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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ATP1A1-SLC12A1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ATP1A1-SLC12A1
	FusionPDB ID: 7790
	FusionGDB2.0 ID: 7790
		Hgene	Tgene
	Gene symbol	ATP1A1	SLC12A1
	Gene ID	480	6557
	Gene name	ATPase Na+/K+ transporting subunit alpha 4	solute carrier family 12 member 1
	Synonyms	ATP1A1\|ATP1AL2	BSC1\|NKCC2
	Cytomap	1q23.2	15q21.1
	Type of gene	protein-coding	protein-coding
	Description	sodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase su	solute carrier family 12 member 1NKCC2A variant ANa-K-2Cl cotransporterbumetanide-sensitive sodium-(potassium)-chloride cotransporter 2kidney-specific Na-K-Cl symportersolute carrier family 12 (sodium/potassium/chloride transporter), member 1solute
	Modification date	20200313	20200313
	UniProtAcc	Q5TC04	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000295598, ENST00000369496, ENST00000537345, ENST00000491156,	ENST00000559723, ENST00000330289, ENST00000380993, ENST00000396577, ENST00000558405, ENST00000561031,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	16 X 18 X 7=2016	6 X 7 X 5=210
	# samples	23	7
	** MAII score	log2(23/2016*10)=-3.13178987255554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/210*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ATP1A1 [Title/Abstract] AND SLC12A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ATP1A1(116933513)-SLC12A1(48513118), # samples:1
Anticipated loss of major functional domain due to fusion event.	ATP1A1-SLC12A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP1A1-SLC12A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATP1A1	GO:0030317	flagellated sperm motility	12112599
Hgene	ATP1A1	GO:0030641	regulation of cellular pH	12112599

Fusion gene breakpoints across ATP1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC12A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-CZ-5469-11A	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000295598	ATP1A1	chr1	116933513	+	ENST00000380993	SLC12A1	chr15	48513118	+	5523	1584	237	4331	1364
ENST00000295598	ATP1A1	chr1	116933513	+	ENST00000396577	SLC12A1	chr15	48513118	+	5525	1584	237	4331	1364
ENST00000295598	ATP1A1	chr1	116933513	+	ENST00000330289	SLC12A1	chr15	48513118	+	2610	1584	237	2324	695
ENST00000295598	ATP1A1	chr1	116933513	+	ENST00000558405	SLC12A1	chr15	48513118	+	4444	1584	237	4331	1364
ENST00000295598	ATP1A1	chr1	116933513	+	ENST00000561031	SLC12A1	chr15	48513118	+	1767	1584	237	1685	482
ENST00000537345	ATP1A1	chr1	116933513	+	ENST00000380993	SLC12A1	chr15	48513118	+	5634	1695	318	4442	1374
ENST00000537345	ATP1A1	chr1	116933513	+	ENST00000396577	SLC12A1	chr15	48513118	+	5636	1695	318	4442	1374
ENST00000537345	ATP1A1	chr1	116933513	+	ENST00000330289	SLC12A1	chr15	48513118	+	2721	1695	318	2435	705
ENST00000537345	ATP1A1	chr1	116933513	+	ENST00000558405	SLC12A1	chr15	48513118	+	4555	1695	318	4442	1374
ENST00000537345	ATP1A1	chr1	116933513	+	ENST00000561031	SLC12A1	chr15	48513118	+	1878	1695	318	1796	492
ENST00000369496	ATP1A1	chr1	116933513	+	ENST00000380993	SLC12A1	chr15	48513118	+	5443	1504	163	4251	1362
ENST00000369496	ATP1A1	chr1	116933513	+	ENST00000396577	SLC12A1	chr15	48513118	+	5445	1504	163	4251	1362
ENST00000369496	ATP1A1	chr1	116933513	+	ENST00000330289	SLC12A1	chr15	48513118	+	2530	1504	163	2244	693
ENST00000369496	ATP1A1	chr1	116933513	+	ENST00000558405	SLC12A1	chr15	48513118	+	4364	1504	163	4251	1362
ENST00000369496	ATP1A1	chr1	116933513	+	ENST00000561031	SLC12A1	chr15	48513118	+	1687	1504	163	1605	480

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000295598	ENST00000380993	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.00043349	0.9995665
ENST00000295598	ENST00000396577	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000426644	0.9995734
ENST00000295598	ENST00000330289	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.003072459	0.99692756
ENST00000295598	ENST00000558405	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000816806	0.99918324
ENST00000295598	ENST00000561031	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.002307956	0.9976921
ENST00000537345	ENST00000380993	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.00040397	0.99959606
ENST00000537345	ENST00000396577	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000396094	0.9996039
ENST00000537345	ENST00000330289	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.00179055	0.9982095
ENST00000537345	ENST00000558405	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000681139	0.99931884
ENST00000537345	ENST00000561031	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.001931676	0.9980684
ENST00000369496	ENST00000380993	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000346293	0.9996537
ENST00000369496	ENST00000396577	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000334278	0.99966574
ENST00000369496	ENST00000330289	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.002072649	0.9979273
ENST00000369496	ENST00000558405	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.000598687	0.99940133
ENST00000369496	ENST00000561031	ATP1A1	chr1	116933513	+	SLC12A1	chr15	48513118	+	0.001999205	0.9980008

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7790_7790_1_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000295598_SLC12A1_chr15_48513118_ENST00000330289_length(amino acids)=695AA_BP=449
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNG
EKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRT
VMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKN
CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKV
RCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMY
VVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASI

--------------------------------------------------------------

>7790_7790_2_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000295598_SLC12A1_chr15_48513118_ENST00000380993_length(amino acids)=1364AA_BP=449
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNG
EKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRT
VMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKN
CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKV
RCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMY
VVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASI
FAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNC
NGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPL
RGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIE
FFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCV
KEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRI
SQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKK
QEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMI
EPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVL

--------------------------------------------------------------

>7790_7790_3_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000295598_SLC12A1_chr15_48513118_ENST00000396577_length(amino acids)=1364AA_BP=449
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNG
EKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRT
VMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKN
CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKV
RCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMY
VVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASI
FAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNC
NGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPL
RGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIE
FFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCV
KEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRI
SQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKK
QEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMI
EPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVL

--------------------------------------------------------------

>7790_7790_4_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000295598_SLC12A1_chr15_48513118_ENST00000558405_length(amino acids)=1364AA_BP=449
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNG
EKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRT
VMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKN
CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKV
RCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMY
VVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASI
FAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNC
NGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPL
RGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIE
FFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCV
KEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRI
SQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKK
QEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMI
EPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVL

--------------------------------------------------------------

>7790_7790_5_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000295598_SLC12A1_chr15_48513118_ENST00000561031_length(amino acids)=482AA_BP=449
MSTATMGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPT
TPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNG
EKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRT
VMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKN
CLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKV

--------------------------------------------------------------

>7790_7790_6_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000369496_SLC12A1_chr15_48513118_ENST00000330289_length(amino acids)=693AA_BP=447
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK
MSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVM
GRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKVRC
MLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVV
GFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFA

--------------------------------------------------------------

>7790_7790_7_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000369496_SLC12A1_chr15_48513118_ENST00000380993_length(amino acids)=1362AA_BP=447
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK
MSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVM
GRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKVRC
MLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVV
GFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFA
ENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNG
SAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRG
YILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFF
LYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKE
MNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQ
GFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQE
KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEP
YRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLV

--------------------------------------------------------------

>7790_7790_8_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000369496_SLC12A1_chr15_48513118_ENST00000396577_length(amino acids)=1362AA_BP=447
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK
MSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVM
GRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKVRC
MLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVV
GFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFA
ENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNG
SAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRG
YILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFF
LYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKE
MNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQ
GFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQE
KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEP
YRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLV

--------------------------------------------------------------

>7790_7790_9_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000369496_SLC12A1_chr15_48513118_ENST00000558405_length(amino acids)=1362AA_BP=447
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK
MSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVM
GRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKVRC
MLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVV
GFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRGFFNYQASIFA
ENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNG
SAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFAKGYGKNNEPLRG
YILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINWWAAVITYVIEFF
LYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKE
MNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFDFEIGVVIVRISQ
GFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKLVEASTQFKKKQE
KGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNKESWKVFEEMIEP
YRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLV

--------------------------------------------------------------

>7790_7790_10_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000369496_SLC12A1_chr15_48513118_ENST00000561031_length(amino acids)=480AA_BP=447
MPKDTLLVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARDGPNALTPPPTTP
EWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEK
MSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVM
GRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCL
VKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQANQENLPILKVRC

--------------------------------------------------------------

>7790_7790_11_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000537345_SLC12A1_chr15_48513118_ENST00000330289_length(amino acids)=705AA_BP=459
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV
PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR
GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLT
LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQA
NQENLPILKVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFA
FANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKS

--------------------------------------------------------------

>7790_7790_12_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000537345_SLC12A1_chr15_48513118_ENST00000380993_length(amino acids)=1374AA_BP=459
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV
PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR
GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLT
LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQA
NQENLPILKVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFA
FANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKS
RGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNM
NDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA
KGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINW
WAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCE
VFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFD
FEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKL
VEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNK
ESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLE

--------------------------------------------------------------

>7790_7790_13_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000537345_SLC12A1_chr15_48513118_ENST00000396577_length(amino acids)=1374AA_BP=459
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV
PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR
GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLT
LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQA
NQENLPILKVRCMLNIWGVMLFIRLSWIVGEAGIGLGVIIIGLSVVVTTLTGISMSAICTNGVVRGGGAYYLISRSLGPEFGGSIGLIFA
FANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKS
RGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNM
NDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA
KGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINW
WAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCE
VFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFD
FEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKL
VEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNK
ESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLE

--------------------------------------------------------------

>7790_7790_14_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000537345_SLC12A1_chr15_48513118_ENST00000558405_length(amino acids)=1374AA_BP=459
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV
PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR
GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLT
LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQA
NQENLPILKVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFA
FANAVAVAMYVVGFAETVVDLLKESDSMMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKS
RGFFNYQASIFAENFGPRFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNM
NDTIISGMNCNGSAACGLGYDFSRCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIYKALQFFA
KGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAVLCCAVMFVINW
WAAVITYVIEFFLYVYVTCKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCE
VFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLTEIENYVGIIHDAFD
FEIGVVIVRISQGFDISQVLQVQEELERLEQERLALEATIKDNECEEESGGIRGLFKKAGKLNITKTTPKKDGSINTSQSMHVGEFNQKL
VEASTQFKKKQEKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGGKINRIEEEKIVMASLLSKFRIKFADIHIIGDINIRPNK
ESWKVFEEMIEPYRLHESCKDLTTAEKLKRETPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLE

--------------------------------------------------------------

>7790_7790_15_ATP1A1-SLC12A1_ATP1A1_chr1_116933513_ENST00000537345_SLC12A1_chr15_48513118_ENST00000561031_length(amino acids)=492AA_BP=459
MGGLVPERVCLHCPKMAFKVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTSARAAEILARD
GPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAATEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMV
PQQALVIRNGEKMSINAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTAR
GIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLT
LTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:116933513/chr15:48513118)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATP1A1 Q5TC04	.
	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

82_84

444.0

1024.0

Region

Phosphoinositide-3 kinase binding

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

82_84

413.0

993.0

Region

Phosphoinositide-3 kinase binding

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

82_84

444.0

1024.0

Region

Phosphoinositide-3 kinase binding

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

109_131

444.0

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

153_288

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

309_320

444.0

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

6_87

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

109_131

413.0

993.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

153_288

413.0

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

309_320

413.0

993.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

6_87

413.0

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

109_131

444.0

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

153_288

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

309_320

444.0

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

6_87

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

132_152

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

289_308

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

321_338

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

88_108

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

132_152

413.0

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

289_308

413.0

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

321_338

413.0

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

88_108

413.0

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

132_152

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

289_308

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

321_338

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

88_108

444.0

1024.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

223_259

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

324_327

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

401_417

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

506_550

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

593_609

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

814_1099

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

223_259

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

324_327

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

401_417

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

506_550

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

593_609

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

814_1099

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

202_222

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

260_280

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

303_323

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

328_348

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

380_400

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

418_438

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

485_505

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

551_571

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

572_592

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

610_630

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

793_813

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

202_222

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

260_280

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

303_323

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

328_348

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

380_400

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

418_438

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

485_505

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

551_571

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

572_592

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

610_630

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

793_813

184.0

1100.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

1007_1023

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

339_772

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

793_802

444.0

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

824_843

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

867_918

444.0

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

939_951

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

971_985

444.0

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

1007_1023

413.0

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

339_772

413.0

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

793_802

413.0

993.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

824_843

413.0

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

867_918

413.0

993.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

939_951

413.0

993.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

971_985

413.0

993.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

1007_1023

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

339_772

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

793_802

444.0

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

824_843

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

867_918

444.0

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

939_951

444.0

1024.0

Topological domain

Cytoplasmic

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

971_985

444.0

1024.0

Topological domain

Extracellular

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

773_792

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

803_823

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

844_866

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

919_938

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

952_970

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000295598

986_1006

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

773_792

413.0

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

803_823

413.0

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

844_866

413.0

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

919_938

413.0

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

952_970

413.0

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000369496

986_1006

413.0

993.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

773_792

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

803_823

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

844_866

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

919_938

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

952_970

444.0

1024.0

Transmembrane

Helical

Hgene

ATP1A1

chr1:116933513

chr15:48513118

ENST00000537345

986_1006

444.0

1024.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

1_177

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

1_177

184.0

1100.0

Topological domain

Cytoplasmic

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000380993

178_198

184.0

1100.0

Transmembrane

Helical

Tgene

SLC12A1

chr1:116933513

chr15:48513118

ENST00000558405

178_198

184.0

1100.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ATP1A1
SLC12A1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ATP1A1-SLC12A1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ATP1A1-SLC12A1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source