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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ASXL1-TM9SF4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ASXL1-TM9SF4
FusionPDB ID: 7299
FusionGDB2.0 ID: 7299
HgeneTgene
Gene symbol

ASXL1

TM9SF4

Gene ID

171023

9777

Gene nameASXL transcriptional regulator 1transmembrane 9 superfamily member 4
SynonymsBOPS|MDSdJ836N17.2
Cytomap

20q11.21

20q11.21

Type of geneprotein-codingprotein-coding
Descriptionpolycomb group protein ASXL1additional sex combs like 1, transcriptional regulatoradditional sex combs like transcriptional regulator 1putative Polycomb group protein ASXL1transmembrane 9 superfamily member 4dinucleotide oxidase disulfide thiol exchanger 3 superfamily member 4transmembrane 9 superfamily protein member 4tumor cannibalism associated protein 1
Modification date2020031320200313
UniProtAcc

Q8IXJ9

.
Ensembl transtripts involved in fusion geneENST idsENST00000470145, ENST00000306058, 
ENST00000375687, ENST00000375689, 
ENST00000542461, 		ENST00000217315, 
ENST00000398022, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 10 X 8=12809 X 9 X 7=567
# samples 2114
** MAII scorelog2(21/1280*10)=-2.60768257722124
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/567*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ASXL1 [Title/Abstract] AND TM9SF4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ASXL1(30956926)-TM9SF4(30720816), # samples:9
Anticipated loss of major functional domain due to fusion event.ASXL1-TM9SF4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL1-TM9SF4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL1-TM9SF4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASXL1-TM9SF4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASXL1

GO:0035522

monoubiquitinated histone H2A deubiquitination

20436459

TgeneTM9SF4

GO:0001666

response to hypoxia

25961573


check buttonFusion gene breakpoints across ASXL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TM9SF4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A13D-01AASXL1chr20

30956926

+TM9SF4chr20

30720816

+
ChimerDB4BRCATCGA-A7-A13D-01BASXL1chr20

30956926

-TM9SF4chr20

30720816

+
ChimerDB4BRCATCGA-A7-A13D-01BASXL1chr20

30956926

+TM9SF4chr20

30720816

+
ChimerDB4BRCATCGA-A7-A13DASXL1chr20

30956926

+TM9SF4chr20

30720815

+
ChimerDB4LUADTCGA-91-7771-01AASXL1chr20

30956926

-TM9SF4chr20

30720816

+
ChimerDB4LUADTCGA-91-7771-01AASXL1chr20

30956926

+TM9SF4chr20

30720816

+
ChimerDB4OVTCGA-13-1410-01AASXL1chr20

30956926

+TM9SF4chr20

30720816

+
ChimerDB4OVTCGA-13-1410ASXL1chr20

30956926

+TM9SF4chr20

30720815

+
ChimerDB4STADTCGA-VQ-A8E2-01AASXL1chr20

30956926

-TM9SF4chr20

30720816

+
ChimerDB4STADTCGA-VQ-A8E2-01AASXL1chr20

30956926

+TM9SF4chr20

30720816

+
ChimerDB4STADTCGA-VQ-A8E2ASXL1chr20

30956926

+TM9SF4chr20

30720815

+
ChimerDB4UCECTCGA-EY-A1GR-01AASXL1chr20

30956926

+TM9SF4chr20

30737437

+
ChimerDB4UCECTCGA-EY-A1GRASXL1chr20

30956926

+TM9SF4chr20

30737436

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375687ASXL1chr2030956926+ENST00000398022TM9SF4chr2030720815+44046761782589803
ENST00000542461ASXL1chr2030956926+ENST00000398022TM9SF4chr2030720815+43946661712579802
ENST00000375689ASXL1chr2030956926+ENST00000398022TM9SF4chr2030720815+41504221822335717
ENST00000306058ASXL1chr2030956926+ENST00000398022TM9SF4chr2030720815+396523702150716
ENST00000375687ASXL1chr2030956926+ENST00000398022TM9SF4chr2030737436+34656761781650490
ENST00000375687ASXL1chr2030956926+ENST00000217315TM9SF4chr2030737436+34656761781650490
ENST00000542461ASXL1chr2030956926+ENST00000398022TM9SF4chr2030737436+34556661711640489
ENST00000542461ASXL1chr2030956926+ENST00000217315TM9SF4chr2030737436+34556661711640489
ENST00000375689ASXL1chr2030956926+ENST00000398022TM9SF4chr2030737436+32114221821396404
ENST00000375689ASXL1chr2030956926+ENST00000217315TM9SF4chr2030737436+32114221821396404
ENST00000306058ASXL1chr2030956926+ENST00000398022TM9SF4chr2030737436+302623701211403
ENST00000306058ASXL1chr2030956926+ENST00000217315TM9SF4chr2030737436+302623701211403
ENST00000375687ASXL1chr2030956926+ENST00000398022TM9SF4chr2030720816+44046761782589803
ENST00000542461ASXL1chr2030956926+ENST00000398022TM9SF4chr2030720816+43946661712579802
ENST00000375689ASXL1chr2030956926+ENST00000398022TM9SF4chr2030720816+41504221822335717
ENST00000306058ASXL1chr2030956926+ENST00000398022TM9SF4chr2030720816+396523702150716
ENST00000375687ASXL1chr2030956926+ENST00000398022TM9SF4chr2030737437+34656761781650490
ENST00000375687ASXL1chr2030956926+ENST00000217315TM9SF4chr2030737437+34656761781650490
ENST00000542461ASXL1chr2030956926+ENST00000398022TM9SF4chr2030737437+34556661711640489
ENST00000542461ASXL1chr2030956926+ENST00000217315TM9SF4chr2030737437+34556661711640489
ENST00000375689ASXL1chr2030956926+ENST00000398022TM9SF4chr2030737437+32114221821396404
ENST00000375689ASXL1chr2030956926+ENST00000217315TM9SF4chr2030737437+32114221821396404
ENST00000306058ASXL1chr2030956926+ENST00000398022TM9SF4chr2030737437+302623701211403
ENST00000306058ASXL1chr2030956926+ENST00000217315TM9SF4chr2030737437+302623701211403

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375687ENST00000398022ASXL1chr2030956926+TM9SF4chr2030720815+0.0051314110.99486864
ENST00000542461ENST00000398022ASXL1chr2030956926+TM9SF4chr2030720815+0.0075215440.9924785
ENST00000375689ENST00000398022ASXL1chr2030956926+TM9SF4chr2030720815+0.0022277370.9977723
ENST00000306058ENST00000398022ASXL1chr2030956926+TM9SF4chr2030720815+0.0024425770.9975574
ENST00000375687ENST00000398022ASXL1chr2030956926+TM9SF4chr2030737436+0.0169779640.9830221
ENST00000375687ENST00000217315ASXL1chr2030956926+TM9SF4chr2030737436+0.0169779640.9830221
ENST00000542461ENST00000398022ASXL1chr2030956926+TM9SF4chr2030737436+0.0158038330.9841962
ENST00000542461ENST00000217315ASXL1chr2030956926+TM9SF4chr2030737436+0.0158038330.9841962
ENST00000375689ENST00000398022ASXL1chr2030956926+TM9SF4chr2030737436+0.0120876820.98791236
ENST00000375689ENST00000217315ASXL1chr2030956926+TM9SF4chr2030737436+0.0120876820.98791236
ENST00000306058ENST00000398022ASXL1chr2030956926+TM9SF4chr2030737436+0.0095450760.99045485
ENST00000306058ENST00000217315ASXL1chr2030956926+TM9SF4chr2030737436+0.0095450760.99045485
ENST00000375687ENST00000398022ASXL1chr2030956926+TM9SF4chr2030720816+0.0051314110.99486864
ENST00000542461ENST00000398022ASXL1chr2030956926+TM9SF4chr2030720816+0.0075215440.9924785
ENST00000375689ENST00000398022ASXL1chr2030956926+TM9SF4chr2030720816+0.0022277370.9977723
ENST00000306058ENST00000398022ASXL1chr2030956926+TM9SF4chr2030720816+0.0024425770.9975574
ENST00000375687ENST00000398022ASXL1chr2030956926+TM9SF4chr2030737437+0.0169779640.9830221
ENST00000375687ENST00000217315ASXL1chr2030956926+TM9SF4chr2030737437+0.0169779640.9830221
ENST00000542461ENST00000398022ASXL1chr2030956926+TM9SF4chr2030737437+0.0158038330.9841962
ENST00000542461ENST00000217315ASXL1chr2030956926+TM9SF4chr2030737437+0.0158038330.9841962
ENST00000375689ENST00000398022ASXL1chr2030956926+TM9SF4chr2030737437+0.0120876820.98791236
ENST00000375689ENST00000217315ASXL1chr2030956926+TM9SF4chr2030737437+0.0120876820.98791236
ENST00000306058ENST00000398022ASXL1chr2030956926+TM9SF4chr2030737437+0.0095450760.99045485
ENST00000306058ENST00000217315ASXL1chr2030956926+TM9SF4chr2030737437+0.0095450760.99045485

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7299_7299_1_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000306058_TM9SF4_chr20_30720815_ENST00000398022_length(amino acids)=716AA_BP=79
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKDWLPWSLLLFS
LMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQ
SNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEE
DQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINS
VVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRG
ALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYL
GYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMV

--------------------------------------------------------------

>7299_7299_2_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000306058_TM9SF4_chr20_30720816_ENST00000398022_length(amino acids)=716AA_BP=79
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKDWLPWSLLLFS
LMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQ
SNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEE
DQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINS
VVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRG
ALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYL
GYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMV

--------------------------------------------------------------

>7299_7299_3_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000306058_TM9SF4_chr20_30737436_ENST00000217315_length(amino acids)=403AA_BP=77
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKL
VHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATL
YPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGIL
PFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEF

--------------------------------------------------------------

>7299_7299_4_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000306058_TM9SF4_chr20_30737436_ENST00000398022_length(amino acids)=403AA_BP=77
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKL
VHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATL
YPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGIL
PFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEF

--------------------------------------------------------------

>7299_7299_5_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000306058_TM9SF4_chr20_30737437_ENST00000217315_length(amino acids)=403AA_BP=77
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKL
VHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATL
YPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGIL
PFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEF

--------------------------------------------------------------

>7299_7299_6_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000306058_TM9SF4_chr20_30737437_ENST00000398022_length(amino acids)=403AA_BP=77
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKL
VHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATL
YPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGIL
PFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEF

--------------------------------------------------------------

>7299_7299_7_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375687_TM9SF4_chr20_30720815_ENST00000398022_length(amino acids)=803AA_BP=166
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKDWLPWSLLLFSLMC
ETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNK
PVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQE
HTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVV
VFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALM
TTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYY
FGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQ

--------------------------------------------------------------

>7299_7299_8_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375687_TM9SF4_chr20_30720816_ENST00000398022_length(amino acids)=803AA_BP=166
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKDWLPWSLLLFSLMC
ETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNK
PVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQE
HTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVV
VFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALM
TTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYY
FGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQ

--------------------------------------------------------------

>7299_7299_9_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375687_TM9SF4_chr20_30737436_ENST00000217315_length(amino acids)=490AA_BP=164
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKLVHG
DVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPG
VVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFG
AMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPS

--------------------------------------------------------------

>7299_7299_10_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375687_TM9SF4_chr20_30737436_ENST00000398022_length(amino acids)=490AA_BP=164
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKLVHG
DVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPG
VVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFG
AMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPS

--------------------------------------------------------------

>7299_7299_11_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375687_TM9SF4_chr20_30737437_ENST00000217315_length(amino acids)=490AA_BP=164
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKLVHG
DVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPG
VVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFG
AMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPS

--------------------------------------------------------------

>7299_7299_12_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375687_TM9SF4_chr20_30737437_ENST00000398022_length(amino acids)=490AA_BP=164
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKLVHG
DVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPG
VVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFG
AMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPS

--------------------------------------------------------------

>7299_7299_13_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375689_TM9SF4_chr20_30720815_ENST00000398022_length(amino acids)=717AA_BP=80
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKDWLPWSLLLF
SLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCS
QSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDME
EDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIIN
SVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSR
GALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVY
LGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVM

--------------------------------------------------------------

>7299_7299_14_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375689_TM9SF4_chr20_30720816_ENST00000398022_length(amino acids)=717AA_BP=80
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKDWLPWSLLLF
SLMCETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCS
QSNKPVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDME
EDQEHTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIIN
SVVVVFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSR
GALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVY
LGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVM

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>7299_7299_15_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375689_TM9SF4_chr20_30737436_ENST00000217315_length(amino acids)=404AA_BP=78
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWK
LVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTAT
LYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGI
LPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVE

--------------------------------------------------------------

>7299_7299_16_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375689_TM9SF4_chr20_30737436_ENST00000398022_length(amino acids)=404AA_BP=78
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWK
LVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTAT
LYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGI
LPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVE

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>7299_7299_17_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375689_TM9SF4_chr20_30737437_ENST00000217315_length(amino acids)=404AA_BP=78
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWK
LVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTAT
LYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGI
LPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVE

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>7299_7299_18_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000375689_TM9SF4_chr20_30737437_ENST00000398022_length(amino acids)=404AA_BP=78
MGVVNFVFRASEDLQVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWK
LVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTAT
LYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGI
LPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVE

--------------------------------------------------------------

>7299_7299_19_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000542461_TM9SF4_chr20_30720815_ENST00000398022_length(amino acids)=802AA_BP=165
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKDWLPWSLLLFSLMCE
TSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKP
VTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEH
TYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVV
FFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMT
TACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYF
GFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQL

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>7299_7299_20_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000542461_TM9SF4_chr20_30720816_ENST00000398022_length(amino acids)=802AA_BP=165
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKDWLPWSLLLFSLMCE
TSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNKP
VTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQEH
TYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVVV
FFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMT
TACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYF
GFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQL

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>7299_7299_21_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000542461_TM9SF4_chr20_30737436_ENST00000217315_length(amino acids)=489AA_BP=163
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKLVHGD
VFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGV
VFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGA
MFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSL

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>7299_7299_22_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000542461_TM9SF4_chr20_30737436_ENST00000398022_length(amino acids)=489AA_BP=163
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKLVHGD
VFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGV
VFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGA
MFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSL

--------------------------------------------------------------

>7299_7299_23_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000542461_TM9SF4_chr20_30737437_ENST00000217315_length(amino acids)=489AA_BP=163
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKLVHGD
VFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGV
VFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGA
MFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSL

--------------------------------------------------------------

>7299_7299_24_ASXL1-TM9SF4_ASXL1_chr20_30956926_ENST00000542461_TM9SF4_chr20_30737437_ENST00000398022_length(amino acids)=489AA_BP=163
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKEDTMEESGWKLVHGD
VFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALMTTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGV
VFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYYFGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGA
MFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQLCAEDYRWWWRNFLVSGGSAFYVLVYAIFYFVNKLDIVEFIPSL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:30956926/chr20:30720816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ASXL1

Q8IXJ9

.
FUNCTION: Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG) (PubMed:16606617). Acts as coactivator of RARA and RXRA through association with NCOA1 (PubMed:16606617). Acts as corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity (By similarity). Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (PubMed:20436459). Acts as a sensor of N(6)-methyladenosine methylation on DNA (m6A): recognizes and binds m6A DNA, leading to its ubiquitination and degradation by TRIP12, thereby inactivating the PR-DUB complex and regulating Polycomb silencing (PubMed:30982744). {ECO:0000250|UniProtKB:P59598, ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:20436459, ECO:0000269|PubMed:30982744}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+4132_984.01542.0Compositional biasNote=Poly-Lys
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+4132_984.01542.0Compositional biasNote=Poly-Lys
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+4132_984.01542.0Compositional biasNote=Poly-Lys
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+4132_984.01542.0Compositional biasNote=Poly-Lys
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+41311_8684.01542.0DomainHTH HARE-type
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+41311_8684.01542.0DomainHTH HARE-type
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+41311_8684.01542.0DomainHTH HARE-type
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+41311_8684.01542.0DomainHTH HARE-type
TgeneTM9SF4chr20:30956926chr20:30720815ENST0000021731501824_2810626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018303_3460626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018368_3760626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018398_4160626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018438_4490626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018471_5010626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018523_5350626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018557_5700626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018592_5980626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018620_6420626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720815ENST0000039802201824_2815.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018303_3465.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018368_3765.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018398_4165.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018438_4495.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018471_5015.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018523_5355.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018557_5705.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018592_5985.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018620_6425.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720816ENST0000021731501824_2810626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018303_3460626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018368_3760626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018398_4160626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018438_4490626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018471_5010626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018523_5350626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018557_5700626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018592_5980626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018620_6420626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720816ENST0000039802201824_2815.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018303_3465.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018368_3765.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018398_4165.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018438_4495.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018471_5015.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018523_5355.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018557_5705.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018592_5985.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018620_6425.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818303_346301.0626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818368_376301.0626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818398_416301.0626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818438_449301.0626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818471_501301.0626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818523_535301.0626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818557_570301.0626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818592_598301.0626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818620_642301.0626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818368_376318.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818398_416318.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818438_449318.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818471_501318.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818523_535318.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818557_570318.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818592_598318.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818620_642318.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818303_346301.0626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818368_376301.0626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818398_416301.0626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818438_449301.0626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818471_501301.0626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818523_535301.0626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818557_570301.0626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818592_598301.0626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818620_642301.0626.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818368_376318.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818398_416318.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818438_449318.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818471_501318.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818523_535318.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818557_570318.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818592_598318.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818620_642318.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018282_3020626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018347_3670626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018377_3970626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018417_4370626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018450_4700626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018502_5220626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018536_5560626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018571_5910626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000217315018599_6190626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018282_3025.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018347_3675.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018377_3975.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018417_4375.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018450_4705.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018502_5225.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018536_5565.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018571_5915.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720815ENST00000398022018599_6195.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018282_3020626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018347_3670626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018377_3970626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018417_4370626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018450_4700626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018502_5220626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018536_5560626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018571_5910626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000217315018599_6190626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018282_3025.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018347_3675.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018377_3975.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018417_4375.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018450_4705.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018502_5225.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018536_5565.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018571_5915.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30720816ENST00000398022018599_6195.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818347_367301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818377_397301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818417_437301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818450_470301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818502_522301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818536_556301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818571_591301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818599_619301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818347_367318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818377_397318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818417_437318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818450_470318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818502_522318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818536_556318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818571_591318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818599_619318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818347_367301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818377_397301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818417_437301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818450_470301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818502_522301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818536_556301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818571_591301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818599_619301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818347_367318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818377_397318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818417_437318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818450_470318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818502_522318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818536_556318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818571_591318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818599_619318.0643.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+4131457_146084.01542.0Compositional biasNote=Poly-Ser
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+413199_20984.01542.0Compositional biasNote=Poly-Ser
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+413641_68484.01542.0Compositional biasNote=Gly-rich
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+4131457_146084.01542.0Compositional biasNote=Poly-Ser
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+413199_20984.01542.0Compositional biasNote=Poly-Ser
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+413641_68484.01542.0Compositional biasNote=Gly-rich
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+4131457_146084.01542.0Compositional biasNote=Poly-Ser
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+413199_20984.01542.0Compositional biasNote=Poly-Ser
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+413641_68484.01542.0Compositional biasNote=Gly-rich
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+4131457_146084.01542.0Compositional biasNote=Poly-Ser
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+413199_20984.01542.0Compositional biasNote=Poly-Ser
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+413641_68484.01542.0Compositional biasNote=Gly-rich
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+413255_36484.01542.0DomainDEUBAD
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+413255_36484.01542.0DomainDEUBAD
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+413255_36484.01542.0DomainDEUBAD
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+413255_36484.01542.0DomainDEUBAD
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+413160_16484.01542.0MotifNuclear localization signal 1
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+413284_28884.01542.0MotifNote=LXXLL motif
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+413409_41384.01542.0MotifNuclear localization signal 2
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+413160_16484.01542.0MotifNuclear localization signal 1
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+413284_28884.01542.0MotifNote=LXXLL motif
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+413409_41384.01542.0MotifNuclear localization signal 2
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+413160_16484.01542.0MotifNuclear localization signal 1
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+413284_28884.01542.0MotifNote=LXXLL motif
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+413409_41384.01542.0MotifNuclear localization signal 2
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+413160_16484.01542.0MotifNuclear localization signal 1
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+413284_28884.01542.0MotifNote=LXXLL motif
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+413409_41384.01542.0MotifNuclear localization signal 2
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+4131503_154084.01542.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+4131503_154084.01542.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+4131503_154084.01542.0Zinc fingerNote=PHD-type%3B atypical
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+4131503_154084.01542.0Zinc fingerNote=PHD-type%3B atypical
TgeneTM9SF4chr20:30956926chr20:30737436ENST0000021731581824_281301.0626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737436ENST0000039802281824_281318.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818303_346318.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737437ENST0000021731581824_281301.0626.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737437ENST0000039802281824_281318.0643.0Topological domainExtracellular
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818303_346318.0643.0Topological domainCytoplasmic
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000217315818282_302301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737436ENST00000398022818282_302318.0643.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000217315818282_302301.0626.0TransmembraneHelical
TgeneTM9SF4chr20:30956926chr20:30737437ENST00000398022818282_302318.0643.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1582_ASXL1_30956926_TM9SF4_30720816_ranked_0.pdbASXL13095692630956926ENST00000217315TM9SF4chr2030720816+
MPPWATDAARARGAAAAPPPPPLSRQPVPACPPLLPGRTRDLARRRCHAPPPPPPPPQPRATAPARPARRSRVELPPPPGRRMKDKQKKK
KERTWAEAARLVLENYSDAPMTPKQILQVIEAEGLKEMRSGTSPLACLNAMLHSNSRGGEGLFYKLPGRISLFTLKDWLPWSLLLFSLMC
ETSAFYVPGVAPINFHQNDPVEIKAVKLTSSRTQLPYEYYSLPFCQPSKITYKAENLGEVLRGDRIVNTPFQVLMNSEKKCEVLCSQSNK
PVTLTVEQSRLVAERITEDYYVHLIADNLPVATRLELYSNRDSDDKKKEKDVQFEHGYRLGFTDVNKIYLHNHLSFILYYHREDMEEDQE
HTYRVVRFEVIPQSIRLEDLKADEKSSCTLPEGTNSSPQEIDPTKENQLYFTYSVHWEESDIKWASRWDTYLTMSDVQIHWFSIINSVVV
VFFLSGILSMIIIRTLRKDIANYNKEDDIEDTMEESGWKLVHGDVFRPPQYPMILSSLLGSGIQLFCMILIVIFVAMLGMLSPSSRGALM
TTACFLFMFMGVFGGFSAGRLYRTLKGHRWKKGAFCTATLYPGVVFGICFVLNCFIWGKHSSGAVPFPTMVALLCMWFGISLPLVYLGYY
FGFRKQPYDNPVRTNQIPRQIPEQRWYMNRFVGILMAGILPFGAMFIELFFIFSAIWENQFYYLFGFLFLVFIILVVSCSQISIVMVYFQ
803


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ASXL1_pLDDT.png
all structure
all structure
TM9SF4_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ASXL1
TM9SF4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneASXL1chr20:30956926chr20:30720815ENST00000375687+413300_65884.01542.0NCOA1
HgeneASXL1chr20:30956926chr20:30720816ENST00000375687+413300_65884.01542.0NCOA1
HgeneASXL1chr20:30956926chr20:30737436ENST00000375687+413300_65884.01542.0NCOA1
HgeneASXL1chr20:30956926chr20:30737437ENST00000375687+413300_65884.01542.0NCOA1


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Related Drugs to ASXL1-TM9SF4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ASXL1-TM9SF4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource