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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ATP1A1-ATP1A3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ATP1A1-ATP1A3
	FusionPDB ID: 7778
	FusionGDB2.0 ID: 7778
		Hgene	Tgene
	Gene symbol	ATP1A1	ATP1A3
	Gene ID	480	478
	Gene name	ATPase Na+/K+ transporting subunit alpha 4	ATPase Na+/K+ transporting subunit alpha 3
	Synonyms	ATP1A1\|ATP1AL2	AHC2\|ATP1A1\|CAPOS\|DYT12\|RDP
	Cytomap	1q23.2	19q13.2
	Type of gene	protein-coding	protein-coding
	Description	sodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase su	sodium/potassium-transporting ATPase subunit alpha-3ATPase, Na+/K+ transporting, alpha 3 polypeptideNa(+)/K(+) ATPase alpha(III) subunitNa(+)/K(+) ATPase alpha-3 subunitNa+, K+ activated adenosine triphosphatase alpha subunitNa+/K+ ATPase 3sodium pu
	Modification date	20200313	20200313
	UniProtAcc	Q5TC04	P13637
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000295598, ENST00000369496, ENST00000537345, ENST00000491156,	ENST00000468774, ENST00000302102, ENST00000543770, ENST00000545399, ENST00000602133,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	16 X 18 X 7=2016	4 X 4 X 3=48
	# samples	23	4
	** MAII score	log2(23/2016*10)=-3.13178987255554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ATP1A1 [Title/Abstract] AND ATP1A3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ATP1A1(116939356)-ATP1A3(42480718), # samples:2
Anticipated loss of major functional domain due to fusion event.	ATP1A1-ATP1A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP1A1-ATP1A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP1A1-ATP1A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ATP1A1-ATP1A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATP1A1	GO:0030317	flagellated sperm motility	12112599
Hgene	ATP1A1	GO:0030641	regulation of cellular pH	12112599
Tgene	ATP1A3	GO:0006883	cellular sodium ion homeostasis	10636900
Tgene	ATP1A3	GO:0030007	cellular potassium ion homeostasis	10636900
Tgene	ATP1A3	GO:0036376	sodium ion export across plasma membrane	10636900
Tgene	ATP1A3	GO:1990573	potassium ion import across plasma membrane	10636900

Fusion gene breakpoints across ATP1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATP1A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	13N	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-
ChimerDB4	Non-Cancer	5381N	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000295598	ATP1A1	chr1	116939356	+	ENST00000302102	ATP1A3	chr19	42480718	-	3679	2225	237	3323	1028
ENST00000295598	ATP1A1	chr1	116939356	+	ENST00000545399	ATP1A3	chr19	42480718	-	3677	2225	237	3323	1028
ENST00000295598	ATP1A1	chr1	116939356	+	ENST00000543770	ATP1A3	chr19	42480718	-	3640	2225	237	3323	1028
ENST00000295598	ATP1A1	chr1	116939356	+	ENST00000602133	ATP1A3	chr19	42480718	-	3479	2225	237	3323	1028
ENST00000537345	ATP1A1	chr1	116939356	+	ENST00000302102	ATP1A3	chr19	42480718	-	3790	2336	318	3434	1038
ENST00000537345	ATP1A1	chr1	116939356	+	ENST00000545399	ATP1A3	chr19	42480718	-	3788	2336	318	3434	1038
ENST00000537345	ATP1A1	chr1	116939356	+	ENST00000543770	ATP1A3	chr19	42480718	-	3751	2336	318	3434	1038
ENST00000537345	ATP1A1	chr1	116939356	+	ENST00000602133	ATP1A3	chr19	42480718	-	3590	2336	318	3434	1038
ENST00000369496	ATP1A1	chr1	116939356	+	ENST00000302102	ATP1A3	chr19	42480718	-	3599	2145	163	3243	1026
ENST00000369496	ATP1A1	chr1	116939356	+	ENST00000545399	ATP1A3	chr19	42480718	-	3597	2145	163	3243	1026
ENST00000369496	ATP1A1	chr1	116939356	+	ENST00000543770	ATP1A3	chr19	42480718	-	3560	2145	163	3243	1026
ENST00000369496	ATP1A1	chr1	116939356	+	ENST00000602133	ATP1A3	chr19	42480718	-	3399	2145	163	3243	1026

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000295598	ENST00000302102	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002813831	0.9971861
ENST00000295598	ENST00000545399	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002800208	0.9971998
ENST00000295598	ENST00000543770	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002904276	0.9970957
ENST00000295598	ENST00000602133	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002927522	0.99707246
ENST00000537345	ENST00000302102	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002416669	0.99758327
ENST00000537345	ENST00000545399	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002409881	0.9975902
ENST00000537345	ENST00000543770	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002519399	0.9974806
ENST00000537345	ENST00000602133	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002528335	0.9974717
ENST00000369496	ENST00000302102	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002044038	0.9979559
ENST00000369496	ENST00000545399	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002036697	0.9979633
ENST00000369496	ENST00000543770	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002127731	0.99787223
ENST00000369496	ENST00000602133	ATP1A1	chr1	116939356	+	ATP1A3	chr19	42480718	-	0.002046306	0.99795365

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7778_7778_1_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000295598_ATP1A3_chr19_42480718_ENST00000302102_length(amino acids)=1028AA_BP=29
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNG
EKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRT
VMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKN
CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKR
AVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELK
DAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAK
AIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVT
GDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTI
TILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTV
NDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKP

--------------------------------------------------------------

>7778_7778_2_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000295598_ATP1A3_chr19_42480718_ENST00000543770_length(amino acids)=1028AA_BP=29
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNG
EKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRT
VMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKN
CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKR
AVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELK
DAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAK
AIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVT
GDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTI
TILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTV
NDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKP

--------------------------------------------------------------

>7778_7778_3_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000295598_ATP1A3_chr19_42480718_ENST00000545399_length(amino acids)=1028AA_BP=29
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNG
EKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRT
VMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKN
CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKR
AVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELK
DAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAK
AIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVT
GDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTI
TILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTV
NDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKP

--------------------------------------------------------------

>7778_7778_4_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000295598_ATP1A3_chr19_42480718_ENST00000602133_length(amino acids)=1028AA_BP=29
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNG
EKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRT
VMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKN
CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKR
AVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELK
DAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAK
AIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVT
GDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTI
TILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTV
NDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKP

--------------------------------------------------------------

>7778_7778_5_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000369496_ATP1A3_chr19_42480718_ENST00000302102_length(amino acids)=1026AA_BP=27
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK
MSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVM
GRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAV
AGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDA
FQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAI
AKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGD
GVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITI
LCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVND
LEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSW

--------------------------------------------------------------

>7778_7778_6_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000369496_ATP1A3_chr19_42480718_ENST00000543770_length(amino acids)=1026AA_BP=27
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK
MSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVM
GRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAV
AGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDA
FQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAI
AKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGD
GVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITI
LCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVND
LEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSW

--------------------------------------------------------------

>7778_7778_7_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000369496_ATP1A3_chr19_42480718_ENST00000545399_length(amino acids)=1026AA_BP=27
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK
MSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVM
GRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAV
AGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDA
FQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAI
AKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGD
GVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITI
LCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVND
LEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSW

--------------------------------------------------------------

>7778_7778_8_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000369496_ATP1A3_chr19_42480718_ENST00000602133_length(amino acids)=1026AA_BP=27
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK
MSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVM
GRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKRAV
AGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDA
FQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAI
AKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGD
GVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITI
LCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVND
LEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSW

--------------------------------------------------------------

>7778_7778_9_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000537345_ATP1A3_chr19_42480718_ENST00000302102_length(amino acids)=1038AA_BP=39
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV
PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR
GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLT
LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQA
NQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHG
KEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIM
VTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGC
QRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIM
ANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVG
IRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMD

--------------------------------------------------------------

>7778_7778_10_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000537345_ATP1A3_chr19_42480718_ENST00000543770_length(amino acids)=1038AA_BP=39
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV
PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR
GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLT
LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQA
NQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHG
KEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIM
VTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGC
QRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIM
ANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVG
IRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMD

--------------------------------------------------------------

>7778_7778_11_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000537345_ATP1A3_chr19_42480718_ENST00000545399_length(amino acids)=1038AA_BP=39
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV
PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR
GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLT
LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQA
NQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHG
KEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIM
VTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGC
QRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIM
ANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVG
IRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMD

--------------------------------------------------------------

>7778_7778_12_ATP1A1-ATP1A3_ATP1A1_chr1_116939356_ENST00000537345_ATP1A3_chr19_42480718_ENST00000602133_length(amino acids)=1038AA_BP=39
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV
PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR
GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLT
LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQA
NQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHG
KEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIM
VTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGC
QRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIM
ANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVG
IRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMD

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:116939356/chr19:42480718)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATP1A1 Q5TC04	ATP1A3 P13637
	FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

82_84

657.6666666666666

1024.0

Region

Phosphoinositide-3 kinase binding

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

82_84

626.6666666666666

993.0

Region

Phosphoinositide-3 kinase binding

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

82_84

657.6666666666666

1024.0

Region

Phosphoinositide-3 kinase binding

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

109_131

657.6666666666666

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

153_288

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

309_320

657.6666666666666

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

6_87

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

109_131

626.6666666666666

993.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

153_288

626.6666666666666

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

309_320

626.6666666666666

993.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

6_87

626.6666666666666

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

109_131

657.6666666666666

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

153_288

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

309_320

657.6666666666666

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

6_87

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

132_152

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

289_308

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

321_338

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

88_108

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

132_152

626.6666666666666

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

289_308

626.6666666666666

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

321_338

626.6666666666666

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

88_108

626.6666666666666

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

132_152

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

289_308

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

321_338

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

88_108

657.6666666666666

1024.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

783_792

647.6666666666666

1014.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

814_833

647.6666666666666

1014.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

857_908

647.6666666666666

1014.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

929_941

647.6666666666666

1014.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

961_975

647.6666666666666

1014.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

997_1013

647.6666666666666

1014.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

783_792

658.6666666666666

1025.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

814_833

658.6666666666666

1025.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

857_908

658.6666666666666

1025.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

929_941

658.6666666666666

1025.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

961_975

658.6666666666666

1025.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

997_1013

658.6666666666666

1025.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

783_792

660.6666666666666

1027.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

814_833

660.6666666666666

1027.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

857_908

660.6666666666666

1027.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

929_941

660.6666666666666

1027.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

961_975

660.6666666666666

1027.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

997_1013

660.6666666666666

1027.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

763_782

647.6666666666666

1014.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

793_813

647.6666666666666

1014.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

834_856

647.6666666666666

1014.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

909_928

647.6666666666666

1014.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

942_960

647.6666666666666

1014.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

976_996

647.6666666666666

1014.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

763_782

658.6666666666666

1025.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

793_813

658.6666666666666

1025.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

834_856

658.6666666666666

1025.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

909_928

658.6666666666666

1025.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

942_960

658.6666666666666

1025.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

976_996

658.6666666666666

1025.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

763_782

660.6666666666666

1027.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

793_813

660.6666666666666

1027.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

834_856

660.6666666666666

1027.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

909_928

660.6666666666666

1027.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

942_960

660.6666666666666

1027.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

976_996

660.6666666666666

1027.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

1007_1023

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

339_772

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

793_802

657.6666666666666

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

824_843

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

867_918

657.6666666666666

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

939_951

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

971_985

657.6666666666666

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

1007_1023

626.6666666666666

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

339_772

626.6666666666666

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

793_802

626.6666666666666

993.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

824_843

626.6666666666666

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

867_918

626.6666666666666

993.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

939_951

626.6666666666666

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

971_985

626.6666666666666

993.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

1007_1023

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

339_772

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

793_802

657.6666666666666

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

824_843

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

867_918

657.6666666666666

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

939_951

657.6666666666666

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

971_985

657.6666666666666

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

773_792

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

803_823

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

844_866

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

919_938

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

952_970

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000295598

986_1006

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

773_792

626.6666666666666

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

803_823

626.6666666666666

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

844_866

626.6666666666666

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

919_938

626.6666666666666

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

952_970

626.6666666666666

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000369496

986_1006

626.6666666666666

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

773_792

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

803_823

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

844_866

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

919_938

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

952_970

657.6666666666666

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116939356

chr19:42480718

ENST00000537345

986_1006

657.6666666666666

1024.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

143_278

647.6666666666666

1014.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

1_77

647.6666666666666

1014.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

299_310

647.6666666666666

1014.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

329_762

647.6666666666666

1014.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

99_121

647.6666666666666

1014.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

143_278

658.6666666666666

1025.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

1_77

658.6666666666666

1025.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

299_310

658.6666666666666

1025.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

329_762

658.6666666666666

1025.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

99_121

658.6666666666666

1025.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

143_278

660.6666666666666

1027.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

1_77

660.6666666666666

1027.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

299_310

660.6666666666666

1027.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

329_762

660.6666666666666

1027.0

Topological domain

Cytoplasmic

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

99_121

660.6666666666666

1027.0

Topological domain

Extracellular

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

122_142

647.6666666666666

1014.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

279_298

647.6666666666666

1014.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

311_328

647.6666666666666

1014.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000302102

78_98

647.6666666666666

1014.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

122_142

658.6666666666666

1025.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

279_298

658.6666666666666

1025.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

311_328

658.6666666666666

1025.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000543770

78_98

658.6666666666666

1025.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

122_142

660.6666666666666

1027.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

279_298

660.6666666666666

1027.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

311_328

660.6666666666666

1027.0

Transmembrane

Helical

Tgene

ATP1A3

chr1:116939356

chr19:42480718

ENST00000545399

78_98

660.6666666666666

1027.0

Transmembrane

Helical

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1818_ATP1A1_116939356_ATP1A3_42480718_ranked_0.pdb	ATP1A1	116939356	116939356	ENST00000602133	ATP1A3	chr19	42480718	-	MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLT LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQA NQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEIPFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHG KEQPLDEELKDAFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIM VTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGC QRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIM ANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVG IRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMD	1038

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ATP1A1_pLDDT.png

ATP1A3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ATP1A1
ATP1A3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	ATP1A3	chr1:116939356	chr19:42480718	ENST00000302102		13	23	72_74	647.6666666666666	1014.0	phosphoinositide-3 kinase
Tgene	ATP1A3	chr1:116939356	chr19:42480718	ENST00000543770		13	23	72_74	658.6666666666666	1025.0	phosphoinositide-3 kinase
Tgene	ATP1A3	chr1:116939356	chr19:42480718	ENST00000545399		13	23	72_74	660.6666666666666	1027.0	phosphoinositide-3 kinase

Top

Related Drugs to ATP1A1-ATP1A3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ATP1A1-ATP1A3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source