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Fusion Protein:SASH1-ARID1B |
Fusion Protein Summary |
Fusion gene summary |
Fusion partner gene information | Fusion gene name: SASH1-ARID1B | FusionPDB ID: 79229 | FusionGDB2.0 ID: 79229 | Hgene | Tgene | Gene symbol | SASH1 | ARID1B | Gene ID | 23328 | 57492 |
Gene name | SAM and SH3 domain containing 1 | AT-rich interaction domain 1B | |
Synonyms | CAPOK|DUH1|SH3D6A|dJ323M4.1 | 6A3-5|BAF250B|BRIGHT|CSS1|DAN15|ELD/OSA1|MRD12|OSA2|P250R | |
Cytomap | 6q24.3-q25.1 | 6q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | SAM and SH3 domain-containing protein 1proline-glutamate repeat-containing protein | AT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA protein | |
Modification date | 20200313 | 20200320 | |
UniProtAcc | O94885 | Q8NFD5 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000367467, ENST00000367469, ENST00000470750, | ENST00000478761, ENST00000275248, ENST00000346085, ENST00000350026, ENST00000367148, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 9 X 6 X 6=324 | 10 X 12 X 6=720 |
# samples | 8 | 12 | |
** MAII score | log2(8/324*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/720*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: SASH1 [Title/Abstract] AND ARID1B [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SASH1(148711398)-ARID1B(157256600), # samples:3 ARID1B(157150555)-SASH1(148711270), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | ARID1B-SASH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARID1B-SASH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SASH1-ARID1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SASH1-ARID1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SASH1-ARID1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SASH1-ARID1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SASH1 | GO:0000209 | protein polyubiquitination | 23776175 |
Hgene | SASH1 | GO:0010595 | positive regulation of endothelial cell migration | 23776175 |
Hgene | SASH1 | GO:1900044 | regulation of protein K63-linked ubiquitination | 23776175 |
Hgene | SASH1 | GO:1902498 | regulation of protein autoubiquitination | 23776175 |
Fusion gene breakpoints across SASH1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Fusion gene breakpoints across ARID1B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
Fusion gene information from FusionGDB2.0. |
Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-E9-A1NF-01A | SASH1 | chr6 | 148711398 | - | ARID1B | chr6 | 157256600 | + |
ChimerDB4 | BRCA | TCGA-E9-A1NF-01A | SASH1 | chr6 | 148711398 | + | ARID1B | chr6 | 157256600 | + |
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Fusion ORF Analysis |
Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000367469 | SASH1 | chr6 | 148711398 | + | ENST00000350026 | ARID1B | chr6 | 157256600 | + | 6286 | 203 | 26 | 5026 | 1666 |
ENST00000367469 | SASH1 | chr6 | 148711398 | + | ENST00000346085 | ARID1B | chr6 | 157256600 | + | 7915 | 203 | 26 | 5026 | 1666 |
ENST00000367469 | SASH1 | chr6 | 148711398 | + | ENST00000367148 | ARID1B | chr6 | 157256600 | + | 6562 | 203 | 26 | 5185 | 1719 |
ENST00000367469 | SASH1 | chr6 | 148711398 | + | ENST00000275248 | ARID1B | chr6 | 157256600 | + | 6562 | 203 | 26 | 5185 | 1719 |
ENST00000367467 | SASH1 | chr6 | 148711398 | + | ENST00000350026 | ARID1B | chr6 | 157256600 | + | 6843 | 760 | 157 | 5583 | 1808 |
ENST00000367467 | SASH1 | chr6 | 148711398 | + | ENST00000346085 | ARID1B | chr6 | 157256600 | + | 8472 | 760 | 157 | 5583 | 1808 |
ENST00000367467 | SASH1 | chr6 | 148711398 | + | ENST00000367148 | ARID1B | chr6 | 157256600 | + | 7119 | 760 | 157 | 5742 | 1861 |
ENST00000367467 | SASH1 | chr6 | 148711398 | + | ENST00000275248 | ARID1B | chr6 | 157256600 | + | 7119 | 760 | 157 | 5742 | 1861 |
DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000367469 | ENST00000350026 | SASH1 | chr6 | 148711398 | + | ARID1B | chr6 | 157256600 | + | 0.002746026 | 0.99725395 |
ENST00000367469 | ENST00000346085 | SASH1 | chr6 | 148711398 | + | ARID1B | chr6 | 157256600 | + | 0.000774177 | 0.99922585 |
ENST00000367469 | ENST00000367148 | SASH1 | chr6 | 148711398 | + | ARID1B | chr6 | 157256600 | + | 0.002538589 | 0.99746144 |
ENST00000367469 | ENST00000275248 | SASH1 | chr6 | 148711398 | + | ARID1B | chr6 | 157256600 | + | 0.002538589 | 0.99746144 |
ENST00000367467 | ENST00000350026 | SASH1 | chr6 | 148711398 | + | ARID1B | chr6 | 157256600 | + | 0.003580844 | 0.9964192 |
ENST00000367467 | ENST00000346085 | SASH1 | chr6 | 148711398 | + | ARID1B | chr6 | 157256600 | + | 0.001209439 | 0.99879056 |
ENST00000367467 | ENST00000367148 | SASH1 | chr6 | 148711398 | + | ARID1B | chr6 | 157256600 | + | 0.003494466 | 0.9965056 |
ENST00000367467 | ENST00000275248 | SASH1 | chr6 | 148711398 | + | ARID1B | chr6 | 157256600 | + | 0.003494466 | 0.9965056 |
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Fusion Amino Acid Sequences |
For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >79229_79229_1_SASH1-ARID1B_SASH1_chr6_148711398_ENST00000367467_ARID1B_chr6_157256600_ENST00000275248_length(amino acids)=1861AA_BP=201 MLLGRANSPPYNSVVRTLPPATLLLRRAGWESFWSCQSRSPWPPRPEVRAPAKGPRGVAGAAGACSAGARLGDAAGGDPASGQAARGCGA RAPRGLGRTARARDTAMEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCF SDVCERMEELRKRRVSQDLEVDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGD QSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQ MAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPC GAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQ PMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPS SASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVK EIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKV PGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAAR NDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLL AESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTE HIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACS KDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLE -------------------------------------------------------------- >79229_79229_2_SASH1-ARID1B_SASH1_chr6_148711398_ENST00000367467_ARID1B_chr6_157256600_ENST00000346085_length(amino acids)=1808AA_BP=201 MLLGRANSPPYNSVVRTLPPATLLLRRAGWESFWSCQSRSPWPPRPEVRAPAKGPRGVAGAAGACSAGARLGDAAGGDPASGQAARGCGA RAPRGLGRTARARDTAMEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCF SDVCERMEELRKRRVSQDLEVDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGD QSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQ MAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPC GAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQ PMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKL WVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKR NSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRER MQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPG SVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKI VKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGL VLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAV QKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD -------------------------------------------------------------- >79229_79229_3_SASH1-ARID1B_SASH1_chr6_148711398_ENST00000367467_ARID1B_chr6_157256600_ENST00000350026_length(amino acids)=1808AA_BP=201 MLLGRANSPPYNSVVRTLPPATLLLRRAGWESFWSCQSRSPWPPRPEVRAPAKGPRGVAGAAGACSAGARLGDAAGGDPASGQAARGCGA RAPRGLGRTARARDTAMEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCF SDVCERMEELRKRRVSQDLEVDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGD QSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQ MAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPC GAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQ PMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKL WVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEE PPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKR NSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEP YGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRER MQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQP YMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPG SVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEY EVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKI VKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVL SARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGL VLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSA EAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAV QKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVICD -------------------------------------------------------------- >79229_79229_4_SASH1-ARID1B_SASH1_chr6_148711398_ENST00000367467_ARID1B_chr6_157256600_ENST00000367148_length(amino acids)=1861AA_BP=201 MLLGRANSPPYNSVVRTLPPATLLLRRAGWESFWSCQSRSPWPPRPEVRAPAKGPRGVAGAAGACSAGARLGDAAGGDPASGQAARGCGA RAPRGLGRTARARDTAMEDAGAAGPGPEPEPEPEPEPEPAPEPEPEPKPGAGTSEAFSRLWTDVMGILDGSLGNIDDLAQQYADYYNTCF SDVCERMEELRKRRVSQDLEVDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQERPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGD QSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQ MAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPC GAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQ PMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPS SASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVK EIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQST GSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKV PGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDG MYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAAR NDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPAS FQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLL AESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECI DDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTE HIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKL LEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACS KDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDL ILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLE -------------------------------------------------------------- >79229_79229_5_SASH1-ARID1B_SASH1_chr6_148711398_ENST00000367469_ARID1B_chr6_157256600_ENST00000275248_length(amino acids)=1719AA_BP=59 MNVWPAAHFMEEQDCRDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQE RPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQ MPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQ EAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK EEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERK LWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGE EPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPK RNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHE PYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRE RMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPP GSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILME YEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIK IVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDV LSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPG LVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPS AEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIA VQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVIC -------------------------------------------------------------- >79229_79229_6_SASH1-ARID1B_SASH1_chr6_148711398_ENST00000367469_ARID1B_chr6_157256600_ENST00000346085_length(amino acids)=1666AA_BP=59 MNVWPAAHFMEEQDCRDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQE RPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQ MPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQ EAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK EEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWR ELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPP TPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPN SSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYN MQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGG PTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSP FLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLY DDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSE KTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPR RRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCT IAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDN TLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYA TLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALL -------------------------------------------------------------- >79229_79229_7_SASH1-ARID1B_SASH1_chr6_148711398_ENST00000367469_ARID1B_chr6_157256600_ENST00000350026_length(amino acids)=1666AA_BP=59 MNVWPAAHFMEEQDCRDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQE RPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQ MPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQ EAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK EEGTPQPESKSKKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWR ELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPP TPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPN SSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYN MQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGG PTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSP FLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLY DDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSE KTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPR RRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCT IAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDN TLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYA TLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALL -------------------------------------------------------------- >79229_79229_8_SASH1-ARID1B_SASH1_chr6_148711398_ENST00000367469_ARID1B_chr6_157256600_ENST00000367148_length(amino acids)=1719AA_BP=59 MNVWPAAHFMEEQDCRDGSLGNIDDLAQQYADYYNTCFSDVCERMEELRKRRVSQDLEVDMSQEGYGTRSQPPLAPGKPNHEDLNLIQQE RPSSLPDLSGSIDDLPTGTEATLSSAVSASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQ MPPQPPGSQSESSSHPALSQSPMPQERGFMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNY SRPPAYSGVPSASYSGPGPGMGISANNQMHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQ EAAAAVMQAAANSAQSRQGSFPGMNQSGLMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGK EEGTPQPESKSKDSYSSQGISQPPTPGNLPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERK LWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGE EPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPK RNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHE PYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRE RMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQ PYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPP GSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILME YEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIK IVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDV LSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPG LVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPS AEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIA VQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVLNSLVASVIC -------------------------------------------------------------- |
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Fusion Protein Functional Features |
Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:148711398/chr6:157256600) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SASH1 | ARID1B |
FUNCTION: Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation (PubMed:23776175). Regulates TRAF6 and MAP3K7 ubiquitination (PubMed:23776175). Involved in the regulation of cell mobility (PubMed:23333244, PubMed:23776175, PubMed:25315659). Regulates lipolysaccharide (LPS)-induced endothelial cell migration (PubMed:23776175). Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis (PubMed:23333244). {ECO:0000269|PubMed:23333244, ECO:0000269|PubMed:23776175, ECO:0000269|PubMed:25315659}. | FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SASH1 | chr6:148711398 | chr6:157256600 | ENST00000367467 | + | 2 | 20 | 9_33 | 95.0 | 1248.0 | Compositional bias | Note=Pro-rich |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 1034_1037 | 642.0 | 2250.0 | Compositional bias | Note=Poly-Ser | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 1441_1444 | 642.0 | 2250.0 | Compositional bias | Note=Poly-Ser | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 1459_1597 | 642.0 | 2250.0 | Compositional bias | Note=Pro-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 1833_1836 | 642.0 | 2250.0 | Compositional bias | Note=Poly-Pro | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 684_771 | 642.0 | 2250.0 | Compositional bias | Note=Ser-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 932_935 | 642.0 | 2250.0 | Compositional bias | Note=Poly-Ala | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 1034_1037 | 629.0 | 2237.0 | Compositional bias | Note=Poly-Ser | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 1441_1444 | 629.0 | 2237.0 | Compositional bias | Note=Poly-Ser | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 1459_1597 | 629.0 | 2237.0 | Compositional bias | Note=Pro-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 1833_1836 | 629.0 | 2237.0 | Compositional bias | Note=Poly-Pro | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 684_771 | 629.0 | 2237.0 | Compositional bias | Note=Ser-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 932_935 | 629.0 | 2237.0 | Compositional bias | Note=Poly-Ala | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 1034_1037 | 629.0 | 2290.0 | Compositional bias | Note=Poly-Ser | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 1441_1444 | 629.0 | 2290.0 | Compositional bias | Note=Poly-Ser | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 1459_1597 | 629.0 | 2290.0 | Compositional bias | Note=Pro-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 1833_1836 | 629.0 | 2290.0 | Compositional bias | Note=Poly-Pro | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 684_771 | 629.0 | 2290.0 | Compositional bias | Note=Ser-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 932_935 | 629.0 | 2290.0 | Compositional bias | Note=Poly-Ala | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 1053_1144 | 642.0 | 2250.0 | Domain | ARID | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 1053_1144 | 629.0 | 2237.0 | Domain | ARID | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 1053_1144 | 629.0 | 2290.0 | Domain | ARID | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 1358_1377 | 642.0 | 2250.0 | Motif | Nuclear localization signal | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 2036_2040 | 642.0 | 2250.0 | Motif | Note=LXXLL | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 1358_1377 | 629.0 | 2237.0 | Motif | Nuclear localization signal | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 2036_2040 | 629.0 | 2237.0 | Motif | Note=LXXLL | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 1358_1377 | 629.0 | 2290.0 | Motif | Nuclear localization signal | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 2036_2040 | 629.0 | 2290.0 | Motif | Note=LXXLL |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SASH1 | chr6:148711398 | chr6:157256600 | ENST00000367467 | + | 2 | 20 | 978_1059 | 95.0 | 1248.0 | Compositional bias | Note=Pro-rich |
Hgene | SASH1 | chr6:148711398 | chr6:157256600 | ENST00000367467 | + | 2 | 20 | 1177_1241 | 95.0 | 1248.0 | Domain | SAM 2 |
Hgene | SASH1 | chr6:148711398 | chr6:157256600 | ENST00000367467 | + | 2 | 20 | 554_615 | 95.0 | 1248.0 | Domain | SH3 |
Hgene | SASH1 | chr6:148711398 | chr6:157256600 | ENST00000367467 | + | 2 | 20 | 633_697 | 95.0 | 1248.0 | Domain | SAM 1 |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 107_131 | 642.0 | 2250.0 | Compositional bias | Note=Gln-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 114_131 | 642.0 | 2250.0 | Compositional bias | Note=Poly-Gln | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 141_401 | 642.0 | 2250.0 | Compositional bias | Note=Gly-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 2_47 | 642.0 | 2250.0 | Compositional bias | Note=Ala-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 329_493 | 642.0 | 2250.0 | Compositional bias | Note=Ala-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 35_57 | 642.0 | 2250.0 | Compositional bias | Note=Ser-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 574_633 | 642.0 | 2250.0 | Compositional bias | Note=Gln-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 81_104 | 642.0 | 2250.0 | Compositional bias | Note=His-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 107_131 | 629.0 | 2237.0 | Compositional bias | Note=Gln-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 114_131 | 629.0 | 2237.0 | Compositional bias | Note=Poly-Gln | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 141_401 | 629.0 | 2237.0 | Compositional bias | Note=Gly-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 2_47 | 629.0 | 2237.0 | Compositional bias | Note=Ala-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 329_493 | 629.0 | 2237.0 | Compositional bias | Note=Ala-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 35_57 | 629.0 | 2237.0 | Compositional bias | Note=Ser-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 574_633 | 629.0 | 2237.0 | Compositional bias | Note=Gln-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 81_104 | 629.0 | 2237.0 | Compositional bias | Note=His-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 107_131 | 629.0 | 2290.0 | Compositional bias | Note=Gln-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 114_131 | 629.0 | 2290.0 | Compositional bias | Note=Poly-Gln | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 141_401 | 629.0 | 2290.0 | Compositional bias | Note=Gly-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 2_47 | 629.0 | 2290.0 | Compositional bias | Note=Ala-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 329_493 | 629.0 | 2290.0 | Compositional bias | Note=Ala-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 35_57 | 629.0 | 2290.0 | Compositional bias | Note=Ser-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 574_633 | 629.0 | 2290.0 | Compositional bias | Note=Gln-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 81_104 | 629.0 | 2290.0 | Compositional bias | Note=His-rich | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000346085 | 3 | 20 | 419_423 | 642.0 | 2250.0 | Motif | Note=LXXLL | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000350026 | 2 | 19 | 419_423 | 629.0 | 2237.0 | Motif | Note=LXXLL | |
Tgene | ARID1B | chr6:148711398 | chr6:157256600 | ENST00000367148 | 2 | 20 | 419_423 | 629.0 | 2290.0 | Motif | Note=LXXLL |
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Fusion Protein-Protein Interaction |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
Gene | PPI interactors |
Protein-protein interactors based on sequence similarity (STRING) |
Gene | STRING network |
SASH1 | |
ARID1B |
- Retained interactions in fusion protein (protein functional feature from UniProt). |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost interactions due to fusion (protein functional feature from UniProt). |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to SASH1-ARID1B |
Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to SASH1-ARID1B |
Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SASH1 | C2675711 | Dyschromatosis Universalis Hereditaria 1 | 6 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | SASH1 | C3492944 | Lentiginosis Profusa | 1 | ORPHANET |