UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RPAIN-FHIT

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RPAIN-FHIT
	FusionPDB ID: 75691
	FusionGDB2.0 ID: 75691
		Hgene	Tgene
	Gene symbol	RPAIN	FHIT
	Gene ID	84268	2272
	Gene name	RPA interacting protein	fragile histidine triad diadenosine triphosphatase
	Synonyms	HRIP\|RIP	AP3Aase\|FRA3B
	Cytomap	17p13.2	3p14.2
	Type of gene	protein-coding	protein-coding
	Description	RPA-interacting proteinRAP interaction proteinnuclear transporter	bis(5'-adenosyl)-triphosphataseAP3A hydrolasediadenosine 5',5'''-P1,P3-triphosphate hydrolasedinucleosidetriphosphatase
	Modification date	20200320	20200313
	UniProtAcc	.	P49789
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000327154, ENST00000381208, ENST00000381209, ENST00000405578, ENST00000536255, ENST00000574003,	ENST00000341848, ENST00000466788, ENST00000468189, ENST00000476844, ENST00000492590,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 8 X 4=256	27 X 20 X 11=5940
	# samples	10	32
	** MAII score	log2(10/256*10)=-1.35614381022528 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(32/5940*10)=-4.21431912080077 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RPAIN [Title/Abstract] AND FHIT [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RPAIN(5326149)-FHIT(59908140), # samples:4
Anticipated loss of major functional domain due to fusion event.	RPAIN-FHIT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RPAIN-FHIT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RPAIN-FHIT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RPAIN-FHIT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RPAIN-FHIT seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. RPAIN-FHIT seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. RPAIN-FHIT seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. RPAIN-FHIT seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RPAIN	GO:0006606	protein import into nucleus	16135809
Tgene	FHIT	GO:0006163	purine nucleotide metabolic process	9323207

Fusion gene breakpoints across RPAIN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FHIT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A7-A0CJ-01A	RPAIN	chr17	5326149	+	FHIT	chr3	59738047	-
ChimerDB4	BRCA	TCGA-A7-A0CJ-01A	RPAIN	chr17	5326149	-	FHIT	chr3	59908140	-
ChimerDB4	BRCA	TCGA-A7-A0CJ-01A	RPAIN	chr17	5326149	+	FHIT	chr3	59908140	-
ChimerDB4	BRCA	TCGA-A7-A0CJ-01A	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-
ChimerDB4	BRCA	TCGA-A7-A0CJ-01A	RPAIN	chr17	5326149	+	FHIT	chr3	59999990	-
ChimerDB4	BRCA	TCGA-A7-A0CJ	RPAIN	chr17	5326149	+	FHIT	chr3	59908140	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000536255	RPAIN	chr17	5326149	+	ENST00000476844	FHIT	chr3	59999878	-	1488	883	468	1223	251
ENST00000536255	RPAIN	chr17	5326149	+	ENST00000492590	FHIT	chr3	59999878	-	1499	883	468	1223	251
ENST00000381208	RPAIN	chr17	5326149	+	ENST00000476844	FHIT	chr3	59999878	-	1488	883	468	1223	251
ENST00000381208	RPAIN	chr17	5326149	+	ENST00000492590	FHIT	chr3	59999878	-	1499	883	468	1223	251
ENST00000381209	RPAIN	chr17	5326149	+	ENST00000476844	FHIT	chr3	59999878	-	1488	883	468	1223	251
ENST00000381209	RPAIN	chr17	5326149	+	ENST00000492590	FHIT	chr3	59999878	-	1499	883	468	1223	251
ENST00000327154	RPAIN	chr17	5326149	+	ENST00000476844	FHIT	chr3	59999878	-	1241	636	221	976	251
ENST00000327154	RPAIN	chr17	5326149	+	ENST00000492590	FHIT	chr3	59999878	-	1252	636	221	976	251
ENST00000405578	RPAIN	chr17	5326149	+	ENST00000476844	FHIT	chr3	59999878	-	929	324	11	664	217
ENST00000405578	RPAIN	chr17	5326149	+	ENST00000492590	FHIT	chr3	59999878	-	940	324	11	664	217
ENST00000574003	RPAIN	chr17	5326149	+	ENST00000476844	FHIT	chr3	59999878	-	927	322	9	662	217
ENST00000574003	RPAIN	chr17	5326149	+	ENST00000492590	FHIT	chr3	59999878	-	938	322	9	662	217

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000536255	ENST00000476844	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.003757431	0.99624264
ENST00000536255	ENST00000492590	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.003467883	0.9965321
ENST00000381208	ENST00000476844	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.003757431	0.99624264
ENST00000381208	ENST00000492590	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.003467883	0.9965321
ENST00000381209	ENST00000476844	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.003757431	0.99624264
ENST00000381209	ENST00000492590	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.003467883	0.9965321
ENST00000327154	ENST00000476844	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.00336837	0.9966317
ENST00000327154	ENST00000492590	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.003365065	0.9966349
ENST00000405578	ENST00000476844	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.002899917	0.99710006
ENST00000405578	ENST00000492590	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.002799886	0.99720013
ENST00000574003	ENST00000476844	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.002855609	0.9971444
ENST00000574003	ENST00000492590	RPAIN	chr17	5326149	+	FHIT	chr3	59999878	-	0.002884568	0.9971154

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>75691_75691_1_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000327154_FHIT_chr3_59999878_ENST00000476844_length(amino acids)=251AA_BP=138
MRSIRGLHPESTPPRGLCAPPGNGSCGFVSREEEMAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQ
NSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGT

--------------------------------------------------------------

>75691_75691_2_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000327154_FHIT_chr3_59999878_ENST00000492590_length(amino acids)=251AA_BP=138
MRSIRGLHPESTPPRGLCAPPGNGSCGFVSREEEMAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQ
NSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGT

--------------------------------------------------------------

>75691_75691_3_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000381208_FHIT_chr3_59999878_ENST00000476844_length(amino acids)=251AA_BP=138
MRSIRGLHPESTPPRGLCAPPGNGSCGFVSREEEMAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQ
NSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGT

--------------------------------------------------------------

>75691_75691_4_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000381208_FHIT_chr3_59999878_ENST00000492590_length(amino acids)=251AA_BP=138
MRSIRGLHPESTPPRGLCAPPGNGSCGFVSREEEMAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQ
NSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGT

--------------------------------------------------------------

>75691_75691_5_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000381209_FHIT_chr3_59999878_ENST00000476844_length(amino acids)=251AA_BP=138
MRSIRGLHPESTPPRGLCAPPGNGSCGFVSREEEMAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQ
NSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGT

--------------------------------------------------------------

>75691_75691_6_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000381209_FHIT_chr3_59999878_ENST00000492590_length(amino acids)=251AA_BP=138
MRSIRGLHPESTPPRGLCAPPGNGSCGFVSREEEMAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQ
NSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGT

--------------------------------------------------------------

>75691_75691_7_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000405578_FHIT_chr3_59999878_ENST00000476844_length(amino acids)=217AA_BP=104
MAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQNSFLVQEVMEEEWNALQSVENCPEDLAQLEELID
MAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRN

--------------------------------------------------------------

>75691_75691_8_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000405578_FHIT_chr3_59999878_ENST00000492590_length(amino acids)=217AA_BP=104
MAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQNSFLVQEVMEEEWNALQSVENCPEDLAQLEELID
MAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRN

--------------------------------------------------------------

>75691_75691_9_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000536255_FHIT_chr3_59999878_ENST00000476844_length(amino acids)=251AA_BP=138
MRSIRGLHPESTPPRGLCAPPGNGSCGFVSREEEMAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQ
NSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGT

--------------------------------------------------------------

>75691_75691_10_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000536255_FHIT_chr3_59999878_ENST00000492590_length(amino acids)=251AA_BP=138
MRSIRGLHPESTPPRGLCAPPGNGSCGFVSREEEMAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQ
NSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGT

--------------------------------------------------------------

>75691_75691_11_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000574003_FHIT_chr3_59999878_ENST00000476844_length(amino acids)=217AA_BP=104
MAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQNSFLVQEVMEEEWNALQSVENCPEDLAQLEELID
MAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRN

--------------------------------------------------------------

>75691_75691_12_RPAIN-FHIT_RPAIN_chr17_5326149_ENST00000574003_FHIT_chr3_59999878_ENST00000492590_length(amino acids)=217AA_BP=104
MAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQNSFLVQEVMEEEWNALQSVENCPEDLAQLEELID
MAVLEEIQQELINQDVLVCPLRPVERFHDLRPDEVADLFQTTQRVGTVVEKHFHGTSLTFSMQDGPEAGQTVKHVHVHVLPRKAGDFHRN

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:5326149/chr3:59908140)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FHIT P49789
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Possesses dinucleoside triphosphate hydrolase activity (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9576908, PubMed:9543008). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (PubMed:12574506, PubMed:15182206, PubMed:8794732, PubMed:9323207, PubMed:9576908, PubMed:9543008). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (PubMed:8794732). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (PubMed:18694747). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:18694747). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (PubMed:26181368). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (PubMed:26181368). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (PubMed:18077326). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (PubMed:16407838). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (PubMed:15313915). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake (PubMed:12574506, PubMed:19622739). Functions as tumor suppressor (By similarity). {ECO:0000250\|UniProtKB:O89106, ECO:0000269\|PubMed:12574506, ECO:0000269\|PubMed:15313915, ECO:0000269\|PubMed:16407838, ECO:0000269\|PubMed:18077326, ECO:0000269\|PubMed:18694747, ECO:0000269\|PubMed:19622739, ECO:0000269\|PubMed:26181368, ECO:0000269\|PubMed:8794732, ECO:0000269\|PubMed:9323207, ECO:0000269\|PubMed:9543008}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000341848

94_98

34.333333333333336

148.0

Motif

Histidine triad motif

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000468189

94_98

34.333333333333336

148.0

Motif

Histidine triad motif

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000476844

94_98

34.333333333333336

214.0

Motif

Histidine triad motif

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000492590

94_98

34.333333333333336

205.33333333333334

Motif

Histidine triad motif

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000341848

89_92

34.333333333333336

148.0

Nucleotide binding

Substrate

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000468189

89_92

34.333333333333336

148.0

Nucleotide binding

Substrate

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000476844

89_92

34.333333333333336

214.0

Nucleotide binding

Substrate

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000492590

89_92

34.333333333333336

205.33333333333334

Nucleotide binding

Substrate

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RPAIN

chr17:5326149

chr3:59999878

ENST00000536255

164_180

104.33333333333333

107.0

Region

Note=Mediates nuclear export

Hgene

RPAIN

chr17:5326149

chr3:59999878

ENST00000536255

137_212

104.33333333333333

107.0

Zinc finger

Note=RIP-type

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000341848

2_109

34.333333333333336

148.0

Domain

HIT

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000468189

2_109

34.333333333333336

148.0

Domain

HIT

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000476844

2_109

34.333333333333336

214.0

Domain

HIT

Tgene

FHIT

chr17:5326149

chr3:59999878

ENST00000492590

2_109

34.333333333333336

205.33333333333334

Domain

HIT

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
FHIT	FHIT, UBE2I, CTNNB1, LEF1, TRIM23, RAB40B, MDM2, REL, TP53, ARHGAP19, MTMR6, RABL2A, CHEK1, DDIT4L, SPERT, FDCSP, GAST, GGH, BCAS2, PRPF6, YTHDF1, Rbm14,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RPAIN
FHIT

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to RPAIN-FHIT

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to RPAIN-FHIT

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	FHIT	C0024121	Lung Neoplasms	2	CTD_human
Tgene	FHIT	C0025500	Mesothelioma	2	CTD_human
Tgene	FHIT	C0242379	Malignant neoplasm of lung	2	CTD_human
Tgene	FHIT	C0007097	Carcinoma	1	CTD_human
Tgene	FHIT	C0007131	Non-Small Cell Lung Carcinoma	1	CTD_human
Tgene	FHIT	C0013146	Drug abuse	1	CTD_human
Tgene	FHIT	C0013170	Drug habituation	1	CTD_human
Tgene	FHIT	C0013222	Drug Use Disorders	1	CTD_human
Tgene	FHIT	C0023903	Liver neoplasms	1	CTD_human
Tgene	FHIT	C0024623	Malignant neoplasm of stomach	1	CTD_human
Tgene	FHIT	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	FHIT	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	FHIT	C0038356	Stomach Neoplasms	1	CTD_human
Tgene	FHIT	C0038580	Substance Dependence	1	CTD_human
Tgene	FHIT	C0038586	Substance Use Disorders	1	CTD_human
Tgene	FHIT	C0042076	Urologic Neoplasms	1	CTD_human
Tgene	FHIT	C0205696	Anaplastic carcinoma	1	CTD_human
Tgene	FHIT	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Tgene	FHIT	C0205698	Undifferentiated carcinoma	1	CTD_human
Tgene	FHIT	C0205699	Carcinomatosis	1	CTD_human
Tgene	FHIT	C0236733	Amphetamine-Related Disorders	1	CTD_human
Tgene	FHIT	C0236804	Amphetamine Addiction	1	CTD_human
Tgene	FHIT	C0236807	Amphetamine Abuse	1	CTD_human
Tgene	FHIT	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	FHIT	C0345904	Malignant neoplasm of liver	1	CTD_human
Tgene	FHIT	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	FHIT	C0740858	Substance abuse problem	1	CTD_human
Tgene	FHIT	C0751571	Cancer of Urinary Tract	1	CTD_human
Tgene	FHIT	C1510472	Drug Dependence	1	CTD_human
Tgene	FHIT	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Tgene	FHIT	C4316881	Prescription Drug Abuse	1	CTD_human