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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ASH2L-MGME1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ASH2L-MGME1
FusionPDB ID: 7131
FusionGDB2.0 ID: 7131
HgeneTgene
Gene symbol

ASH2L

MGME1

Gene ID

9070

92667

Gene nameASH2 like, histone lysine methyltransferase complex subunitmitochondrial genome maintenance exonuclease 1
SynonymsASH2|ASH2L1|ASH2L2|Bre2C20orf72|DDK1|MTDPS11|bA504H3.4
Cytomap

8p11.23

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionset1/Ash2 histone methyltransferase complex subunit ASH2ASH2-like proteinash2 (absent, small, or homeotic)-likemitochondrial genome maintenance exonuclease 1
Modification date2020031320200313
UniProtAcc

Q9UBL3

Q9BQP7

Ensembl transtripts involved in fusion geneENST idsENST00000524263, ENST00000250635, 
ENST00000343823, ENST00000428278, 
ENST00000521652, ENST00000545394, 
ENST00000377704, ENST00000377709, 
ENST00000377710, ENST00000467391, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 10 X 6=7806 X 5 X 4=120
# samples 147
** MAII scorelog2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ASH2L [Title/Abstract] AND MGME1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ASH2L(37971805)-MGME1(17968809), # samples:3
Anticipated loss of major functional domain due to fusion event.ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASH2L

GO:0006974

cellular response to DNA damage stimulus

17500065

HgeneASH2L

GO:0043627

response to estrogen

16603732

HgeneASH2L

GO:0051568

histone H3-K4 methylation

17355966|19556245


check buttonFusion gene breakpoints across ASH2L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MGME1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A15A-01AASH2Lchr8

37968351

+MGME1chr20

17968809

+
ChimerDB4BRCATCGA-E2-A15A-01AASH2Lchr8

37968351

+MGME1chr20

17970582

+
ChimerDB4BRCATCGA-E2-A15A-01AASH2Lchr8

37971805

+MGME1chr20

17968809

+
ChimerDB4BRCATCGA-E2-A15A-01AASH2Lchr8

37971805

+MGME1chr20

17970582

+
ChimerDB4BRCATCGA-E2-A15A-06AASH2Lchr8

37968351

+MGME1chr20

17970582

+
ChimerDB4BRCATCGA-E2-A15A-06AASH2Lchr8

37971805

+MGME1chr20

17968809

+
ChimerDB4BRCATCGA-E2-A15A-06AASH2Lchr8

37971805

+MGME1chr20

17970582

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343823ASH2Lchr837968351+ENST00000377704MGME1chr2017970582+20788943091064251
ENST00000250635ASH2Lchr837968351+ENST00000377704MGME1chr2017970582+182764358813251
ENST00000545394ASH2Lchr837968351+ENST00000377704MGME1chr2017970582+16244401366121
ENST00000428278ASH2Lchr837968351+ENST00000377704MGME1chr2017970582+1928744357914185
ENST00000521652ASH2Lchr837968351+ENST00000377704MGME1chr2017970582+1782598211768185
ENST00000343823ASH2Lchr837971805+ENST00000377704MGME1chr2017970582+21749903091160283
ENST00000250635ASH2Lchr837971805+ENST00000377704MGME1chr2017970582+192373958909283
ENST00000545394ASH2Lchr837971805+ENST00000377704MGME1chr2017970582+1720536272706144
ENST00000428278ASH2Lchr837971805+ENST00000377704MGME1chr2017970582+20248403571010217
ENST00000521652ASH2Lchr837971805+ENST00000377704MGME1chr2017970582+1878694211864217

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343823ENST00000377704ASH2Lchr837968351+MGME1chr2017970582+0.0047731990.99522674
ENST00000250635ENST00000377704ASH2Lchr837968351+MGME1chr2017970582+0.0041301940.9958698
ENST00000545394ENST00000377704ASH2Lchr837968351+MGME1chr2017970582+0.0104250070.98957497
ENST00000428278ENST00000377704ASH2Lchr837968351+MGME1chr2017970582+0.025954740.9740452
ENST00000521652ENST00000377704ASH2Lchr837968351+MGME1chr2017970582+0.0470970050.952903
ENST00000343823ENST00000377704ASH2Lchr837971805+MGME1chr2017970582+0.0016524840.9983475
ENST00000250635ENST00000377704ASH2Lchr837971805+MGME1chr2017970582+0.0017173020.9982827
ENST00000545394ENST00000377704ASH2Lchr837971805+MGME1chr2017970582+0.0150294580.98497057
ENST00000428278ENST00000377704ASH2Lchr837971805+MGME1chr2017970582+0.0103314830.98966855
ENST00000521652ENST00000377704ASH2Lchr837971805+MGME1chr2017970582+0.0093228630.9906771

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7131_7131_1_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000250635_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=251AA_BP=195
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS

--------------------------------------------------------------

>7131_7131_2_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000343823_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=251AA_BP=195
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS

--------------------------------------------------------------

>7131_7131_3_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000428278_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=185AA_BP=129
MVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNT
YFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKKKNQNIQK

--------------------------------------------------------------

>7131_7131_4_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000521652_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=185AA_BP=129
MVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNT
YFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKKKNQNIQK

--------------------------------------------------------------

>7131_7131_5_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000545394_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=121AA_BP=
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLILSTF

--------------------------------------------------------------

>7131_7131_6_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000250635_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=283AA_BP=227
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEK

--------------------------------------------------------------

>7131_7131_7_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000343823_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=283AA_BP=227
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEK

--------------------------------------------------------------

>7131_7131_8_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000428278_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=217AA_BP=161
MVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNT
YFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQCGLIVVAYKDGSPAHPH

--------------------------------------------------------------

>7131_7131_9_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000521652_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=217AA_BP=161
MVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNT
YFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQCGLIVVAYKDGSPAHPH

--------------------------------------------------------------

>7131_7131_10_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000545394_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=144AA_BP=88
MTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:37971805/chr20:17968809)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASH2L

Q9UBL3

MGME1

Q9BQP7

FUNCTION: Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells. {ECO:0000255|HAMAP-Rule:MF_03030, ECO:0000269|PubMed:23313956, ECO:0000269|PubMed:23358826}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASH2Lchr8:37968351chr20:17970582ENST00000343823+51667_177195.0629.0RegionNote=DNA-binding
HgeneASH2Lchr8:37971805chr20:17970582ENST00000343823+61667_177227.0629.0RegionNote=DNA-binding
HgeneASH2Lchr8:37968351chr20:17970582ENST00000250635+5151_66101.0502.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37968351chr20:17970582ENST00000343823+516117_150195.0629.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37968351chr20:17970582ENST00000343823+5161_66195.0629.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37968351chr20:17970582ENST00000428278+5161_66101.0535.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37968351chr20:17970582ENST00000521652+5151_66101.0502.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37971805chr20:17970582ENST00000250635+6151_66133.0502.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37971805chr20:17970582ENST00000343823+616117_150227.0629.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37971805chr20:17970582ENST00000343823+6161_66227.0629.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37971805chr20:17970582ENST00000428278+6161_66133.0535.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37971805chr20:17970582ENST00000521652+6151_66133.0502.0Zinc fingerNote=PHD-type%3B atypical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASH2Lchr8:37968351chr20:17970582ENST00000250635+515360_583101.0502.0DomainB30.2/SPRY
HgeneASH2Lchr8:37968351chr20:17970582ENST00000343823+516360_583195.0629.0DomainB30.2/SPRY
HgeneASH2Lchr8:37968351chr20:17970582ENST00000428278+516360_583101.0535.0DomainB30.2/SPRY
HgeneASH2Lchr8:37968351chr20:17970582ENST00000521652+515360_583101.0502.0DomainB30.2/SPRY
HgeneASH2Lchr8:37971805chr20:17970582ENST00000250635+615360_583133.0502.0DomainB30.2/SPRY
HgeneASH2Lchr8:37971805chr20:17970582ENST00000343823+616360_583227.0629.0DomainB30.2/SPRY
HgeneASH2Lchr8:37971805chr20:17970582ENST00000428278+616360_583133.0535.0DomainB30.2/SPRY
HgeneASH2Lchr8:37971805chr20:17970582ENST00000521652+615360_583133.0502.0DomainB30.2/SPRY
HgeneASH2Lchr8:37968351chr20:17970582ENST00000250635+51567_177101.0502.0RegionNote=DNA-binding
HgeneASH2Lchr8:37968351chr20:17970582ENST00000428278+51667_177101.0535.0RegionNote=DNA-binding
HgeneASH2Lchr8:37968351chr20:17970582ENST00000521652+51567_177101.0502.0RegionNote=DNA-binding
HgeneASH2Lchr8:37971805chr20:17970582ENST00000250635+61567_177133.0502.0RegionNote=DNA-binding
HgeneASH2Lchr8:37971805chr20:17970582ENST00000428278+61667_177133.0535.0RegionNote=DNA-binding
HgeneASH2Lchr8:37971805chr20:17970582ENST00000521652+61567_177133.0502.0RegionNote=DNA-binding
HgeneASH2Lchr8:37968351chr20:17970582ENST00000250635+515117_150101.0502.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37968351chr20:17970582ENST00000428278+516117_150101.0535.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37968351chr20:17970582ENST00000521652+515117_150101.0502.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37971805chr20:17970582ENST00000250635+615117_150133.0502.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37971805chr20:17970582ENST00000428278+616117_150133.0535.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37971805chr20:17970582ENST00000521652+615117_150133.0502.0Zinc fingerNote=C4-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>490_ASH2L_37971805_MGME1_17970582_ranked_0.pdbASH2L3797180537971805ENST00000377704MGME1chr2017970582+
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEK
283


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ASH2L_pLDDT.png
all structure
all structure
MGME1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ASH2L
MGME1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneASH2Lchr8:37968351chr20:17970582ENST00000250635+515316_628101.0502.0RBBP5
HgeneASH2Lchr8:37968351chr20:17970582ENST00000343823+516316_628195.0629.0RBBP5
HgeneASH2Lchr8:37968351chr20:17970582ENST00000428278+516316_628101.0535.0RBBP5
HgeneASH2Lchr8:37968351chr20:17970582ENST00000521652+515316_628101.0502.0RBBP5
HgeneASH2Lchr8:37971805chr20:17970582ENST00000250635+615316_628133.0502.0RBBP5
HgeneASH2Lchr8:37971805chr20:17970582ENST00000343823+616316_628227.0629.0RBBP5
HgeneASH2Lchr8:37971805chr20:17970582ENST00000428278+616316_628133.0535.0RBBP5
HgeneASH2Lchr8:37971805chr20:17970582ENST00000521652+615316_628133.0502.0RBBP5


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Related Drugs to ASH2L-MGME1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ASH2L-MGME1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource