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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP1A1-VANGL1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP1A1-VANGL1
FusionPDB ID: 7793
FusionGDB2.0 ID: 7793
HgeneTgene
Gene symbol

ATP1A1

VANGL1

Gene ID

480

81839

Gene nameATPase Na+/K+ transporting subunit alpha 4VANGL planar cell polarity protein 1
SynonymsATP1A1|ATP1AL2KITENIN|LPP2|STB2|STBM2
Cytomap

1q23.2

1p13.1

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase suvang-like protein 1KAI1 C-terminal interacting tetraspaninloop-tail protein 2 homologstrabismus 2van Gogh-like protein 1vang-like 1 (van gogh, Drosophila)
Modification date2020031320200322
UniProtAcc

Q5TC04

.
Ensembl transtripts involved in fusion geneENST idsENST00000295598, ENST00000369496, 
ENST00000491156, ENST00000537345, 
ENST00000474344, ENST00000310260, 
ENST00000355485, ENST00000369509, 
ENST00000369510, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 18 X 7=20168 X 8 X 4=256
# samples 239
** MAII scorelog2(23/2016*10)=-3.13178987255554
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP1A1 [Title/Abstract] AND VANGL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP1A1(116916145)-VANGL1(116206282), # samples:3
VANGL1(116213768)-ATP1A1(116926636), # samples:1
Anticipated loss of major functional domain due to fusion event.ATP1A1-VANGL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP1A1-VANGL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATP1A1-VANGL1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ATP1A1-VANGL1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP1A1

GO:0030317

flagellated sperm motility

12112599

HgeneATP1A1

GO:0030641

regulation of cellular pH

12112599


check buttonFusion gene breakpoints across ATP1A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VANGL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A15A-01AATP1A1chr1

116916145

-VANGL1chr1

116206282

+
ChimerDB4BRCATCGA-E2-A15A-01AATP1A1chr1

116916145

+VANGL1chr1

116206282

+
ChimerDB4BRCATCGA-E2-A15A-01AATP1A1chr1

116916145

+VANGL1chr1

116224985

+
ChimerDB4BRCATCGA-E2-A15AATP1A1chr1

116916145

+VANGL1chr1

116206281

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000295598ATP1A1chr1116916145+ENST00000355485VANGL1chr1116206282+84802642371634465
ENST00000295598ATP1A1chr1116916145+ENST00000369510VANGL1chr1116206282+84802642371634465
ENST00000295598ATP1A1chr1116916145+ENST00000310260VANGL1chr1116206282+21102642371634465
ENST00000295598ATP1A1chr1116916145+ENST00000369509VANGL1chr1116206282+21102642371634465
ENST00000295598ATP1A1chr1116916145+ENST00000355485VANGL1chr1116206281+84802642371634465
ENST00000295598ATP1A1chr1116916145+ENST00000369510VANGL1chr1116206281+84802642371634465
ENST00000295598ATP1A1chr1116916145+ENST00000310260VANGL1chr1116206281+21102642371634465
ENST00000295598ATP1A1chr1116916145+ENST00000369509VANGL1chr1116206281+21102642371634465

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000295598ENST00000355485ATP1A1chr1116916145+VANGL1chr1116206282+0.0005698550.9994301
ENST00000295598ENST00000369510ATP1A1chr1116916145+VANGL1chr1116206282+0.0005698550.9994301
ENST00000295598ENST00000310260ATP1A1chr1116916145+VANGL1chr1116206282+0.0048920910.9951079
ENST00000295598ENST00000369509ATP1A1chr1116916145+VANGL1chr1116206282+0.0048920910.9951079
ENST00000295598ENST00000355485ATP1A1chr1116916145+VANGL1chr1116206281+0.0005698550.9994301
ENST00000295598ENST00000369510ATP1A1chr1116916145+VANGL1chr1116206281+0.0005698550.9994301
ENST00000295598ENST00000310260ATP1A1chr1116916145+VANGL1chr1116206281+0.0048920910.9951079
ENST00000295598ENST00000369509ATP1A1chr1116916145+VANGL1chr1116206281+0.0048920910.9951079

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7793_7793_1_ATP1A1-VANGL1_ATP1A1_chr1_116916145_ENST00000295598_VANGL1_chr1_116206281_ENST00000310260_length(amino acids)=465AA_BP=9
MSTATMGKGDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTIC
EGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIV
LLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMI
AAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHS
MESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDP

--------------------------------------------------------------

>7793_7793_2_ATP1A1-VANGL1_ATP1A1_chr1_116916145_ENST00000295598_VANGL1_chr1_116206281_ENST00000355485_length(amino acids)=465AA_BP=9
MSTATMGKGDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTIC
EGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIV
LLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMI
AAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHS
MESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDP

--------------------------------------------------------------

>7793_7793_3_ATP1A1-VANGL1_ATP1A1_chr1_116916145_ENST00000295598_VANGL1_chr1_116206281_ENST00000369509_length(amino acids)=465AA_BP=9
MSTATMGKGDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTIC
EGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIV
LLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMI
AAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHS
MESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDP

--------------------------------------------------------------

>7793_7793_4_ATP1A1-VANGL1_ATP1A1_chr1_116916145_ENST00000295598_VANGL1_chr1_116206281_ENST00000369510_length(amino acids)=465AA_BP=9
MSTATMGKGDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTIC
EGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIV
LLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMI
AAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHS
MESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDP

--------------------------------------------------------------

>7793_7793_5_ATP1A1-VANGL1_ATP1A1_chr1_116916145_ENST00000295598_VANGL1_chr1_116206282_ENST00000310260_length(amino acids)=465AA_BP=9
MSTATMGKGDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTIC
EGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIV
LLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMI
AAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHS
MESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDP

--------------------------------------------------------------

>7793_7793_6_ATP1A1-VANGL1_ATP1A1_chr1_116916145_ENST00000295598_VANGL1_chr1_116206282_ENST00000355485_length(amino acids)=465AA_BP=9
MSTATMGKGDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTIC
EGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIV
LLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMI
AAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHS
MESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDP

--------------------------------------------------------------

>7793_7793_7_ATP1A1-VANGL1_ATP1A1_chr1_116916145_ENST00000295598_VANGL1_chr1_116206282_ENST00000369509_length(amino acids)=465AA_BP=9
MSTATMGKGDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTIC
EGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIV
LLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMI
AAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHS
MESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDP

--------------------------------------------------------------

>7793_7793_8_ATP1A1-VANGL1_ATP1A1_chr1_116916145_ENST00000295598_VANGL1_chr1_116206282_ENST00000369510_length(amino acids)=465AA_BP=9
MSTATMGKGDDNWGETTTAITGTSEHSISQEDIARISKDMEDSVGLDCKRYLGLTVASFLGLLVFLTPIAFILLPPILWRDELEPCGTIC
EGLFISMAFKLLILLIGTWALFFRKRRADMPRVFVFRALLLVLIFLFVVSYWLFYGVRILDSRDRNYQGIVQYAVSLVDALLFIHYLAIV
LLELRQLQPMFTLQVVRSTDGESRFYSLGHLSIQRAALVVLENYYKDFTIYNPNLLTASKFRAAKHMAGLKVYNVDGPSNNATGQSRAMI
AAAARRRDSSHNELYYEEAEHERRVKKRKARLVVAVEEAFIHIQRLQAEEQQKAPGEVMDPREAAQAIFPSMARALQKYLRITRQQNYHS
MESILQHLAFCITNGMTPKAFLERYLSAGPTLQYDKDRWLSTQWRLVSDEAVTNGLRDGIVFVLKCLDFSLVVNVKKIPFIILSEEFIDP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:116916145/chr1:116206282)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP1A1

Q5TC04

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneVANGL1chr1:116916145chr1:116206281ENST0000031026028139_15168.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206281ENST0000031026028173_18268.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST0000031026028204_22268.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206281ENST0000031026028244_52468.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST0000035548528139_15168.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206281ENST0000035548528173_18268.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST0000035548528204_22268.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206281ENST0000035548528244_52468.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036950917139_15168.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036950917173_18268.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036950917204_22268.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036950917244_52468.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036951028139_15166.0523.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036951028173_18266.0523.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036951028204_22266.0523.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036951028244_52466.0523.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST0000031026028139_15168.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206282ENST0000031026028173_18268.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST0000031026028204_22268.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206282ENST0000031026028244_52468.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST0000035548528139_15168.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206282ENST0000035548528173_18268.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST0000035548528204_22268.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206282ENST0000035548528244_52468.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036950917139_15168.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036950917173_18268.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036950917204_22268.0525.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036950917244_52468.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036951028139_15166.0523.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036951028173_18266.0523.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036951028204_22266.0523.0Topological domainExtracellular
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036951028244_52466.0523.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST0000031026028118_13868.0525.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:116916145chr1:116206281ENST0000031026028152_17268.0525.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:116916145chr1:116206281ENST0000031026028183_20368.0525.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:116916145chr1:116206281ENST0000031026028223_24368.0525.0TransmembraneHelical%3B Name%3D4
TgeneVANGL1chr1:116916145chr1:116206281ENST0000035548528118_13868.0525.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:116916145chr1:116206281ENST0000035548528152_17268.0525.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:116916145chr1:116206281ENST0000035548528183_20368.0525.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:116916145chr1:116206281ENST0000035548528223_24368.0525.0TransmembraneHelical%3B Name%3D4
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036950917118_13868.0525.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036950917152_17268.0525.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036950917183_20368.0525.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036950917223_24368.0525.0TransmembraneHelical%3B Name%3D4
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036951028118_13866.0523.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036951028152_17266.0523.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036951028183_20366.0523.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:116916145chr1:116206281ENST0000036951028223_24366.0523.0TransmembraneHelical%3B Name%3D4
TgeneVANGL1chr1:116916145chr1:116206282ENST0000031026028118_13868.0525.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:116916145chr1:116206282ENST0000031026028152_17268.0525.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:116916145chr1:116206282ENST0000031026028183_20368.0525.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:116916145chr1:116206282ENST0000031026028223_24368.0525.0TransmembraneHelical%3B Name%3D4
TgeneVANGL1chr1:116916145chr1:116206282ENST0000035548528118_13868.0525.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:116916145chr1:116206282ENST0000035548528152_17268.0525.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:116916145chr1:116206282ENST0000035548528183_20368.0525.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:116916145chr1:116206282ENST0000035548528223_24368.0525.0TransmembraneHelical%3B Name%3D4
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036950917118_13868.0525.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036950917152_17268.0525.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036950917183_20368.0525.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036950917223_24368.0525.0TransmembraneHelical%3B Name%3D4
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036951028118_13866.0523.0TransmembraneHelical%3B Name%3D1
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036951028152_17266.0523.0TransmembraneHelical%3B Name%3D2
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036951028183_20366.0523.0TransmembraneHelical%3B Name%3D3
TgeneVANGL1chr1:116916145chr1:116206282ENST0000036951028223_24366.0523.0TransmembraneHelical%3B Name%3D4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+12382_844.01024.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+12382_840993.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+12382_8401024.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+12382_844.01024.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+12382_840993.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+12382_8401024.0RegionPhosphoinositide-3 kinase binding
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+1231007_10234.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123109_1314.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123153_2884.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123309_3204.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123339_7724.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+1236_874.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123793_8024.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123824_8434.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123867_9184.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123939_9514.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123971_9854.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+1231007_10230993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123109_1310993.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123153_2880993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123309_3200993.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123339_7720993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+1236_870993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123793_8020993.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123824_8430993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123867_9180993.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123939_9510993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123971_9850993.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+1231007_102301024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123109_13101024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123153_28801024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123309_32001024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123339_77201024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+1236_8701024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123793_80201024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123824_84301024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123867_91801024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123939_95101024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123971_98501024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+1231007_10234.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123109_1314.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123153_2884.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123309_3204.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123339_7724.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+1236_874.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123793_8024.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123824_8434.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123867_9184.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123939_9514.01024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123971_9854.01024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+1231007_10230993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123109_1310993.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123153_2880993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123309_3200993.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123339_7720993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+1236_870993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123793_8020993.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123824_8430993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123867_9180993.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123939_9510993.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123971_9850993.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+1231007_102301024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123109_13101024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123153_28801024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123309_32001024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123339_77201024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+1236_8701024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123793_80201024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123824_84301024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123867_91801024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123939_95101024.0Topological domainCytoplasmic
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123971_98501024.0Topological domainExtracellular
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123132_1524.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123289_3084.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123321_3384.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123773_7924.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123803_8234.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123844_8664.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+12388_1084.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123919_9384.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123952_9704.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000295598+123986_10064.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123132_1520993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123289_3080993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123321_3380993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123773_7920993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123803_8230993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123844_8660993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+12388_1080993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123919_9380993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123952_9700993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000369496+123986_10060993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123132_15201024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123289_30801024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123321_33801024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123773_79201024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123803_82301024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123844_86601024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+12388_10801024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123919_93801024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123952_97001024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206281ENST00000537345+123986_100601024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123132_1524.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123289_3084.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123321_3384.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123773_7924.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123803_8234.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123844_8664.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+12388_1084.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123919_9384.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123952_9704.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000295598+123986_10064.01024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123132_1520993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123289_3080993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123321_3380993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123773_7920993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123803_8230993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123844_8660993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+12388_1080993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123919_9380993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123952_9700993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000369496+123986_10060993.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123132_15201024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123289_30801024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123321_33801024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123773_79201024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123803_82301024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123844_86601024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+12388_10801024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123919_93801024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123952_97001024.0TransmembraneHelical
HgeneATP1A1chr1:116916145chr1:116206282ENST00000537345+123986_100601024.0TransmembraneHelical
TgeneVANGL1chr1:116916145chr1:116206281ENST00000310260281_11768.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST00000355485281_11768.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST00000369509171_11768.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206281ENST00000369510281_11766.0523.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST00000310260281_11768.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST00000355485281_11768.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST00000369509171_11768.0525.0Topological domainCytoplasmic
TgeneVANGL1chr1:116916145chr1:116206282ENST00000369510281_11766.0523.0Topological domainCytoplasmic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP1A1
VANGL1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATP1A1-VANGL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP1A1-VANGL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource