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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ROBO1-HMCN1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ROBO1-HMCN1
	FusionPDB ID: 75256
	FusionGDB2.0 ID: 75256
		Hgene	Tgene
	Gene symbol	ROBO1	HMCN1
	Gene ID	6091	83872
	Gene name	roundabout guidance receptor 1	hemicentin 1
	Synonyms	DUTT1\|SAX3	ARMD1\|FBLN6\|FIBL-6\|FIBL6
	Cytomap	3p12.3	1q25.3-q31.1
	Type of gene	protein-coding	protein-coding
	Description	roundabout homolog 1deleted in U twenty twentyroundabout, axon guidance receptor, homolog 1	hemicentin-1LOC100507250/HMCN1 fusionfibulin-6
	Modification date	20200313	20200313
	UniProtAcc	.	Q96RW7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000436010, ENST00000464233, ENST00000467549, ENST00000495273, ENST00000466906,	ENST00000485744, ENST00000271588, ENST00000367492,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 16 X 7=2016	11 X 10 X 5=550
	# samples	18	12
	** MAII score	log2(18/2016*10)=-3.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(12/550*10)=-2.1963972128035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ROBO1 [Title/Abstract] AND HMCN1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ROBO1(78987751)-HMCN1(185966561), # samples:2
Anticipated loss of major functional domain due to fusion event.	ROBO1-HMCN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ROBO1-HMCN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ROBO1-HMCN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ROBO1-HMCN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ROBO1-HMCN1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ROBO1	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules	12504588
Hgene	ROBO1	GO:0021836	chemorepulsion involved in postnatal olfactory bulb interneuron migration	15207848
Hgene	ROBO1	GO:0050772	positive regulation of axonogenesis	12504588
Hgene	ROBO1	GO:0050925	negative regulation of negative chemotaxis	11748139

Fusion gene breakpoints across ROBO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HMCN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-ER-A3EV-06A	ROBO1	chr3	78987751	-	HMCN1	chr1	185966561	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000436010	ROBO1	chr3	78987751	-	ENST00000271588	HMCN1	chr1	185966561	+	15581	1380	998	14509	4503
ENST00000436010	ROBO1	chr3	78987751	-	ENST00000367492	HMCN1	chr1	185966561	+	15234	1380	998	14158	4386
ENST00000495273	ROBO1	chr3	78987751	-	ENST00000271588	HMCN1	chr1	185966561	+	15137	936	554	14065	4503
ENST00000495273	ROBO1	chr3	78987751	-	ENST00000367492	HMCN1	chr1	185966561	+	14790	936	554	13714	4386
ENST00000467549	ROBO1	chr3	78987751	-	ENST00000271588	HMCN1	chr1	185966561	+	14666	465	83	13594	4503
ENST00000467549	ROBO1	chr3	78987751	-	ENST00000367492	HMCN1	chr1	185966561	+	14319	465	83	13243	4386

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000436010	ENST00000271588	ROBO1	chr3	78987751	-	HMCN1	chr1	185966561	+	0.00058928	0.99941075
ENST00000436010	ENST00000367492	ROBO1	chr3	78987751	-	HMCN1	chr1	185966561	+	0.001517818	0.99848217
ENST00000495273	ENST00000271588	ROBO1	chr3	78987751	-	HMCN1	chr1	185966561	+	0.000353045	0.9996469
ENST00000495273	ENST00000367492	ROBO1	chr3	78987751	-	HMCN1	chr1	185966561	+	0.000865836	0.99913424
ENST00000467549	ENST00000271588	ROBO1	chr3	78987751	-	HMCN1	chr1	185966561	+	0.000202306	0.99979776
ENST00000467549	ENST00000367492	ROBO1	chr3	78987751	-	HMCN1	chr1	185966561	+	0.000491743	0.99950826

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>75256_75256_1_ROBO1-HMCN1_ROBO1_chr3_78987751_ENST00000436010_HMCN1_chr1_185966561_ENST00000271588_length(amino acids)=4503AA_BP=1134
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAKPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREP
GISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT
ESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGK
PLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWY
KDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI
LTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP
PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANG
IPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC
KAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLE
CEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE
LLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGN
LISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI
IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRS
PENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVG
ENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPT
IAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVK
VYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG
EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVED
AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILN
TQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQI
IRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG
QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRI
LSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGET
ERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLP
LPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRD
GQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW
MKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV
ITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP
RITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPK
PSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASG
VPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEAT
GTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEA
DGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVA
DGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK
ATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCE
VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQ
ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKR
SRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPV
HGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVP
QYGGRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHS
WSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKI
TNVPRSLGSAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAE
VTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQC
PSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFR
RTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCID
IDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN
YGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQHECKNTFGS
YQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLP
FGIATNQDLIRLVAYTQDGVMHPRTTFLMVDEEQTVPFALRDENLKGVVYTTRPLREAETYRMRVRASSYSANGTIEYQTTFIVYIAVSA

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>75256_75256_2_ROBO1-HMCN1_ROBO1_chr3_78987751_ENST00000436010_HMCN1_chr1_185966561_ENST00000367492_length(amino acids)=4386AA_BP=1134
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAKPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREP
GISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT
ESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGK
PLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWY
KDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI
LTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP
PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANG
IPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC
KAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLE
CEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE
LLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGN
LISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI
IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRS
PENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVG
ENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPT
IAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVK
VYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG
EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVED
AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILN
TQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQI
IRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG
QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRI
LSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGET
ERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLP
LPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRD
GQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW
MKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV
ITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP
RITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPK
PSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASG
VPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEAT
GTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEA
DGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVA
DGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK
ATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCE
VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQ
ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKR
SRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPV
HGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVP
QYGGRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHS
WSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKI
TNVPRSLGSAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAE
VTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQC
PSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFR
RTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCID
IDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQ
NVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRTTF

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>75256_75256_3_ROBO1-HMCN1_ROBO1_chr3_78987751_ENST00000467549_HMCN1_chr1_185966561_ENST00000271588_length(amino acids)=4503AA_BP=1134
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAKPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREP
GISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT
ESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGK
PLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWY
KDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI
LTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP
PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANG
IPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC
KAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLE
CEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE
LLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGN
LISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI
IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRS
PENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVG
ENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPT
IAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVK
VYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG
EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVED
AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILN
TQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQI
IRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG
QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRI
LSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGET
ERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLP
LPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRD
GQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW
MKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV
ITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP
RITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPK
PSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASG
VPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEAT
GTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEA
DGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVA
DGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK
ATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCE
VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQ
ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKR
SRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPV
HGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVP
QYGGRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHS
WSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKI
TNVPRSLGSAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAE
VTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQC
PSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFR
RTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCID
IDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN
YGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQHECKNTFGS
YQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLP
FGIATNQDLIRLVAYTQDGVMHPRTTFLMVDEEQTVPFALRDENLKGVVYTTRPLREAETYRMRVRASSYSANGTIEYQTTFIVYIAVSA

--------------------------------------------------------------

>75256_75256_4_ROBO1-HMCN1_ROBO1_chr3_78987751_ENST00000467549_HMCN1_chr1_185966561_ENST00000367492_length(amino acids)=4386AA_BP=1134
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAKPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREP
GISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT
ESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGK
PLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWY
KDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI
LTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP
PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANG
IPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC
KAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLE
CEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE
LLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGN
LISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI
IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRS
PENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVG
ENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPT
IAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVK
VYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG
EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVED
AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILN
TQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQI
IRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG
QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRI
LSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGET
ERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLP
LPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRD
GQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW
MKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV
ITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP
RITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPK
PSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASG
VPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEAT
GTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEA
DGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVA
DGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK
ATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCE
VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQ
ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKR
SRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPV
HGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVP
QYGGRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHS
WSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKI
TNVPRSLGSAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAE
VTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQC
PSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFR
RTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCID
IDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQ
NVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRTTF

--------------------------------------------------------------

>75256_75256_5_ROBO1-HMCN1_ROBO1_chr3_78987751_ENST00000495273_HMCN1_chr1_185966561_ENST00000271588_length(amino acids)=4503AA_BP=1134
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAKPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREP
GISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT
ESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGK
PLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWY
KDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI
LTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP
PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANG
IPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC
KAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLE
CEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE
LLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGN
LISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI
IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRS
PENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVG
ENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPT
IAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVK
VYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG
EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVED
AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILN
TQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQI
IRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG
QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRI
LSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGET
ERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLP
LPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRD
GQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW
MKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV
ITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP
RITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPK
PSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASG
VPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEAT
GTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEA
DGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVA
DGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK
ATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCE
VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQ
ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKR
SRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPV
HGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVP
QYGGRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHS
WSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKI
TNVPRSLGSAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAE
VTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQC
PSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFR
RTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCID
IDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQCSNTPGSFKCICPPGQHLLGDGKSCAGLERLPN
YGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYSEYRNSRTSLSRTRRTIRKTCPEGSEASHDTCVDIDECENTDACQHECKNTFGS
YQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLP
FGIATNQDLIRLVAYTQDGVMHPRTTFLMVDEEQTVPFALRDENLKGVVYTTRPLREAETYRMRVRASSYSANGTIEYQTTFIVYIAVSA

--------------------------------------------------------------

>75256_75256_6_ROBO1-HMCN1_ROBO1_chr3_78987751_ENST00000495273_HMCN1_chr1_185966561_ENST00000367492_length(amino acids)=4386AA_BP=1134
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF
LRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAKPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREP
GISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT
ESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGK
PLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWY
KDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPI
LTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP
PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANG
IPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC
KAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLE
CEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVE
LLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGN
LISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEI
IVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRS
PENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVG
ENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPT
IAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVK
VYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG
EDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVED
AGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILN
TQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQI
IRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG
QMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRI
LSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGET
ERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLP
LPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRD
GQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTW
MKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPV
ITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTP
RITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPK
PSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASG
VPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEAT
GTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEA
DGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVA
DGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCK
ATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCE
VKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQ
ATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKR
SRLCNQPLPANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPV
HGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTRGCSDPVP
QYGGRKCEGSDVQSDFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGSWGSWHS
WSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACPGGPQRARGSVIGNINDVEFGIAFLNATITDSPNSDTRIIRAKI
TNVPRSLGSAMRKIVSILNPIYWTTAKEIGEAVNGFTLTNAVFKRETQVEFATGEILQMSHIARGLDSDGSLLLDIVVSGYVLQLQSPAE
VTVKDYTEDYIQTGPGQLYAYSTRLFTIDGISIPYTWNHTVFYDQAQGRMPFLVETLHASSVESDYNQIEETLGFKIHASISKGDRSNQC
PSGFTLDSVGPFCADEDECAAGNPCSHSCHNAMGTYYCSCPKGLTIAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFR
RTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKNTRGGYKCIDLCPNGMTKAENGTCID
IDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGVGRPCMDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQ
NVHCGPNRMCFNMRGSYQCIDTPCPPNYQRDPVSGFCLKNCPPNDLECALSPYALEYKLVSLPFGIATNQDLIRLVAYTQDGVMHPRTTF

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:78987751/chr1:185966561)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HMCN1 Q96RW7
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Promotes cleavage furrow maturation during cytokinesis in preimplantation embryos. May play a role in the architecture of adhesive and flexible epithelial cell junctions. May play a role during myocardial remodeling by imparting an effect on cardiac fibroblast migration. {ECO:0000250\|UniProtKB:D3YXG0}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

68_164

166.33333333333334

1652.0

Domain

Note=Ig-like C2-type 1

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

1262_1354

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 10

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

1358_1447

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 11

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

1452_1541

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 12

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

1546_1634

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 13

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

1638_1724

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 14

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

1733_1821

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 15

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

1826_1914

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 16

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

1919_2007

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 17

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2012_2097

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 18

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2104_2190

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 19

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2195_2285

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 20

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2290_2379

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 21

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2384_2470

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 22

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2478_2564

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 23

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2571_2662

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 24

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2666_2763

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 25

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2766_2864

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 26

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2868_2959

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 27

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

2964_3051

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 28

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3056_3146

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 29

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3151_3240

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 30

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3245_3335

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 31

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3340_3429

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 32

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3434_3516

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 33

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3527_3615

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 34

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3620_3708

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 35

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3713_3797

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 36

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3804_3892

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 37

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3897_3983

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 38

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

3988_4076

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 39

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4079_4164

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 40

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4169_4255

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 41

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4260_4344

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 42

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4348_4435

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 43

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4440_4527

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 44

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4529_4584

1259.3333333333333

5636.0

Domain

TSP type-1 1

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4586_4641

1259.3333333333333

5636.0

Domain

TSP type-1 2

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4643_4698

1259.3333333333333

5636.0

Domain

TSP type-1 3

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4700_4755

1259.3333333333333

5636.0

Domain

TSP type-1 4

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4757_4812

1259.3333333333333

5636.0

Domain

TSP type-1 5

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4814_4869

1259.3333333333333

5636.0

Domain

TSP type-1 6

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

4871_5093

1259.3333333333333

5636.0

Domain

Nidogen G2 beta-barrel

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

5107_5146

1259.3333333333333

5636.0

Domain

EGF-like 1%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

5147_5191

1259.3333333333333

5636.0

Domain

EGF-like 2%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

5192_5229

1259.3333333333333

5636.0

Domain

EGF-like 3%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

5230_5271

1259.3333333333333

5636.0

Domain

EGF-like 4%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

5272_5307

1259.3333333333333

5636.0

Domain

EGF-like 5%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

5315_5355

1259.3333333333333

5636.0

Domain

EGF-like 6%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

5432_5471

1259.3333333333333

5636.0

Domain

EGF-like 7%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

1262_1354

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 10

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

1358_1447

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 11

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

1452_1541

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 12

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

1546_1634

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 13

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

1638_1724

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 14

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

1733_1821

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 15

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

1826_1914

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 16

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

1919_2007

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 17

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2012_2097

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 18

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2104_2190

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 19

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2195_2285

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 20

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2290_2379

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 21

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2384_2470

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 22

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2478_2564

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 23

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2571_2662

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 24

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2666_2763

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 25

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2766_2864

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 26

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2868_2959

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 27

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

2964_3051

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 28

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3056_3146

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 29

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3151_3240

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 30

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3245_3335

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 31

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3340_3429

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 32

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3434_3516

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 33

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3527_3615

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 34

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3620_3708

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 35

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3713_3797

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 36

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3804_3892

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 37

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3897_3983

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 38

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

3988_4076

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 39

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4079_4164

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 40

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4169_4255

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 41

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4260_4344

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 42

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4348_4435

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 43

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4440_4527

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 44

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4529_4584

1259.3333333333333

5519.0

Domain

TSP type-1 1

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4586_4641

1259.3333333333333

5519.0

Domain

TSP type-1 2

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4643_4698

1259.3333333333333

5519.0

Domain

TSP type-1 3

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4700_4755

1259.3333333333333

5519.0

Domain

TSP type-1 4

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4757_4812

1259.3333333333333

5519.0

Domain

TSP type-1 5

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4814_4869

1259.3333333333333

5519.0

Domain

TSP type-1 6

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

4871_5093

1259.3333333333333

5519.0

Domain

Nidogen G2 beta-barrel

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

5107_5146

1259.3333333333333

5519.0

Domain

EGF-like 1%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

5147_5191

1259.3333333333333

5519.0

Domain

EGF-like 2%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

5192_5229

1259.3333333333333

5519.0

Domain

EGF-like 3%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

5230_5271

1259.3333333333333

5519.0

Domain

EGF-like 4%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

5272_5307

1259.3333333333333

5519.0

Domain

EGF-like 5%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

5315_5355

1259.3333333333333

5519.0

Domain

EGF-like 6%3B calcium-binding

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

5432_5471

1259.3333333333333

5519.0

Domain

EGF-like 7%3B calcium-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

170_257

127.33333333333333

1613.0

Domain

Note=Ig-like C2-type 2

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

262_346

127.33333333333333

1613.0

Domain

Note=Ig-like C2-type 3

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

351_446

127.33333333333333

1613.0

Domain

Note=Ig-like C2-type 4

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

455_541

127.33333333333333

1613.0

Domain

Note=Ig-like C2-type 5

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

563_657

127.33333333333333

1613.0

Domain

Fibronectin type-III 1

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

676_773

127.33333333333333

1613.0

Domain

Fibronectin type-III 2

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

68_164

127.33333333333333

1613.0

Domain

Note=Ig-like C2-type 1

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

778_874

127.33333333333333

1613.0

Domain

Fibronectin type-III 3

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

170_257

166.33333333333334

1652.0

Domain

Note=Ig-like C2-type 2

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

262_346

166.33333333333334

1652.0

Domain

Note=Ig-like C2-type 3

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

351_446

166.33333333333334

1652.0

Domain

Note=Ig-like C2-type 4

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

455_541

166.33333333333334

1652.0

Domain

Note=Ig-like C2-type 5

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

563_657

166.33333333333334

1652.0

Domain

Fibronectin type-III 1

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

676_773

166.33333333333334

1652.0

Domain

Fibronectin type-III 2

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

778_874

166.33333333333334

1652.0

Domain

Fibronectin type-III 3

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

170_257

127.33333333333333

1552.0

Domain

Note=Ig-like C2-type 2

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

262_346

127.33333333333333

1552.0

Domain

Note=Ig-like C2-type 3

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

351_446

127.33333333333333

1552.0

Domain

Note=Ig-like C2-type 4

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

455_541

127.33333333333333

1552.0

Domain

Note=Ig-like C2-type 5

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

563_657

127.33333333333333

1552.0

Domain

Fibronectin type-III 1

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

676_773

127.33333333333333

1552.0

Domain

Fibronectin type-III 2

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

68_164

127.33333333333333

1552.0

Domain

Note=Ig-like C2-type 1

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

778_874

127.33333333333333

1552.0

Domain

Fibronectin type-III 3

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

170_257

127.33333333333333

1607.0

Domain

Note=Ig-like C2-type 2

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

262_346

127.33333333333333

1607.0

Domain

Note=Ig-like C2-type 3

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

351_446

127.33333333333333

1607.0

Domain

Note=Ig-like C2-type 4

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

455_541

127.33333333333333

1607.0

Domain

Note=Ig-like C2-type 5

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

563_657

127.33333333333333

1607.0

Domain

Fibronectin type-III 1

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

676_773

127.33333333333333

1607.0

Domain

Fibronectin type-III 2

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

68_164

127.33333333333333

1607.0

Domain

Note=Ig-like C2-type 1

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

778_874

127.33333333333333

1607.0

Domain

Fibronectin type-III 3

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

26_897

127.33333333333333

1613.0

Topological domain

Extracellular

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

919_1651

127.33333333333333

1613.0

Topological domain

Cytoplasmic

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

26_897

166.33333333333334

1652.0

Topological domain

Extracellular

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

919_1651

166.33333333333334

1652.0

Topological domain

Cytoplasmic

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

26_897

127.33333333333333

1552.0

Topological domain

Extracellular

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

919_1651

127.33333333333333

1552.0

Topological domain

Cytoplasmic

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

26_897

127.33333333333333

1607.0

Topological domain

Extracellular

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

919_1651

127.33333333333333

1607.0

Topological domain

Cytoplasmic

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000436010

898_918

127.33333333333333

1613.0

Transmembrane

Helical

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000464233

898_918

166.33333333333334

1652.0

Transmembrane

Helical

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000467549

898_918

127.33333333333333

1552.0

Transmembrane

Helical

Hgene

ROBO1

chr3:78987751

chr1:185966561

ENST00000495273

898_918

127.33333333333333

1607.0

Transmembrane

Helical

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

1072_1166

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 8

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

1171_1255

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 9

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

41_216

1259.3333333333333

5636.0

Domain

Note=VWFA

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

431_517

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 1

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

520_607

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 2

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

612_697

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 3

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

702_788

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 4

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

793_883

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 5

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

890_976

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 6

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000271588

107

981_1067

1259.3333333333333

5636.0

Domain

Note=Ig-like C2-type 7

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

1072_1166

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 8

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

1171_1255

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 9

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

41_216

1259.3333333333333

5519.0

Domain

Note=VWFA

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

431_517

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 1

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

520_607

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 2

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

612_697

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 3

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

702_788

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 4

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

793_883

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 5

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

890_976

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 6

Tgene

HMCN1

chr3:78987751

chr1:185966561

ENST00000367492

106

981_1067

1259.3333333333333

5519.0

Domain

Note=Ig-like C2-type 7

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ROBO1
HMCN1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ROBO1-HMCN1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ROBO1-HMCN1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source