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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RASAL2-COPA

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RASAL2-COPA
	FusionPDB ID: 72419
	FusionGDB2.0 ID: 72419
		Hgene	Tgene
	Gene symbol	RASAL2	COPA
	Gene ID	9462	1314
	Gene name	RAS protein activator like 2	COPI coat complex subunit alpha
	Synonyms	NGAP	AILJK\|HEP-COP\|alpha-COP
	Cytomap	1q25.2	1q23.2
	Type of gene	protein-coding	protein-coding
	Description	ras GTPase-activating protein nGAPRASAL2/ACVR1 fusionRas protein activator like 1	coatomer subunit alphaalpha coat proteincoatomer protein complex subunit alphaproxeninxenin
	Modification date	20200313	20200327
	UniProtAcc	.	P53621
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000462775, ENST00000367649, ENST00000448150, ENST00000465723,	ENST00000241704, ENST00000368069,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 13 X 10=2470	12 X 9 X 8=864
	# samples	20	13
	** MAII score	log2(20/2470*10)=-3.62643913669732 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/864*10)=-2.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RASAL2 [Title/Abstract] AND COPA [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RASAL2(178269253)-COPA(160310084), # samples:3
Anticipated loss of major functional domain due to fusion event.	RASAL2-COPA seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RASAL2-COPA seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RASAL2-COPA seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. RASAL2-COPA seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	COPA	GO:0030157	pancreatic juice secretion	1429581

Fusion gene breakpoints across RASAL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across COPA (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CHOL	TCGA-4G-AAZO-01A	RASAL2	chr1	178269253	-	COPA	chr1	160310084	-
ChimerDB4	CHOL	TCGA-4G-AAZO-01A	RASAL2	chr1	178269253	+	COPA	chr1	160310084	-
ChimerDB4	PRAD	TCGA-EJ-5518	RASAL2	chr1	178310743	+	COPA	chr1	160305112	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000448150	RASAL2	chr1	178269253	+	ENST00000368069	COPA	chr1	160310084	-	5767	1221	410	4882	1490
ENST00000448150	RASAL2	chr1	178269253	+	ENST00000241704	COPA	chr1	160310084	-	5740	1221	410	4855	1481
ENST00000367649	RASAL2	chr1	178269253	+	ENST00000368069	COPA	chr1	160310084	-	5355	809	166	4470	1434
ENST00000367649	RASAL2	chr1	178269253	+	ENST00000241704	COPA	chr1	160310084	-	5328	809	166	4443	1425

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000448150	ENST00000368069	RASAL2	chr1	178269253	+	COPA	chr1	160310084	-	0.001692468	0.99830747
ENST00000448150	ENST00000241704	RASAL2	chr1	178269253	+	COPA	chr1	160310084	-	0.001792927	0.9982071
ENST00000367649	ENST00000368069	RASAL2	chr1	178269253	+	COPA	chr1	160310084	-	0.000812912	0.99918705
ENST00000367649	ENST00000241704	RASAL2	chr1	178269253	+	COPA	chr1	160310084	-	0.000880711	0.99911934

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>72419_72419_1_RASAL2-COPA_RASAL2_chr1_178269253_ENST00000367649_COPA_chr1_160310084_ENST00000241704_length(amino acids)=1425AA_BP=214
MHRPSLGQWATGKEVRGVRAGCRSGPCPRCALSSSPYRRQGAEPRASPPRSRRLVPLPPRGTMELSPSSGGAAEALSWPEMFPALESDSP
LPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQE
QQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSG
GDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTV
RVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHY
NNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDR
FLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVL
DRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHAIVICNRKLD
ALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYD
EVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKN
FDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDPEKETIPDID
PNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGG
WDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTT
YQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICRE
YIVGLSVETERKKLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACE

--------------------------------------------------------------

>72419_72419_2_RASAL2-COPA_RASAL2_chr1_178269253_ENST00000367649_COPA_chr1_160310084_ENST00000368069_length(amino acids)=1434AA_BP=214
MHRPSLGQWATGKEVRGVRAGCRSGPCPRCALSSSPYRRQGAEPRASPPRSRRLVPLPPRGTMELSPSSGGAAEALSWPEMFPALESDSP
LPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQSWVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQE
QQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKLGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSG
GDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTV
RVWDISGLRKKNLSPGAVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHY
NNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDR
FLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPAENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVL
DRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGNLLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHEHSCPLPLTA
IVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFK
LALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIV
EMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDP
EKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIASKGKGGALAADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDAL
GKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFL
QTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKLNDLIQRLQLCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEA
QQLITICREYIVGLSVETERKKLPKETLEQQKRICEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQ

--------------------------------------------------------------

>72419_72419_3_RASAL2-COPA_RASAL2_chr1_178269253_ENST00000448150_COPA_chr1_160310084_ENST00000241704_length(amino acids)=1481AA_BP=270
MKKAAPRRWEGEPPLPGSSASSPGRDPHTPEPGPTLGRGHAGSSSRPGSRPPTAGGLHRPSLGQWATGKEVRGVRAGCRSGPCPRCALSS
SPYRRQGAEPRASPPRSRRLVPLPPRGTMELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQS
WVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKL
GLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHH
EYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTT
DAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTG
VQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPA
ENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGN
LLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYTTSNHIKYAV
TTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGYPEVALHFVK
DEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAEIRKDMSGHY
QNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVSKGFFEGTIA
SKGKGGALAADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAEDGFFVPPTKG
TSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKNGVPAVGLKL
NDLIQRLQLCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRICEMAAYFTH
SNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYRPIYRGKPVE

--------------------------------------------------------------

>72419_72419_4_RASAL2-COPA_RASAL2_chr1_178269253_ENST00000448150_COPA_chr1_160310084_ENST00000368069_length(amino acids)=1490AA_BP=270
MKKAAPRRWEGEPPLPGSSASSPGRDPHTPEPGPTLGRGHAGSSSRPGSRPPTAGGLHRPSLGQWATGKEVRGVRAGCRSGPCPRCALSS
SPYRRQGAEPRASPPRSRRLVPLPPRGTMELSPSSGGAAEALSWPEMFPALESDSPLPPEDLDAVVPVSGAVAGGMLDRILLESVCQQQS
WVRVYDVKGPPTHRLSCGQSPYTETTTWERKYCILTDSQLVLLNKEKEIPVEGGQEQQTDSTKGRCLRRTVSVPSEGQFPEYPPEGATKL
GLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHH
EYPWILSASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPGAVESDVRGITGVDLFGTT
DAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTG
VQTFRRDHDRFWVLAAHPNLNLFAAGHDGGMIVFKLERERPAYAVHGNMLHYVKDRFLRQLDFNSSKDVAVMQLRSGSKFPVFNMSYNPA
ENAVLLCTRASNLENSTYDLYTIPKDADSQNPDAPEGKRSSGLTAVWVARNRFAVLDRMHSLLIKNLKNEITKKVQVPNCDEIFYAGTGN
LLLRDADSITLFDVQQKRTLASVKISKVKYVIWSADMSHVALLAKHEHSCPLPLTAIVICNRKLDALCNIHENIRVKSGAWDESGVFIYT
TSNHIKYAVTTGDHGIIRTLDLPIYVTRVKGNNVYCLDRECRPRVLTIDPTEFKFKLALINRKYDEVLHMVRNAKLVGQSIIAYLQKKGY
PEVALHFVKDEKTRFSLALECGNIEIALEAAKALDDKNCWEKLGEVALLQGNHQIVEMCYQRTKNFDKLSFLYLITGNLEKLRKMMKIAE
IRKDMSGHYQNALYLGDVSERVRILKNCGQKSLAYLTAATHGLDEEAESLKETFDPEKETIPDIDPNAKLLQPPAPIMPLDTNWPLLTVS
KGFFEGTIASKGKGGALAADIDIDTVGTEGWGEDAELQLDEDGFVEATEGLGDDALGKGQEEGGGWDVEEDLELPPELDISPGAAGGAED
GFFVPPTKGTSPTQIWCNNSQLPVDHILAGSFETAMRLLHDQVGVIQFGPYKQLFLQTYARGRTTYQALPCLPSMYGYPNRNWKDAGLKN
GVPAVGLKLNDLIQRLQLCYQLTTVGKFEEAVEKFRSILLSVPLLVVDNKQEIAEAQQLITICREYIVGLSVETERKKLPKETLEQQKRI
CEMAAYFTHSNLQPVHMILVLRTALNLFFKLKNFKTAATFARRLLELGPKPEVAQQTRKILSACEKNPTDAYQLNYDMHNPFDICAASYR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:178269253/chr1:160310084)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	COPA P53621
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.; FUNCTION: Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000241704

126_164

13.333333333333334

1225.0

Repeat

Note=WD 4

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000241704

195_234

13.333333333333334

1225.0

Repeat

Note=WD 5

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000241704

241_278

13.333333333333334

1225.0

Repeat

Note=WD 6

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000241704

282_319

13.333333333333334

1225.0

Repeat

Note=WD 7

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000241704

42_80

13.333333333333334

1225.0

Repeat

Note=WD 2

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000241704

84_122

13.333333333333334

1225.0

Repeat

Note=WD 3

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000368069

126_164

13.333333333333334

1234.0

Repeat

Note=WD 4

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000368069

195_234

13.333333333333334

1234.0

Repeat

Note=WD 5

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000368069

241_278

13.333333333333334

1234.0

Repeat

Note=WD 6

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000368069

282_319

13.333333333333334

1234.0

Repeat

Note=WD 7

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000368069

42_80

13.333333333333334

1234.0

Repeat

Note=WD 2

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000368069

84_122

13.333333333333334

1234.0

Repeat

Note=WD 3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RASAL2

chr1:178269253

chr1:160310084

ENST00000367649

237_243

152.33333333333334

1281.0

Compositional bias

Note=Poly-Lys

Hgene

RASAL2

chr1:178269253

chr1:160310084

ENST00000367649

922_925

152.33333333333334

1281.0

Compositional bias

Note=Poly-Ser

Hgene

RASAL2

chr1:178269253

chr1:160310084

ENST00000462775

237_243

1140.0

Compositional bias

Note=Poly-Lys

Hgene

RASAL2

chr1:178269253

chr1:160310084

ENST00000462775

922_925

1140.0

Compositional bias

Note=Poly-Ser

Hgene

RASAL2

chr1:178269253

chr1:160310084

ENST00000367649

149_267

152.33333333333334

1281.0

Domain

Hgene

RASAL2

chr1:178269253

chr1:160310084

ENST00000367649

327_519

152.33333333333334

1281.0

Domain

Ras-GAP

Hgene

RASAL2

chr1:178269253

chr1:160310084

ENST00000367649

41_158

152.33333333333334

1281.0

Domain

Note=PH

Hgene

RASAL2

chr1:178269253

chr1:160310084

ENST00000462775

149_267

1140.0

Domain

Hgene

RASAL2

chr1:178269253

chr1:160310084

ENST00000462775

327_519

1140.0

Domain

Ras-GAP

Hgene

RASAL2

chr1:178269253

chr1:160310084

ENST00000462775

41_158

1140.0

Domain

Note=PH

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000241704

3_38

13.333333333333334

1225.0

Repeat

Note=WD 1

Tgene

COPA

chr1:178269253

chr1:160310084

ENST00000368069

3_38

13.333333333333334

1234.0

Repeat

Note=WD 1

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RASAL2
COPA

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to RASAL2-COPA

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RASAL2-COPA

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source