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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SART3-ATP2A2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SART3-ATP2A2
FusionPDB ID: 79218
FusionGDB2.0 ID: 79218
HgeneTgene
Gene symbol

SART3

ATP2A2

Gene ID

9733

488

Gene namespliceosome associated factor 3, U4/U6 recycling proteinATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
SynonymsDSAP1|P100|RP11-13G14|TIP110|p110|p110(nrb)ATP2B|DAR|DD|SERCA2
Cytomap

12q23.3

12q24.11

Type of geneprotein-codingprotein-coding
Descriptionsquamous cell carcinoma antigen recognized by T-cells 3HIV-1 Tat-interacting protein of 110kDaPRP24 homologSART-3hSART-3p110 nuclear RNA-binding proteinsquamous cell carcinoma antigen recognized by T cells 3tat-interacting protein of 110 kDasarcoplasmic/endoplasmic reticulum calcium ATPase 2ATPase Ca++ transporting cardiac muscle slow twitch 2ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2SR Ca(2+)-ATPase 2calcium pump 2calcium-transporting ATPase sarcoplasmic reticulum type, slow
Modification date2020031320200313
UniProtAcc.

P16615

Ensembl transtripts involved in fusion geneENST idsENST00000228284, ENST00000431469, 
ENST00000546611, ENST00000552221, 
ENST00000552636, ENST00000550248, 
ENST00000308664, ENST00000395494, 
ENST00000539276, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 11 X 6=59419 X 23 X 6=2622
# samples 1123
** MAII scorelog2(11/594*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/2622*10)=-3.51096191927738
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SART3 [Title/Abstract] AND ATP2A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SART3(108938915)-ATP2A2(110729825), # samples:1
Anticipated loss of major functional domain due to fusion event.SART3-ATP2A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SART3-ATP2A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SART3-ATP2A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SART3-ATP2A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSART3

GO:0000244

spliceosomal tri-snRNP complex assembly

12032085|20595234

HgeneSART3

GO:0000387

spliceosomal snRNP assembly

14749385|15314151

HgeneSART3

GO:0000398

mRNA splicing, via spliceosome

15314151

HgeneSART3

GO:0006334

nucleosome assembly

24526689

HgeneSART3

GO:0010468

regulation of gene expression

21447833

HgeneSART3

GO:1903586

positive regulation of histone deubiquitination

24526689

TgeneATP2A2

GO:0032469

endoplasmic reticulum calcium ion homeostasis

16402920

TgeneATP2A2

GO:0032470

positive regulation of endoplasmic reticulum calcium ion concentration

16402920

TgeneATP2A2

GO:0070588

calcium ion transmembrane transport

16402920

TgeneATP2A2

GO:1903515

calcium ion transport from cytosol to endoplasmic reticulum

16402920


check buttonFusion gene breakpoints across SART3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP2A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GN-01ASART3chr12

108938915

-ATP2A2chr12

110729825

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000228284SART3chr12108938915-ENST00000308664ATP2A2chr12110729825+452496423537381167
ENST00000228284SART3chr12108938915-ENST00000395494ATP2A2chr12110729825+841196423537921185
ENST00000228284SART3chr12108938915-ENST00000539276ATP2A2chr12110729825+473096423538731212
ENST00000431469SART3chr12108938915-ENST00000308664ATP2A2chr12110729825+4294734535081167
ENST00000431469SART3chr12108938915-ENST00000395494ATP2A2chr12110729825+8181734535621185
ENST00000431469SART3chr12108938915-ENST00000539276ATP2A2chr12110729825+4500734536431212

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000228284ENST00000308664SART3chr12108938915-ATP2A2chr12110729825+0.0003242340.99967575
ENST00000228284ENST00000395494SART3chr12108938915-ATP2A2chr12110729825+0.0005024430.99949753
ENST00000228284ENST00000539276SART3chr12108938915-ATP2A2chr12110729825+0.0001700910.9998299
ENST00000431469ENST00000308664SART3chr12108938915-ATP2A2chr12110729825+0.0003175010.99968255
ENST00000431469ENST00000395494SART3chr12108938915-ATP2A2chr12110729825+0.0004294050.99957055
ENST00000431469ENST00000539276SART3chr12108938915-ATP2A2chr12110729825+0.0001610210.99983895

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79218_79218_1_SART3-ATP2A2_SART3_chr12_108938915_ENST00000228284_ATP2A2_chr12_110729825_ENST00000308664_length(amino acids)=1167AA_BP=243
MATAAETSASEPEAESKAGPKADGEEDEVKAARTRRKVLSRAVAAATYKTMGPAWDQQEEGVSESDGDEYAMASSAESSPGEYEWEYDEE
EEKNQLEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDY
ICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARVLAWFEEGEETITAFVEPFVILLILVA
NAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKH
TDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFN
DPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILD
RVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELK
GLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIRE
WGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGI
FGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTAS
EMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPP
RNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCN

--------------------------------------------------------------

>79218_79218_2_SART3-ATP2A2_SART3_chr12_108938915_ENST00000228284_ATP2A2_chr12_110729825_ENST00000395494_length(amino acids)=1185AA_BP=243
MATAAETSASEPEAESKAGPKADGEEDEVKAARTRRKVLSRAVAAATYKTMGPAWDQQEEGVSESDGDEYAMASSAESSPGEYEWEYDEE
EEKNQLEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDY
ICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARVLAWFEEGEETITAFVEPFVILLILVA
NAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAG
KAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAI
PEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHK
DDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEF
SRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHL
EDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRD
ACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMK
QFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAAT
VGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSIC
LSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVI

--------------------------------------------------------------

>79218_79218_3_SART3-ATP2A2_SART3_chr12_108938915_ENST00000228284_ATP2A2_chr12_110729825_ENST00000539276_length(amino acids)=1212AA_BP=243
MATAAETSASEPEAESKAGPKADGEEDEVKAARTRRKVLSRAVAAATYKTMGPAWDQQEEGVSESDGDEYAMASSAESSPGEYEWEYDEE
EEKNQLEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDY
ICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARVLAWFEEGEETITAFVEPFVILLILVA
NAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKH
TDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFN
DPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILD
RVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELK
GLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIRE
WGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGI
FGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTAS
EMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPP
RNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCN
ALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQP

--------------------------------------------------------------

>79218_79218_4_SART3-ATP2A2_SART3_chr12_108938915_ENST00000431469_ATP2A2_chr12_110729825_ENST00000308664_length(amino acids)=1167AA_BP=243
MATAAETSASEPEAESKAGPKADGEEDEVKAARTRRKVLSRAVAAATYKTMGPAWDQQEEGVSESDGDEYAMASSAESSPGEYEWEYDEE
EEKNQLEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDY
ICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARVLAWFEEGEETITAFVEPFVILLILVA
NAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKH
TDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFN
DPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILD
RVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELK
GLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIRE
WGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGI
FGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTAS
EMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPP
RNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCN

--------------------------------------------------------------

>79218_79218_5_SART3-ATP2A2_SART3_chr12_108938915_ENST00000431469_ATP2A2_chr12_110729825_ENST00000395494_length(amino acids)=1185AA_BP=243
MATAAETSASEPEAESKAGPKADGEEDEVKAARTRRKVLSRAVAAATYKTMGPAWDQQEEGVSESDGDEYAMASSAESSPGEYEWEYDEE
EEKNQLEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDY
ICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARVLAWFEEGEETITAFVEPFVILLILVA
NAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAGESVSVIKHTDPVPDPRAVNQDKKNMLFSGTNIAAG
KAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFNDPVHGGSWIRGAIYYFKIAVALAVAAI
PEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILDRVEGDTCSLNEFTITGSTYAPIGEVHK
DDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELKGLSKIERANACNSVIKQLMKKEFTLEF
SRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIREWGSGSDTLRCLALATHDNPLRREEMHL
EDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGIFGQDEDVTSKAFTGREFDELNPSAQRD
ACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTASEMVLADDNFSTIVAAVEEGRAIYNNMK
QFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPPRNPKEPLISGWLFFRYLAIGCYVGAAT
VGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCNALNSLSENQSLLRMPPWENIWLVGSIC
LSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQPATKSCSFSACTDGISWPFVLLIMPLVI

--------------------------------------------------------------

>79218_79218_6_SART3-ATP2A2_SART3_chr12_108938915_ENST00000431469_ATP2A2_chr12_110729825_ENST00000539276_length(amino acids)=1212AA_BP=243
MATAAETSASEPEAESKAGPKADGEEDEVKAARTRRKVLSRAVAAATYKTMGPAWDQQEEGVSESDGDEYAMASSAESSPGEYEWEYDEE
EEKNQLEIERLEEQLSINVYDYNCHVDLIRLLRLEGELTKVRMARQKMSEIFPLTEELWLEWLHDEISMAQDGLDREHVYDLFEKAVKDY
ICPNIWLEYGQYSVGGIGQKGGLEKVRSVFERALSSVGLHMTKGLALWEAYREFESAIVEAARVLAWFEEGEETITAFVEPFVILLILVA
NAIVGVWQERNAENAIEALKEYEPEMGKVYRQDRKSVQRIKAKDIVPGDIVEIAVGDKVPADIRLTSIKSTTLRVDQSILTGESVSVIKH
TDPVPDPRAVNQDKKNMLFSGTNIAAGKAMGVVVATGVNTEIGKIRDEMVATEQERTPLQQKLDEFGEQLSKVISLICIAVWIINIGHFN
DPVHGGSWIRGAIYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFILD
RVEGDTCSLNEFTITGSTYAPIGEVHKDDKPVNCHQYDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTELK
GLSKIERANACNSVIKQLMKKEFTLEFSRDRKSMSVYCTPNKPSRTSMSKMFVKGAPEGVIDRCTHIRVGSTKVPMTSGVKQKIMSVIRE
WGSGSDTLRCLALATHDNPLRREEMHLEDSANFIKYETNLTFVGCVGMLDPPRIEVASSVKLCRQAGIRVIMITGDNKGTAVAICRRIGI
FGQDEDVTSKAFTGREFDELNPSAQRDACLNARCFARVEPSHKSKIVEFLQSFDEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKTAS
EMVLADDNFSTIVAAVEEGRAIYNNMKQFIRYLISSNVGEVVCIFLTAALGFPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMNKPP
RNPKEPLISGWLFFRYLAIGCYVGAATVGAAAWWFIAADGGPRVSFYQLSHFLQCKEDNPDFEGVDCAIFESPYPMTMALSVLVTIEMCN
ALNSLSENQSLLRMPPWENIWLVGSICLSMSLHFLILYVEPLPLIFQITPLNVTQWLMVLKISLPVILMDETLKFVARNYLEPGKECVQP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:108938915/chr12:110729825)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATP2A2

P16615

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:16402920). Involved in autophagy in response to starvation. Upon interaction with VMP1 and activation, controls ER-isolation membrane contacts for autophagosome formation (PubMed:28890335). Also modulates ER contacts with lipid droplets, mitochondria and endosomes (PubMed:28890335). {ECO:0000269|PubMed:16402920, ECO:0000269|PubMed:28890335}.; FUNCTION: [Isoform 2]: Involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca(2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca(2+) signaling cascades that promote osteoclast differentiation and activation. {ECO:0000250|UniProtKB:O55143}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-41921_46243.0964.0Coiled coilOntology_term=ECO:0000255
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-41982_110243.0964.0Coiled coilOntology_term=ECO:0000255
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-41989_92243.0964.0Compositional biasNote=Poly-Glu
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419126_158243.0964.0RepeatNote=HAT 1
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419164_195243.0964.0RepeatNote=HAT 2
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419201_237243.0964.0RepeatNote=HAT 3
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221111_25373.0998.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221274_29573.0998.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221314_75673.0998.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST0000030866422170_8973.0998.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221777_78673.0998.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221808_82773.0998.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221851_89673.0998.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221917_92973.0998.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221949_96373.0998.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221985_104273.0998.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219111_25373.01016.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219274_29573.01016.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219314_75673.01016.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST0000039549421970_8973.01016.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219777_78673.01016.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219808_82773.01016.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219851_89673.01016.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219917_92973.01016.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219949_96373.01016.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219985_104273.01016.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220111_25373.01043.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220274_29573.01043.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220314_75673.01043.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST0000053927622070_8973.01043.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220777_78673.01043.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220808_82773.01043.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220851_89673.01043.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220917_92973.01043.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220949_96373.01043.0Topological domainLumenal
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220985_104273.01043.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221254_27373.0998.0TransmembraneHelical%3B Name%3D3
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221296_31373.0998.0TransmembraneHelical%3B Name%3D4
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221757_77673.0998.0TransmembraneHelical%3B Name%3D5
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221828_85073.0998.0TransmembraneHelical%3B Name%3D7
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221897_91673.0998.0TransmembraneHelical%3B Name%3D8
TgeneATP2A2chr12:108938915chr12:110729825ENST0000030866422190_11073.0998.0TransmembraneHelical%3B Name%3D2
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221930_94873.0998.0TransmembraneHelical%3B Name%3D9
TgeneATP2A2chr12:108938915chr12:110729825ENST00000308664221964_98473.0998.0TransmembraneHelical%3B Name%3D10
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219254_27373.01016.0TransmembraneHelical%3B Name%3D3
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219296_31373.01016.0TransmembraneHelical%3B Name%3D4
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219757_77673.01016.0TransmembraneHelical%3B Name%3D5
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219828_85073.01016.0TransmembraneHelical%3B Name%3D7
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219897_91673.01016.0TransmembraneHelical%3B Name%3D8
TgeneATP2A2chr12:108938915chr12:110729825ENST0000039549421990_11073.01016.0TransmembraneHelical%3B Name%3D2
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219930_94873.01016.0TransmembraneHelical%3B Name%3D9
TgeneATP2A2chr12:108938915chr12:110729825ENST00000395494219964_98473.01016.0TransmembraneHelical%3B Name%3D10
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220254_27373.01043.0TransmembraneHelical%3B Name%3D3
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220296_31373.01043.0TransmembraneHelical%3B Name%3D4
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220757_77673.01043.0TransmembraneHelical%3B Name%3D5
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220828_85073.01043.0TransmembraneHelical%3B Name%3D7
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220897_91673.01043.0TransmembraneHelical%3B Name%3D8
TgeneATP2A2chr12:108938915chr12:110729825ENST0000053927622090_11073.01043.0TransmembraneHelical%3B Name%3D2
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220930_94873.01043.0TransmembraneHelical%3B Name%3D9
TgeneATP2A2chr12:108938915chr12:110729825ENST00000539276220964_98473.01043.0TransmembraneHelical%3B Name%3D10

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419559_619243.0964.0Coiled coilOntology_term=ECO:0000255
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-1121_460130.0Coiled coilOntology_term=ECO:0000255
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11559_6190130.0Coiled coilOntology_term=ECO:0000255
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-1182_1100130.0Coiled coilOntology_term=ECO:0000255
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419612_616243.0964.0Compositional biasNote=Poly-Lys
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11612_6160130.0Compositional biasNote=Poly-Lys
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-1189_920130.0Compositional biasNote=Poly-Glu
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419704_782243.0964.0DomainRRM 1
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419801_878243.0964.0DomainRRM 2
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11704_7820130.0DomainRRM 1
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11801_8780130.0DomainRRM 2
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419601_617243.0964.0MotifNuclear localization signal
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11601_6170130.0MotifNuclear localization signal
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419537_953243.0964.0RegionNecessary and sufficient for U6 snRNA binding
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419600_670243.0964.0RegionRequired for nuclear localization
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11537_9530130.0RegionNecessary and sufficient for U6 snRNA binding
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11600_6700130.0RegionRequired for nuclear localization
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419242_275243.0964.0RepeatNote=HAT 4
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419324_356243.0964.0RepeatNote=HAT 5
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419359_391243.0964.0RepeatNote=HAT 6
HgeneSART3chr12:108938915chr12:110729825ENST00000228284-419394_430243.0964.0RepeatNote=HAT 7
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11126_1580130.0RepeatNote=HAT 1
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11164_1950130.0RepeatNote=HAT 2
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11201_2370130.0RepeatNote=HAT 3
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11242_2750130.0RepeatNote=HAT 4
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11324_3560130.0RepeatNote=HAT 5
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11359_3910130.0RepeatNote=HAT 6
HgeneSART3chr12:108938915chr12:110729825ENST00000546611-11394_4300130.0RepeatNote=HAT 7
TgeneATP2A2chr12:108938915chr12:110729825ENST000003086642211_4873.0998.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST000003954942191_4873.01016.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST000005392762201_4873.01043.0Topological domainCytoplasmic
TgeneATP2A2chr12:108938915chr12:110729825ENST0000030866422149_6973.0998.0TransmembraneHelical%3B Name%3D1
TgeneATP2A2chr12:108938915chr12:110729825ENST0000039549421949_6973.01016.0TransmembraneHelical%3B Name%3D1
TgeneATP2A2chr12:108938915chr12:110729825ENST0000053927622049_6973.01043.0TransmembraneHelical%3B Name%3D1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SART3
ATP2A2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SART3-ATP2A2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SART3-ATP2A2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource