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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PUM2-C2orf43

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PUM2-C2orf43
FusionPDB ID: 70697
FusionGDB2.0 ID: 70697
HgeneTgene
Gene symbol

PUM2

C2orf43

Gene ID

23369

60526

Gene namepumilio RNA binding family member 2lipid droplet associated hydrolase
SynonymsPUMH2|PUML2C2orf43|hLDAH
Cytomap

2p24.1

2p24.1

Type of geneprotein-codingprotein-coding
Descriptionpumilio homolog 2pumilio-2lipid droplet-associated hydrolaseUPF0554 protein C2orf43lipid droplet-associated serine hydrolase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000338086, ENST00000361078, 
ENST00000403432, ENST00000536417, 
ENST00000319801, ENST00000420234, 
ENST00000440866, ENST00000541941, 
ENST00000237822, ENST00000419825, 
ENST00000435420, ENST00000381090, 
ENST00000403006, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 15 X 8=18001 X 2 X 2=4
# samples 182
** MAII scorelog2(18/1800*10)=-3.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/4*10)=2.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: PUM2 [Title/Abstract] AND C2orf43 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PUM2(20478344)-C2orf43(20886854), # samples:2
Anticipated loss of major functional domain due to fusion event.PUM2-C2orf43 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PUM2-C2orf43 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PUM2-C2orf43 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PUM2-C2orf43 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PUM2-C2orf43 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgenePUM2

GO:0010608

posttranscriptional regulation of gene expression

25100735

HgenePUM2

GO:0043488

regulation of mRNA stability

26724866

HgenePUM2

GO:0051983

regulation of chromosome segregation

26724866

HgenePUM2

GO:1900246

positive regulation of RIG-I signaling pathway

25340845


check buttonFusion gene breakpoints across PUM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C2orf43 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-14-0789-01APUM2chr2

20490413

-C2orf43chr2

20884683

-
ChimerDB4LUSCTCGA-77-A5GH-01APUM2chr2

20478344

-C2orf43chr2

20886854

-
ChimerDB4LUSCTCGA-77-A5GHPUM2chr2

20478344

-C2orf43chr2

20886854

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000338086PUM2chr220478344-ENST00000435420C2orf43chr220886854-24501980232032669
ENST00000361078PUM2chr220478344-ENST00000435420C2orf43chr220886854-24501980232032669
ENST00000536417PUM2chr220478344-ENST00000403006C2orf43chr220886854-308618911021943613
ENST00000536417PUM2chr220478344-ENST00000381090C2orf43chr220886854-307018911021943613
ENST00000536417PUM2chr220478344-ENST00000237822C2orf43chr220886854-392818911021943613
ENST00000403432PUM2chr220478344-ENST00000403006C2orf43chr220886854-327620811242133669
ENST00000403432PUM2chr220478344-ENST00000381090C2orf43chr220886854-326020811242133669
ENST00000403432PUM2chr220478344-ENST00000237822C2orf43chr220886854-411820811242133669
ENST00000338086PUM2chr220490413-ENST00000403006C2orf43chr220884683-22101314231507494
ENST00000319801PUM2chr220490413-ENST00000403006C2orf43chr220884683-22101314231507494
ENST00000361078PUM2chr220490413-ENST00000403006C2orf43chr220884683-22101314231507494
ENST00000536417PUM2chr220490413-ENST00000381090C2orf43chr220884683-210512251021418438
ENST00000403432PUM2chr220490413-ENST00000381090C2orf43chr220884683-229514151241608494

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000338086ENST00000435420PUM2chr220478344-C2orf43chr220886854-0.0068396560.99316037
ENST00000361078ENST00000435420PUM2chr220478344-C2orf43chr220886854-0.0068396560.99316037
ENST00000536417ENST00000403006PUM2chr220478344-C2orf43chr220886854-0.0048335120.99516654
ENST00000536417ENST00000381090PUM2chr220478344-C2orf43chr220886854-0.0049511470.9950488
ENST00000536417ENST00000237822PUM2chr220478344-C2orf43chr220886854-0.00379590.9962041
ENST00000403432ENST00000403006PUM2chr220478344-C2orf43chr220886854-0.0051671990.99483275
ENST00000403432ENST00000381090PUM2chr220478344-C2orf43chr220886854-0.0053518820.99464816
ENST00000403432ENST00000237822PUM2chr220478344-C2orf43chr220886854-0.0042162650.9957838
ENST00000338086ENST00000403006PUM2chr220490413-C2orf43chr220884683-0.0023367360.99766326
ENST00000319801ENST00000403006PUM2chr220490413-C2orf43chr220884683-0.0023367360.99766326
ENST00000361078ENST00000403006PUM2chr220490413-C2orf43chr220884683-0.0023367360.99766326
ENST00000536417ENST00000381090PUM2chr220490413-C2orf43chr220884683-0.0055938310.9944062
ENST00000403432ENST00000381090PUM2chr220490413-C2orf43chr220884683-0.002775930.9972241

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>70697_70697_1_PUM2-C2orf43_PUM2_chr2_20478344_ENST00000338086_C2orf43_chr2_20886854_ENST00000435420_length(amino acids)=669AA_BP=652
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVG
PGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFS
HGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQT

--------------------------------------------------------------

>70697_70697_2_PUM2-C2orf43_PUM2_chr2_20478344_ENST00000361078_C2orf43_chr2_20886854_ENST00000435420_length(amino acids)=669AA_BP=652
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVG
PGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFS
HGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQT

--------------------------------------------------------------

>70697_70697_3_PUM2-C2orf43_PUM2_chr2_20478344_ENST00000403432_C2orf43_chr2_20886854_ENST00000237822_length(amino acids)=669AA_BP=652
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVG
PGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFS
HGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQT

--------------------------------------------------------------

>70697_70697_4_PUM2-C2orf43_PUM2_chr2_20478344_ENST00000403432_C2orf43_chr2_20886854_ENST00000381090_length(amino acids)=669AA_BP=652
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVG
PGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFS
HGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQT

--------------------------------------------------------------

>70697_70697_5_PUM2-C2orf43_PUM2_chr2_20478344_ENST00000403432_C2orf43_chr2_20886854_ENST00000403006_length(amino acids)=669AA_BP=652
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVG
PGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQPPQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFS
HGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQT

--------------------------------------------------------------

>70697_70697_6_PUM2-C2orf43_PUM2_chr2_20478344_ENST00000536417_C2orf43_chr2_20886854_ENST00000237822_length(amino acids)=613AA_BP=596
MSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDL
KQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQ
FDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTA
AGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAAN
PTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQP
PQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYK

--------------------------------------------------------------

>70697_70697_7_PUM2-C2orf43_PUM2_chr2_20478344_ENST00000536417_C2orf43_chr2_20886854_ENST00000381090_length(amino acids)=613AA_BP=596
MSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDL
KQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQ
FDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTA
AGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAAN
PTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQP
PQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYK

--------------------------------------------------------------

>70697_70697_8_PUM2-C2orf43_PUM2_chr2_20478344_ENST00000536417_C2orf43_chr2_20886854_ENST00000403006_length(amino acids)=613AA_BP=596
MSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDL
KQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQ
FDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTA
AGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAAN
PTLAFGQGLATGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSAAAQAAAAAAAGGTASSLTGSTNGLFRPIGTQP
PQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSTSLGFGSGNSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYK

--------------------------------------------------------------

>70697_70697_9_PUM2-C2orf43_PUM2_chr2_20490413_ENST00000319801_C2orf43_chr2_20884683_ENST00000403006_length(amino acids)=494AA_BP=430
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGGRIRFQETEVHSVSLGIRL

--------------------------------------------------------------

>70697_70697_10_PUM2-C2orf43_PUM2_chr2_20490413_ENST00000338086_C2orf43_chr2_20884683_ENST00000403006_length(amino acids)=494AA_BP=430
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGGRIRFQETEVHSVSLGIRL

--------------------------------------------------------------

>70697_70697_11_PUM2-C2orf43_PUM2_chr2_20490413_ENST00000361078_C2orf43_chr2_20884683_ENST00000403006_length(amino acids)=494AA_BP=430
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGGRIRFQETEVHSVSLGIRL

--------------------------------------------------------------

>70697_70697_12_PUM2-C2orf43_PUM2_chr2_20490413_ENST00000403432_C2orf43_chr2_20884683_ENST00000381090_length(amino acids)=494AA_BP=430
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGASHHSMSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGL
GVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQ
ASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNA
LTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQ
QAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAANPTLAFGQGLATGMPGGRIRFQETEVHSVSLGIRL

--------------------------------------------------------------

>70697_70697_13_PUM2-C2orf43_PUM2_chr2_20490413_ENST00000536417_C2orf43_chr2_20884683_ENST00000381090_length(amino acids)=438AA_BP=374
MSQPIMVQRRSGQGFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGNFGTRDAETDGPEKGDQKGKASPFEEDQNRDL
KQGDDDDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPNTNPSEGLGPLPNPTANKPLVEEFSNPETQNLDAMEQVGLESLQ
FDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTNALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTA
AGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAANNTASQQAASQAQPGQQQVLRAGAGQRPLTPNQGQQGQQAESLAAAAAAN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:20478344/chr2:20886854)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220278_488652.33333333333341065.0Compositional biasNote=Ala-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220359_405652.33333333333341065.0Compositional biasNote=Gln-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220278_488652.33333333333341067.0Compositional biasNote=Ala-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220359_405652.33333333333341067.0Compositional biasNote=Gln-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321278_488652.33333333333341065.0Compositional biasNote=Ala-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321359_405652.33333333333341065.0Compositional biasNote=Gln-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919359_405430.3333333333333988.0Compositional biasNote=Gln-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920359_405430.33333333333331065.0Compositional biasNote=Gln-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920359_405430.33333333333331067.0Compositional biasNote=Gln-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021359_405430.33333333333331065.0Compositional biasNote=Gln-rich

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119278_4880988.0Compositional biasNote=Ala-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119359_4050988.0Compositional biasNote=Gln-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119520_6870988.0Compositional biasNote=Ser-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220520_687652.33333333333341065.0Compositional biasNote=Ser-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220520_687652.33333333333341067.0Compositional biasNote=Ser-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321520_687652.33333333333341065.0Compositional biasNote=Ser-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919278_488430.3333333333333988.0Compositional biasNote=Ala-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919520_687430.3333333333333988.0Compositional biasNote=Ser-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920278_488430.33333333333331065.0Compositional biasNote=Ala-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920520_687430.33333333333331065.0Compositional biasNote=Ser-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920278_488430.33333333333331067.0Compositional biasNote=Ala-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920520_687430.33333333333331067.0Compositional biasNote=Ser-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021278_488430.33333333333331065.0Compositional biasNote=Ala-rich
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021520_687430.33333333333331065.0Compositional biasNote=Ser-rich
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119706_10480988.0DomainPUM-HD
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220706_1048652.33333333333341065.0DomainPUM-HD
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220706_1048652.33333333333341067.0DomainPUM-HD
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321706_1048652.33333333333341065.0DomainPUM-HD
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919706_1048430.3333333333333988.0DomainPUM-HD
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920706_1048430.33333333333331065.0DomainPUM-HD
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920706_1048430.33333333333331067.0DomainPUM-HD
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021706_1048430.33333333333331065.0DomainPUM-HD
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-1191002_10060988.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119741_7450988.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119777_7810988.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119813_8170988.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119851_8550988.0RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119887_8910988.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119923_9270988.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119959_9630988.0RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-12201002_1006652.33333333333341065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220741_745652.33333333333341065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220777_781652.33333333333341065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220813_817652.33333333333341065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220851_855652.33333333333341065.0RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220887_891652.33333333333341065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220923_927652.33333333333341065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220959_963652.33333333333341065.0RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-12201002_1006652.33333333333341067.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220741_745652.33333333333341067.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220777_781652.33333333333341067.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220813_817652.33333333333341067.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220851_855652.33333333333341067.0RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220887_891652.33333333333341067.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220923_927652.33333333333341067.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220959_963652.33333333333341067.0RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-13211002_1006652.33333333333341065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321741_745652.33333333333341065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321777_781652.33333333333341065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321813_817652.33333333333341065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321851_855652.33333333333341065.0RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321887_891652.33333333333341065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321923_927652.33333333333341065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321959_963652.33333333333341065.0RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-9191002_1006430.3333333333333988.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919741_745430.3333333333333988.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919777_781430.3333333333333988.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919813_817430.3333333333333988.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919851_855430.3333333333333988.0RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919887_891430.3333333333333988.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919923_927430.3333333333333988.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919959_963430.3333333333333988.0RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-9201002_1006430.33333333333331065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920741_745430.33333333333331065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920777_781430.33333333333331065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920813_817430.33333333333331065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920851_855430.33333333333331065.0RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920887_891430.33333333333331065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920923_927430.33333333333331065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920959_963430.33333333333331065.0RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-9201002_1006430.33333333333331067.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920741_745430.33333333333331067.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920777_781430.33333333333331067.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920813_817430.33333333333331067.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920851_855430.33333333333331067.0RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920887_891430.33333333333331067.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920923_927430.33333333333331067.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920959_963430.33333333333331067.0RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-10211002_1006430.33333333333331065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021741_745430.33333333333331065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021777_781430.33333333333331065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021813_817430.33333333333331065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021851_855430.33333333333331065.0RegionNon-specific-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021887_891430.33333333333331065.0RegionAdenine-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021923_927430.33333333333331065.0RegionUracil-nucleotide binding in RNA target
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021959_963430.33333333333331065.0RegionGuanine-nucleotide binding in RNA target
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119726_7610988.0RepeatPumilio 1
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119762_7970988.0RepeatPumilio 2
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119798_8350988.0RepeatPumilio 3
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119836_8710988.0RepeatPumilio 4
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119872_9070988.0RepeatPumilio 5
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119908_9430988.0RepeatPumilio 6
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119944_9790988.0RepeatPumilio 7
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-119983_10220988.0RepeatPumilio 8
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220726_761652.33333333333341065.0RepeatPumilio 1
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220762_797652.33333333333341065.0RepeatPumilio 2
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220798_835652.33333333333341065.0RepeatPumilio 3
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220836_871652.33333333333341065.0RepeatPumilio 4
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220872_907652.33333333333341065.0RepeatPumilio 5
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220908_943652.33333333333341065.0RepeatPumilio 6
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220944_979652.33333333333341065.0RepeatPumilio 7
HgenePUM2chr2:20478344chr2:20886854ENST00000338086-1220983_1022652.33333333333341065.0RepeatPumilio 8
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220726_761652.33333333333341067.0RepeatPumilio 1
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220762_797652.33333333333341067.0RepeatPumilio 2
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220798_835652.33333333333341067.0RepeatPumilio 3
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220836_871652.33333333333341067.0RepeatPumilio 4
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220872_907652.33333333333341067.0RepeatPumilio 5
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220908_943652.33333333333341067.0RepeatPumilio 6
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220944_979652.33333333333341067.0RepeatPumilio 7
HgenePUM2chr2:20478344chr2:20886854ENST00000361078-1220983_1022652.33333333333341067.0RepeatPumilio 8
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321726_761652.33333333333341065.0RepeatPumilio 1
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321762_797652.33333333333341065.0RepeatPumilio 2
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321798_835652.33333333333341065.0RepeatPumilio 3
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321836_871652.33333333333341065.0RepeatPumilio 4
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321872_907652.33333333333341065.0RepeatPumilio 5
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321908_943652.33333333333341065.0RepeatPumilio 6
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321944_979652.33333333333341065.0RepeatPumilio 7
HgenePUM2chr2:20478344chr2:20886854ENST00000403432-1321983_1022652.33333333333341065.0RepeatPumilio 8
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919726_761430.3333333333333988.0RepeatPumilio 1
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919762_797430.3333333333333988.0RepeatPumilio 2
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919798_835430.3333333333333988.0RepeatPumilio 3
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919836_871430.3333333333333988.0RepeatPumilio 4
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919872_907430.3333333333333988.0RepeatPumilio 5
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919908_943430.3333333333333988.0RepeatPumilio 6
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919944_979430.3333333333333988.0RepeatPumilio 7
HgenePUM2chr2:20490413chr2:20884683ENST00000319801-919983_1022430.3333333333333988.0RepeatPumilio 8
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920726_761430.33333333333331065.0RepeatPumilio 1
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920762_797430.33333333333331065.0RepeatPumilio 2
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920798_835430.33333333333331065.0RepeatPumilio 3
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920836_871430.33333333333331065.0RepeatPumilio 4
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920872_907430.33333333333331065.0RepeatPumilio 5
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920908_943430.33333333333331065.0RepeatPumilio 6
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920944_979430.33333333333331065.0RepeatPumilio 7
HgenePUM2chr2:20490413chr2:20884683ENST00000338086-920983_1022430.33333333333331065.0RepeatPumilio 8
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920726_761430.33333333333331067.0RepeatPumilio 1
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920762_797430.33333333333331067.0RepeatPumilio 2
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920798_835430.33333333333331067.0RepeatPumilio 3
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920836_871430.33333333333331067.0RepeatPumilio 4
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920872_907430.33333333333331067.0RepeatPumilio 5
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920908_943430.33333333333331067.0RepeatPumilio 6
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920944_979430.33333333333331067.0RepeatPumilio 7
HgenePUM2chr2:20490413chr2:20884683ENST00000361078-920983_1022430.33333333333331067.0RepeatPumilio 8
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021726_761430.33333333333331065.0RepeatPumilio 1
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021762_797430.33333333333331065.0RepeatPumilio 2
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021798_835430.33333333333331065.0RepeatPumilio 3
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021836_871430.33333333333331065.0RepeatPumilio 4
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021872_907430.33333333333331065.0RepeatPumilio 5
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021908_943430.33333333333331065.0RepeatPumilio 6
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021944_979430.33333333333331065.0RepeatPumilio 7
HgenePUM2chr2:20490413chr2:20884683ENST00000403432-1021983_1022430.33333333333331065.0RepeatPumilio 8


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PUM2_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PUM2
C2orf43


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePUM2chr2:20478344chr2:20886854ENST00000319801-1191_2600988.0SNAPIN


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Related Drugs to PUM2-C2orf43


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PUM2-C2orf43


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource