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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RCOR3-KCNH1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RCOR3-KCNH1
FusionPDB ID: 73336
FusionGDB2.0 ID: 73336
HgeneTgene
Gene symbol

RCOR3

KCNH1

Gene ID

55758

3756

Gene nameREST corepressor 3potassium voltage-gated channel subfamily H member 1
Synonyms-EAG|EAG1|Kv10.1|TMBTS|ZLS1|h-eag|hEAG|hEAG1
Cytomap

1q32.2-q32.3

1q32.2

Type of geneprotein-codingprotein-coding
DescriptionREST corepressor 3potassium voltage-gated channel subfamily H member 1EAG channel 1ether-a-go-go 1ether-a-go-go potassium channel 1ether-a-go-go, Drosophila, homolog ofpotassium channel, voltage gated eag related subfamily H, member 1potassium voltage-gated channel,
Modification date2020032720200313
UniProtAcc.

O95259

Ensembl transtripts involved in fusion geneENST idsENST00000367005, ENST00000367006, 
ENST00000419091, ENST00000452621, 
ENST00000526255, 		ENST00000271751, 
ENST00000367007, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 4=646 X 5 X 6=180
# samples 46
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RCOR3 [Title/Abstract] AND KCNH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RCOR3(211469095)-KCNH1(211192598), # samples:1
Anticipated loss of major functional domain due to fusion event.RCOR3-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RCOR3-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RCOR3-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RCOR3-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKCNH1

GO:0071805

potassium ion transmembrane transport

22732247|27005320|27325704


check buttonFusion gene breakpoints across RCOR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AX-A2HF-01ARCOR3chr1

211469095

+KCNH1chr1

211192598

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367006RCOR3chr1211469095+ENST00000271751KCNH1chr1211192598-3779129928237101142
ENST00000367006RCOR3chr1211469095+ENST00000367007KCNH1chr1211192598-3673129928236291115
ENST00000452621RCOR3chr1211469095+ENST00000271751KCNH1chr1211192598-3670119017336011142
ENST00000452621RCOR3chr1211469095+ENST00000367007KCNH1chr1211192598-3564119017335201115
ENST00000419091RCOR3chr1211469095+ENST00000271751KCNH1chr1211192598-3625114512835561142
ENST00000419091RCOR3chr1211469095+ENST00000367007KCNH1chr1211192598-3519114512834751115
ENST00000367005RCOR3chr1211469095+ENST00000271751KCNH1chr1211192598-346498414133951084
ENST00000367005RCOR3chr1211469095+ENST00000367007KCNH1chr1211192598-335898414133141057

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367006ENST00000271751RCOR3chr1211469095+KCNH1chr1211192598-0.0003836430.9996164
ENST00000367006ENST00000367007RCOR3chr1211469095+KCNH1chr1211192598-0.0012206960.99877936
ENST00000452621ENST00000271751RCOR3chr1211469095+KCNH1chr1211192598-0.000379340.9996207
ENST00000452621ENST00000367007RCOR3chr1211469095+KCNH1chr1211192598-0.0012221430.9987778
ENST00000419091ENST00000271751RCOR3chr1211469095+KCNH1chr1211192598-0.0003552690.99964476
ENST00000419091ENST00000367007RCOR3chr1211469095+KCNH1chr1211192598-0.0011515760.99884844
ENST00000367005ENST00000271751RCOR3chr1211469095+KCNH1chr1211192598-0.0002060220.99979395
ENST00000367005ENST00000367007RCOR3chr1211469095+KCNH1chr1211192598-0.0007327010.9992673

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73336_73336_1_RCOR3-KCNH1_RCOR3_chr1_211469095_ENST00000367005_KCNH1_chr1_211192598_ENST00000271751_length(amino acids)=1084AA_BP=281
MRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWT
VEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAK
KEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKM
EGGIEEFKPPEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDI
VLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKV
VRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPS
KNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSER
VMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGS
LEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKR
EEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAAST
SGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVG
EARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDI

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>73336_73336_2_RCOR3-KCNH1_RCOR3_chr1_211469095_ENST00000367005_KCNH1_chr1_211192598_ENST00000367007_length(amino acids)=1057AA_BP=281
MRVGAEYQARIPEFDPGATKYTDKDNGGMLVWSPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWT
VEDKVLFEQAFSFHGKSFHRIQQMLPDKTIASLVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAK
KEGNTEQPVQTSKIGLGRREYQSLQHRHHSQRSKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKM
EGGIEEFKPPEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDI
VLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLL
VCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPS
TDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKD
MRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEA
TLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQ
RFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCA
KRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTL

--------------------------------------------------------------

>73336_73336_3_RCOR3-KCNH1_RCOR3_chr1_211469095_ENST00000367006_KCNH1_chr1_211192598_ENST00000271751_length(amino acids)=1142AA_BP=339
MPGMMEKGPELLGKNRSANGSAKSPAGGGGSGASSTNGGLHYSEPESGCSSDDEHDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVW
SPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIAS
LVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQR
SKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPEVLQLGSDILPQYKQEAPKTPP
HIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFV
IDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFG
LAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEK
IFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADI
CVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQS
CANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQ
KEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSW
ARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVL

--------------------------------------------------------------

>73336_73336_4_RCOR3-KCNH1_RCOR3_chr1_211469095_ENST00000367006_KCNH1_chr1_211192598_ENST00000367007_length(amino acids)=1115AA_BP=339
MPGMMEKGPELLGKNRSANGSAKSPAGGGGSGASSTNGGLHYSEPESGCSSDDEHDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVW
SPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIAS
LVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQR
SKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPEVLQLGSDILPQYKQEAPKTPP
HIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFV
IDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIR
NNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQ
MYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALA
MEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFY
TAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTE
HASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPE
RTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEI

--------------------------------------------------------------

>73336_73336_5_RCOR3-KCNH1_RCOR3_chr1_211469095_ENST00000419091_KCNH1_chr1_211192598_ENST00000271751_length(amino acids)=1142AA_BP=339
MPGMMEKGPELLGKNRSANGSAKSPAGGGGSGASSTNGGLHYSEPESGCSSDDEHDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVW
SPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIAS
LVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQR
SKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPEVLQLGSDILPQYKQEAPKTPP
HIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFV
IDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFG
LAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEK
IFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADI
CVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQS
CANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQ
KEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSW
ARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVL

--------------------------------------------------------------

>73336_73336_6_RCOR3-KCNH1_RCOR3_chr1_211469095_ENST00000419091_KCNH1_chr1_211192598_ENST00000367007_length(amino acids)=1115AA_BP=339
MPGMMEKGPELLGKNRSANGSAKSPAGGGGSGASSTNGGLHYSEPESGCSSDDEHDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVW
SPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIAS
LVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQR
SKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPEVLQLGSDILPQYKQEAPKTPP
HIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFV
IDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIR
NNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQ
MYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALA
MEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFY
TAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTE
HASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPE
RTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEI

--------------------------------------------------------------

>73336_73336_7_RCOR3-KCNH1_RCOR3_chr1_211469095_ENST00000452621_KCNH1_chr1_211192598_ENST00000271751_length(amino acids)=1142AA_BP=339
MPGMMEKGPELLGKNRSANGSAKSPAGGGGSGASSTNGGLHYSEPESGCSSDDEHDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVW
SPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIAS
LVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQR
SKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPEVLQLGSDILPQYKQEAPKTPP
HIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFV
IDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFG
LAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEK
IFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADI
CVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQS
CANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQ
KEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSW
ARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVL

--------------------------------------------------------------

>73336_73336_8_RCOR3-KCNH1_RCOR3_chr1_211469095_ENST00000452621_KCNH1_chr1_211192598_ENST00000367007_length(amino acids)=1115AA_BP=339
MPGMMEKGPELLGKNRSANGSAKSPAGGGGSGASSTNGGLHYSEPESGCSSDDEHDVGMRVGAEYQARIPEFDPGATKYTDKDNGGMLVW
SPYHSIPDAKLDEYIAIAKEKHGYNVEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKSFHRIQQMLPDKTIAS
LVKYYYSWKKTRSRTSLMDRQARKLANRHNQGDSDDDVEETHPMDGNDSDYDPKKEAKKEGNTEQPVQTSKIGLGRREYQSLQHRHHSQR
SKCRPPKGMYLTQEDVVAVSCSPNAANTILRQLDMELISLKRQVQNAKQVNSALKQKMEGGIEEFKPPEVLQLGSDILPQYKQEAPKTPP
HIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFV
IDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIR
NNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQ
MYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALA
MEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFY
TAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTE
HASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPE
RTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEI

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:211469095/chr1:211192598)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KCNH1

O95259

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:9738473}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRCOR3chr1:211469095chr1:211192598ENST00000367005+811237_273281.0496.0Coiled coilOntology_term=ECO:0000255
HgeneRCOR3chr1:211469095chr1:211192598ENST00000367006+911237_273339.0437.0Coiled coilOntology_term=ECO:0000255
HgeneRCOR3chr1:211469095chr1:211192598ENST00000419091+912237_273339.0554.0Coiled coilOntology_term=ECO:0000255
HgeneRCOR3chr1:211469095chr1:211192598ENST00000452621+911237_273339.0450.0Coiled coilOntology_term=ECO:0000255
HgeneRCOR3chr1:211469095chr1:211192598ENST00000367005+8111_83281.0496.0DomainELM2
HgeneRCOR3chr1:211469095chr1:211192598ENST00000367005+81184_135281.0496.0DomainSANT 1
HgeneRCOR3chr1:211469095chr1:211192598ENST00000367006+9111_83339.0437.0DomainELM2
HgeneRCOR3chr1:211469095chr1:211192598ENST00000367006+911285_336339.0437.0DomainSANT 2
HgeneRCOR3chr1:211469095chr1:211192598ENST00000367006+91184_135339.0437.0DomainSANT 1
HgeneRCOR3chr1:211469095chr1:211192598ENST00000419091+9121_83339.0554.0DomainELM2
HgeneRCOR3chr1:211469095chr1:211192598ENST00000419091+912285_336339.0554.0DomainSANT 2
HgeneRCOR3chr1:211469095chr1:211192598ENST00000419091+91284_135339.0554.0DomainSANT 1
HgeneRCOR3chr1:211469095chr1:211192598ENST00000452621+9111_83339.0450.0DomainELM2
HgeneRCOR3chr1:211469095chr1:211192598ENST00000452621+911285_336339.0450.0DomainSANT 2
HgeneRCOR3chr1:211469095chr1:211192598ENST00000452621+91184_135339.0450.0DomainSANT 1
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411449_470186.0990.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411449_470186.0963.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411463_468186.0990.0MotifSelectivity filter
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411463_468186.0963.0MotifSelectivity filter
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411673_770186.0990.0RegionCalmodulin-binding
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411924_964186.0990.0RegionCAD (involved in subunit assembly)
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411673_770186.0963.0RegionCalmodulin-binding
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411924_964186.0963.0RegionCAD (involved in subunit assembly)
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411242_248186.0990.0Topological domainExtracellular
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411270_290186.0990.0Topological domainCytoplasmic
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411310_345186.0990.0Topological domainExtracellular
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411369_377186.0990.0Topological domainCytoplasmic
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411400_448186.0990.0Topological domainExtracellular
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411471_477186.0990.0Topological domainExtracellular
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411499_989186.0990.0Topological domainCytoplasmic
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411242_248186.0963.0Topological domainExtracellular
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411270_290186.0963.0Topological domainCytoplasmic
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411310_345186.0963.0Topological domainExtracellular
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411369_377186.0963.0Topological domainCytoplasmic
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411400_448186.0963.0Topological domainExtracellular
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411471_477186.0963.0Topological domainExtracellular
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411499_989186.0963.0Topological domainCytoplasmic
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411221_241186.0990.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411249_269186.0990.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411291_309186.0990.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411346_368186.0990.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411378_399186.0990.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411478_498186.0990.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411221_241186.0963.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411249_269186.0963.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411291_309186.0963.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411346_368186.0963.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411378_399186.0963.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411478_498186.0963.0TransmembraneHelical%3B Name%3DSegment S6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRCOR3chr1:211469095chr1:211192598ENST00000367005+811385_481281.0496.0Compositional biasNote=Pro-rich
HgeneRCOR3chr1:211469095chr1:211192598ENST00000367006+911385_481339.0437.0Compositional biasNote=Pro-rich
HgeneRCOR3chr1:211469095chr1:211192598ENST00000419091+912385_481339.0554.0Compositional biasNote=Pro-rich
HgeneRCOR3chr1:211469095chr1:211192598ENST00000452621+911385_481339.0450.0Compositional biasNote=Pro-rich
HgeneRCOR3chr1:211469095chr1:211192598ENST00000367005+811285_336281.0496.0DomainSANT 2
TgeneKCNH1chr1:211469095chr1:211192598ENST0000027175141114_94186.0990.0DomainPAS
TgeneKCNH1chr1:211469095chr1:211192598ENST0000027175141193_145186.0990.0DomainPAC
TgeneKCNH1chr1:211469095chr1:211192598ENST0000036700741114_94186.0963.0DomainPAS
TgeneKCNH1chr1:211469095chr1:211192598ENST0000036700741193_145186.0963.0DomainPAC
TgeneKCNH1chr1:211469095chr1:211192598ENST00000271751411151_162186.0990.0RegionRequired for phosphatidylinositol bisphosphate binding
TgeneKCNH1chr1:211469095chr1:211192598ENST00000367007411151_162186.0963.0RegionRequired for phosphatidylinositol bisphosphate binding
TgeneKCNH1chr1:211469095chr1:211192598ENST000002717514111_220186.0990.0Topological domainCytoplasmic
TgeneKCNH1chr1:211469095chr1:211192598ENST000003670074111_220186.0963.0Topological domainCytoplasmic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RCOR3
KCNH1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RCOR3-KCNH1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RCOR3-KCNH1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource