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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RPS19-CEACAM5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RPS19-CEACAM5
FusionPDB ID: 77528
FusionGDB2.0 ID: 77528
HgeneTgene
Gene symbol

RPS19

CEACAM5

Gene ID

6223

1048

Gene nameribosomal protein S19CEA cell adhesion molecule 5
SynonymsDBA|DBA1|LOH19CR1|S19|eS19CD66e|CEA
Cytomap

19q13.2

19q13.2

Type of geneprotein-codingprotein-coding
Description40S ribosomal protein S19loss of heterozygosity on chromosome 19, region 1loss of heterozygosity, 19, chromosomal region 1small ribosomal subunit protein eS19carcinoembryonic antigen-related cell adhesion molecule 5carcinoembryonic antigen related cell adhesion molecule 5meconium antigen 100
Modification date2020031320200313
UniProtAcc.

P06731

Ensembl transtripts involved in fusion geneENST idsENST00000221975, ENST00000593863, 
ENST00000598742, 		ENST00000221992, 
ENST00000398599, ENST00000405816, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 12 X 11=277211 X 16 X 6=1056
# samples 2614
** MAII scorelog2(26/2772*10)=-3.41434372910876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1056*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: RPS19 [Title/Abstract] AND CEACAM5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RPS19(42365281)-CEACAM5(42231154), # samples:2
Anticipated loss of major functional domain due to fusion event.RPS19-CEACAM5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RPS19-CEACAM5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RPS19-CEACAM5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RPS19-CEACAM5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RPS19-CEACAM5 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
RPS19-CEACAM5 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRPS19

GO:0002548

monocyte chemotaxis

11226885

HgeneRPS19

GO:0031640

killing of cells of other organism

15019208

HgeneRPS19

GO:0050829

defense response to Gram-negative bacterium

15019208

HgeneRPS19

GO:0060265

positive regulation of respiratory burst involved in inflammatory response

15750715

HgeneRPS19

GO:0060266

negative regulation of respiratory burst involved in inflammatory response

15750715

HgeneRPS19

GO:0061844

antimicrobial humoral immune response mediated by antimicrobial peptide

15019208

TgeneCEACAM5

GO:0010832

negative regulation of myotube differentiation

8408226|10931872

TgeneCEACAM5

GO:0034109

homotypic cell-cell adhesion

10864933

TgeneCEACAM5

GO:0043066

negative regulation of apoptotic process

11448920

TgeneCEACAM5

GO:2000811

negative regulation of anoikis

10910050


check buttonFusion gene breakpoints across RPS19 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CEACAM5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-58-8387-01ARPS19chr19

42365280

+CEACAM5chr19

42224841

+
ChimerDB4LUSCTCGA-58-8387-01ARPS19chr19

42365281

-CEACAM5chr19

42231154

+
ChimerDB4LUSCTCGA-58-8387RPS19chr19

42365281

+CEACAM5chr19

42224841

+
ChimerDB4LUSCTCGA-58-8387RPS19chr19

42365281

+CEACAM5chr19

42224842

+
ChimerDB4LUSCTCGA-58-8387RPS19chr19

42365281

+CEACAM5chr19

42231153

+
ChimerDB4LUSCTCGA-58-8387RPS19chr19

42365281

+CEACAM5chr19

42231154

+
ChimerDB4READTCGA-EI-6506RPS19chr19

42365281

+CEACAM5chr19

42213598

+
ChimerDB4READTCGA-EI-6506RPS19chr19

42365281

+CEACAM5chr19

42213599

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000598742RPS19chr1942365281+ENST00000398599CEACAM5chr1942224841+1080544372881169
ENST00000598742RPS19chr1942365281+ENST00000221992CEACAM5chr1942224841+1533544372881169
ENST00000598742RPS19chr1942365281+ENST00000405816CEACAM5chr1942224841+1044544372881169
ENST00000593863RPS19chr1942365281+ENST00000398599CEACAM5chr1942224841+75722149558169
ENST00000593863RPS19chr1942365281+ENST00000221992CEACAM5chr1942224841+121022149558169
ENST00000593863RPS19chr1942365281+ENST00000405816CEACAM5chr1942224841+72122149558169
ENST00000598742RPS19chr1942365281+ENST00000398599CEACAM5chr1942213598+27845443722585737
ENST00000598742RPS19chr1942365281+ENST00000221992CEACAM5chr1942213598+32405443722588738
ENST00000598742RPS19chr1942365281+ENST00000405816CEACAM5chr1942213598+27515443722588738
ENST00000593863RPS19chr1942365281+ENST00000398599CEACAM5chr1942213598+2461221492262737
ENST00000593863RPS19chr1942365281+ENST00000221992CEACAM5chr1942213598+2917221492265738
ENST00000593863RPS19chr1942365281+ENST00000405816CEACAM5chr1942213598+2428221492265738
ENST00000598742RPS19chr1942365281+ENST00000398599CEACAM5chr1942224842+1080544372881169
ENST00000598742RPS19chr1942365281+ENST00000221992CEACAM5chr1942224842+1533544372881169
ENST00000598742RPS19chr1942365281+ENST00000405816CEACAM5chr1942224842+1044544372881169
ENST00000593863RPS19chr1942365281+ENST00000398599CEACAM5chr1942224842+75722149558169
ENST00000593863RPS19chr1942365281+ENST00000221992CEACAM5chr1942224842+121022149558169
ENST00000593863RPS19chr1942365281+ENST00000405816CEACAM5chr1942224842+72122149558169
ENST00000598742RPS19chr1942365281+ENST00000398599CEACAM5chr1942213599+27845443722585737
ENST00000598742RPS19chr1942365281+ENST00000221992CEACAM5chr1942213599+32405443722588738
ENST00000598742RPS19chr1942365281+ENST00000405816CEACAM5chr1942213599+27515443722588738
ENST00000593863RPS19chr1942365281+ENST00000398599CEACAM5chr1942213599+2461221492262737
ENST00000593863RPS19chr1942365281+ENST00000221992CEACAM5chr1942213599+2917221492265738
ENST00000593863RPS19chr1942365281+ENST00000405816CEACAM5chr1942213599+2428221492265738
ENST00000598742RPS19chr1942365280+ENST00000398599CEACAM5chr1942224841+1080544372881169
ENST00000598742RPS19chr1942365280+ENST00000221992CEACAM5chr1942224841+1533544372881169
ENST00000598742RPS19chr1942365280+ENST00000405816CEACAM5chr1942224841+1044544372881169
ENST00000593863RPS19chr1942365280+ENST00000398599CEACAM5chr1942224841+75722149558169
ENST00000593863RPS19chr1942365280+ENST00000221992CEACAM5chr1942224841+121022149558169
ENST00000593863RPS19chr1942365280+ENST00000405816CEACAM5chr1942224841+72122149558169

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000598742ENST00000398599RPS19chr1942365281+CEACAM5chr1942224841+0.0235218260.9764782
ENST00000598742ENST00000221992RPS19chr1942365281+CEACAM5chr1942224841+0.012104770.98789525
ENST00000598742ENST00000405816RPS19chr1942365281+CEACAM5chr1942224841+0.0215839020.9784161
ENST00000593863ENST00000398599RPS19chr1942365281+CEACAM5chr1942224841+0.0101754860.9898245
ENST00000593863ENST00000221992RPS19chr1942365281+CEACAM5chr1942224841+0.0077502180.99224985
ENST00000593863ENST00000405816RPS19chr1942365281+CEACAM5chr1942224841+0.0094732320.9905268
ENST00000598742ENST00000398599RPS19chr1942365281+CEACAM5chr1942213598+0.0022052030.99779487
ENST00000598742ENST00000221992RPS19chr1942365281+CEACAM5chr1942213598+0.00147650.99852353
ENST00000598742ENST00000405816RPS19chr1942365281+CEACAM5chr1942213598+0.002274850.9977252
ENST00000593863ENST00000398599RPS19chr1942365281+CEACAM5chr1942213598+0.0021717980.9978282
ENST00000593863ENST00000221992RPS19chr1942365281+CEACAM5chr1942213598+0.0014296670.9985703
ENST00000593863ENST00000405816RPS19chr1942365281+CEACAM5chr1942213598+0.002260520.99773943
ENST00000598742ENST00000398599RPS19chr1942365281+CEACAM5chr1942224842+0.0235218260.9764782
ENST00000598742ENST00000221992RPS19chr1942365281+CEACAM5chr1942224842+0.012104770.98789525
ENST00000598742ENST00000405816RPS19chr1942365281+CEACAM5chr1942224842+0.0215839020.9784161
ENST00000593863ENST00000398599RPS19chr1942365281+CEACAM5chr1942224842+0.0101754860.9898245
ENST00000593863ENST00000221992RPS19chr1942365281+CEACAM5chr1942224842+0.0077502180.99224985
ENST00000593863ENST00000405816RPS19chr1942365281+CEACAM5chr1942224842+0.0094732320.9905268
ENST00000598742ENST00000398599RPS19chr1942365281+CEACAM5chr1942213599+0.0022052030.99779487
ENST00000598742ENST00000221992RPS19chr1942365281+CEACAM5chr1942213599+0.00147650.99852353
ENST00000598742ENST00000405816RPS19chr1942365281+CEACAM5chr1942213599+0.002274850.9977252
ENST00000593863ENST00000398599RPS19chr1942365281+CEACAM5chr1942213599+0.0021717980.9978282
ENST00000593863ENST00000221992RPS19chr1942365281+CEACAM5chr1942213599+0.0014296670.9985703
ENST00000593863ENST00000405816RPS19chr1942365281+CEACAM5chr1942213599+0.002260520.99773943
ENST00000598742ENST00000398599RPS19chr1942365280+CEACAM5chr1942224841+0.0235218260.9764782
ENST00000598742ENST00000221992RPS19chr1942365280+CEACAM5chr1942224841+0.012104770.98789525
ENST00000598742ENST00000405816RPS19chr1942365280+CEACAM5chr1942224841+0.0215839020.9784161
ENST00000593863ENST00000398599RPS19chr1942365280+CEACAM5chr1942224841+0.0101754860.9898245
ENST00000593863ENST00000221992RPS19chr1942365280+CEACAM5chr1942224841+0.0077502180.99224985
ENST00000593863ENST00000405816RPS19chr1942365280+CEACAM5chr1942224841+0.0094732320.9905268

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>77528_77528_1_RPS19-CEACAM5_RPS19_chr19_42365280_ENST00000593863_CEACAM5_chr19_42224841_ENST00000221992_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_2_RPS19-CEACAM5_RPS19_chr19_42365280_ENST00000593863_CEACAM5_chr19_42224841_ENST00000398599_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_3_RPS19-CEACAM5_RPS19_chr19_42365280_ENST00000593863_CEACAM5_chr19_42224841_ENST00000405816_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_4_RPS19-CEACAM5_RPS19_chr19_42365280_ENST00000598742_CEACAM5_chr19_42224841_ENST00000221992_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_5_RPS19-CEACAM5_RPS19_chr19_42365280_ENST00000598742_CEACAM5_chr19_42224841_ENST00000398599_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_6_RPS19-CEACAM5_RPS19_chr19_42365280_ENST00000598742_CEACAM5_chr19_42224841_ENST00000405816_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_7_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42213598_ENST00000221992_length(amino acids)=738AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK
PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYG
PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS
ISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD
TPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLS

--------------------------------------------------------------

>77528_77528_8_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42213598_ENST00000398599_length(amino acids)=737AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYEPPKP
FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGP
DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSI
SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDT
PIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSA

--------------------------------------------------------------

>77528_77528_9_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42213598_ENST00000405816_length(amino acids)=738AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK
PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYG
PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS
ISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD
TPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLS

--------------------------------------------------------------

>77528_77528_10_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42213599_ENST00000221992_length(amino acids)=738AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK
PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYG
PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS
ISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD
TPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLS

--------------------------------------------------------------

>77528_77528_11_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42213599_ENST00000398599_length(amino acids)=737AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYEPPKP
FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGP
DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSI
SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDT
PIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSA

--------------------------------------------------------------

>77528_77528_12_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42213599_ENST00000405816_length(amino acids)=738AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK
PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYG
PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS
ISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD
TPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLS

--------------------------------------------------------------

>77528_77528_13_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42224841_ENST00000221992_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_14_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42224841_ENST00000398599_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_15_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42224841_ENST00000405816_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_16_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42224842_ENST00000221992_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_17_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42224842_ENST00000398599_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_18_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000593863_CEACAM5_chr19_42224842_ENST00000405816_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_19_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42213598_ENST00000221992_length(amino acids)=738AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK
PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYG
PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS
ISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD
TPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLS

--------------------------------------------------------------

>77528_77528_20_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42213598_ENST00000398599_length(amino acids)=737AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYEPPKP
FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGP
DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSI
SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDT
PIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSA

--------------------------------------------------------------

>77528_77528_21_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42213598_ENST00000405816_length(amino acids)=738AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK
PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYG
PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS
ISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD
TPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLS

--------------------------------------------------------------

>77528_77528_22_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42213599_ENST00000221992_length(amino acids)=738AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK
PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYG
PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS
ISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD
TPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLS

--------------------------------------------------------------

>77528_77528_23_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42213599_ENST00000398599_length(amino acids)=737AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYEPPKP
FITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYGP
DDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPSI
SSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPDT
PIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLSA

--------------------------------------------------------------

>77528_77528_24_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42213599_ENST00000405816_length(amino acids)=738AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRAASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLL
VHNLPQHLFGYSWYKGERVDGNRQIIGYVIGTQQATPGPAYSGREIIYPNASLLIQNIIQNDTGFYTLHVIKSDLVNEEATGQFRVYPEL
PKPSISSNNSKPVEDKDAVAFTCEPETQDATYLWWVNNQSLPVSPRLQLSNGNRTLTLFNVTRNDTASYKCETQNPVSARRSDSVILNVL
YGPDAPTISPLNTSYRSGENLNLSCHAASNPPAQYSWFVNGTFQQSTQELFIPNITVNNSGSYTCQAHNSDTGLNRTTVTTITVYAEPPK
PFITSNNSNPVEDEDAVALTCEPEIQNTTYLWWVNNQSLPVSPRLQLSNDNRTLTLLSVTRNDVGPYECGIQNKLSVDHSDPVILNVLYG
PDDPTISPSYTYYRPGVNLSLSCHAASNPPAQYSWLIDGNIQQHTQELFISNITEKNSGLYTCQANNSASGHSRTTVKTITVSAELPKPS
ISSNNSKPVEDKDAVAFTCEPEAQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRSDPVTLDVLYGPD
TPIISPPDSSYLSGANLNLSCHSASNPSPQYSWRINGIPQQHTQVLFIAKITPNNNGTYACFVSNLATGRNNSIVKSITVSASGTSPGLS

--------------------------------------------------------------

>77528_77528_25_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42224841_ENST00000221992_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_26_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42224841_ENST00000398599_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_27_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42224841_ENST00000405816_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_28_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42224842_ENST00000221992_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_29_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42224842_ENST00000398599_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

>77528_77528_30_RPS19-CEACAM5_RPS19_chr19_42365281_ENST00000598742_CEACAM5_chr19_42224842_ENST00000405816_length(amino acids)=169AA_BP=57
MPGVTVKDVNQQEFVRALAAFLKKSGKLKVPEWVDTVKLAKHKELAPYDENWFYTRADGPDTPIISPPDSSYLSGANLNLSCHSASNPSP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:42365281/chr19:42231154)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CEACAM5

P06731

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:2803308}.; FUNCTION: (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. {ECO:0000269|PubMed:18086185}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000221992610593_675590.3333333333334848.6666666666666DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000398599610593_675589.3333333333334685.6666666666666DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000405816610593_675590.3333333333334696.0DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000221992010145_23221.333333333333332848.6666666666666DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000221992010240_31521.333333333333332848.6666666666666DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000221992010323_41021.333333333333332848.6666666666666DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42213598ENST0000022199201035_14421.333333333333332848.6666666666666DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000221992010418_49521.333333333333332848.6666666666666DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000221992010501_58821.333333333333332848.6666666666666DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000221992010593_67521.333333333333332848.6666666666666DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000398599010145_23221.333333333333332685.6666666666666DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000398599010240_31521.333333333333332685.6666666666666DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000398599010323_41021.333333333333332685.6666666666666DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42213598ENST0000039859901035_14421.333333333333332685.6666666666666DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000398599010418_49521.333333333333332685.6666666666666DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000398599010501_58821.333333333333332685.6666666666666DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000398599010593_67521.333333333333332685.6666666666666DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000405816010145_23221.333333333333332696.0DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000405816010240_31521.333333333333332696.0DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000405816010323_41021.333333333333332696.0DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42213598ENST0000040581601035_14421.333333333333332696.0DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000405816010418_49521.333333333333332696.0DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000405816010501_58821.333333333333332696.0DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42213598ENST00000405816010593_67521.333333333333332696.0DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000221992010145_23221.333333333333332848.6666666666666DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000221992010240_31521.333333333333332848.6666666666666DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000221992010323_41021.333333333333332848.6666666666666DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42213599ENST0000022199201035_14421.333333333333332848.6666666666666DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000221992010418_49521.333333333333332848.6666666666666DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000221992010501_58821.333333333333332848.6666666666666DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000221992010593_67521.333333333333332848.6666666666666DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000398599010145_23221.333333333333332685.6666666666666DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000398599010240_31521.333333333333332685.6666666666666DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000398599010323_41021.333333333333332685.6666666666666DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42213599ENST0000039859901035_14421.333333333333332685.6666666666666DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000398599010418_49521.333333333333332685.6666666666666DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000398599010501_58821.333333333333332685.6666666666666DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000398599010593_67521.333333333333332685.6666666666666DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000405816010145_23221.333333333333332696.0DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000405816010240_31521.333333333333332696.0DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000405816010323_41021.333333333333332696.0DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42213599ENST0000040581601035_14421.333333333333332696.0DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000405816010418_49521.333333333333332696.0DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000405816010501_58821.333333333333332696.0DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42213599ENST00000405816010593_67521.333333333333332696.0DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000221992610593_675590.3333333333334848.6666666666666DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000398599610593_675589.3333333333334685.6666666666666DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000405816610593_675590.3333333333334696.0DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000221992610593_675590.3333333333334848.6666666666666DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000398599610593_675589.3333333333334685.6666666666666DomainIg-like C2-type 6
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000405816610593_675590.3333333333334696.0DomainIg-like C2-type 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000221992610145_232590.3333333333334848.6666666666666DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000221992610240_315590.3333333333334848.6666666666666DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000221992610323_410590.3333333333334848.6666666666666DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365280chr19:42224841ENST0000022199261035_144590.3333333333334848.6666666666666DomainIg-like V-type
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000221992610418_495590.3333333333334848.6666666666666DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000221992610501_588590.3333333333334848.6666666666666DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000398599610145_232589.3333333333334685.6666666666666DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000398599610240_315589.3333333333334685.6666666666666DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000398599610323_410589.3333333333334685.6666666666666DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365280chr19:42224841ENST0000039859961035_144589.3333333333334685.6666666666666DomainIg-like V-type
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000398599610418_495589.3333333333334685.6666666666666DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000398599610501_588589.3333333333334685.6666666666666DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000405816610145_232590.3333333333334696.0DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000405816610240_315590.3333333333334696.0DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000405816610323_410590.3333333333334696.0DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365280chr19:42224841ENST0000040581661035_144590.3333333333334696.0DomainIg-like V-type
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000405816610418_495590.3333333333334696.0DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365280chr19:42224841ENST00000405816610501_588590.3333333333334696.0DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000221992610145_232590.3333333333334848.6666666666666DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000221992610240_315590.3333333333334848.6666666666666DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000221992610323_410590.3333333333334848.6666666666666DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42224841ENST0000022199261035_144590.3333333333334848.6666666666666DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000221992610418_495590.3333333333334848.6666666666666DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000221992610501_588590.3333333333334848.6666666666666DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000398599610145_232589.3333333333334685.6666666666666DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000398599610240_315589.3333333333334685.6666666666666DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000398599610323_410589.3333333333334685.6666666666666DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42224841ENST0000039859961035_144589.3333333333334685.6666666666666DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000398599610418_495589.3333333333334685.6666666666666DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000398599610501_588589.3333333333334685.6666666666666DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000405816610145_232590.3333333333334696.0DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000405816610240_315590.3333333333334696.0DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000405816610323_410590.3333333333334696.0DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42224841ENST0000040581661035_144590.3333333333334696.0DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000405816610418_495590.3333333333334696.0DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42224841ENST00000405816610501_588590.3333333333334696.0DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000221992610145_232590.3333333333334848.6666666666666DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000221992610240_315590.3333333333334848.6666666666666DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000221992610323_410590.3333333333334848.6666666666666DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42224842ENST0000022199261035_144590.3333333333334848.6666666666666DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000221992610418_495590.3333333333334848.6666666666666DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000221992610501_588590.3333333333334848.6666666666666DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000398599610145_232589.3333333333334685.6666666666666DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000398599610240_315589.3333333333334685.6666666666666DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000398599610323_410589.3333333333334685.6666666666666DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42224842ENST0000039859961035_144589.3333333333334685.6666666666666DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000398599610418_495589.3333333333334685.6666666666666DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000398599610501_588589.3333333333334685.6666666666666DomainIg-like C2-type 5
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000405816610145_232590.3333333333334696.0DomainIg-like C2-type 1
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000405816610240_315590.3333333333334696.0DomainIg-like C2-type 2
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000405816610323_410590.3333333333334696.0DomainIg-like C2-type 3
TgeneCEACAM5chr19:42365281chr19:42224842ENST0000040581661035_144590.3333333333334696.0DomainIg-like V-type
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000405816610418_495590.3333333333334696.0DomainIg-like C2-type 4
TgeneCEACAM5chr19:42365281chr19:42224842ENST00000405816610501_588590.3333333333334696.0DomainIg-like C2-type 5


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RPS19
CEACAM5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RPS19-CEACAM5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RPS19-CEACAM5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource