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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RAI14-MAPK9

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RAI14-MAPK9
FusionPDB ID: 71853
FusionGDB2.0 ID: 71853
HgeneTgene
Gene symbol

RAI14

MAPK9

Gene ID

26064

5601

Gene nameretinoic acid induced 14mitogen-activated protein kinase 9
SynonymsNORPEG|RAI13JNK-55|JNK2|JNK2A|JNK2ALPHA|JNK2B|JNK2BETA|PRKM9|SAPK|SAPK1a|p54a|p54aSAPK
Cytomap

5p13.2

5q35.3

Type of geneprotein-codingprotein-coding
Descriptionankycorbinankyrin repeat and coiled-coil structure-containing proteinnovel retinal pigment epithelial cell proteinretinoic acid-induced protein 14mitogen-activated protein kinase 9Jun kinaseMAP kinase 9MAPK 9c-Jun N-terminal kinase 2c-Jun kinase 2stress-activated protein kinase 1astress-activated protein kinase JNK2
Modification date2020031320200327
UniProtAcc.

P45984

Ensembl transtripts involved in fusion geneENST idsENST00000507276, ENST00000265109, 
ENST00000397449, ENST00000428746, 
ENST00000503673, ENST00000506376, 
ENST00000512629, ENST00000515799, 
ENST00000343111, ENST00000347470, 
ENST00000393360, ENST00000397072, 
ENST00000425491, ENST00000452135, 
ENST00000455781, ENST00000539014, 
ENST00000524170, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 11 X 6=11225 X 6 X 3=90
# samples 176
** MAII scorelog2(17/1122*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RAI14 [Title/Abstract] AND MAPK9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RAI14(34757703)-MAPK9(179696409), # samples:3
Anticipated loss of major functional domain due to fusion event.RAI14-MAPK9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAI14-MAPK9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAI14-MAPK9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAI14-MAPK9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAI14-MAPK9 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RAI14-MAPK9 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
RAI14-MAPK9 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAPK9

GO:0007254

JNK cascade

8654373

TgeneMAPK9

GO:0018105

peptidyl-serine phosphorylation

21856198


check buttonFusion gene breakpoints across RAI14 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAPK9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A1Q3-06ARAI14chr5

34757703

-MAPK9chr5

179696409

-
ChimerDB4SKCMTCGA-D3-A1Q3-06ARAI14chr5

34757703

+MAPK9chr5

179696409

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265109RAI14chr534757703+ENST00000452135MAPK9chr5179696409-48484542721606444
ENST00000265109RAI14chr534757703+ENST00000393360MAPK9chr5179696409-44024542721480402
ENST00000265109RAI14chr534757703+ENST00000455781MAPK9chr5179696409-43974542721606444
ENST00000265109RAI14chr534757703+ENST00000343111MAPK9chr5179696409-44024542721480402
ENST00000265109RAI14chr534757703+ENST00000347470MAPK9chr5179696409-15494542721351359
ENST00000265109RAI14chr534757703+ENST00000425491MAPK9chr5179696409-24314542721060262
ENST00000512629RAI14chr534757703+ENST00000452135MAPK9chr5179696409-4646252701404444
ENST00000512629RAI14chr534757703+ENST00000393360MAPK9chr5179696409-4200252701278402
ENST00000512629RAI14chr534757703+ENST00000455781MAPK9chr5179696409-4195252701404444
ENST00000512629RAI14chr534757703+ENST00000343111MAPK9chr5179696409-4200252701278402
ENST00000512629RAI14chr534757703+ENST00000347470MAPK9chr5179696409-1347252701149359
ENST00000512629RAI14chr534757703+ENST00000425491MAPK9chr5179696409-222925270858262
ENST00000428746RAI14chr534757703+ENST00000452135MAPK9chr5179696409-48364422601594444
ENST00000428746RAI14chr534757703+ENST00000393360MAPK9chr5179696409-43904422601468402
ENST00000428746RAI14chr534757703+ENST00000455781MAPK9chr5179696409-43854422601594444
ENST00000428746RAI14chr534757703+ENST00000343111MAPK9chr5179696409-43904422601468402
ENST00000428746RAI14chr534757703+ENST00000347470MAPK9chr5179696409-15374422601339359
ENST00000428746RAI14chr534757703+ENST00000425491MAPK9chr5179696409-24194422601048262
ENST00000503673RAI14chr534757703+ENST00000452135MAPK9chr5179696409-49175233411675444
ENST00000503673RAI14chr534757703+ENST00000393360MAPK9chr5179696409-44715233411549402
ENST00000503673RAI14chr534757703+ENST00000455781MAPK9chr5179696409-44665233411675444
ENST00000503673RAI14chr534757703+ENST00000343111MAPK9chr5179696409-44715233411549402
ENST00000503673RAI14chr534757703+ENST00000347470MAPK9chr5179696409-16185233411420359
ENST00000503673RAI14chr534757703+ENST00000425491MAPK9chr5179696409-25005233411129262
ENST00000515799RAI14chr534757703+ENST00000452135MAPK9chr5179696409-50626684831820445
ENST00000515799RAI14chr534757703+ENST00000393360MAPK9chr5179696409-46166684831694403
ENST00000515799RAI14chr534757703+ENST00000455781MAPK9chr5179696409-46116684831820445
ENST00000515799RAI14chr534757703+ENST00000343111MAPK9chr5179696409-46166684831694403
ENST00000515799RAI14chr534757703+ENST00000347470MAPK9chr5179696409-17636684831565360
ENST00000515799RAI14chr534757703+ENST00000425491MAPK9chr5179696409-26456684831274263
ENST00000506376RAI14chr534757703+ENST00000452135MAPK9chr5179696409-46892951521447431
ENST00000506376RAI14chr534757703+ENST00000393360MAPK9chr5179696409-42432951521321389
ENST00000506376RAI14chr534757703+ENST00000455781MAPK9chr5179696409-42382951521447431
ENST00000506376RAI14chr534757703+ENST00000343111MAPK9chr5179696409-42432951521321389
ENST00000506376RAI14chr534757703+ENST00000347470MAPK9chr5179696409-13902951521192346
ENST00000506376RAI14chr534757703+ENST00000425491MAPK9chr5179696409-2272295152901249
ENST00000397449RAI14chr534757703+ENST00000452135MAPK9chr5179696409-454014601298432
ENST00000397449RAI14chr534757703+ENST00000393360MAPK9chr5179696409-409414601172390
ENST00000397449RAI14chr534757703+ENST00000455781MAPK9chr5179696409-408914601298432
ENST00000397449RAI14chr534757703+ENST00000343111MAPK9chr5179696409-409414601172390
ENST00000397449RAI14chr534757703+ENST00000347470MAPK9chr5179696409-124114601043347
ENST00000397449RAI14chr534757703+ENST00000425491MAPK9chr5179696409-21231460752250

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265109ENST00000452135RAI14chr534757703+MAPK9chr5179696409-0.0005454390.99945456
ENST00000265109ENST00000393360RAI14chr534757703+MAPK9chr5179696409-0.0007105890.9992894
ENST00000265109ENST00000455781RAI14chr534757703+MAPK9chr5179696409-0.0005424840.99945754
ENST00000265109ENST00000343111RAI14chr534757703+MAPK9chr5179696409-0.0006217560.9993782
ENST00000265109ENST00000347470RAI14chr534757703+MAPK9chr5179696409-0.0033258680.99667406
ENST00000265109ENST00000425491RAI14chr534757703+MAPK9chr5179696409-0.0013715320.9986285
ENST00000512629ENST00000452135RAI14chr534757703+MAPK9chr5179696409-0.0004767890.9995233
ENST00000512629ENST00000393360RAI14chr534757703+MAPK9chr5179696409-0.0006204050.9993795
ENST00000512629ENST00000455781RAI14chr534757703+MAPK9chr5179696409-0.0004797020.9995203
ENST00000512629ENST00000343111RAI14chr534757703+MAPK9chr5179696409-0.0005632220.9994368
ENST00000512629ENST00000347470RAI14chr534757703+MAPK9chr5179696409-0.0028507840.9971493
ENST00000512629ENST00000425491RAI14chr534757703+MAPK9chr5179696409-0.001463880.9985361
ENST00000428746ENST00000452135RAI14chr534757703+MAPK9chr5179696409-0.0005050080.999495
ENST00000428746ENST00000393360RAI14chr534757703+MAPK9chr5179696409-0.0006648950.9993351
ENST00000428746ENST00000455781RAI14chr534757703+MAPK9chr5179696409-0.0005129850.99948704
ENST00000428746ENST00000343111RAI14chr534757703+MAPK9chr5179696409-0.0006069780.999393
ENST00000428746ENST00000347470RAI14chr534757703+MAPK9chr5179696409-0.0035120250.996488
ENST00000428746ENST00000425491RAI14chr534757703+MAPK9chr5179696409-0.0016249350.99837506
ENST00000503673ENST00000452135RAI14chr534757703+MAPK9chr5179696409-0.000565690.9994343
ENST00000503673ENST00000393360RAI14chr534757703+MAPK9chr5179696409-0.0007310460.99926895
ENST00000503673ENST00000455781RAI14chr534757703+MAPK9chr5179696409-0.0005608970.99943906
ENST00000503673ENST00000343111RAI14chr534757703+MAPK9chr5179696409-0.0006430990.9993569
ENST00000503673ENST00000347470RAI14chr534757703+MAPK9chr5179696409-0.0030862690.9969137
ENST00000503673ENST00000425491RAI14chr534757703+MAPK9chr5179696409-0.0016283710.99837166
ENST00000515799ENST00000452135RAI14chr534757703+MAPK9chr5179696409-0.0002014970.9997985
ENST00000515799ENST00000393360RAI14chr534757703+MAPK9chr5179696409-0.0001909260.9998091
ENST00000515799ENST00000455781RAI14chr534757703+MAPK9chr5179696409-0.0002657390.9997342
ENST00000515799ENST00000343111RAI14chr534757703+MAPK9chr5179696409-0.0002268110.9997732
ENST00000515799ENST00000347470RAI14chr534757703+MAPK9chr5179696409-0.0008170710.9991829
ENST00000515799ENST00000425491RAI14chr534757703+MAPK9chr5179696409-0.0003615250.99963844
ENST00000506376ENST00000452135RAI14chr534757703+MAPK9chr5179696409-0.0003387420.9996612
ENST00000506376ENST00000393360RAI14chr534757703+MAPK9chr5179696409-0.0003868320.9996132
ENST00000506376ENST00000455781RAI14chr534757703+MAPK9chr5179696409-0.0003418250.9996582
ENST00000506376ENST00000343111RAI14chr534757703+MAPK9chr5179696409-0.0003537750.9996462
ENST00000506376ENST00000347470RAI14chr534757703+MAPK9chr5179696409-0.0014019650.99859804
ENST00000506376ENST00000425491RAI14chr534757703+MAPK9chr5179696409-0.0006879040.99931204
ENST00000397449ENST00000452135RAI14chr534757703+MAPK9chr5179696409-0.0003268510.9996731
ENST00000397449ENST00000393360RAI14chr534757703+MAPK9chr5179696409-0.0003216250.9996784
ENST00000397449ENST00000455781RAI14chr534757703+MAPK9chr5179696409-0.0003645690.99963546
ENST00000397449ENST00000343111RAI14chr534757703+MAPK9chr5179696409-0.0003264350.9996736
ENST00000397449ENST00000347470RAI14chr534757703+MAPK9chr5179696409-0.000750940.99924904
ENST00000397449ENST00000425491RAI14chr534757703+MAPK9chr5179696409-0.0003163790.9996836

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71853_71853_1_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000265109_MAPK9_chr5_179696409_ENST00000343111_length(amino acids)=402AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_2_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000265109_MAPK9_chr5_179696409_ENST00000347470_length(amino acids)=359AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENASQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPP

--------------------------------------------------------------

>71853_71853_3_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000265109_MAPK9_chr5_179696409_ENST00000393360_length(amino acids)=402AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_4_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000265109_MAPK9_chr5_179696409_ENST00000425491_length(amino acids)=262AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK

--------------------------------------------------------------

>71853_71853_5_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000265109_MAPK9_chr5_179696409_ENST00000452135_length(amino acids)=444AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_6_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000265109_MAPK9_chr5_179696409_ENST00000455781_length(amino acids)=444AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_7_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000397449_MAPK9_chr5_179696409_ENST00000343111_length(amino acids)=390AA_BP=49
MVKGKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL
ARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVEN
RPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEW

--------------------------------------------------------------

>71853_71853_8_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000397449_MAPK9_chr5_179696409_ENST00000347470_length(amino acids)=347AA_BP=49
MVKGKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL
ARTACTNFMMTPYVVTRYYRAPEVILGMGYKENASQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREH

--------------------------------------------------------------

>71853_71853_9_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000397449_MAPK9_chr5_179696409_ENST00000393360_length(amino acids)=390AA_BP=49
MVKGKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL
ARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVEN
RPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEW

--------------------------------------------------------------

>71853_71853_10_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000397449_MAPK9_chr5_179696409_ENST00000425491_length(amino acids)=250AA_BP=49
MVKGKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL

--------------------------------------------------------------

>71853_71853_11_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000397449_MAPK9_chr5_179696409_ENST00000452135_length(amino acids)=432AA_BP=49
MVKGKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL
ARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVEN
RPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEW

--------------------------------------------------------------

>71853_71853_12_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000397449_MAPK9_chr5_179696409_ENST00000455781_length(amino acids)=432AA_BP=49
MVKGKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL
ARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVEN
RPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEW

--------------------------------------------------------------

>71853_71853_13_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000428746_MAPK9_chr5_179696409_ENST00000343111_length(amino acids)=402AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_14_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000428746_MAPK9_chr5_179696409_ENST00000347470_length(amino acids)=359AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENASQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPP

--------------------------------------------------------------

>71853_71853_15_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000428746_MAPK9_chr5_179696409_ENST00000393360_length(amino acids)=402AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_16_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000428746_MAPK9_chr5_179696409_ENST00000425491_length(amino acids)=262AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK

--------------------------------------------------------------

>71853_71853_17_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000428746_MAPK9_chr5_179696409_ENST00000452135_length(amino acids)=444AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_18_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000428746_MAPK9_chr5_179696409_ENST00000455781_length(amino acids)=444AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_19_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000503673_MAPK9_chr5_179696409_ENST00000343111_length(amino acids)=402AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_20_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000503673_MAPK9_chr5_179696409_ENST00000347470_length(amino acids)=359AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENASQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPP

--------------------------------------------------------------

>71853_71853_21_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000503673_MAPK9_chr5_179696409_ENST00000393360_length(amino acids)=402AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_22_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000503673_MAPK9_chr5_179696409_ENST00000425491_length(amino acids)=262AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK

--------------------------------------------------------------

>71853_71853_23_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000503673_MAPK9_chr5_179696409_ENST00000452135_length(amino acids)=444AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_24_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000503673_MAPK9_chr5_179696409_ENST00000455781_length(amino acids)=444AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_25_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000506376_MAPK9_chr5_179696409_ENST00000343111_length(amino acids)=389AA_BP=48
MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHK
NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA
RTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENR
PKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWK

--------------------------------------------------------------

>71853_71853_26_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000506376_MAPK9_chr5_179696409_ENST00000347470_length(amino acids)=346AA_BP=48
MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHK
NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA
RTACTNFMMTPYVVTRYYRAPEVILGMGYKENASQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHA

--------------------------------------------------------------

>71853_71853_27_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000506376_MAPK9_chr5_179696409_ENST00000393360_length(amino acids)=389AA_BP=48
MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHK
NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA
RTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENR
PKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWK

--------------------------------------------------------------

>71853_71853_28_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000506376_MAPK9_chr5_179696409_ENST00000425491_length(amino acids)=249AA_BP=48
MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHK
NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA

--------------------------------------------------------------

>71853_71853_29_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000506376_MAPK9_chr5_179696409_ENST00000452135_length(amino acids)=431AA_BP=48
MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHK
NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA
RTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENR
PKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWK

--------------------------------------------------------------

>71853_71853_30_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000506376_MAPK9_chr5_179696409_ENST00000455781_length(amino acids)=431AA_BP=48
MEAKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHK
NIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLA
RTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENR
PKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWK

--------------------------------------------------------------

>71853_71853_31_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000512629_MAPK9_chr5_179696409_ENST00000343111_length(amino acids)=402AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_32_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000512629_MAPK9_chr5_179696409_ENST00000347470_length(amino acids)=359AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENASQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPP

--------------------------------------------------------------

>71853_71853_33_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000512629_MAPK9_chr5_179696409_ENST00000393360_length(amino acids)=402AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_34_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000512629_MAPK9_chr5_179696409_ENST00000425491_length(amino acids)=262AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK

--------------------------------------------------------------

>71853_71853_35_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000512629_MAPK9_chr5_179696409_ENST00000452135_length(amino acids)=444AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_36_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000512629_MAPK9_chr5_179696409_ENST00000455781_length(amino acids)=444AA_BP=61
MNALNMKSLKAKFRKSDTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKRA
YRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVK
SDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFMK
KLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDA

--------------------------------------------------------------

>71853_71853_37_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000515799_MAPK9_chr5_179696409_ENST00000343111_length(amino acids)=403AA_BP=62
MYVMQPTYLPWLSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKR
AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV
KSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFM
KKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYD

--------------------------------------------------------------

>71853_71853_38_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000515799_MAPK9_chr5_179696409_ENST00000347470_length(amino acids)=360AA_BP=62
MYVMQPTYLPWLSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKR
AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV
KSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENASQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPP
PQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR

--------------------------------------------------------------

>71853_71853_39_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000515799_MAPK9_chr5_179696409_ENST00000393360_length(amino acids)=403AA_BP=62
MYVMQPTYLPWLSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKR
AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV
KSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFM
KKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYD

--------------------------------------------------------------

>71853_71853_40_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000515799_MAPK9_chr5_179696409_ENST00000425491_length(amino acids)=263AA_BP=62
MYVMQPTYLPWLSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKR
AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV

--------------------------------------------------------------

>71853_71853_41_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000515799_MAPK9_chr5_179696409_ENST00000452135_length(amino acids)=445AA_BP=62
MYVMQPTYLPWLSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKR
AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV
KSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFM
KKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYD

--------------------------------------------------------------

>71853_71853_42_RAI14-MAPK9_RAI14_chr5_34757703_ENST00000515799_MAPK9_chr5_179696409_ENST00000455781_length(amino acids)=445AA_BP=62
MYVMQPTYLPWLSAKEKKTNEWNKNDDRLLQAVENGDAEKVASLLGKKGASATKHDSEGKTAAAFDTVLGINVAVKKLSRPFQNQTHAKR
AYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVV
KSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMAEMVLHKVLFPGRDYIDQWNKVIEQLGTPSAEFM
KKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYD

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:34757703/chr5:179696409)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAPK9

P45984

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteosomal degradation (By similarity). {ECO:0000250|UniProtKB:Q9WTU6, ECO:0000269|PubMed:22441692}.; FUNCTION: MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAI14chr5:34757703chr5:179696409ENST00000265109+31818_5155.666666666666664981.0RepeatNote=ANK 1
HgeneRAI14chr5:34757703chr5:179696409ENST00000428746+31818_5155.666666666666664981.0RepeatNote=ANK 1
HgeneRAI14chr5:34757703chr5:179696409ENST00000503673+41918_5155.666666666666664981.0RepeatNote=ANK 1
HgeneRAI14chr5:34757703chr5:179696409ENST00000512629+31718_5155.666666666666664952.0RepeatNote=ANK 1
HgeneRAI14chr5:34757703chr5:179696409ENST00000515799+52018_5158.666666666666664984.0RepeatNote=ANK 1
TgeneMAPK9chr5:34757703chr5:179696409ENST00000343111112183_18540.666666666666664383.0MotifNote=TXY
TgeneMAPK9chr5:34757703chr5:179696409ENST00000393360112183_18540.666666666666664383.0MotifNote=TXY
TgeneMAPK9chr5:34757703chr5:179696409ENST0000042549117183_18540.666666666666664243.0MotifNote=TXY
TgeneMAPK9chr5:34757703chr5:179696409ENST00000452135112183_18540.666666666666664425.0MotifNote=TXY
TgeneMAPK9chr5:34757703chr5:179696409ENST00000455781112183_18540.666666666666664425.0MotifNote=TXY

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAI14chr5:34757703chr5:179696409ENST00000265109+318349_37455.666666666666664981.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000265109+318425_94755.666666666666664981.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000428746+318349_37455.666666666666664981.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000428746+318425_94755.666666666666664981.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000503673+419349_37455.666666666666664981.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000503673+419425_94755.666666666666664981.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000506376+217349_37447.666666666666664973.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000506376+217425_94747.666666666666664973.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000512629+317349_37455.666666666666664952.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000512629+317425_94755.666666666666664952.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000515799+520349_37458.666666666666664984.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000515799+520425_94758.666666666666664984.0Coiled coilOntology_term=ECO:0000255
HgeneRAI14chr5:34757703chr5:179696409ENST00000265109+318270_27655.666666666666664981.0MotifNuclear localization signal
HgeneRAI14chr5:34757703chr5:179696409ENST00000428746+318270_27655.666666666666664981.0MotifNuclear localization signal
HgeneRAI14chr5:34757703chr5:179696409ENST00000503673+419270_27655.666666666666664981.0MotifNuclear localization signal
HgeneRAI14chr5:34757703chr5:179696409ENST00000506376+217270_27647.666666666666664973.0MotifNuclear localization signal
HgeneRAI14chr5:34757703chr5:179696409ENST00000512629+317270_27655.666666666666664952.0MotifNuclear localization signal
HgeneRAI14chr5:34757703chr5:179696409ENST00000515799+520270_27658.666666666666664984.0MotifNuclear localization signal
HgeneRAI14chr5:34757703chr5:179696409ENST00000265109+318118_14755.666666666666664981.0RepeatNote=ANK 4
HgeneRAI14chr5:34757703chr5:179696409ENST00000265109+318151_18055.666666666666664981.0RepeatNote=ANK 5
HgeneRAI14chr5:34757703chr5:179696409ENST00000265109+318184_21355.666666666666664981.0RepeatNote=ANK 6
HgeneRAI14chr5:34757703chr5:179696409ENST00000265109+318217_24755.666666666666664981.0RepeatNote=ANK 7
HgeneRAI14chr5:34757703chr5:179696409ENST00000265109+31852_8155.666666666666664981.0RepeatNote=ANK 2
HgeneRAI14chr5:34757703chr5:179696409ENST00000265109+31885_11455.666666666666664981.0RepeatNote=ANK 3
HgeneRAI14chr5:34757703chr5:179696409ENST00000428746+318118_14755.666666666666664981.0RepeatNote=ANK 4
HgeneRAI14chr5:34757703chr5:179696409ENST00000428746+318151_18055.666666666666664981.0RepeatNote=ANK 5
HgeneRAI14chr5:34757703chr5:179696409ENST00000428746+318184_21355.666666666666664981.0RepeatNote=ANK 6
HgeneRAI14chr5:34757703chr5:179696409ENST00000428746+318217_24755.666666666666664981.0RepeatNote=ANK 7
HgeneRAI14chr5:34757703chr5:179696409ENST00000428746+31852_8155.666666666666664981.0RepeatNote=ANK 2
HgeneRAI14chr5:34757703chr5:179696409ENST00000428746+31885_11455.666666666666664981.0RepeatNote=ANK 3
HgeneRAI14chr5:34757703chr5:179696409ENST00000503673+419118_14755.666666666666664981.0RepeatNote=ANK 4
HgeneRAI14chr5:34757703chr5:179696409ENST00000503673+419151_18055.666666666666664981.0RepeatNote=ANK 5
HgeneRAI14chr5:34757703chr5:179696409ENST00000503673+419184_21355.666666666666664981.0RepeatNote=ANK 6
HgeneRAI14chr5:34757703chr5:179696409ENST00000503673+419217_24755.666666666666664981.0RepeatNote=ANK 7
HgeneRAI14chr5:34757703chr5:179696409ENST00000503673+41952_8155.666666666666664981.0RepeatNote=ANK 2
HgeneRAI14chr5:34757703chr5:179696409ENST00000503673+41985_11455.666666666666664981.0RepeatNote=ANK 3
HgeneRAI14chr5:34757703chr5:179696409ENST00000506376+217118_14747.666666666666664973.0RepeatNote=ANK 4
HgeneRAI14chr5:34757703chr5:179696409ENST00000506376+217151_18047.666666666666664973.0RepeatNote=ANK 5
HgeneRAI14chr5:34757703chr5:179696409ENST00000506376+217184_21347.666666666666664973.0RepeatNote=ANK 6
HgeneRAI14chr5:34757703chr5:179696409ENST00000506376+21718_5147.666666666666664973.0RepeatNote=ANK 1
HgeneRAI14chr5:34757703chr5:179696409ENST00000506376+217217_24747.666666666666664973.0RepeatNote=ANK 7
HgeneRAI14chr5:34757703chr5:179696409ENST00000506376+21752_8147.666666666666664973.0RepeatNote=ANK 2
HgeneRAI14chr5:34757703chr5:179696409ENST00000506376+21785_11447.666666666666664973.0RepeatNote=ANK 3
HgeneRAI14chr5:34757703chr5:179696409ENST00000512629+317118_14755.666666666666664952.0RepeatNote=ANK 4
HgeneRAI14chr5:34757703chr5:179696409ENST00000512629+317151_18055.666666666666664952.0RepeatNote=ANK 5
HgeneRAI14chr5:34757703chr5:179696409ENST00000512629+317184_21355.666666666666664952.0RepeatNote=ANK 6
HgeneRAI14chr5:34757703chr5:179696409ENST00000512629+317217_24755.666666666666664952.0RepeatNote=ANK 7
HgeneRAI14chr5:34757703chr5:179696409ENST00000512629+31752_8155.666666666666664952.0RepeatNote=ANK 2
HgeneRAI14chr5:34757703chr5:179696409ENST00000512629+31785_11455.666666666666664952.0RepeatNote=ANK 3
HgeneRAI14chr5:34757703chr5:179696409ENST00000515799+520118_14758.666666666666664984.0RepeatNote=ANK 4
HgeneRAI14chr5:34757703chr5:179696409ENST00000515799+520151_18058.666666666666664984.0RepeatNote=ANK 5
HgeneRAI14chr5:34757703chr5:179696409ENST00000515799+520184_21358.666666666666664984.0RepeatNote=ANK 6
HgeneRAI14chr5:34757703chr5:179696409ENST00000515799+520217_24758.666666666666664984.0RepeatNote=ANK 7
HgeneRAI14chr5:34757703chr5:179696409ENST00000515799+52052_8158.666666666666664984.0RepeatNote=ANK 2
HgeneRAI14chr5:34757703chr5:179696409ENST00000515799+52085_11458.666666666666664984.0RepeatNote=ANK 3
TgeneMAPK9chr5:34757703chr5:179696409ENST0000034311111226_32140.666666666666664383.0DomainProtein kinase
TgeneMAPK9chr5:34757703chr5:179696409ENST0000039336011226_32140.666666666666664383.0DomainProtein kinase
TgeneMAPK9chr5:34757703chr5:179696409ENST000004254911726_32140.666666666666664243.0DomainProtein kinase
TgeneMAPK9chr5:34757703chr5:179696409ENST0000045213511226_32140.666666666666664425.0DomainProtein kinase
TgeneMAPK9chr5:34757703chr5:179696409ENST0000045578111226_32140.666666666666664425.0DomainProtein kinase
TgeneMAPK9chr5:34757703chr5:179696409ENST0000034311111232_4040.666666666666664383.0Nucleotide bindingATP
TgeneMAPK9chr5:34757703chr5:179696409ENST0000039336011232_4040.666666666666664383.0Nucleotide bindingATP
TgeneMAPK9chr5:34757703chr5:179696409ENST000004254911732_4040.666666666666664243.0Nucleotide bindingATP
TgeneMAPK9chr5:34757703chr5:179696409ENST0000045213511232_4040.666666666666664425.0Nucleotide bindingATP
TgeneMAPK9chr5:34757703chr5:179696409ENST0000045578111232_4040.666666666666664425.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RAI14
MAPK9


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RAI14-MAPK9


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RAI14-MAPK9


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource