UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:RET-FGFR3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RET-FGFR3
FusionPDB ID: 73557
FusionGDB2.0 ID: 73557
HgeneTgene
Gene symbol

RET

FGFR3

Gene ID

5979

2261

Gene nameret proto-oncogenefibroblast growth factor receptor 3
SynonymsCDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1ACH|CD333|CEK2|HSFGFR3EX|JTK4
Cytomap

10q11.21

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionproto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullaryfibroblast growth factor receptor 3FGFR-3fibroblast growth factor receptor 3 variant 4fibroblast growth factor receptor 3-Shydroxyaryl-protein kinasetyrosine kinase JTK4
Modification date2020032220200313
UniProtAcc

RTL1

P22607

Ensembl transtripts involved in fusion geneENST idsENST00000340058, ENST00000355710, 
ENST00000474521, ENST00000260795, 
ENST00000340107, ENST00000352904, 
ENST00000412135, ENST00000440486, 
ENST00000481110, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 4=2166 X 11 X 9=594
# samples 99
** MAII scorelog2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/594*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RET [Title/Abstract] AND FGFR3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RET(43612179)-FGFR3(1807285), # samples:1
Anticipated loss of major functional domain due to fusion event.RET-FGFR3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RET-FGFR3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RET-FGFR3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RET-FGFR3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRET

GO:0030155

regulation of cell adhesion

21357690

HgeneRET

GO:0030335

positive regulation of cell migration

20702524

HgeneRET

GO:0033619

membrane protein proteolysis

21357690

HgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

HgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

HgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099

TgeneFGFR3

GO:0008543

fibroblast growth factor receptor signaling pathway

8663044

TgeneFGFR3

GO:0018108

peptidyl-tyrosine phosphorylation

11294897

TgeneFGFR3

GO:0046777

protein autophosphorylation

11294897


check buttonFusion gene breakpoints across RET (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FGFR3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-7916RETchr10

43612179

+FGFR3chr4

1807285

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355710RETchr1043612179+ENST00000481110FGFR3chr41807285+4935251623233571041
ENST00000355710RETchr1043612179+ENST00000440486FGFR3chr41807285+5013251623234021056
ENST00000355710RETchr1043612179+ENST00000412135FGFR3chr41807285+5013251623234021056
ENST00000355710RETchr1043612179+ENST00000340107FGFR3chr41807285+5013251623234021056
ENST00000355710RETchr1043612179+ENST00000260795FGFR3chr41807285+5012251623234021056
ENST00000355710RETchr1043612179+ENST00000352904FGFR3chr41807285+5012251623234021056
ENST00000340058RETchr1043612179+ENST00000481110FGFR3chr41807285+4883246418033051041
ENST00000340058RETchr1043612179+ENST00000440486FGFR3chr41807285+4961246418033501056
ENST00000340058RETchr1043612179+ENST00000412135FGFR3chr41807285+4961246418033501056
ENST00000340058RETchr1043612179+ENST00000340107FGFR3chr41807285+4961246418033501056
ENST00000340058RETchr1043612179+ENST00000260795FGFR3chr41807285+4960246418033501056
ENST00000340058RETchr1043612179+ENST00000352904FGFR3chr41807285+4960246418033501056

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355710ENST00000481110RETchr1043612179+FGFR3chr41807285+0.0012159830.998784
ENST00000355710ENST00000440486RETchr1043612179+FGFR3chr41807285+0.0005377980.9994622
ENST00000355710ENST00000412135RETchr1043612179+FGFR3chr41807285+0.0005377980.9994622
ENST00000355710ENST00000340107RETchr1043612179+FGFR3chr41807285+0.0005377980.9994622
ENST00000355710ENST00000260795RETchr1043612179+FGFR3chr41807285+0.000538570.9994615
ENST00000355710ENST00000352904RETchr1043612179+FGFR3chr41807285+0.000538570.9994615
ENST00000340058ENST00000481110RETchr1043612179+FGFR3chr41807285+0.0011685730.99883145
ENST00000340058ENST00000440486RETchr1043612179+FGFR3chr41807285+0.0005218090.99947816
ENST00000340058ENST00000412135RETchr1043612179+FGFR3chr41807285+0.0005218090.99947816
ENST00000340058ENST00000340107RETchr1043612179+FGFR3chr41807285+0.0005218090.99947816
ENST00000340058ENST00000260795RETchr1043612179+FGFR3chr41807285+0.0005225670.99947745
ENST00000340058ENST00000352904RETchr1043612179+FGFR3chr41807285+0.0005225670.99947745

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>73557_73557_1_RET-FGFR3_RET_chr10_43612179_ENST00000340058_FGFR3_chr4_1807285_ENST00000260795_length(amino acids)=1056AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT

--------------------------------------------------------------

>73557_73557_2_RET-FGFR3_RET_chr10_43612179_ENST00000340058_FGFR3_chr4_1807285_ENST00000340107_length(amino acids)=1056AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT

--------------------------------------------------------------

>73557_73557_3_RET-FGFR3_RET_chr10_43612179_ENST00000340058_FGFR3_chr4_1807285_ENST00000352904_length(amino acids)=1056AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT

--------------------------------------------------------------

>73557_73557_4_RET-FGFR3_RET_chr10_43612179_ENST00000340058_FGFR3_chr4_1807285_ENST00000412135_length(amino acids)=1056AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT

--------------------------------------------------------------

>73557_73557_5_RET-FGFR3_RET_chr10_43612179_ENST00000340058_FGFR3_chr4_1807285_ENST00000440486_length(amino acids)=1056AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT

--------------------------------------------------------------

>73557_73557_6_RET-FGFR3_RET_chr10_43612179_ENST00000340058_FGFR3_chr4_1807285_ENST00000481110_length(amino acids)=1041AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNLVLWGPALGDLHAGGLPVPRHPCGGALQAAEGGPPHGQARQLHTRPVHDHAGVLACRALPEAHLQAAGGGPGPCPYRDVHRRVPGPV

--------------------------------------------------------------

>73557_73557_7_RET-FGFR3_RET_chr10_43612179_ENST00000355710_FGFR3_chr4_1807285_ENST00000260795_length(amino acids)=1056AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT

--------------------------------------------------------------

>73557_73557_8_RET-FGFR3_RET_chr10_43612179_ENST00000355710_FGFR3_chr4_1807285_ENST00000340107_length(amino acids)=1056AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT

--------------------------------------------------------------

>73557_73557_9_RET-FGFR3_RET_chr10_43612179_ENST00000355710_FGFR3_chr4_1807285_ENST00000352904_length(amino acids)=1056AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT

--------------------------------------------------------------

>73557_73557_10_RET-FGFR3_RET_chr10_43612179_ENST00000355710_FGFR3_chr4_1807285_ENST00000412135_length(amino acids)=1056AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT

--------------------------------------------------------------

>73557_73557_11_RET-FGFR3_RET_chr10_43612179_ENST00000355710_FGFR3_chr4_1807285_ENST00000440486_length(amino acids)=1056AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPT

--------------------------------------------------------------

>73557_73557_12_RET-FGFR3_RET_chr10_43612179_ENST00000355710_FGFR3_chr4_1807285_ENST00000481110_length(amino acids)=1041AA_BP=6
MAKATSGAAGLRLLLLLLLPLLGKVALGLYFSRDAYWEKLYVDQAAGTPLLYVHALRDAPEEVPSFRLGQHLYGTYRTRLHENNWICIQE
DTGLLYLNRSLDHSSWEKLSVRNRGFPLLTVYLKVFLSPTSLREGECQWPGCARVYFSFFNTSFPACSSLKPRELCFPETRPSFRIRENR
PPGTFHQFRLLPVQFLCPNISVAYRLLEGEGLPFRCAPDSLEVSTRWALDREQREKYELVAVCTVHAGAREEVVMVPFPVTVYDEDDSAP
TFPAGVDTASAVVEFKRKEDTVVATLRVFDADVVPASGELVRRYTSTLLPGDTWAQQTFRVEHWPNETSVQANGSFVRATVHDYRLVLNR
NLSISENRTMQLAVLVNDSDFQGPGAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSGINVQYKLHSSGANCS
TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQTSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGR
CEWRQGDGKGITRNFSTCSPSTKTCPDGHCDVVETQDINICPQDCLRGSIVGGHEPGEPRGIKAGYGTCNCFPEEEKCFCEPEDIQDPLC
DELCRTVIAAAVLFSFIVSVLLSAFCIHCYHKFAHKPPISSAEMTFRRPAQAFPVSYSSSGARRPSLDSMENQVSVDAFKILEDPKWEFP
RKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAK
GNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKK
TTNLVLWGPALGDLHAGGLPVPRHPCGGALQAAEGGPPHGQARQLHTRPVHDHAGVLACRALPEAHLQAAGGGPGPCPYRDVHRRVPGPV

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:43612179/chr4:1807285)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
RET

RTL1

FGFR3

P22607

1358FUNCTION: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling. {ECO:0000269|PubMed:10611230, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:11703096, ECO:0000269|PubMed:14534538, ECO:0000269|PubMed:16410555, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17145761, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17509076, ECO:0000269|PubMed:17561467, ECO:0000269|PubMed:19088846, ECO:0000269|PubMed:19286672, ECO:0000269|PubMed:8663044}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRETchr10:43612179chr4:1807285ENST00000340058+1219168_272761.33333333333341073.0DomainCadherin
HgeneRETchr10:43612179chr4:1807285ENST00000355710+1220168_272761.33333333333341115.0DomainCadherin
HgeneRETchr10:43612179chr4:1807285ENST00000340058+1219730_738761.33333333333341073.0Nucleotide bindingATP
HgeneRETchr10:43612179chr4:1807285ENST00000355710+1220730_738761.33333333333341115.0Nucleotide bindingATP
HgeneRETchr10:43612179chr4:1807285ENST00000340058+121929_635761.33333333333341073.0Topological domainExtracellular
HgeneRETchr10:43612179chr4:1807285ENST00000355710+122029_635761.33333333333341115.0Topological domainExtracellular
HgeneRETchr10:43612179chr4:1807285ENST00000340058+1219636_657761.33333333333341073.0TransmembraneHelical
HgeneRETchr10:43612179chr4:1807285ENST00000355710+1220636_657761.33333333333341115.0TransmembraneHelical
TgeneFGFR3chr10:43612179chr4:1807285ENST00000352904715472_761399.3333333333333695.0DomainProtein kinase
TgeneFGFR3chr10:43612179chr4:1807285ENST00000412135816472_761399.3333333333333695.0DomainProtein kinase
TgeneFGFR3chr10:43612179chr4:1807285ENST00000352904715478_486399.3333333333333695.0Nucleotide bindingATP
TgeneFGFR3chr10:43612179chr4:1807285ENST00000412135816478_486399.3333333333333695.0Nucleotide bindingATP
TgeneFGFR3chr10:43612179chr4:1807285ENST00000352904715397_806399.3333333333333695.0Topological domainCytoplasmic
TgeneFGFR3chr10:43612179chr4:1807285ENST00000412135816397_806399.3333333333333695.0Topological domainCytoplasmic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRETchr10:43612179chr4:1807285ENST00000340058+1219724_1016761.33333333333341073.0DomainProtein kinase
HgeneRETchr10:43612179chr4:1807285ENST00000355710+1220724_1016761.33333333333341115.0DomainProtein kinase
HgeneRETchr10:43612179chr4:1807285ENST00000340058+1219805_807761.33333333333341073.0RegionNote=Inhibitors binding
HgeneRETchr10:43612179chr4:1807285ENST00000355710+1220805_807761.33333333333341115.0RegionNote=Inhibitors binding
HgeneRETchr10:43612179chr4:1807285ENST00000340058+1219658_1114761.33333333333341073.0Topological domainCytoplasmic
HgeneRETchr10:43612179chr4:1807285ENST00000355710+1220658_1114761.33333333333341115.0Topological domainCytoplasmic
TgeneFGFR3chr10:43612179chr4:1807285ENST00000260795917151_244511.3333333333333807.0DomainNote=Ig-like C2-type 2
TgeneFGFR3chr10:43612179chr4:1807285ENST0000026079591724_126511.3333333333333807.0DomainNote=Ig-like C2-type 1
TgeneFGFR3chr10:43612179chr4:1807285ENST00000260795917253_355511.3333333333333807.0DomainNote=Ig-like C2-type 3
TgeneFGFR3chr10:43612179chr4:1807285ENST00000260795917472_761511.3333333333333807.0DomainProtein kinase
TgeneFGFR3chr10:43612179chr4:1807285ENST000003401071018151_244513.3333333333334809.0DomainNote=Ig-like C2-type 2
TgeneFGFR3chr10:43612179chr4:1807285ENST00000340107101824_126513.3333333333334809.0DomainNote=Ig-like C2-type 1
TgeneFGFR3chr10:43612179chr4:1807285ENST000003401071018253_355513.3333333333334809.0DomainNote=Ig-like C2-type 3
TgeneFGFR3chr10:43612179chr4:1807285ENST000003401071018472_761513.3333333333334809.0DomainProtein kinase
TgeneFGFR3chr10:43612179chr4:1807285ENST00000352904715151_244399.3333333333333695.0DomainNote=Ig-like C2-type 2
TgeneFGFR3chr10:43612179chr4:1807285ENST0000035290471524_126399.3333333333333695.0DomainNote=Ig-like C2-type 1
TgeneFGFR3chr10:43612179chr4:1807285ENST00000352904715253_355399.3333333333333695.0DomainNote=Ig-like C2-type 3
TgeneFGFR3chr10:43612179chr4:1807285ENST00000412135816151_244399.3333333333333695.0DomainNote=Ig-like C2-type 2
TgeneFGFR3chr10:43612179chr4:1807285ENST0000041213581624_126399.3333333333333695.0DomainNote=Ig-like C2-type 1
TgeneFGFR3chr10:43612179chr4:1807285ENST00000412135816253_355399.3333333333333695.0DomainNote=Ig-like C2-type 3
TgeneFGFR3chr10:43612179chr4:1807285ENST000004404861018151_244511.3333333333333807.0DomainNote=Ig-like C2-type 2
TgeneFGFR3chr10:43612179chr4:1807285ENST00000440486101824_126511.3333333333333807.0DomainNote=Ig-like C2-type 1
TgeneFGFR3chr10:43612179chr4:1807285ENST000004404861018253_355511.3333333333333807.0DomainNote=Ig-like C2-type 3
TgeneFGFR3chr10:43612179chr4:1807285ENST000004404861018472_761511.3333333333333807.0DomainProtein kinase
TgeneFGFR3chr10:43612179chr4:1807285ENST00000260795917478_486511.3333333333333807.0Nucleotide bindingATP
TgeneFGFR3chr10:43612179chr4:1807285ENST000003401071018478_486513.3333333333334809.0Nucleotide bindingATP
TgeneFGFR3chr10:43612179chr4:1807285ENST000004404861018478_486511.3333333333333807.0Nucleotide bindingATP
TgeneFGFR3chr10:43612179chr4:1807285ENST0000026079591723_375511.3333333333333807.0Topological domainExtracellular
TgeneFGFR3chr10:43612179chr4:1807285ENST00000260795917397_806511.3333333333333807.0Topological domainCytoplasmic
TgeneFGFR3chr10:43612179chr4:1807285ENST00000340107101823_375513.3333333333334809.0Topological domainExtracellular
TgeneFGFR3chr10:43612179chr4:1807285ENST000003401071018397_806513.3333333333334809.0Topological domainCytoplasmic
TgeneFGFR3chr10:43612179chr4:1807285ENST0000035290471523_375399.3333333333333695.0Topological domainExtracellular
TgeneFGFR3chr10:43612179chr4:1807285ENST0000041213581623_375399.3333333333333695.0Topological domainExtracellular
TgeneFGFR3chr10:43612179chr4:1807285ENST00000440486101823_375511.3333333333333807.0Topological domainExtracellular
TgeneFGFR3chr10:43612179chr4:1807285ENST000004404861018397_806511.3333333333333807.0Topological domainCytoplasmic
TgeneFGFR3chr10:43612179chr4:1807285ENST00000260795917376_396511.3333333333333807.0TransmembraneHelical
TgeneFGFR3chr10:43612179chr4:1807285ENST000003401071018376_396513.3333333333334809.0TransmembraneHelical
TgeneFGFR3chr10:43612179chr4:1807285ENST00000352904715376_396399.3333333333333695.0TransmembraneHelical
TgeneFGFR3chr10:43612179chr4:1807285ENST00000412135816376_396399.3333333333333695.0TransmembraneHelical
TgeneFGFR3chr10:43612179chr4:1807285ENST000004404861018376_396511.3333333333333807.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
FGFR3C6orf47, SMG7, BORA, CCDC17, HBZ, HNRNPL, NDUFS6, RNF130, ATF3, ARAP1, CHGB, CTSK, RADIL, GTF3C1, KRT8, POLA2, KIAA1377, RPL8, SLC25A6, Sh2b1, SH2B1, FGF9, FGF1, GRB2, FGF8, HSP90AA1, HSP90AB1, HSPA1B, HSPA8, CDC37, HSPA4, SOCS1, SOCS3, FGFR3, SNX11, TMEM231, ILKAP, SRPK2, PVRL1, BRD4, VHL, FNTA, CDK6, FGFR2, TMEM30B, ARRDC3, SDC2, EPHA4, KAL1, RPS6KA3, fgf3, KLB, CSPG4, HEXIM1, LARP7, MAP3K4, CDC25A, DCXR, ERBB2, BRD2, OXT, PRKAR1A, POMC, CUL4B, ATG5, MKRN2, ABCA2, CTLA4, POTEI, TNFRSF10A, MPDZ, SDC4, CLEC4A, CRLF2, FBXO2, ALG6, TM2D3, KLK1, PI15, FSTL4, PRG2, TMEM87A, PDGFRA, LY86, MFAP4, FHL3, DNASE1L1, CELA2B, FBXO6, SIRPD, CBLN4, KLK3, EDN3, PRTN3, ELSPBP1, LYPD4, GGH, GPIHBP1, IL5RA, DNAJB9, TCTN1, UQCC1, LIPG, FCGR3B, SDF2L1, EPDR1, ADAMTS12, IGLL5, CFC1, C1QB,
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RETall structure
FGFR3all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to RET-FGFR3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to RET-FGFR3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
HgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
HgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
HgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
HgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
HgeneRETC0009404Colorectal Neoplasms2CTD_human
HgeneRETC0019569Hirschsprung Disease2CTD_human
HgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
HgeneRETC0085758Aganglionosis, Colonic2CTD_human
HgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
HgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
HgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
HgeneRETC0006413Burkitt Lymphoma1CTD_human
HgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneRETC0038220Status Epilepticus1CTD_human
HgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
HgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
HgeneRETC0206693Medullary carcinoma1CTD_human
HgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
HgeneRETC0270823Petit mal status1CTD_human
HgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
HgeneRETC0343640African Burkitt's lymphoma1CTD_human
HgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
HgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
HgeneRETC0740340Amyloidosis, Familial1CTD_human
HgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
HgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
HgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
HgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
HgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
HgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
HgeneRETC4721444Burkitt Leukemia1CTD_human
TgeneFGFR3C0001080Achondroplasia13CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR3C0410529Hypochondroplasia (disorder)10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR3C1864436Muenke Syndrome9CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR3C1868678THANATOPHORIC DYSPLASIA, TYPE I (disorder)9CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFGFR3C2677099CROUZON SYNDROME WITH ACANTHOSIS NIGRICANS (disorder)7CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFGFR3C0005684Malignant neoplasm of urinary bladder6CGI;CTD_human;UNIPROT
TgeneFGFR3C0005695Bladder Neoplasm4CGI;CTD_human
TgeneFGFR3C1300257Thanatophoric dysplasia, type 24CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneFGFR3C1864852CATSHL syndrome4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR3C2674173Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR3C0265269Lacrimoauriculodentodigital syndrome2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneFGFR3C0007138Carcinoma, Transitional Cell1CTD_human
TgeneFGFR3C0008924Cleft upper lip1CTD_human
TgeneFGFR3C0008925Cleft Palate1CTD_human
TgeneFGFR3C0014544Epilepsy1GENOMICS_ENGLAND
TgeneFGFR3C0014547Epilepsies, Partial1GENOMICS_ENGLAND
TgeneFGFR3C0022603Seborrheic keratosis1UNIPROT
TgeneFGFR3C0026764Multiple Myeloma1CGI;CTD_human
TgeneFGFR3C0036631Seminoma1CTD_human
TgeneFGFR3C0039743Thanatophoric Dysplasia1CTD_human
TgeneFGFR3C0152423Congenital small ears1GENOMICS_ENGLAND
TgeneFGFR3C0206726gliosarcoma1ORPHANET
TgeneFGFR3C0221356Brachycephaly1ORPHANET
TgeneFGFR3C0265529Plagiocephaly1ORPHANET
TgeneFGFR3C0334082NEVUS, EPIDERMAL (disorder)1CTD_human;UNIPROT
TgeneFGFR3C0334588Giant Cell Glioblastoma1ORPHANET
TgeneFGFR3C0406803Syringocystadenoma Papilliferum1GENOMICS_ENGLAND
TgeneFGFR3C1336708Testicular Germ Cell Tumor1CTD_human;UNIPROT
TgeneFGFR3C1837218Cleft palate, isolated1CTD_human
TgeneFGFR3C4048328cervical cancer1CTD_human;UNIPROT