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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RAD23B-U2SURP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RAD23B-U2SURP
FusionPDB ID: 71720
FusionGDB2.0 ID: 71720
HgeneTgene
Gene symbol

RAD23B

U2SURP

Gene ID

5887

23350

Gene nameRAD23 homolog B, nucleotide excision repair proteinU2 snRNP associated SURP domain containing
SynonymsHHR23B|HR23B|P58SR140|fSAPa
Cytomap

9q31.2

3q23

Type of geneprotein-codingprotein-coding
DescriptionUV excision repair protein RAD23 homolog BRAD23, yeast homolog of, BXP-C repair complementing complex 58 kDaXP-C repair complementing proteinXP-C repair-complementing complex 58 kDa proteinU2 snRNP-associated SURP motif-containing protein140 kDa Ser/Arg-rich domain proteinSer/Arg-rich domain protein, 140 kDaU2-associated SR140 proteinU2-associated protein SR140functional spliceosome-associated protein a
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000358015, ENST00000416373, 
ENST00000397933, ENST00000473835, 
ENST00000493598, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 7 X 4=2249 X 10 X 3=270
# samples 811
** MAII scorelog2(8/224*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/270*10)=-1.29545588352617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RAD23B [Title/Abstract] AND U2SURP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RAD23B(110068928)-U2SURP(142745990), # samples:1
Anticipated loss of major functional domain due to fusion event.RAD23B-U2SURP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAD23B-U2SURP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAD23B-U2SURP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAD23B-U2SURP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAD23B

GO:0000715

nucleotide-excision repair, DNA damage recognition

19941824

HgeneRAD23B

GO:0006289

nucleotide-excision repair

8168482|9734359

HgeneRAD23B

GO:0032434

regulation of proteasomal ubiquitin-dependent protein catabolic process

19435460


check buttonFusion gene breakpoints across RAD23B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across U2SURP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A91ZRAD23Bchr9

110068928

+U2SURPchr3

142745990

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358015RAD23Bchr9110068928+ENST00000397933U2SURPchr3142745990+69398483362663775
ENST00000358015RAD23Bchr9110068928+ENST00000473835U2SURPchr3142745990+67608483362663775
ENST00000358015RAD23Bchr9110068928+ENST00000493598U2SURPchr3142745990+30608483362663775
ENST00000416373RAD23Bchr9110068928+ENST00000397933U2SURPchr3142745990+66575661442381745
ENST00000416373RAD23Bchr9110068928+ENST00000473835U2SURPchr3142745990+64785661442381745
ENST00000416373RAD23Bchr9110068928+ENST00000493598U2SURPchr3142745990+27785661442381745

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358015ENST00000397933RAD23Bchr9110068928+U2SURPchr3142745990+0.0002447890.9997552
ENST00000358015ENST00000473835RAD23Bchr9110068928+U2SURPchr3142745990+0.0002538250.99974614
ENST00000358015ENST00000493598RAD23Bchr9110068928+U2SURPchr3142745990+0.0025857610.99741423
ENST00000416373ENST00000397933RAD23Bchr9110068928+U2SURPchr3142745990+0.0003530090.999647
ENST00000416373ENST00000473835RAD23Bchr9110068928+U2SURPchr3142745990+0.0003666370.9996333
ENST00000416373ENST00000493598RAD23Bchr9110068928+U2SURPchr3142745990+0.0028130970.99718684

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71720_71720_1_RAD23B-U2SURP_RAD23B_chr9_110068928_ENST00000358015_U2SURP_chr3_142745990_ENST00000397933_length(amino acids)=775AA_BP=170
MRGGTMQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPKAVSTPAP
ATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDRNLLALIHRM
IEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAF
VEEPSKKGALKEEQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASY
YRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEEELD
GAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQ
NQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQ
REKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDS

--------------------------------------------------------------

>71720_71720_2_RAD23B-U2SURP_RAD23B_chr9_110068928_ENST00000358015_U2SURP_chr3_142745990_ENST00000473835_length(amino acids)=775AA_BP=170
MRGGTMQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPKAVSTPAP
ATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDRNLLALIHRM
IEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAF
VEEPSKKGALKEEQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASY
YRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEEELD
GAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQ
NQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQ
REKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDS

--------------------------------------------------------------

>71720_71720_3_RAD23B-U2SURP_RAD23B_chr9_110068928_ENST00000358015_U2SURP_chr3_142745990_ENST00000493598_length(amino acids)=775AA_BP=170
MRGGTMQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPKAVSTPAP
ATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDRNLLALIHRM
IEFVVREGPMFEAMIMNREINNPMFRFLFENQTPAHVYYRWKLYSILQANSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAF
VEEPSKKGALKEEQRDKLEEILRGLTPRKNDIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASY
YRKFFETKLCQIFSDLNATYRTIQGHLQSENFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEEELD
GAPLEDVDGIPIDATPIDDLDGVPIKSLDDDLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQ
NQEEESEDEEDTQSSKSEEHHLYSNPIKEEMTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQ
REKEKELERERERDKKDKEKLESRSKDKKEKDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDS

--------------------------------------------------------------

>71720_71720_4_RAD23B-U2SURP_RAD23B_chr9_110068928_ENST00000416373_U2SURP_chr3_142745990_ENST00000397933_length(amino acids)=745AA_BP=140
MKEKIESEKGKDAFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVP
ALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDRNLLALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFE
NQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPSKKGALKEEQRDKLEEILRGLTPRKN
DIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKFFETKLCQIFSDLNATYRTIQGHLQSE
NFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDD
DLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEE
MTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKE
KDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPK

--------------------------------------------------------------

>71720_71720_5_RAD23B-U2SURP_RAD23B_chr9_110068928_ENST00000416373_U2SURP_chr3_142745990_ENST00000473835_length(amino acids)=745AA_BP=140
MKEKIESEKGKDAFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVP
ALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDRNLLALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFE
NQTPAHVYYRWKLYSILQGDSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPSKKGALKEEQRDKLEEILRGLTPRKN
DIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKFFETKLCQIFSDLNATYRTIQGHLQSE
NFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDD
DLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEE
MTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKE
KDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPK

--------------------------------------------------------------

>71720_71720_6_RAD23B-U2SURP_RAD23B_chr9_110068928_ENST00000416373_U2SURP_chr3_142745990_ENST00000493598_length(amino acids)=745AA_BP=140
MKEKIESEKGKDAFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVP
ALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDRNLLALIHRMIEFVVREGPMFEAMIMNREINNPMFRFLFE
NQTPAHVYYRWKLYSILQANSPTKWRTEDFRMFKNGSFWRPPPLNPYLHGMSEEQETEAFVEEPSKKGALKEEQRDKLEEILRGLTPRKN
DIGDAMVFCLNNAEAAEEIVDCITESLSILKTPLPKKIARLYLVSDVLYNSSAKVANASYYRKFFETKLCQIFSDLNATYRTIQGHLQSE
NFKQRVMTCFRAWEDWAIYPEPFLIKLQNIFLGLVNIIEEKETEDVPDDLDGAPIEEELDGAPLEDVDGIPIDATPIDDLDGVPIKSLDD
DLDGVPLDATEDSKKNEPIFKVAPSKWEAVDESELEAQAVTTSKWELFDQHEESEEEENQNQEEESEDEEDTQSSKSEEHHLYSNPIKEE
MTESKFSKYSEMSEEKRAKLREIELKVMKFQDELESGKRPKKPGQSFQEQVEHYRDKLLQREKEKELERERERDKKDKEKLESRSKDKKE
KDECTPTRKERKRRHSTSPSPSRSSSGRRVKSPSPKSERSERSERSHKESSRSRSSHKDSPRDVSKKAKRSPSGSRTPKRSRRSRSRSPK

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:110068928/chr3:142745990)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000358015+410103_106165.66666666666666410.0Compositional biasNote=Poly-Thr
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000358015+4101_79165.66666666666666410.0DomainUbiquitin-like
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000416373+4101_7993.66666666666667338.0DomainUbiquitin-like
TgeneU2SURPchr9:110068928chr3:142745990ENST000003979331127192_23215.666666666666666621.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr9:110068928chr3:142745990ENST000003979331127837_91515.666666666666666621.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr9:110068928chr3:142745990ENST00000397933112792_12115.666666666666666621.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr9:110068928chr3:142745990ENST000004738351228837_915424.66666666666671030.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr9:110068928chr3:142745990ENST000003979331127357_40215.666666666666666621.0Compositional biasNote=Pro-rich
TgeneU2SURPchr9:110068928chr3:142745990ENST000003979331127689_74615.666666666666666621.0Compositional biasNote=Asp-rich
TgeneU2SURPchr9:110068928chr3:142745990ENST000003979331127762_91715.666666666666666621.0Compositional biasNote=Glu-rich
TgeneU2SURPchr9:110068928chr3:142745990ENST000003979331127922_100115.666666666666666621.0Compositional biasNote=Arg/Ser-rich
TgeneU2SURPchr9:110068928chr3:142745990ENST000004738351228689_746424.66666666666671030.0Compositional biasNote=Asp-rich
TgeneU2SURPchr9:110068928chr3:142745990ENST000004738351228762_917424.66666666666671030.0Compositional biasNote=Glu-rich
TgeneU2SURPchr9:110068928chr3:142745990ENST000004738351228922_1001424.66666666666671030.0Compositional biasNote=Arg/Ser-rich
TgeneU2SURPchr9:110068928chr3:142745990ENST000003979331127274_35515.666666666666666621.0DomainRRM
TgeneU2SURPchr9:110068928chr3:142745990ENST000003979331127534_67915.666666666666666621.0DomainCID
TgeneU2SURPchr9:110068928chr3:142745990ENST000004738351228534_679424.66666666666671030.0DomainCID
TgeneU2SURPchr9:110068928chr3:142745990ENST000003979331127430_47315.666666666666666621.0RepeatNote=SURP motif
TgeneU2SURPchr9:110068928chr3:142745990ENST000004738351228430_473424.66666666666671030.0RepeatNote=SURP motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000358015+410254_260165.66666666666666410.0Compositional biasNote=Poly-Ala
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000358015+410261_269165.66666666666666410.0Compositional biasNote=Poly-Thr
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000358015+410336_348165.66666666666666410.0Compositional biasNote=Poly-Gly
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000416373+410103_10693.66666666666667338.0Compositional biasNote=Poly-Thr
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000416373+410254_26093.66666666666667338.0Compositional biasNote=Poly-Ala
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000416373+410261_26993.66666666666667338.0Compositional biasNote=Poly-Thr
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000416373+410336_34893.66666666666667338.0Compositional biasNote=Poly-Gly
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000358015+410188_228165.66666666666666410.0DomainUBA 1
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000358015+410274_317165.66666666666666410.0DomainNote=STI1
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000358015+410364_404165.66666666666666410.0DomainUBA 2
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000416373+410188_22893.66666666666667338.0DomainUBA 1
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000416373+410274_31793.66666666666667338.0DomainNote=STI1
HgeneRAD23Bchr9:110068928chr3:142745990ENST00000416373+410364_40493.66666666666667338.0DomainUBA 2
TgeneU2SURPchr9:110068928chr3:142745990ENST000004738351228192_232424.66666666666671030.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr9:110068928chr3:142745990ENST00000473835122892_121424.66666666666671030.0Coiled coilOntology_term=ECO:0000255
TgeneU2SURPchr9:110068928chr3:142745990ENST000004738351228357_402424.66666666666671030.0Compositional biasNote=Pro-rich
TgeneU2SURPchr9:110068928chr3:142745990ENST000004738351228274_355424.66666666666671030.0DomainRRM


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RAD23B
U2SURP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RAD23B-U2SURP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RAD23B-U2SURP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource