UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:SCAP-CAMK2G

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SCAP-CAMK2G
FusionPDB ID: 79489
FusionGDB2.0 ID: 79489
HgeneTgene
Gene symbol

SCAP

CAMK2G

Gene ID

22937

818

Gene nameSREBF chaperonecalcium/calmodulin dependent protein kinase II gamma
Synonyms-CAMK|CAMK-II|CAMKG|MRD59
Cytomap

3p21.31

10q22.2

Type of geneprotein-codingprotein-coding
Descriptionsterol regulatory element-binding protein cleavage-activating proteinSREBP cleavage-activating proteincalcium/calmodulin-dependent protein kinase type II subunit gammacaMK-II subunit gammacalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
Modification date2020031320200313
UniProtAcc.

Q13555

Ensembl transtripts involved in fusion geneENST idsENST00000265565, ENST00000441517, 
ENST00000465628, ENST00000545718, 
ENST00000444854, ENST00000472912, 
ENST00000305762, ENST00000322635, 
ENST00000322680, ENST00000351293, 
ENST00000372765, ENST00000394762, 
ENST00000423381, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 8 X 6=3369 X 8 X 6=432
# samples 1211
** MAII scorelog2(12/336*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/432*10)=-1.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SCAP [Title/Abstract] AND CAMK2G [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SCAP(47466975)-CAMK2G(75620647), # samples:1
Anticipated loss of major functional domain due to fusion event.SCAP-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCAP-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SCAP-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SCAP-CAMK2G seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SCAP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAMK2G (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315334SCAPchr3

47466975

-CAMK2Gchr10

75620647

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265565SCAPchr347466975-ENST00000351293CAMK2Gchr1075620647-4795145014432777444
ENST00000265565SCAPchr347466975-ENST00000322635CAMK2Gchr1075620647-4891145014432873476
ENST00000265565SCAPchr347466975-ENST00000394762CAMK2Gchr1075620647-4909145014432891482
ENST00000265565SCAPchr347466975-ENST00000423381CAMK2Gchr1075620647-5074145014433056537
ENST00000265565SCAPchr347466975-ENST00000322680CAMK2Gchr1075620647-4978145014432960505
ENST00000265565SCAPchr347466975-ENST00000305762CAMK2Gchr1075620647-3110145014432879478
ENST00000265565SCAPchr347466975-ENST00000372765CAMK2Gchr1075620647-3071145014432840465
ENST00000441517SCAPchr347466975-ENST00000351293CAMK2Gchr1075620647-40467016942028444
ENST00000441517SCAPchr347466975-ENST00000322635CAMK2Gchr1075620647-41427016942124476
ENST00000441517SCAPchr347466975-ENST00000394762CAMK2Gchr1075620647-41607016942142482
ENST00000441517SCAPchr347466975-ENST00000423381CAMK2Gchr1075620647-43257016942307537
ENST00000441517SCAPchr347466975-ENST00000322680CAMK2Gchr1075620647-42297016942211505
ENST00000441517SCAPchr347466975-ENST00000305762CAMK2Gchr1075620647-23617016942130478
ENST00000441517SCAPchr347466975-ENST00000372765CAMK2Gchr1075620647-23227016942091465

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265565ENST00000351293SCAPchr347466975-CAMK2Gchr1075620647-0.0020563580.9979436
ENST00000265565ENST00000322635SCAPchr347466975-CAMK2Gchr1075620647-0.0024097860.9975902
ENST00000265565ENST00000394762SCAPchr347466975-CAMK2Gchr1075620647-0.0029047720.9970952
ENST00000265565ENST00000423381SCAPchr347466975-CAMK2Gchr1075620647-0.0045132490.9954867
ENST00000265565ENST00000322680SCAPchr347466975-CAMK2Gchr1075620647-0.0027836810.99721634
ENST00000265565ENST00000305762SCAPchr347466975-CAMK2Gchr1075620647-0.0029420520.9970579
ENST00000265565ENST00000372765SCAPchr347466975-CAMK2Gchr1075620647-0.0034321210.99656785
ENST00000441517ENST00000351293SCAPchr347466975-CAMK2Gchr1075620647-0.0022381070.99776185
ENST00000441517ENST00000322635SCAPchr347466975-CAMK2Gchr1075620647-0.0026767710.9973232
ENST00000441517ENST00000394762SCAPchr347466975-CAMK2Gchr1075620647-0.0032234110.99677664
ENST00000441517ENST00000423381SCAPchr347466975-CAMK2Gchr1075620647-0.0052520640.99474794
ENST00000441517ENST00000322680SCAPchr347466975-CAMK2Gchr1075620647-0.0031076210.9968924
ENST00000441517ENST00000305762SCAPchr347466975-CAMK2Gchr1075620647-0.0035020090.996498
ENST00000441517ENST00000372765SCAPchr347466975-CAMK2Gchr1075620647-0.0042861930.99571383

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>79489_79489_1_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000265565_CAMK2G_chr10_75620647_ENST00000305762_length(amino acids)=478AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLL
NKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEA
INNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSE

--------------------------------------------------------------

>79489_79489_2_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000265565_CAMK2G_chr10_75620647_ENST00000322635_length(amino acids)=476AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSS
APASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAIN
NGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEET

--------------------------------------------------------------

>79489_79489_3_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000265565_CAMK2G_chr10_75620647_ENST00000322680_length(amino acids)=505AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLL
NKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAG
MQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIG

--------------------------------------------------------------

>79489_79489_4_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000265565_CAMK2G_chr10_75620647_ENST00000351293_length(amino acids)=444AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLL
NKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDF

--------------------------------------------------------------

>79489_79489_5_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000265565_CAMK2G_chr10_75620647_ENST00000372765_length(amino acids)=465AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSS
APASPAASAAGLAGQAAKSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKIC
DPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWL

--------------------------------------------------------------

>79489_79489_6_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000265565_CAMK2G_chr10_75620647_ENST00000394762_length(amino acids)=482AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLL
NKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQ
LIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRT

--------------------------------------------------------------

>79489_79489_7_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000265565_CAMK2G_chr10_75620647_ENST00000423381_length(amino acids)=537AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSS
APASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTE
DEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEG

--------------------------------------------------------------

>79489_79489_8_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000441517_CAMK2G_chr10_75620647_ENST00000305762_length(amino acids)=478AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLL
NKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEA
INNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSE

--------------------------------------------------------------

>79489_79489_9_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000441517_CAMK2G_chr10_75620647_ENST00000322635_length(amino acids)=476AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSS
APASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAIN
NGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEET

--------------------------------------------------------------

>79489_79489_10_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000441517_CAMK2G_chr10_75620647_ENST00000322680_length(amino acids)=505AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLL
NKKSDGGVKPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAG
MQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIG

--------------------------------------------------------------

>79489_79489_11_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000441517_CAMK2G_chr10_75620647_ENST00000351293_length(amino acids)=444AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLL
NKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDF

--------------------------------------------------------------

>79489_79489_12_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000441517_CAMK2G_chr10_75620647_ENST00000372765_length(amino acids)=465AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSS
APASPAASAAGLAGQAAKSLLNKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKIC
DPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWL

--------------------------------------------------------------

>79489_79489_13_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000441517_CAMK2G_chr10_75620647_ENST00000394762_length(amino acids)=482AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSAAKSLL
NKKSDGGVKEPQTTVVHNATDGIKGSTESCNTTTEDEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQ
LIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRT

--------------------------------------------------------------

>79489_79489_14_SCAP-CAMK2G_SCAP_chr3_47466975_ENST00000441517_CAMK2G_chr10_75620647_ENST00000423381_length(amino acids)=537AA_BP=2
MADHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPEN
LLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAY
DFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSS
APASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMPQSNNKNSLVSPAQEPAPLQTAMEPQTTVVHNATDGIKGSTESCNTTTE
DEDLKAAPLRTGNGSSVPEGRSSRDRTAPSAGMQPQPSLCSSAMRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEG

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:47466975/chr10:75620647)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAMK2G

Q13555

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. {ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-82346_284345.66666666666671280.0RegionLoop-1
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-8231_18345.66666666666671280.0Topological domainCytoplasmic
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823301_312345.66666666666671280.0Topological domainCytoplasmic
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823334_344345.66666666666671280.0Topological domainLumenal
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-82340_279345.66666666666671280.0Topological domainLumenal
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-82319_39345.66666666666671280.0TransmembraneHelical%3B Name%3D1
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823280_300345.66666666666671280.0TransmembraneHelical%3B Name%3D2
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823313_333345.66666666666671280.0TransmembraneHelical%3B Name%3D3
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000305762121283_29253.333333333333336631.0RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000305762121291_30153.333333333333336631.0RegionCalmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000305762121294_31653.333333333333336631.0RegionNote=Calmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000322635121283_29253.3333333333333361185.0RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000322635121291_30153.3333333333333361185.0RegionCalmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000322635121294_31653.3333333333333361185.0RegionNote=Calmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000322680121283_29253.3333333333333361212.3333333333333RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000322680121291_30153.3333333333333361212.3333333333333RegionCalmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000322680121294_31653.3333333333333361212.3333333333333RegionNote=Calmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000351293119283_29253.3333333333333361173.3333333333333RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000351293119291_30153.3333333333333361173.3333333333333RegionCalmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000351293119294_31653.3333333333333361173.3333333333333RegionNote=Calmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000394762120283_29253.3333333333333361189.3333333333333RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000394762120291_30153.3333333333333361189.3333333333333RegionCalmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000394762120294_31653.3333333333333361189.3333333333333RegionNote=Calmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000423381123283_29253.3333333333333361244.3333333333333RegionNote=Autoinhibitory domain
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000423381123291_30153.3333333333333361244.3333333333333RegionCalmodulin-binding
TgeneCAMK2Gchr3:47466975chr10:75620647ENST00000423381123294_31653.3333333333333361244.3333333333333RegionNote=Calmodulin-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823722_729345.66666666666671280.0Compositional biasNote=Poly-Leu
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823747_750345.66666666666671280.0Compositional biasNote=Poly-Arg
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823861_864345.66666666666671280.0Compositional biasNote=Poly-Pro
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118722_7290887.0Compositional biasNote=Poly-Leu
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118747_7500887.0Compositional biasNote=Poly-Arg
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118861_8640887.0Compositional biasNote=Poly-Pro
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823284_442345.66666666666671280.0DomainSSD
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118284_4420887.0DomainSSD
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823447_452345.66666666666671280.0MotifER export signal
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118447_4520887.0MotifER export signal
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823535_710345.66666666666671280.0RegionLoop-7
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-11846_2840887.0RegionLoop-1
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118535_7100887.0RegionLoop-7
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-8231005_1042345.66666666666671280.0RepeatNote=WD 3
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-8231077_1114345.66666666666671280.0RepeatNote=WD 4
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-8231117_1155345.66666666666671280.0RepeatNote=WD 5
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-8231158_1195345.66666666666671280.0RepeatNote=WD 6
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-8231197_1235345.66666666666671280.0RepeatNote=WD 7
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823771_811345.66666666666671280.0RepeatNote=WD 1
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823952_1002345.66666666666671280.0RepeatNote=WD 2
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-1181005_10420887.0RepeatNote=WD 3
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-1181077_11140887.0RepeatNote=WD 4
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-1181117_11550887.0RepeatNote=WD 5
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-1181158_11950887.0RepeatNote=WD 6
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-1181197_12350887.0RepeatNote=WD 7
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118771_8110887.0RepeatNote=WD 1
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118952_10020887.0RepeatNote=WD 2
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823366_401345.66666666666671280.0Topological domainCytoplasmic
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823423_423345.66666666666671280.0Topological domainLumenal
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823445_518345.66666666666671280.0Topological domainCytoplasmic
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823540_709345.66666666666671280.0Topological domainLumenal
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-1181_180887.0Topological domainCytoplasmic
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118301_3120887.0Topological domainCytoplasmic
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118334_3440887.0Topological domainLumenal
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118366_4010887.0Topological domainCytoplasmic
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-11840_2790887.0Topological domainLumenal
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118423_4230887.0Topological domainLumenal
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118445_5180887.0Topological domainCytoplasmic
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118540_7090887.0Topological domainLumenal
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823345_365345.66666666666671280.0TransmembraneHelical%3B Name%3D4
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823402_422345.66666666666671280.0TransmembraneHelical%3B Name%3D5
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823424_444345.66666666666671280.0TransmembraneHelical%3B Name%3D6
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823519_539345.66666666666671280.0TransmembraneHelical%3B Name%3D7
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823710_730345.66666666666671280.0TransmembraneHelical%3B Name%3D8
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-11819_390887.0TransmembraneHelical%3B Name%3D1
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118280_3000887.0TransmembraneHelical%3B Name%3D2
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118313_3330887.0TransmembraneHelical%3B Name%3D3
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118345_3650887.0TransmembraneHelical%3B Name%3D4
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118402_4220887.0TransmembraneHelical%3B Name%3D5
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118424_4440887.0TransmembraneHelical%3B Name%3D6
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118519_5390887.0TransmembraneHelical%3B Name%3D7
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118710_7300887.0TransmembraneHelical%3B Name%3D8
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000030576212114_27253.333333333333336631.0DomainProtein kinase
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000032263512114_27253.3333333333333361185.0DomainProtein kinase
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000032268012114_27253.3333333333333361212.3333333333333DomainProtein kinase
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000035129311914_27253.3333333333333361173.3333333333333DomainProtein kinase
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000039476212014_27253.3333333333333361189.3333333333333DomainProtein kinase
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000042338112314_27253.3333333333333361244.3333333333333DomainProtein kinase
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000030576212120_2853.333333333333336631.0Nucleotide bindingATP
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000032263512120_2853.3333333333333361185.0Nucleotide bindingATP
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000032268012120_2853.3333333333333361212.3333333333333Nucleotide bindingATP
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000035129311920_2853.3333333333333361173.3333333333333Nucleotide bindingATP
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000039476212020_2853.3333333333333361189.3333333333333Nucleotide bindingATP
TgeneCAMK2Gchr3:47466975chr10:75620647ENST0000042338112320_2853.3333333333333361244.3333333333333Nucleotide bindingATP


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SCAP
CAMK2G


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSCAPchr3:47466975chr10:75620647ENST00000265565-823731_1279345.66666666666671280.0SREBF2
HgeneSCAPchr3:47466975chr10:75620647ENST00000545718-118731_12790887.0SREBF2


Top

Related Drugs to SCAP-CAMK2G


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to SCAP-CAMK2G


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource