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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RNH1-COL5A1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RNH1-COL5A1
FusionPDB ID: 75160
FusionGDB2.0 ID: 75160
HgeneTgene
Gene symbol

RNH1

COL5A1

Gene ID

246243

1289

Gene nameribonuclease H1collagen type V alpha 1 chain
SynonymsH1RNA|PEOB2|RNH1EDSC|EDSCL1
Cytomap

2p25.3

9q34.3

Type of geneprotein-codingprotein-coding
Descriptionribonuclease H1ribonuclease H type IIcollagen alpha-1(V) chaincollagen, type V, alpha 1
Modification date2020031320200313
UniProtAcc.

P20908

Ensembl transtripts involved in fusion geneENST idsENST00000397604, ENST00000397614, 
ENST00000397615, ENST00000534797, 
ENST00000354420, ENST00000356187, 
ENST00000438658, ENST00000533410, 
ENST00000533592, 		ENST00000464187, 
ENST00000371817, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 7=37810 X 10 X 7=700
# samples 1212
** MAII scorelog2(12/378*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/700*10)=-2.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RNH1 [Title/Abstract] AND COL5A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RNH1(494515)-COL5A1(137533620), # samples:1
Anticipated loss of major functional domain due to fusion event.RNH1-COL5A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNH1-COL5A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RNH1-COL5A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RNH1-COL5A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RNH1-COL5A1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCOL5A1

GO:1903225

negative regulation of endodermal cell differentiation

23154389


check buttonFusion gene breakpoints across RNH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COL5A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-AB2H-01ARNH1chr11

494515

-COL5A1chr9

137533620

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397604RNH1chr11494515-ENST00000371817COL5A1chr9137533620+101901722213676521838

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397604ENST00000371817RNH1chr11494515-COL5A1chr9137533620+0.0080824290.99191755

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>75160_75160_1_RNH1-COL5A1_RNH1_chr11_494515_ENST00000397604_COL5A1_chr9_137533620_ENST00000371817_length(amino acids)=1838AA_BP=9
MDVHTRWKARSALRPGAPLLPPLLLLLLWAPPPSRAAQPADLLKVLDFHNLPDGITKTTGFCATRRSSKGPDVAYRVTKDAQLSAPTKQL
YPASAFPEDFSILTTVKAKKGSQAFLVSIYNEQGIQQIGLELGRSPVFLYEDHTGKPGPEDYPLFRGINLSDGKWHRIALSVHKKNVTLI
LDCKKKTTKFLDRSDHPMIDINGIIVFGTRILDEEVFEGDIQQLLFVSDHRAAYDYCEHYSPDCDTAVPDTPQSQDPNPDEYYTEGDGEG
ETYYYEYPYYEDPEDLGKEPTPSKKPVEAAKETTEVPEELTPTPTEAAPMPETSEGAGKEEDVGIGDYDYVPSEDYYTPSPYDDLTYGEG
EENPDQPTDPGAGAEIPTSTADTSNSSNPAPPPGEGADDLEGEFTEETIRNLDENYYDPYYDPTSSPSEIGPGMPANQDTIYEGIGGPRG
EKGQKGEPAIIEPGMLIEGPPGPEGPAGLPGPPGTMGPTGQVGDPGERGPPGRPGLPGADGLPGPPGTMLMLPFRFGGGGDAGSKGPMVS
AQESQAQAILQQARLALRGPAGPMGLTGRPGPVGPPGSGGLKGEPGDVGPQGPRGVQGPPGPAGKPGRRGRAGSDGARGMPGQTGPKGDR
GFDGLAGLPGEKGHRGDPGPSGPPGPPGDDGERGDDGEVGPRGLPGEPGPRGLLGPKGPPGPPGPPGVTGMDGQPGPKGNVGPQGEPGPP
GQQGNPGAQGLPGPQGAIGPPGEKGPLGKPGLPGMPGADGPPGHPGKEGPPGEKGGQGPPGPQGPIGYPGPRGVKGADGIRGLKGTKGEK
GEDGFPGFKGDMGIKGDRGEIGPPGPRGEDGPEGPKGRGGPNGDPGPLGPPGEKGKLGVPGLPGYPGRQGPKGSIGFPGFPGANGEKGGR
GTPGKPGPRGQRGPTGPRGERGPRGITGKPGPKGNSGGDGPAGPPGERGPNGPQGPTGFPGPKGPPGPPGKDGLPGHPGQRGETGFQGKT
GPPGPPGVVGPQGPTGETGPMGERGHPGPPGPPGEQGLPGLAGKEGTKGDPGPAGLPGKDGPPGLRGFPGDRGLPGPVGALGLKGNEGPP
GPPGPAGSPGERGPAGAAGPIGIPGRPGPQGPPGPAGEKGAPGEKGPQGPAGRDGLQGPVGLPGPAGPVGPPGEDGDKGEIGEPGQKGSK
GDKGEQGPPGPTGPQGPIGQPGPSGADGEPGPRGQQGLFGQKGDEGPRGFPGPPGPVGLQGLPGPPGEKGETGDVGQMGPPGPPGPRGPS
GAPGADGPQGPPGGIGNPGAVGEKGEPGEAGEPGLPGEGGPPGPKGERGEKGESGPSGAAGPPGPKGPPGDDGPKGSPGPVGFPGDPGPP
GEPGPAGQDGPPGDKGDDGEPGQTGSPGPTGEPGPSGPPGKRGPPGPAGPEGRQGEKGAKGEAGLEGPPGKTGPIGPQGAPGKPGPDGLR
GIPGPVGEQGLPGSPGPDGPPGPMGPPGLPGLKGDSGPKGEKGHPGLIGLIGPPGEQGEKGDRGLPGPQGSSGPKGEQGITGPSGPIGPP
GPPGLPGPPGPKGAKGSSGPTGPKGEAGHPGPPGPPGPPGEVIQPLPIQASRTRRNIDASQLLDDGNGENYVDYADGMEEIFGSLNSLKL
EIEQMKRPLGTQQNPARTCKDLQLCHPDFPDGEYWVDPNQGCSRDSFKVYCNFTAGGSTCVFPDKKSEGARITSWPKENPGSWFSEFKRG
KLLSYVDAEGNPVGVVQMTFLRLLSASAHQNVTYHCYQSVAWQDAATGSYDKALRFLGSNDEEMSYDNNPYIRALVDGCATKKGYQKTVL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:494515/chr9:137533620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COL5A1

P20908

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-10102_11520.6666666666666462.0RegionNote=2 X 5 AA tandem repeats of S-L-D-I-Q
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-10102_11521.3333333333334462.0RegionNote=2 X 5 AA tandem repeats of S-L-D-I-Q
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-11112_11520.6666666666666462.0RegionNote=2 X 5 AA tandem repeats of S-L-D-I-Q
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-992_11521.6666666666666462.0RegionNote=2 X 5 AA tandem repeats of S-L-D-I-Q
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010106_133520.6666666666666462.0RepeatNote=LRR 4
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010134_162520.6666666666666462.0RepeatNote=LRR 5
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010163_190520.6666666666666462.0RepeatNote=LRR 6
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010191_219520.6666666666666462.0RepeatNote=LRR 7
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-101020_48520.6666666666666462.0RepeatNote=LRR 1
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010220_247520.6666666666666462.0RepeatNote=LRR 8
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010248_276520.6666666666666462.0RepeatNote=LRR 9
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010277_304520.6666666666666462.0RepeatNote=LRR 10
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010305_333520.6666666666666462.0RepeatNote=LRR 11
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010334_361520.6666666666666462.0RepeatNote=LRR 12
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010362_390520.6666666666666462.0RepeatNote=LRR 13
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010391_418520.6666666666666462.0RepeatNote=LRR 14
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-1010419_447520.6666666666666462.0RepeatNote=LRR 15
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-101049_76520.6666666666666462.0RepeatNote=LRR 2
HgeneRNH1chr11:494515chr9:137533620ENST00000397604-101077_105520.6666666666666462.0RepeatNote=LRR 3
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010106_133521.3333333333334462.0RepeatNote=LRR 4
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010134_162521.3333333333334462.0RepeatNote=LRR 5
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010163_190521.3333333333334462.0RepeatNote=LRR 6
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010191_219521.3333333333334462.0RepeatNote=LRR 7
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-101020_48521.3333333333334462.0RepeatNote=LRR 1
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010220_247521.3333333333334462.0RepeatNote=LRR 8
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010248_276521.3333333333334462.0RepeatNote=LRR 9
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010277_304521.3333333333334462.0RepeatNote=LRR 10
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010305_333521.3333333333334462.0RepeatNote=LRR 11
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010334_361521.3333333333334462.0RepeatNote=LRR 12
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010362_390521.3333333333334462.0RepeatNote=LRR 13
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010391_418521.3333333333334462.0RepeatNote=LRR 14
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-1010419_447521.3333333333334462.0RepeatNote=LRR 15
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-101049_76521.3333333333334462.0RepeatNote=LRR 2
HgeneRNH1chr11:494515chr9:137533620ENST00000397614-101077_105521.3333333333334462.0RepeatNote=LRR 3
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111106_133520.6666666666666462.0RepeatNote=LRR 4
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111134_162520.6666666666666462.0RepeatNote=LRR 5
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111163_190520.6666666666666462.0RepeatNote=LRR 6
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111191_219520.6666666666666462.0RepeatNote=LRR 7
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-111120_48520.6666666666666462.0RepeatNote=LRR 1
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111220_247520.6666666666666462.0RepeatNote=LRR 8
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111248_276520.6666666666666462.0RepeatNote=LRR 9
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111277_304520.6666666666666462.0RepeatNote=LRR 10
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111305_333520.6666666666666462.0RepeatNote=LRR 11
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111334_361520.6666666666666462.0RepeatNote=LRR 12
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111362_390520.6666666666666462.0RepeatNote=LRR 13
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111391_418520.6666666666666462.0RepeatNote=LRR 14
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-1111419_447520.6666666666666462.0RepeatNote=LRR 15
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-111149_76520.6666666666666462.0RepeatNote=LRR 2
HgeneRNH1chr11:494515chr9:137533620ENST00000397615-111177_105520.6666666666666462.0RepeatNote=LRR 3
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99106_133521.6666666666666462.0RepeatNote=LRR 4
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99134_162521.6666666666666462.0RepeatNote=LRR 5
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99163_190521.6666666666666462.0RepeatNote=LRR 6
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99191_219521.6666666666666462.0RepeatNote=LRR 7
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-9920_48521.6666666666666462.0RepeatNote=LRR 1
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99220_247521.6666666666666462.0RepeatNote=LRR 8
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99248_276521.6666666666666462.0RepeatNote=LRR 9
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99277_304521.6666666666666462.0RepeatNote=LRR 10
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99305_333521.6666666666666462.0RepeatNote=LRR 11
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99334_361521.6666666666666462.0RepeatNote=LRR 12
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99362_390521.6666666666666462.0RepeatNote=LRR 13
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99391_418521.6666666666666462.0RepeatNote=LRR 14
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-99419_447521.6666666666666462.0RepeatNote=LRR 15
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-9949_76521.6666666666666462.0RepeatNote=LRR 2
HgeneRNH1chr11:494515chr9:137533620ENST00000534797-9977_105521.6666666666666462.0RepeatNote=LRR 3
TgeneCOL5A1chr11:494515chr9:137533620ENST00000371817-1661609_183736.3333333333333361839.0DomainFibrillar collagen NC1
TgeneCOL5A1chr11:494515chr9:137533620ENST00000371817-16672_24436.3333333333333361839.0DomainNote=Laminin G-like
TgeneCOL5A1chr11:494515chr9:137533620ENST00000371817-1661571_160536.3333333333333361839.0RegionNote=Nonhelical region
TgeneCOL5A1chr11:494515chr9:137533620ENST00000371817-166231_44336.3333333333333361839.0RegionNote=Nonhelical region
TgeneCOL5A1chr11:494515chr9:137533620ENST00000371817-166444_55836.3333333333333361839.0RegionNote=Interrupted collagenous region
TgeneCOL5A1chr11:494515chr9:137533620ENST00000371817-166559_157036.3333333333333361839.0RegionNote=Triple-helical region

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-1112_110462.0RegionNote=2 X 5 AA tandem repeats of S-L-D-I-Q
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-1102_110462.0RegionNote=2 X 5 AA tandem repeats of S-L-D-I-Q
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-1102_110462.0RegionNote=2 X 5 AA tandem repeats of S-L-D-I-Q
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-1112_110462.0RegionNote=2 X 5 AA tandem repeats of S-L-D-I-Q
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111106_1330462.0RepeatNote=LRR 4
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111134_1620462.0RepeatNote=LRR 5
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111163_1900462.0RepeatNote=LRR 6
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111191_2190462.0RepeatNote=LRR 7
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-11120_480462.0RepeatNote=LRR 1
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111220_2470462.0RepeatNote=LRR 8
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111248_2760462.0RepeatNote=LRR 9
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111277_3040462.0RepeatNote=LRR 10
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111305_3330462.0RepeatNote=LRR 11
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111334_3610462.0RepeatNote=LRR 12
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111362_3900462.0RepeatNote=LRR 13
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111391_4180462.0RepeatNote=LRR 14
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-111419_4470462.0RepeatNote=LRR 15
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-11149_760462.0RepeatNote=LRR 2
HgeneRNH1chr11:494515chr9:137533620ENST00000354420-11177_1050462.0RepeatNote=LRR 3
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110106_1330462.0RepeatNote=LRR 4
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110134_1620462.0RepeatNote=LRR 5
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110163_1900462.0RepeatNote=LRR 6
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110191_2190462.0RepeatNote=LRR 7
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-11020_480462.0RepeatNote=LRR 1
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110220_2470462.0RepeatNote=LRR 8
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110248_2760462.0RepeatNote=LRR 9
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110277_3040462.0RepeatNote=LRR 10
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110305_3330462.0RepeatNote=LRR 11
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110334_3610462.0RepeatNote=LRR 12
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110362_3900462.0RepeatNote=LRR 13
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110391_4180462.0RepeatNote=LRR 14
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-110419_4470462.0RepeatNote=LRR 15
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-11049_760462.0RepeatNote=LRR 2
HgeneRNH1chr11:494515chr9:137533620ENST00000356187-11077_1050462.0RepeatNote=LRR 3
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110106_1330462.0RepeatNote=LRR 4
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110134_1620462.0RepeatNote=LRR 5
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110163_1900462.0RepeatNote=LRR 6
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110191_2190462.0RepeatNote=LRR 7
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-11020_480462.0RepeatNote=LRR 1
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110220_2470462.0RepeatNote=LRR 8
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110248_2760462.0RepeatNote=LRR 9
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110277_3040462.0RepeatNote=LRR 10
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110305_3330462.0RepeatNote=LRR 11
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110334_3610462.0RepeatNote=LRR 12
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110362_3900462.0RepeatNote=LRR 13
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110391_4180462.0RepeatNote=LRR 14
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-110419_4470462.0RepeatNote=LRR 15
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-11049_760462.0RepeatNote=LRR 2
HgeneRNH1chr11:494515chr9:137533620ENST00000438658-11077_1050462.0RepeatNote=LRR 3
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111106_1330462.0RepeatNote=LRR 4
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111134_1620462.0RepeatNote=LRR 5
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111163_1900462.0RepeatNote=LRR 6
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111191_2190462.0RepeatNote=LRR 7
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-11120_480462.0RepeatNote=LRR 1
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111220_2470462.0RepeatNote=LRR 8
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111248_2760462.0RepeatNote=LRR 9
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111277_3040462.0RepeatNote=LRR 10
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111305_3330462.0RepeatNote=LRR 11
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111334_3610462.0RepeatNote=LRR 12
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111362_3900462.0RepeatNote=LRR 13
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111391_4180462.0RepeatNote=LRR 14
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-111419_4470462.0RepeatNote=LRR 15
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-11149_760462.0RepeatNote=LRR 2
HgeneRNH1chr11:494515chr9:137533620ENST00000533410-11177_1050462.0RepeatNote=LRR 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RNH1
COL5A1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RNH1-COL5A1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RNH1-COL5A1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource