616ENST000003738001119714_864336.3333333333333658.6666666666666RegionNote=C-terminal (CTD)

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+8311176_1439484.33333333333331447.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+831485_591484.33333333333331447.0DomainFibronectin type-III 3
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+831592_674484.33333333333331447.0DomainFibronectin type-III 4
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+831888_1144484.33333333333331447.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+8301176_1439484.33333333333331437.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+830485_591484.33333333333331437.0DomainFibronectin type-III 3
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+830592_674484.33333333333331437.0DomainFibronectin type-III 4
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+830888_1144484.33333333333331437.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+8301176_1439484.33333333333331434.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+830485_591484.33333333333331434.0DomainFibronectin type-III 3
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+830592_674484.33333333333331434.0DomainFibronectin type-III 4
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+830888_1144484.33333333333331434.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+8311176_1439484.33333333333331441.0DomainTyrosine-protein phosphatase 2
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+831485_591484.33333333333331441.0DomainFibronectin type-III 3
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+831592_674484.33333333333331441.0DomainFibronectin type-III 4
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+831888_1144484.33333333333331441.0DomainTyrosine-protein phosphatase 1
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+8311085_1091484.33333333333331447.0RegionSubstrate binding
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+8301085_1091484.33333333333331437.0RegionSubstrate binding
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+8301085_1091484.33333333333331434.0RegionSubstrate binding
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+8311085_1091484.33333333333331441.0RegionSubstrate binding
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+83119_749484.33333333333331447.0Topological domainExtracellular
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+831771_1446484.33333333333331447.0Topological domainCytoplasmic
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+83019_749484.33333333333331437.0Topological domainExtracellular
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+830771_1446484.33333333333331437.0Topological domainCytoplasmic
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+83019_749484.33333333333331434.0Topological domainExtracellular
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+830771_1446484.33333333333331434.0Topological domainCytoplasmic
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+83119_749484.33333333333331441.0Topological domainExtracellular
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+831771_1446484.33333333333331441.0Topological domainCytoplasmic
HgenePTPRUchr1:29602268chr1:29379616ENST00000345512+831750_770484.33333333333331447.0TransmembraneHelical
HgenePTPRUchr1:29602268chr1:29379616ENST00000373779+830750_770484.33333333333331437.0TransmembraneHelical
HgenePTPRUchr1:29602268chr1:29379616ENST00000428026+830750_770484.33333333333331434.0TransmembraneHelical
HgenePTPRUchr1:29602268chr1:29379616ENST00000460170+831750_770484.33333333333331441.0TransmembraneHelical
TgeneEPB41chr1:29602268chr1:29379616ENST000003430671021210_491545.33333333333341892.3333333333333DomainFERM
TgeneEPB41chr1:29602268chr1:29379616ENST00000347529917210_491510.3333333333333861.6666666666666DomainFERM
TgeneEPB41chr1:29602268chr1:29379616ENST000003494601121210_491336.3333333333333711.6666666666666DomainFERM
TgeneEPB41chr1:29602268chr1:29379616ENST000003560931019210_491545.33333333333341859.3333333333333DomainFERM
TgeneEPB41chr1:29602268chr1:29379616ENST000003737971015210_491545.3333333333334721.0DomainFERM
TgeneEPB41chr1:29602268chr1:29379616ENST000003737981021210_491545.33333333333341907.0DomainFERM
TgeneEPB41chr1:29602268chr1:29379616ENST000003738001119210_491336.3333333333333658.6666666666666DomainFERM
TgeneEPB41chr1:29602268chr1:29379616ENST000003430671021494_614545.33333333333341892.3333333333333RegionNote=Hydrophilic
TgeneEPB41chr1:29602268chr1:29379616ENST00000347529917494_614510.3333333333333861.6666666666666RegionNote=Hydrophilic
TgeneEPB41chr1:29602268chr1:29379616ENST000003560931019494_614545.33333333333341859.3333333333333RegionNote=Hydrophilic
TgeneEPB41chr1:29602268chr1:29379616ENST000003737971015494_614545.3333333333334721.0RegionNote=Hydrophilic
TgeneEPB41chr1:29602268chr1:29379616ENST000003737981021494_614545.33333333333341907.0RegionNote=Hydrophilic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PTPRU
EPB41


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to PTPRU-EPB41


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PTPRU-EPB41


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource