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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RAC1-CKAP5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RAC1-CKAP5
FusionPDB ID: 71616
FusionGDB2.0 ID: 71616
HgeneTgene
Gene symbol

RAC1

CKAP5

Gene ID

6035

9793

Gene nameribonuclease A family member 1, pancreaticcytoskeleton associated protein 5
SynonymsRAC1|RIB1|RNS1CHTOG|MSPS|TOG|TOGp|ch-TOG
Cytomap

14q11.2

11p11.2

Type of geneprotein-codingprotein-coding
Descriptionribonuclease pancreaticHP-RNaseRIB-1RNase 1RNase ARNase upI-1ribonuclease 1ribonuclease A C1ribonuclease, RNase A family, 1 (pancreatic)cytoskeleton-associated protein 5colonic and hepatic tumor over-expressed gene proteincolonic and hepatic tumor overexpressed gene protein
Modification date2020031320200313
UniProtAcc.

Q14008

Ensembl transtripts involved in fusion geneENST idsENST00000488373, ENST00000348035, 
ENST00000356142, 		ENST00000312055, 
ENST00000354558, ENST00000415402, 
ENST00000529230, ENST00000532321, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 12 X 6=136812 X 11 X 5=660
# samples 1913
** MAII scorelog2(19/1368*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/660*10)=-2.34395440121736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RAC1 [Title/Abstract] AND CKAP5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RAC1(6431672)-CKAP5(46792532), # samples:1
Anticipated loss of major functional domain due to fusion event.RAC1-CKAP5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAC1-CKAP5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAC1-CKAP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAC1-CKAP5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAC1

GO:0051607

defense response to virus

9826755

HgeneRAC1

GO:0090501

RNA phosphodiester bond hydrolysis

9826755

TgeneCKAP5

GO:0090063

positive regulation of microtubule nucleation

26414402


check buttonFusion gene breakpoints across RAC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CKAP5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-A486-01ARAC1chr7

6431672

+CKAP5chr11

46792532

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000348035RAC1chr76431672+ENST00000529230CKAP5chr1146792532-45214381235451177
ENST00000348035RAC1chr76431672+ENST00000415402CKAP5chr1146792532-40544381235661184
ENST00000348035RAC1chr76431672+ENST00000312055CKAP5chr1146792532-38534381233651117
ENST00000348035RAC1chr76431672+ENST00000354558CKAP5chr1146792532-38494381233651117
ENST00000356142RAC1chr76431672+ENST00000529230CKAP5chr1146792532-45054221435291171
ENST00000356142RAC1chr76431672+ENST00000415402CKAP5chr1146792532-40384221435501178
ENST00000356142RAC1chr76431672+ENST00000312055CKAP5chr1146792532-38374221433491111
ENST00000356142RAC1chr76431672+ENST00000354558CKAP5chr1146792532-38334221433491111

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000348035ENST00000529230RAC1chr76431672+CKAP5chr1146792532-0.0012352620.99876475
ENST00000348035ENST00000415402RAC1chr76431672+CKAP5chr1146792532-0.0010714250.9989286
ENST00000348035ENST00000312055RAC1chr76431672+CKAP5chr1146792532-0.0010050840.9989949
ENST00000348035ENST00000354558RAC1chr76431672+CKAP5chr1146792532-0.0010094510.9989906
ENST00000356142ENST00000529230RAC1chr76431672+CKAP5chr1146792532-0.0011974240.99880254
ENST00000356142ENST00000415402RAC1chr76431672+CKAP5chr1146792532-0.0010342210.99896574
ENST00000356142ENST00000312055RAC1chr76431672+CKAP5chr1146792532-0.0009694940.9990305
ENST00000356142ENST00000354558RAC1chr76431672+CKAP5chr1146792532-0.000973650.9990263

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71616_71616_1_RAC1-CKAP5_RAC1_chr7_6431672_ENST00000348035_CKAP5_chr11_46792532_ENST00000312055_length(amino acids)=1117AA_BP=142
MQFSSALGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISY
TTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTLLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDRNGDVR
KKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPK
KAKAPGLSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHS
DFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVI
RKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYN
VHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQ
LDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQLFQIESLAREAS
TGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTIN
SINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEK
GASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISP
QMEVTCVPTPTSTVSSIGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHS

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>71616_71616_2_RAC1-CKAP5_RAC1_chr7_6431672_ENST00000348035_CKAP5_chr11_46792532_ENST00000354558_length(amino acids)=1117AA_BP=142
MQFSSALGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISY
TTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTLLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDRNGDVR
KKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPK
KAKAPGLSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHS
DFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVI
RKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYN
VHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQ
LDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQLFQIESLAREAS
TGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTIN
SINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEK
GASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISP
QMEVTCVPTPTSTVSSIGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHS

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>71616_71616_3_RAC1-CKAP5_RAC1_chr7_6431672_ENST00000348035_CKAP5_chr11_46792532_ENST00000415402_length(amino acids)=1184AA_BP=142
MQFSSALGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISY
TTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTLLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDRNGDVR
KKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPK
KAKAPGLSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHS
DFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVI
RKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYN
VHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQ
LDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQIDEVLRQEDKAE
AMSGHIDQFLIATFMQLRLIYNTHMADEKLEKDEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVI
RSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEF
PIRTLKTLLHTLCKLKGPKSCMCLPQILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFK
KIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVSSIGNTNGE
EVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQTHSSGTVTSSSSTANID

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>71616_71616_4_RAC1-CKAP5_RAC1_chr7_6431672_ENST00000348035_CKAP5_chr11_46792532_ENST00000529230_length(amino acids)=1177AA_BP=142
MQFSSALGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISY
TTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTLLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDRNGDVR
KKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPK
KAKAPGLSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHS
DFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVI
RKDVRAILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYN
VHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQ
LDLDEIENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQIDEVLRQEDKAE
AMSGHIDQFLIATFMQLRLIYNTHMADEKLEKDEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVI
RSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEF
PIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKEN
TKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVSSIGNTNGEEVGPSVY
LERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQTHSSGTVTSSSSTANIDDLKKRLE

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>71616_71616_5_RAC1-CKAP5_RAC1_chr7_6431672_ENST00000356142_CKAP5_chr11_46792532_ENST00000312055_length(amino acids)=1111AA_BP=136
MGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISYTTNAFP
GEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTLLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDRNGDVRKKAQDA
LPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPKKAKAPG
LSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHN
KALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRA
ILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVHGDQV
FKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEI
ENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQLFQIESLAREASTGVLKD
LMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDR
ILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRID
EKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTC
VPTPTSTVSSIGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQ

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>71616_71616_6_RAC1-CKAP5_RAC1_chr7_6431672_ENST00000356142_CKAP5_chr11_46792532_ENST00000354558_length(amino acids)=1111AA_BP=136
MGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISYTTNAFP
GEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTLLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDRNGDVRKKAQDA
LPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPKKAKAPG
LSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHN
KALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRA
ILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVHGDQV
FKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEI
ENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQLFQIESLAREASTGVLKD
LMHGLITLMLDSRIEDLEEGQQVIRSVNLLVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDR
ILLDIHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRID
EKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTC
VPTPTSTVSSIGNTNGEEVGPSVYLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQ

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>71616_71616_7_RAC1-CKAP5_RAC1_chr7_6431672_ENST00000356142_CKAP5_chr11_46792532_ENST00000415402_length(amino acids)=1178AA_BP=136
MGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISYTTNAFP
GEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTLLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDRNGDVRKKAQDA
LPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPKKAKAPG
LSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHN
KALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRA
ILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVHGDQV
FKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEI
ENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQIDEVLRQEDKAEAMSGHI
DQFLIATFMQLRLIYNTHMADEKLEKDEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLL
VVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLK
TLLHTLCKLKGPKSCMCLPQILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKE
NTKEGLAELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVSSIGNTNGEEVGPSV
YLERLKILRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQTHSSGTVTSSSSTANIDDLKKRL

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>71616_71616_8_RAC1-CKAP5_RAC1_chr7_6431672_ENST00000356142_CKAP5_chr11_46792532_ENST00000529230_length(amino acids)=1171AA_BP=136
MGGGRCRASASSPRRARRRGQRPRHPAPRRPQAARPSAAPRARRFLSQRPAAAAAAQRAALMQAIKCVVVGDGAVGKTCLLISYTTNAFP
GEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTLLGWLAEKLPTLRSTPTDLILCVPHLYSCLEDRNGDVRKKAQDA
LPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNMPAKPAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPKKAKAPG
LSSKAKSAQGKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQMSSCVAKWLQDEMFHSDFQHHN
KALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSVLMKALEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRA
ILNRMCLVYPASKMFPFIMEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVYNVHGDQV
FKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVEEKPQRAQNISSNANMLRKGPAEDMSSKLNQARSMSGHPEAAQMVRREFQLDLDEI
ENDNGTVRCEMPELVQHKLDDIFEPVLIPEPKIRAVSPHFDDMHSNTASTINFIISQVASGDINTSIQALTQIDEVLRQEDKAEAMSGHI
DQFLIATFMQLRLIYNTHMADEKLEKDEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLL
VVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIHIFMKVFPKEKLKQCKSEFPIRTLK
TLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLA
ELYEYKKKYSDADIEPFLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVSSIGNTNGEEVGPSVYLERLKI
LRQRCGLDNTKQDDRPPLTSLLSKPAVPTVASSTDMLHSKLSQLRESREQHQHSDLDSNQTHSSGTVTSSSSTANIDDLKKRLERIKSSR

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:6431672/chr11:46792532)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CKAP5

Q14008

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Binds to the plus end of microtubules and regulates microtubule dynamics and microtubule organization. Acts as processive microtubule polymerase. Promotes cytoplasmic microtubule nucleation and elongation. Plays a major role in organizing spindle poles. In spindle formation protects kinetochore microtubules from depolymerization by KIF2C and has an essential role in centrosomal microtubule assembly independently of KIF2C activity. Contributes to centrosome integrity. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:23532825). Enhances the strength of NDC80 complex-mediated kinetochore-tip microtubule attachments (PubMed:27156448). {ECO:0000269|PubMed:12569123, ECO:0000269|PubMed:18809577, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23532825, ECO:0000269|PubMed:27156448, ECO:0000269|PubMed:9570755}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAC1chr7:6431672chr11:46792532ENST00000348035+3632_4075.0193.0MotifEffector region
HgeneRAC1chr7:6431672chr11:46792532ENST00000356142+3732_4075.0212.0MotifEffector region
HgeneRAC1chr7:6431672chr11:46792532ENST00000348035+3613_1875.0193.0Nucleotide bindingGTP
HgeneRAC1chr7:6431672chr11:46792532ENST00000348035+3630_3575.0193.0Nucleotide bindingGTP
HgeneRAC1chr7:6431672chr11:46792532ENST00000356142+3713_1875.0212.0Nucleotide bindingGTP
HgeneRAC1chr7:6431672chr11:46792532ENST00000356142+3730_3575.0212.0Nucleotide bindingGTP
TgeneCKAP5chr7:6431672chr11:46792532ENST0000031205523431193_1428997.01973.0RegionTOG 5
TgeneCKAP5chr7:6431672chr11:46792532ENST0000035455822421193_1428997.01973.0RegionTOG 5
TgeneCKAP5chr7:6431672chr11:46792532ENST0000041540223441193_1428997.02040.0RegionTOG 5
TgeneCKAP5chr7:6431672chr11:46792532ENST0000052923023441193_1428997.02033.0RegionTOG 5
TgeneCKAP5chr7:6431672chr11:46792532ENST0000031205523431013_1051997.01973.0RepeatNote=HEAT 7
TgeneCKAP5chr7:6431672chr11:46792532ENST0000031205523431284_1322997.01973.0RepeatNote=HEAT 8
TgeneCKAP5chr7:6431672chr11:46792532ENST0000031205523431324_1357997.01973.0RepeatNote=HEAT 9
TgeneCKAP5chr7:6431672chr11:46792532ENST0000031205523431361_1399997.01973.0RepeatNote=HEAT 10
TgeneCKAP5chr7:6431672chr11:46792532ENST0000035455822421013_1051997.01973.0RepeatNote=HEAT 7
TgeneCKAP5chr7:6431672chr11:46792532ENST0000035455822421284_1322997.01973.0RepeatNote=HEAT 8
TgeneCKAP5chr7:6431672chr11:46792532ENST0000035455822421324_1357997.01973.0RepeatNote=HEAT 9
TgeneCKAP5chr7:6431672chr11:46792532ENST0000035455822421361_1399997.01973.0RepeatNote=HEAT 10
TgeneCKAP5chr7:6431672chr11:46792532ENST0000041540223441013_1051997.02040.0RepeatNote=HEAT 7
TgeneCKAP5chr7:6431672chr11:46792532ENST0000041540223441284_1322997.02040.0RepeatNote=HEAT 8
TgeneCKAP5chr7:6431672chr11:46792532ENST0000041540223441324_1357997.02040.0RepeatNote=HEAT 9
TgeneCKAP5chr7:6431672chr11:46792532ENST0000041540223441361_1399997.02040.0RepeatNote=HEAT 10
TgeneCKAP5chr7:6431672chr11:46792532ENST0000052923023441013_1051997.02033.0RepeatNote=HEAT 7
TgeneCKAP5chr7:6431672chr11:46792532ENST0000052923023441284_1322997.02033.0RepeatNote=HEAT 8
TgeneCKAP5chr7:6431672chr11:46792532ENST0000052923023441324_1357997.02033.0RepeatNote=HEAT 9
TgeneCKAP5chr7:6431672chr11:46792532ENST0000052923023441361_1399997.02033.0RepeatNote=HEAT 10

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAC1chr7:6431672chr11:46792532ENST00000348035+36116_11875.0193.0Nucleotide bindingGTP
HgeneRAC1chr7:6431672chr11:46792532ENST00000348035+36159_16075.0193.0Nucleotide bindingGTP
HgeneRAC1chr7:6431672chr11:46792532ENST00000356142+37116_11875.0212.0Nucleotide bindingGTP
HgeneRAC1chr7:6431672chr11:46792532ENST00000356142+37159_16075.0212.0Nucleotide bindingGTP
TgeneCKAP5chr7:6431672chr11:46792532ENST0000031205523431_223997.01973.0RegionTOG 1
TgeneCKAP5chr7:6431672chr11:46792532ENST000003120552343268_502997.01973.0RegionTOG 2
TgeneCKAP5chr7:6431672chr11:46792532ENST000003120552343588_817997.01973.0RegionTOG 3
TgeneCKAP5chr7:6431672chr11:46792532ENST000003120552343853_1081997.01973.0RegionTOG 4
TgeneCKAP5chr7:6431672chr11:46792532ENST0000035455822421_223997.01973.0RegionTOG 1
TgeneCKAP5chr7:6431672chr11:46792532ENST000003545582242268_502997.01973.0RegionTOG 2
TgeneCKAP5chr7:6431672chr11:46792532ENST000003545582242588_817997.01973.0RegionTOG 3
TgeneCKAP5chr7:6431672chr11:46792532ENST000003545582242853_1081997.01973.0RegionTOG 4
TgeneCKAP5chr7:6431672chr11:46792532ENST0000041540223441_223997.02040.0RegionTOG 1
TgeneCKAP5chr7:6431672chr11:46792532ENST000004154022344268_502997.02040.0RegionTOG 2
TgeneCKAP5chr7:6431672chr11:46792532ENST000004154022344588_817997.02040.0RegionTOG 3
TgeneCKAP5chr7:6431672chr11:46792532ENST000004154022344853_1081997.02040.0RegionTOG 4
TgeneCKAP5chr7:6431672chr11:46792532ENST0000052923023441_223997.02033.0RegionTOG 1
TgeneCKAP5chr7:6431672chr11:46792532ENST000005292302344268_502997.02033.0RegionTOG 2
TgeneCKAP5chr7:6431672chr11:46792532ENST000005292302344588_817997.02033.0RegionTOG 3
TgeneCKAP5chr7:6431672chr11:46792532ENST000005292302344853_1081997.02033.0RegionTOG 4
TgeneCKAP5chr7:6431672chr11:46792532ENST000003120552343159_197997.01973.0RepeatNote=HEAT 1
TgeneCKAP5chr7:6431672chr11:46792532ENST000003120552343356_394997.01973.0RepeatNote=HEAT 2
TgeneCKAP5chr7:6431672chr11:46792532ENST000003120552343434_472997.01973.0RepeatNote=HEAT 3
TgeneCKAP5chr7:6431672chr11:46792532ENST000003120552343750_788997.01973.0RepeatNote=HEAT 4
TgeneCKAP5chr7:6431672chr11:46792532ENST000003120552343855_893997.01973.0RepeatNote=HEAT 5
TgeneCKAP5chr7:6431672chr11:46792532ENST000003120552343936_974997.01973.0RepeatNote=HEAT 6
TgeneCKAP5chr7:6431672chr11:46792532ENST000003545582242159_197997.01973.0RepeatNote=HEAT 1
TgeneCKAP5chr7:6431672chr11:46792532ENST000003545582242356_394997.01973.0RepeatNote=HEAT 2
TgeneCKAP5chr7:6431672chr11:46792532ENST000003545582242434_472997.01973.0RepeatNote=HEAT 3
TgeneCKAP5chr7:6431672chr11:46792532ENST000003545582242750_788997.01973.0RepeatNote=HEAT 4
TgeneCKAP5chr7:6431672chr11:46792532ENST000003545582242855_893997.01973.0RepeatNote=HEAT 5
TgeneCKAP5chr7:6431672chr11:46792532ENST000003545582242936_974997.01973.0RepeatNote=HEAT 6
TgeneCKAP5chr7:6431672chr11:46792532ENST000004154022344159_197997.02040.0RepeatNote=HEAT 1
TgeneCKAP5chr7:6431672chr11:46792532ENST000004154022344356_394997.02040.0RepeatNote=HEAT 2
TgeneCKAP5chr7:6431672chr11:46792532ENST000004154022344434_472997.02040.0RepeatNote=HEAT 3
TgeneCKAP5chr7:6431672chr11:46792532ENST000004154022344750_788997.02040.0RepeatNote=HEAT 4
TgeneCKAP5chr7:6431672chr11:46792532ENST000004154022344855_893997.02040.0RepeatNote=HEAT 5
TgeneCKAP5chr7:6431672chr11:46792532ENST000004154022344936_974997.02040.0RepeatNote=HEAT 6
TgeneCKAP5chr7:6431672chr11:46792532ENST000005292302344159_197997.02033.0RepeatNote=HEAT 1
TgeneCKAP5chr7:6431672chr11:46792532ENST000005292302344356_394997.02033.0RepeatNote=HEAT 2
TgeneCKAP5chr7:6431672chr11:46792532ENST000005292302344434_472997.02033.0RepeatNote=HEAT 3
TgeneCKAP5chr7:6431672chr11:46792532ENST000005292302344750_788997.02033.0RepeatNote=HEAT 4
TgeneCKAP5chr7:6431672chr11:46792532ENST000005292302344855_893997.02033.0RepeatNote=HEAT 5
TgeneCKAP5chr7:6431672chr11:46792532ENST000005292302344936_974997.02033.0RepeatNote=HEAT 6


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RAC1
CKAP5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RAC1-CKAP5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RAC1-CKAP5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource