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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RERE-CYP4A11

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RERE-CYP4A11
	FusionPDB ID: 73492
	FusionGDB2.0 ID: 73492
		Hgene	Tgene
	Gene symbol	RERE	CYP4A11
	Gene ID	473	1579
	Gene name	arginine-glutamic acid dipeptide repeats	cytochrome P450 family 4 subfamily A member 11
	Synonyms	ARG\|ARP\|ATN1L\|DNB1\|NEDBEH	CP4Y\|CYP4A2\|CYP4AII\|CYPIVA11
	Cytomap	1p36.23	1p33
	Type of gene	protein-coding	protein-coding
	Description	arginine-glutamic acid dipeptide repeats proteinarginine-glutamic acid dipeptide (RE) repeatsatrophin 2atrophin-1 like proteinatrophin-1 related protein	cytochrome P450 4A1120-HETE synthase20-hydroxyeicosatetraenoic acid synthaseP450HL-omegaalkane-1 monooxygenasecytochrome P-450HK-omegacytochrome P450, family 4, subfamily A, polypeptide 11cytochrome P450, subfamily IVA, polypeptide 11cytochrome P4
	Modification date	20200313	20200313
	UniProtAcc	.	Q02928
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000337907, ENST00000377464, ENST00000400907, ENST00000400908, ENST00000460659, ENST00000476556,	ENST00000457840, ENST00000496519, ENST00000310638, ENST00000371904, ENST00000371905, ENST00000462347,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	27 X 28 X 11=8316	1 X 1 X 1=1
	# samples	43	1
	** MAII score	log2(43/8316*10)=-4.27348119326891 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: RERE [Title/Abstract] AND CYP4A11 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RERE(8525985)-CYP4A11(47403809), # samples:3
Anticipated loss of major functional domain due to fusion event.	RERE-CYP4A11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RERE-CYP4A11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RERE-CYP4A11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RERE-CYP4A11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RERE-CYP4A11 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	CYP4A11	GO:0001676	long-chain fatty acid metabolic process	18433732
Tgene	CYP4A11	GO:0006691	leukotriene metabolic process	9799565
Tgene	CYP4A11	GO:0019369	arachidonic acid metabolic process	10660572
Tgene	CYP4A11	GO:0019373	epoxygenase P450 pathway	9618440
Tgene	CYP4A11	GO:0055114	oxidation-reduction process	9618440\|9799565\|18433732

Fusion gene breakpoints across RERE (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CYP4A11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-D8-A1XZ-01A	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000337907	RERE	chr1	8525985	-	ENST00000310638	CYP4A11	chr1	47403809	-	4141	1838	533	3202	889
ENST00000337907	RERE	chr1	8525985	-	ENST00000371904	CYP4A11	chr1	47403809	-	3380	1838	533	3205	890
ENST00000337907	RERE	chr1	8525985	-	ENST00000462347	CYP4A11	chr1	47403809	-	3387	1838	533	2908	791
ENST00000337907	RERE	chr1	8525985	-	ENST00000371905	CYP4A11	chr1	47403809	-	3337	1838	533	3010	825
ENST00000377464	RERE	chr1	8525985	-	ENST00000310638	CYP4A11	chr1	47403809	-	2857	554	155	1918	587
ENST00000377464	RERE	chr1	8525985	-	ENST00000371904	CYP4A11	chr1	47403809	-	2096	554	155	1921	588
ENST00000377464	RERE	chr1	8525985	-	ENST00000462347	CYP4A11	chr1	47403809	-	2103	554	155	1624	489
ENST00000377464	RERE	chr1	8525985	-	ENST00000371905	CYP4A11	chr1	47403809	-	2053	554	155	1726	523
ENST00000400907	RERE	chr1	8525985	-	ENST00000310638	CYP4A11	chr1	47403809	-	3580	1277	74	2641	855
ENST00000400907	RERE	chr1	8525985	-	ENST00000371904	CYP4A11	chr1	47403809	-	2819	1277	74	2644	856
ENST00000400907	RERE	chr1	8525985	-	ENST00000462347	CYP4A11	chr1	47403809	-	2826	1277	74	2347	757
ENST00000400907	RERE	chr1	8525985	-	ENST00000371905	CYP4A11	chr1	47403809	-	2776	1277	74	2449	791

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000337907	ENST00000310638	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.001417378	0.9985826
ENST00000337907	ENST00000371904	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.002346561	0.9976534
ENST00000337907	ENST00000462347	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.003002701	0.99699736
ENST00000337907	ENST00000371905	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.001988069	0.99801195
ENST00000377464	ENST00000310638	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.010778805	0.9892212
ENST00000377464	ENST00000371904	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.012364891	0.9876351
ENST00000377464	ENST00000462347	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.033593964	0.966406
ENST00000377464	ENST00000371905	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.011682247	0.9883178
ENST00000400907	ENST00000310638	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.001610611	0.99838936
ENST00000400907	ENST00000371904	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.00280792	0.9971921
ENST00000400907	ENST00000462347	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.00355919	0.9964408
ENST00000400907	ENST00000371905	RERE	chr1	8525985	-	CYP4A11	chr1	47403809	-	0.002334131	0.9976659

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73492_73492_1_RERE-CYP4A11_RERE_chr1_8525985_ENST00000337907_CYP4A11_chr1_47403809_ENST00000310638_length(amino acids)=889AA_BP=824
MELSEKFRRLKPRLTVYLSRRPSRERTEEGTWRIMTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHS
EDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPA
LCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTY
HAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCD
LLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVE
TFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVML
DKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAH
QHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREE
IHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS

--------------------------------------------------------------

>73492_73492_2_RERE-CYP4A11_RERE_chr1_8525985_ENST00000337907_CYP4A11_chr1_47403809_ENST00000371904_length(amino acids)=890AA_BP=825
MELSEKFRRLKPRLTVYLSRRPSRERTEEGTWRIMTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHS
EDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPA
LCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTY
HAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCD
LLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVE
TFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVML
DKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAH
QHTGDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCRE
EIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPG

--------------------------------------------------------------

>73492_73492_3_RERE-CYP4A11_RERE_chr1_8525985_ENST00000337907_CYP4A11_chr1_47403809_ENST00000371905_length(amino acids)=825AA_BP=435
MELSEKFRRLKPRLTVYLSRRPSRERTEEGTWRIMTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHS
EDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPA
LCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTY
HAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCD
LLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVE
TFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVML
DKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAH
QHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREE
IHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGS

--------------------------------------------------------------

>73492_73492_4_RERE-CYP4A11_RERE_chr1_8525985_ENST00000337907_CYP4A11_chr1_47403809_ENST00000462347_length(amino acids)=791AA_BP=726
MELSEKFRRLKPRLTVYLSRRPSRERTEEGTWRIMTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHS
EDEDNDNNSATAEESTKKNKKKPPKKKSRYERTDTGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPA
LCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHLLMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTY
HAAALRGKCNISHFSDIFAAREFKARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCD
LLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVE
TFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVML
DKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRPSDPTEEGSTTEGGGAGEDQEEEAFGFSGYPPLGQRAPGLPRPCWCSG
WNCFRNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFL

--------------------------------------------------------------

>73492_73492_5_RERE-CYP4A11_RERE_chr1_8525985_ENST00000377464_CYP4A11_chr1_47403809_ENST00000310638_length(amino acids)=587AA_BP=522
MDDPFSPCRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASR
DDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRS
DPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAF
SHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFL
DILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRL
YPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATA

--------------------------------------------------------------

>73492_73492_6_RERE-CYP4A11_RERE_chr1_8525985_ENST00000377464_CYP4A11_chr1_47403809_ENST00000371904_length(amino acids)=588AA_BP=523
MDDPFSPCRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASR
DDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRS
DPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAF
SHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTGDQVIQLRKAQLQKEGELEKIKRKRHLDF
LDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALR
LYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVAT

--------------------------------------------------------------

>73492_73492_7_RERE-CYP4A11_RERE_chr1_8525985_ENST00000377464_CYP4A11_chr1_47403809_ENST00000371905_length(amino acids)=523AA_BP=133
MDDPFSPCRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASR
DDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRS
DPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAF
SHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFL
DILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRL

--------------------------------------------------------------

>73492_73492_8_RERE-CYP4A11_RERE_chr1_8525985_ENST00000377464_CYP4A11_chr1_47403809_ENST00000462347_length(amino acids)=489AA_BP=424
MDDPFSPCRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASR
DDTTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRS
DPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAF
SHQGSIQVDRPSDPTEEGSTTEGGGAGEDQEEEAFGFSGYPPLGQRAPGLPRPCWCSGWNCFRNHLDQMPYTTMCIKEALRLYPPVPGIG
RELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL

--------------------------------------------------------------

>73492_73492_9_RERE-CYP4A11_RERE_chr1_8525985_ENST00000400907_CYP4A11_chr1_47403809_ENST00000310638_length(amino acids)=855AA_BP=790
MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTD
TGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHL
LMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYIL
GYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDD
TTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDP
KSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSH
QGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDI
LLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYP
PVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALT

--------------------------------------------------------------

>73492_73492_10_RERE-CYP4A11_RERE_chr1_8525985_ENST00000400907_CYP4A11_chr1_47403809_ENST00000371904_length(amino acids)=856AA_BP=791
MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTD
TGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHL
LMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYIL
GYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDD
TTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDP
KSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSH
QGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTGDQVIQLRKAQLQKEGELEKIKRKRHLDFLD
ILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLY
PPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATAL

--------------------------------------------------------------

>73492_73492_11_RERE-CYP4A11_RERE_chr1_8525985_ENST00000400907_CYP4A11_chr1_47403809_ENST00000371905_length(amino acids)=791AA_BP=401
MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTD
TGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHL
LMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYIL
GYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDD
TTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDP
KSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSH
QGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDI
LLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYP

--------------------------------------------------------------

>73492_73492_12_RERE-CYP4A11_RERE_chr1_8525985_ENST00000400907_CYP4A11_chr1_47403809_ENST00000462347_length(amino acids)=757AA_BP=692
MTADKDKDKDKEKDRDRDRDREREKRDKARESENSRPRRSCTLEGGAKNYAESDHSEDEDNDNNSATAEESTKKNKKKPPKKKSRYERTD
TGEITSYITEDDVVYRPGDCVYIESRRPNTPYFICSIQDFKLVHNSQACCRSPTPALCDPPACSLPVASQPPQHLSEAGRGPVGSKRDHL
LMNVKWYYRQSEVPDSVYQHLVQDRHNENDSGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFKARVDSFFYIL
GYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMPGVNDCDLLMYLRAARSMAAFAGMCDGGSTEDGCVAASRDD
TTLNALNTLHESGYDAGKALQRLVKKPVPKLIEKCWTEDEVLQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDP
KSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSH
QGSIQVDRPSDPTEEGSTTEGGGAGEDQEEEAFGFSGYPPLGQRAPGLPRPCWCSGWNCFRNHLDQMPYTTMCIKEALRLYPPVPGIGRE
LSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:8525985/chr1:47403809)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CYP4A11 Q02928
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:10553002, PubMed:10660572, PubMed:15611369). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PubMed:10553002, PubMed:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:7679927, PubMed:1739747, PubMed:8914854, PubMed:15611369). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749). Has little activity toward prostaglandins A1 and E1 (PubMed:7679927). {ECO:0000269\|PubMed:10553002, ECO:0000269\|PubMed:10620324, ECO:0000269\|PubMed:10660572, ECO:0000269\|PubMed:15145985, ECO:0000269\|PubMed:15611369, ECO:0000269\|PubMed:1739747, ECO:0000269\|PubMed:18065749, ECO:0000269\|PubMed:18182499, ECO:0000269\|PubMed:7679927, ECO:0000269\|PubMed:8914854}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000337907

103_283

401.0

1567.0

Domain

BAH

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000337907

284_387

401.0

1567.0

Domain

ELM2

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000400908

103_283

401.0

1567.0

Domain

BAH

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000400908

284_387

401.0

1567.0

Domain

ELM2

Tgene

CYP4A11

chr1:8525985

chr1:47403809

ENST00000310638

131_134

65.0

520.0

Compositional bias

Note=Poly-Leu

Tgene

CYP4A11

chr1:8525985

chr1:47403809

ENST00000371905

131_134

65.0

456.0

Compositional bias

Note=Poly-Leu

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000337907

1156_1211

401.0

1567.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000400908

1156_1211

401.0

1567.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000476556

1156_1211

1013.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000337907

1179_1204

401.0

1567.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000337907

1300_1322

401.0

1567.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000337907

1425_1445

401.0

1567.0

Compositional bias

Note=His-rich

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000337907

1451_1510

401.0

1567.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000337907

738_1118

401.0

1567.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000400908

1179_1204

401.0

1567.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000400908

1300_1322

401.0

1567.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000400908

1425_1445

401.0

1567.0

Compositional bias

Note=His-rich

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000400908

1451_1510

401.0

1567.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000400908

738_1118

401.0

1567.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000476556

1179_1204

1013.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000476556

1300_1322

1013.0

Compositional bias

Note=Arg/Glu-rich (mixed charge)

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000476556

1425_1445

1013.0

Compositional bias

Note=His-rich

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000476556

1451_1510

1013.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000476556

738_1118

1013.0

Compositional bias

Note=Pro-rich

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000337907

391_443

401.0

1567.0

Domain

SANT

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000400908

391_443

401.0

1567.0

Domain

SANT

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000476556

103_283

1013.0

Domain

BAH

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000476556

284_387

1013.0

Domain

ELM2

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000476556

391_443

1013.0

Domain

SANT

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000337907

507_532

401.0

1567.0

Zinc finger

Note=GATA-type

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000400908

507_532

401.0

1567.0

Zinc finger

Note=GATA-type

Hgene

RERE

chr1:8525985

chr1:47403809

ENST00000476556

507_532

1013.0

Zinc finger

Note=GATA-type

Tgene

CYP4A11

chr1:8525985

chr1:47403809

ENST00000310638

24_31

65.0

520.0

Compositional bias

Note=Poly-Leu

Tgene

CYP4A11

chr1:8525985

chr1:47403809

ENST00000371905

24_31

65.0

456.0

Compositional bias

Note=Poly-Leu

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RERE
CYP4A11

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to RERE-CYP4A11

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RERE-CYP4A11

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source