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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ATP2A2-TNS1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ATP2A2-TNS1
	FusionPDB ID: 7842
	FusionGDB2.0 ID: 7842
		Hgene	Tgene
	Gene symbol	ATP2A2	TNS1
	Gene ID	488	7145
	Gene name	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	tensin 1
	Synonyms	ATP2B\|DAR\|DD\|SERCA2	MST091\|MST122\|MST127\|MSTP091\|MSTP122\|MSTP127\|MXRA6\|PPP1R155\|TNS
	Cytomap	12q24.11	2q35
	Type of gene	protein-coding	protein-coding
	Description	sarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slow	tensin-1Matrix-remodelling-associated protein 6matrix-remodelling associated 6protein phosphatase 1, regulatory subunit 155
	Modification date	20200313	20200313
	UniProtAcc	P16615	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000308664, ENST00000395494, ENST00000539276, ENST00000550248, ENST00000552636,	ENST00000310858, ENST00000480665, ENST00000171887, ENST00000419504, ENST00000430930,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 22 X 11=4114	11 X 10 X 3=330
	# samples	27	11
	** MAII score	log2(27/4114*10)=-3.9295104814741 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/330*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ATP2A2 [Title/Abstract] AND TNS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ATP2A2(110784126)-TNS1(218686661), # samples:1
Anticipated loss of major functional domain due to fusion event.	ATP2A2-TNS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP2A2-TNS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP2A2-TNS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ATP2A2-TNS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ATP2A2	GO:0032469	endoplasmic reticulum calcium ion homeostasis	16402920
Hgene	ATP2A2	GO:0032470	positive regulation of endoplasmic reticulum calcium ion concentration	16402920
Hgene	ATP2A2	GO:0070588	calcium ion transmembrane transport	16402920
Hgene	ATP2A2	GO:1903515	calcium ion transport from cytosol to endoplasmic reticulum	16402920

Fusion gene breakpoints across ATP2A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TNS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8059-01A	ATP2A2	chr12	110784126	+	TNS1	chr2	218686661	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000308664	ATP2A2	chr12	110784126	+	ENST00000171887	TNS1	chr2	218686661	-	10471	3654	329	5800	1823
ENST00000308664	ATP2A2	chr12	110784126	+	ENST00000419504	TNS1	chr2	218686661	-	6391	3654	329	5797	1822
ENST00000308664	ATP2A2	chr12	110784126	+	ENST00000430930	TNS1	chr2	218686661	-	6394	3654	329	5800	1823
ENST00000395494	ATP2A2	chr12	110784126	+	ENST00000171887	TNS1	chr2	218686661	-	14925	8108	218	3427	1069
ENST00000395494	ATP2A2	chr12	110784126	+	ENST00000419504	TNS1	chr2	218686661	-	10845	8108	218	3427	1069
ENST00000395494	ATP2A2	chr12	110784126	+	ENST00000430930	TNS1	chr2	218686661	-	10848	8108	218	3427	1069
ENST00000539276	ATP2A2	chr12	110784126	+	ENST00000171887	TNS1	chr2	218686661	-	10790	3973	109	3054	981
ENST00000539276	ATP2A2	chr12	110784126	+	ENST00000419504	TNS1	chr2	218686661	-	6710	3973	109	3054	981
ENST00000539276	ATP2A2	chr12	110784126	+	ENST00000430930	TNS1	chr2	218686661	-	6713	3973	109	3054	981

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000308664	ENST00000171887	ATP2A2	chr12	110784126	+	TNS1	chr2	218686661	-	0.000978554	0.9990214
ENST00000308664	ENST00000419504	ATP2A2	chr12	110784126	+	TNS1	chr2	218686661	-	0.002283392	0.99771667
ENST00000308664	ENST00000430930	ATP2A2	chr12	110784126	+	TNS1	chr2	218686661	-	0.002338172	0.9976618
ENST00000395494	ENST00000171887	ATP2A2	chr12	110784126	+	TNS1	chr2	218686661	-	0.000581032	0.999419
ENST00000395494	ENST00000419504	ATP2A2	chr12	110784126	+	TNS1	chr2	218686661	-	0.000900368	0.9990996
ENST00000395494	ENST00000430930	ATP2A2	chr12	110784126	+	TNS1	chr2	218686661	-	0.000900902	0.99909914
ENST00000539276	ENST00000171887	ATP2A2	chr12	110784126	+	TNS1	chr2	218686661	-	0.000705467	0.9992945
ENST00000539276	ENST00000419504	ATP2A2	chr12	110784126	+	TNS1	chr2	218686661	-	0.001288353	0.9987117
ENST00000539276	ENST00000430930	ATP2A2	chr12	110784126	+	TNS1	chr2	218686661	-	0.001289584	0.9987104

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>7842_7842_1_ATP2A2-TNS1_ATP2A2_chr12_110784126_ENST00000308664_TNS1_chr2_218686661_ENST00000171887_length(amino acids)=1823AA_BP=56
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAV
GDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQE
RTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS
LPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSAL
DYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKG
APEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIE
VASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDE
ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEA
LIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQC
KEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQ
WLMVLKISLPVILMDETLKFVARNYLEPEPRSYVESVARTAVAGPRAQDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPI
LSADSTSVGSFPSGESSDQGPRTPTQPLLESGFRSGSLGQPSPSAQRNYQSSSPLPTVGSSYSSPDYSLQHFSSSPESQARAQFSVAGVH
TVPGSPQARHRTVGTNTPPSPGFGWRAINPSMAAPSSPSLSHHQMMGPPGTGFHGSTVSSPQSSAATTPGSPSLCRHPAGVYQVSGLHNK
VATTPGSPSLGRHPGAHQGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAPSTPS
FPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSPVASGMSSPSGGSTVSFSHTLPDFSKYSM
PDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETG
PRGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAACNVLFVNSVDMESLTGPQAISKAT
SETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELD

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>7842_7842_2_ATP2A2-TNS1_ATP2A2_chr12_110784126_ENST00000308664_TNS1_chr2_218686661_ENST00000419504_length(amino acids)=1822AA_BP=56
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAV
GDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQE
RTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS
LPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSAL
DYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKG
APEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIE
VASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDE
ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEA
LIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQC
KEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQ
WLMVLKISLPVILMDETLKFVARNYLEPEPRSYVESVARTAVAGPRAQDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPI
LSADSTSVGSFPSGESSDQGPRTPTQPLLESGFRSGSLGQPSPSAQRNYQSSSPLPTVGSSYSSPDYSLQHFSSSPESQARAQFSVAGVH
TVPGSPQARHRTVGTNTPPSPGFGWRAINPSMAAPSSPSLSHHQMMGPPGTGFHGSTVSSPQSSAATTPGSPSLCRHPAGVYQVSGLHNK
VATTPGSPSLGRHPGAHQGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAPSTPS
FPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSPVASGMSSPSGGSTVSFSHTLPDFSKYSM
PDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKDMTHELVRHFLIETGP
RGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAACNVLFVNSVDMESLTGPQAISKATS
ETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELDP

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>7842_7842_3_ATP2A2-TNS1_ATP2A2_chr12_110784126_ENST00000308664_TNS1_chr2_218686661_ENST00000430930_length(amino acids)=1823AA_BP=56
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAV
GDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQE
RTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRS
LPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSAL
DYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKG
APEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIE
VASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDE
ITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEA
LIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQC
KEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQ
WLMVLKISLPVILMDETLKFVARNYLEPEPRSYVESVARTAVAGPRAQDSEPKSFSAPATQAYGHEIPLRNGTLGGSFVSPSPLSTSSPI
LSADSTSVGSFPSGESSDQGPRTPTQPLLESGFRSGSLGQPSPSAQRNYQSSSPLPTVGSSYSSPDYSLQHFSSSPESQARAQFSVAGVH
TVPGSPQARHRTVGTNTPPSPGFGWRAINPSMAAPSSPSLSHHQMMGPPGTGFHGSTVSSPQSSAATTPGSPSLCRHPAGVYQVSGLHNK
VATTPGSPSLGRHPGAHQGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSPCLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAPSTPS
FPVSPAYYPGLSSPATSPSPDSAAFRQGSPTPALPEKRRMSVGDRAGSLPNYATINGKVSSPVASGMSSPSGGSTVSFSHTLPDFSKYSM
PDNSPETRAKVKFVQDTSKYWYKPEISREQAIALLKDQEPGAFIIRDSHSFRGAYGLAMKVSSPPPTIMQQNKKGDMTHELVRHFLIETG
PRGVKLKGCPNEPNFGSLSALVYQHSIIPLALPCKLVIPNRDPTDESKDSSGPANSTADLLKQGAACNVLFVNSVDMESLTGPQAISKAT
SETLAADPTPAATIVHFKVSAQGITLTDNQRKLFFRRHYPLNTVTFCDLDPQERKWMKTEGGAPAKLFGFVARKQGSTTDNACHLFAELD

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>7842_7842_4_ATP2A2-TNS1_ATP2A2_chr12_110784126_ENST00000395494_TNS1_chr2_218686661_ENST00000171887_length(amino acids)=1069AA_BP=
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAG
ESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVW
IINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMS
VCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM
NVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQ
KIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAV
AICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSG
TAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPD
LDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSV

--------------------------------------------------------------

>7842_7842_5_ATP2A2-TNS1_ATP2A2_chr12_110784126_ENST00000395494_TNS1_chr2_218686661_ENST00000419504_length(amino acids)=1069AA_BP=
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAG
ESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVW
IINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMS
VCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM
NVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQ
KIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAV
AICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSG
TAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPD
LDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSV

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>7842_7842_6_ATP2A2-TNS1_ATP2A2_chr12_110784126_ENST00000395494_TNS1_chr2_218686661_ENST00000430930_length(amino acids)=1069AA_BP=
MIASRERGGGSGAAACPPGGRLRAREALPSGEGREGGSGAPNPPCGARGRARGGCLGEGARGDSAPGEAEAAARGGGESPSAPGLPGWHE
PAAGVRGGGEEAAGTGGEAGRAPEAMENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRIL
LLAACISFVLAWFEEGEETITAFVEPFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAG
ESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVW
IINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMS
VCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKM
NVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQ
KIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAV
AICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSG
TAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPD
LDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSV

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>7842_7842_7_ATP2A2-TNS1_ATP2A2_chr12_110784126_ENST00000539276_TNS1_chr2_218686661_ENST00000171887_length(amino acids)=981AA_BP=
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA
VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGV
KQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGT
AVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNP
PDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMAL

--------------------------------------------------------------

>7842_7842_8_ATP2A2-TNS1_ATP2A2_chr12_110784126_ENST00000539276_TNS1_chr2_218686661_ENST00000419504_length(amino acids)=981AA_BP=
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA
VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGV
KQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGT
AVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNP
PDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMAL

--------------------------------------------------------------

>7842_7842_9_ATP2A2-TNS1_ATP2A2_chr12_110784126_ENST00000539276_TNS1_chr2_218686661_ENST00000430930_length(amino acids)=981AA_BP=
MENAHTKTVEEVLGHFGVNESTGLSLEQVKKLKERWGSNELPAEEGKTLLELVIEQFEDLLVRILLLAACISFVLAWFEEGEETITAFVE
PFVILLILVANAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSIL
TGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIA
VWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQ
MSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVE
KMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGV
KQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGT
AVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMG
SGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNP
PDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMAL

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:110784126/chr2:218686661)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATP2A2 P16615	.
FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). {ECO:0000269\|PubMed:16402920, ECO:0000269\|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250\|UniProtKB:O55143}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

111_253

993.3333333333334

998.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

1_48

993.3333333333334

998.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

274_295

993.3333333333334

998.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

314_756

993.3333333333334

998.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

70_89

993.3333333333334

998.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

777_786

993.3333333333334

998.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

808_827

993.3333333333334

998.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

851_896

993.3333333333334

998.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

917_929

993.3333333333334

998.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

949_963

993.3333333333334

998.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

254_273

993.3333333333334

998.0

Transmembrane

Helical%3B Name%3D3

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

296_313

993.3333333333334

998.0

Transmembrane

Helical%3B Name%3D4

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

49_69

993.3333333333334

998.0

Transmembrane

Helical%3B Name%3D1

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

757_776

993.3333333333334

998.0

Transmembrane

Helical%3B Name%3D5

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

828_850

993.3333333333334

998.0

Transmembrane

Helical%3B Name%3D7

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

897_916

993.3333333333334

998.0

Transmembrane

Helical%3B Name%3D8

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

90_110

993.3333333333334

998.0

Transmembrane

Helical%3B Name%3D2

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

930_948

993.3333333333334

998.0

Transmembrane

Helical%3B Name%3D9

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

964_984

993.3333333333334

998.0

Transmembrane

Helical%3B Name%3D10

Tgene

TNS1

chr12:110784126

chr2:218686661

ENST00000171887

1069_1160

1020.3333333333334

1736.0

Compositional bias

Note=Ser-rich

Tgene

TNS1

chr12:110784126

chr2:218686661

ENST00000171887

1463_1572

1020.3333333333334

1736.0

Domain

SH2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000308664

985_1042

993.3333333333334

998.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

111_253

1016.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

1_48

1016.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

274_295

1016.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

314_756

1016.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

70_89

1016.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

777_786

1016.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

808_827

1016.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

851_896

1016.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

917_929

1016.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

949_963

1016.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

985_1042

1016.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

111_253

1043.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

1_48

1043.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

274_295

1043.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

314_756

1043.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

70_89

1043.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

777_786

1043.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

808_827

1043.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

851_896

1043.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

917_929

1043.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

949_963

1043.0

Topological domain

Lumenal

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

985_1042

1043.0

Topological domain

Cytoplasmic

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

254_273

1016.0

Transmembrane

Helical%3B Name%3D3

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

296_313

1016.0

Transmembrane

Helical%3B Name%3D4

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

49_69

1016.0

Transmembrane

Helical%3B Name%3D1

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

757_776

1016.0

Transmembrane

Helical%3B Name%3D5

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

828_850

1016.0

Transmembrane

Helical%3B Name%3D7

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

897_916

1016.0

Transmembrane

Helical%3B Name%3D8

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

90_110

1016.0

Transmembrane

Helical%3B Name%3D2

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

930_948

1016.0

Transmembrane

Helical%3B Name%3D9

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000395494

964_984

1016.0

Transmembrane

Helical%3B Name%3D10

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

254_273

1043.0

Transmembrane

Helical%3B Name%3D3

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

296_313

1043.0

Transmembrane

Helical%3B Name%3D4

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

49_69

1043.0

Transmembrane

Helical%3B Name%3D1

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

757_776

1043.0

Transmembrane

Helical%3B Name%3D5

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

828_850

1043.0

Transmembrane

Helical%3B Name%3D7

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

897_916

1043.0

Transmembrane

Helical%3B Name%3D8

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

90_110

1043.0

Transmembrane

Helical%3B Name%3D2

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

930_948

1043.0

Transmembrane

Helical%3B Name%3D9

Hgene

ATP2A2

chr12:110784126

chr2:218686661

ENST00000539276

964_984

1043.0

Transmembrane

Helical%3B Name%3D10

Tgene

TNS1

chr12:110784126

chr2:218686661

ENST00000171887

651_667

1020.3333333333334

1736.0

Compositional bias

Note=Gln-rich

Tgene

TNS1

chr12:110784126

chr2:218686661

ENST00000171887

181_307

1020.3333333333334

1736.0

Domain

C2 tensin-type

Tgene

TNS1

chr12:110784126

chr2:218686661

ENST00000171887

4_176

1020.3333333333334

1736.0

Domain

Phosphatase tensin-type

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ATP2A2
TNS1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ATP2A2	chr12:110784126	chr2:218686661	ENST00000395494	+	1	19	575_594	0	1016.0	HAX1
Hgene	ATP2A2	chr12:110784126	chr2:218686661	ENST00000539276	+	1	20	575_594	0	1043.0	HAX1
Hgene	ATP2A2	chr12:110784126	chr2:218686661	ENST00000395494	+	1	19	787_807	0	1016.0	PLN
Hgene	ATP2A2	chr12:110784126	chr2:218686661	ENST00000395494	+	1	19	931_942	0	1016.0	PLN
Hgene	ATP2A2	chr12:110784126	chr2:218686661	ENST00000539276	+	1	20	787_807	0	1043.0	PLN
Hgene	ATP2A2	chr12:110784126	chr2:218686661	ENST00000539276	+	1	20	931_942	0	1043.0	PLN
Hgene	ATP2A2	chr12:110784126	chr2:218686661	ENST00000308664	+	20	21	788_1042	993.3333333333334	998.0	TMEM64 and PDIA3
Hgene	ATP2A2	chr12:110784126	chr2:218686661	ENST00000395494	+	1	19	788_1042	0	1016.0	TMEM64 and PDIA3
Hgene	ATP2A2	chr12:110784126	chr2:218686661	ENST00000539276	+	1	20	788_1042	0	1043.0	TMEM64 and PDIA3

Top

Related Drugs to ATP2A2-TNS1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ATP2A2-TNS1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source