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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SENP2-MAP3K13

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SENP2-MAP3K13
FusionPDB ID: 80380
FusionGDB2.0 ID: 80380
HgeneTgene
Gene symbol

SENP2

MAP3K13

Gene ID

59343

9175

Gene nameSUMO specific peptidase 2mitogen-activated protein kinase kinase kinase 13
SynonymsAXAM2|SMT3IP2LZK|MEKK13|MLK
Cytomap

3q27.2

3q27.2

Type of geneprotein-codingprotein-coding
Descriptionsentrin-specific protease 2SMT3-specific isopeptidase 2SUMO1/sentrin/SMT3 specific peptidase 2SUMO1/sentrin/SMT3 specific protease 2sentrin (SUMO1) specific peptidase 2sentrin/SUMO-specific protease SENP2mitogen-activated protein kinase kinase kinase 13leucine zipper-bearing kinasemixed lineage kinase
Modification date2020031320200313
UniProtAcc.

O43283

Ensembl transtripts involved in fusion geneENST idsENST00000296257, ENST00000427465, 
ENST00000545472, ENST00000465201, 
ENST00000438798, ENST00000448876, 
ENST00000454237, ENST00000265026, 
ENST00000424227, ENST00000443863, 
ENST00000446828, ENST00000535426, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 12 X 10=156012 X 14 X 9=1512
# samples 1614
** MAII scorelog2(16/1560*10)=-3.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1512*10)=-3.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SENP2 [Title/Abstract] AND MAP3K13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SENP2(185344181)-MAP3K13(185181338), # samples:2
Anticipated loss of major functional domain due to fusion event.SENP2-MAP3K13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SENP2-MAP3K13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SENP2-MAP3K13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SENP2-MAP3K13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSENP2

GO:0016926

protein desumoylation

20194620

HgeneSENP2

GO:0031397

negative regulation of protein ubiquitination

22028379

TgeneMAP3K13

GO:0000186

activation of MAPKK activity

11726277

TgeneMAP3K13

GO:0006468

protein phosphorylation

9353328|11726277

TgeneMAP3K13

GO:0007254

JNK cascade

9353328|11726277

TgeneMAP3K13

GO:0046777

protein autophosphorylation

9353328

TgeneMAP3K13

GO:0051092

positive regulation of NF-kappaB transcription factor activity

12492477


check buttonFusion gene breakpoints across SENP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP3K13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A25B-01ASENP2chr3

185304302

+MAP3K13chr3

185190763

+
ChimerDB4UCSTCGA-N8-A56S-01ASENP2chr3

185344181

+MAP3K13chr3

185181338

+
ChimerDB4UCSTCGA-N8-A56SSENP2chr3

185344181

+MAP3K13chr3

185181338

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296257SENP2chr3185304302+ENST00000446828MAP3K13chr3185190763+189234191598529
ENST00000296257SENP2chr3185304302+ENST00000424227MAP3K13chr3185190763+159934191598529
ENST00000296257SENP2chr3185304302+ENST00000443863MAP3K13chr3185190763+195434191598529
ENST00000296257SENP2chr3185304302+ENST00000535426MAP3K13chr3185190763+195434191598529
ENST00000296257SENP2chr3185304302+ENST00000265026MAP3K13chr3185190763+824034191598529
ENST00000545472SENP2chr3185344181+ENST00000446828MAP3K13chr3185181338+362117052833271099
ENST00000545472SENP2chr3185344181+ENST00000424227MAP3K13chr3185181338+332817052833271100
ENST00000545472SENP2chr3185344181+ENST00000443863MAP3K13chr3185181338+368317052833271099
ENST00000545472SENP2chr3185344181+ENST00000535426MAP3K13chr3185181338+368317052833271099
ENST00000545472SENP2chr3185344181+ENST00000265026MAP3K13chr3185181338+996917052833271099
ENST00000296257SENP2chr3185344181+ENST00000446828MAP3K13chr3185181338+38631947935691186
ENST00000296257SENP2chr3185344181+ENST00000424227MAP3K13chr3185181338+35701947935691186
ENST00000296257SENP2chr3185344181+ENST00000443863MAP3K13chr3185181338+39251947935691186
ENST00000296257SENP2chr3185344181+ENST00000535426MAP3K13chr3185181338+39251947935691186
ENST00000296257SENP2chr3185344181+ENST00000265026MAP3K13chr3185181338+102111947935691186
ENST00000427465SENP2chr3185344181+ENST00000446828MAP3K13chr3185181338+367517594873381964
ENST00000427465SENP2chr3185344181+ENST00000424227MAP3K13chr3185181338+338217594873381965
ENST00000427465SENP2chr3185344181+ENST00000443863MAP3K13chr3185181338+373717594873381964
ENST00000427465SENP2chr3185344181+ENST00000535426MAP3K13chr3185181338+373717594873381964
ENST00000427465SENP2chr3185344181+ENST00000265026MAP3K13chr3185181338+1002317594873381964

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296257ENST00000446828SENP2chr3185304302+MAP3K13chr3185190763+0.081082680.91891736
ENST00000296257ENST00000424227SENP2chr3185304302+MAP3K13chr3185190763+0.072604660.92739534
ENST00000296257ENST00000443863SENP2chr3185304302+MAP3K13chr3185190763+0.085719830.9142801
ENST00000296257ENST00000535426SENP2chr3185304302+MAP3K13chr3185190763+0.085719830.9142801
ENST00000296257ENST00000265026SENP2chr3185304302+MAP3K13chr3185190763+0.0133624330.9866376
ENST00000545472ENST00000446828SENP2chr3185344181+MAP3K13chr3185181338+0.000547040.999453
ENST00000545472ENST00000424227SENP2chr3185344181+MAP3K13chr3185181338+0.0005840080.999416
ENST00000545472ENST00000443863SENP2chr3185344181+MAP3K13chr3185181338+0.000525330.9994747
ENST00000545472ENST00000535426SENP2chr3185344181+MAP3K13chr3185181338+0.000525330.9994747
ENST00000545472ENST00000265026SENP2chr3185344181+MAP3K13chr3185181338+0.0001871980.9998128
ENST00000296257ENST00000446828SENP2chr3185344181+MAP3K13chr3185181338+0.0007085960.9992914
ENST00000296257ENST00000424227SENP2chr3185344181+MAP3K13chr3185181338+0.00076270.9992373
ENST00000296257ENST00000443863SENP2chr3185344181+MAP3K13chr3185181338+0.0006814590.9993186
ENST00000296257ENST00000535426SENP2chr3185344181+MAP3K13chr3185181338+0.0006814590.9993186
ENST00000296257ENST00000265026SENP2chr3185344181+MAP3K13chr3185181338+0.000239860.9997601
ENST00000427465ENST00000446828SENP2chr3185344181+MAP3K13chr3185181338+0.001002310.99899775
ENST00000427465ENST00000424227SENP2chr3185344181+MAP3K13chr3185181338+0.0010597030.9989403
ENST00000427465ENST00000443863SENP2chr3185344181+MAP3K13chr3185181338+0.000958060.999042
ENST00000427465ENST00000535426SENP2chr3185344181+MAP3K13chr3185181338+0.000958060.999042
ENST00000427465ENST00000265026SENP2chr3185344181+MAP3K13chr3185181338+0.0003704290.9996295

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>80380_80380_1_SENP2-MAP3K13_SENP2_chr3_185304302_ENST00000296257_MAP3K13_chr3_185190763_ENST00000265026_length(amino acids)=529AA_BP=110
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPH
PTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADC
WRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGT
PPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDD

--------------------------------------------------------------

>80380_80380_2_SENP2-MAP3K13_SENP2_chr3_185304302_ENST00000296257_MAP3K13_chr3_185190763_ENST00000424227_length(amino acids)=529AA_BP=110
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPH
PTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADC
WRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGT
PPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDD

--------------------------------------------------------------

>80380_80380_3_SENP2-MAP3K13_SENP2_chr3_185304302_ENST00000296257_MAP3K13_chr3_185190763_ENST00000443863_length(amino acids)=529AA_BP=110
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPH
PTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADC
WRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGT
PPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDD

--------------------------------------------------------------

>80380_80380_4_SENP2-MAP3K13_SENP2_chr3_185304302_ENST00000296257_MAP3K13_chr3_185190763_ENST00000446828_length(amino acids)=529AA_BP=110
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPH
PTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADC
WRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGT
PPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDD

--------------------------------------------------------------

>80380_80380_5_SENP2-MAP3K13_SENP2_chr3_185304302_ENST00000296257_MAP3K13_chr3_185190763_ENST00000535426_length(amino acids)=529AA_BP=110
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPH
PTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADC
WRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGT
PPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDD

--------------------------------------------------------------

>80380_80380_6_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000296257_MAP3K13_chr3_185181338_ENST00000265026_length(amino acids)=1186AA_BP=644
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSS
SCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEES
GKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLC
SLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDME
KEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNL
FEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTC
KYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKEL
IKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRH
RRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALR
SPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENA
QSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEE
GNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGEC

--------------------------------------------------------------

>80380_80380_7_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000296257_MAP3K13_chr3_185181338_ENST00000424227_length(amino acids)=1186AA_BP=644
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSS
SCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEES
GKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLC
SLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDME
KEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNL
FEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTC
KYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKEL
IKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRH
RRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALR
SPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENA
QSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEE
GNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGEC

--------------------------------------------------------------

>80380_80380_8_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000296257_MAP3K13_chr3_185181338_ENST00000443863_length(amino acids)=1186AA_BP=644
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSS
SCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEES
GKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLC
SLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDME
KEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNL
FEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTC
KYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKEL
IKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRH
RRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALR
SPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENA
QSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEE
GNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGEC

--------------------------------------------------------------

>80380_80380_9_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000296257_MAP3K13_chr3_185181338_ENST00000446828_length(amino acids)=1186AA_BP=644
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSS
SCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEES
GKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLC
SLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDME
KEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNL
FEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTC
KYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKEL
IKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRH
RRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALR
SPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENA
QSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEE
GNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGEC

--------------------------------------------------------------

>80380_80380_10_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000296257_MAP3K13_chr3_185181338_ENST00000535426_length(amino acids)=1186AA_BP=644
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSS
SCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEES
GKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLC
SLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDME
KEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNL
FEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTC
KYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKEL
IKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRH
RRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALR
SPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENA
QSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEE
GNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGEC

--------------------------------------------------------------

>80380_80380_11_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000427465_MAP3K13_chr3_185181338_ENST00000265026_length(amino acids)=964AA_BP=422
MPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPV
TSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEV
SARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEV
INFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRIC
EILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDE
ELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKS
GMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLH
HHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWG
CCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSG
DDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSH

--------------------------------------------------------------

>80380_80380_12_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000427465_MAP3K13_chr3_185181338_ENST00000424227_length(amino acids)=965AA_BP=422
MPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPV
TSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEV
SARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEV
INFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRIC
EILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDE
ELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKS
GMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLH
HHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWG
CCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSG
DDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSH

--------------------------------------------------------------

>80380_80380_13_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000427465_MAP3K13_chr3_185181338_ENST00000443863_length(amino acids)=964AA_BP=422
MPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPV
TSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEV
SARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEV
INFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRIC
EILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDE
ELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKS
GMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLH
HHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWG
CCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSG
DDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSH

--------------------------------------------------------------

>80380_80380_14_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000427465_MAP3K13_chr3_185181338_ENST00000446828_length(amino acids)=964AA_BP=422
MPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPV
TSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEV
SARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEV
INFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRIC
EILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDE
ELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKS
GMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLH
HHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWG
CCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSG
DDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSH

--------------------------------------------------------------

>80380_80380_15_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000427465_MAP3K13_chr3_185181338_ENST00000535426_length(amino acids)=964AA_BP=422
MPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPV
TSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEV
SARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEV
INFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRIC
EILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDE
ELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKS
GMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLH
HHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWG
CCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSG
DDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSH

--------------------------------------------------------------

>80380_80380_16_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000545472_MAP3K13_chr3_185181338_ENST00000265026_length(amino acids)=1099AA_BP=557
MDSHPCLYCGPQDSEGTNWQTSPSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFS
NSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMIS
EESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRG
PLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTE
DMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKG
VNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGM
FTCKYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMRE
KELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSK
PRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAA
ALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLL
ENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSD
GEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSD

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>80380_80380_17_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000545472_MAP3K13_chr3_185181338_ENST00000424227_length(amino acids)=1100AA_BP=557
MDSHPCLYCGPQDSEGTNWQTSPSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFS
NSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMIS
EESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRG
PLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTE
DMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKG
VNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGM
FTCKYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMRE
KELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSK
PRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAA
ALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLL
ENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSD
GEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSD

--------------------------------------------------------------

>80380_80380_18_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000545472_MAP3K13_chr3_185181338_ENST00000443863_length(amino acids)=1099AA_BP=557
MDSHPCLYCGPQDSEGTNWQTSPSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFS
NSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMIS
EESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRG
PLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTE
DMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKG
VNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGM
FTCKYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMRE
KELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSK
PRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAA
ALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLL
ENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSD
GEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSD

--------------------------------------------------------------

>80380_80380_19_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000545472_MAP3K13_chr3_185181338_ENST00000446828_length(amino acids)=1099AA_BP=557
MDSHPCLYCGPQDSEGTNWQTSPSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFS
NSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMIS
EESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRG
PLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTE
DMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKG
VNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGM
FTCKYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMRE
KELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSK
PRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAA
ALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLL
ENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSD
GEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSD

--------------------------------------------------------------

>80380_80380_20_SENP2-MAP3K13_SENP2_chr3_185344181_ENST00000545472_MAP3K13_chr3_185181338_ENST00000535426_length(amino acids)=1099AA_BP=557
MDSHPCLYCGPQDSEGTNWQTSPSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFS
NSSSCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMIS
EESGKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRG
PLCSLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTE
DMEKEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKG
VNLFEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGM
FTCKYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMRE
KELIKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSK
PRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAA
ALRSPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLL
ENAQSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSD
GEEGNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSD

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:185344181/chr3:185181338)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP3K13

O43283

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B. {ECO:0000269|PubMed:11726277, ECO:0000269|PubMed:12492477, ECO:0000269|PubMed:9353328}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSENP2chr3:185304302chr3:185190763ENST00000296257+11728_3133.666666666666664590.0MotifNuclear localization signal
HgeneSENP2chr3:185344181chr3:185181338ENST00000296257+161728_31569.0590.0MotifNuclear localization signal
HgeneSENP2chr3:185344181chr3:185181338ENST00000296257+1617317_332569.0590.0MotifNote=Nuclear export signal
HgeneSENP2chr3:185344181chr3:185181338ENST00000296257+161746_51569.0590.0MotifNuclear localization signal
HgeneSENP2chr3:185344181chr3:185181338ENST00000296257+1617396_560569.0590.0RegionNote=Protease
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000265026914815_828547.6666666666666967.0RegionAcidic
TgeneMAP3K13chr3:185304302chr3:185190763ENST000004242271015815_828547.6666666666666967.0RegionAcidic
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000443863914433_454403.6666666666667823.0RegionNote=Leucine-zipper 1
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000443863914486_507403.6666666666667823.0RegionNote=Leucine-zipper 2
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000443863914815_828403.6666666666667823.0RegionAcidic
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000446828813433_454340.6666666666667760.0RegionNote=Leucine-zipper 1
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000446828813486_507340.6666666666667760.0RegionNote=Leucine-zipper 2
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000446828813815_828340.6666666666667760.0RegionAcidic
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000535426813433_454403.6666666666667823.0RegionNote=Leucine-zipper 1
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000535426813486_507403.6666666666667823.0RegionNote=Leucine-zipper 2
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000535426813815_828403.6666666666667823.0RegionAcidic
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000265026614433_454426.0967.0RegionNote=Leucine-zipper 1
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000265026614486_507426.0967.0RegionNote=Leucine-zipper 2
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000265026614815_828426.0967.0RegionAcidic
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000424227715433_454426.0967.0RegionNote=Leucine-zipper 1
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000424227715486_507426.0967.0RegionNote=Leucine-zipper 2
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000424227715815_828426.0967.0RegionAcidic
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000443863614433_454282.0823.0RegionNote=Leucine-zipper 1
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000443863614486_507282.0823.0RegionNote=Leucine-zipper 2
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000443863614815_828282.0823.0RegionAcidic
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000446828513433_454219.0760.0RegionNote=Leucine-zipper 1
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000446828513486_507219.0760.0RegionNote=Leucine-zipper 2
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000446828513815_828219.0760.0RegionAcidic
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000535426513433_454282.0823.0RegionNote=Leucine-zipper 1
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000535426513486_507282.0823.0RegionNote=Leucine-zipper 2
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000535426513815_828282.0823.0RegionAcidic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSENP2chr3:185304302chr3:185190763ENST00000296257+117317_33233.666666666666664590.0MotifNote=Nuclear export signal
HgeneSENP2chr3:185304302chr3:185190763ENST00000296257+11746_5133.666666666666664590.0MotifNuclear localization signal
HgeneSENP2chr3:185304302chr3:185190763ENST00000296257+117396_56033.666666666666664590.0RegionNote=Protease
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000265026914168_409547.6666666666666967.0DomainProtein kinase
TgeneMAP3K13chr3:185304302chr3:185190763ENST000004242271015168_409547.6666666666666967.0DomainProtein kinase
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000443863914168_409403.6666666666667823.0DomainProtein kinase
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000446828813168_409340.6666666666667760.0DomainProtein kinase
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000535426813168_409403.6666666666667823.0DomainProtein kinase
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000265026614168_409426.0967.0DomainProtein kinase
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000424227715168_409426.0967.0DomainProtein kinase
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000443863614168_409282.0823.0DomainProtein kinase
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000446828513168_409219.0760.0DomainProtein kinase
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000535426513168_409282.0823.0DomainProtein kinase
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000265026914174_182547.6666666666666967.0Nucleotide bindingATP
TgeneMAP3K13chr3:185304302chr3:185190763ENST000004242271015174_182547.6666666666666967.0Nucleotide bindingATP
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000443863914174_182403.6666666666667823.0Nucleotide bindingATP
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000446828813174_182340.6666666666667760.0Nucleotide bindingATP
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000535426813174_182403.6666666666667823.0Nucleotide bindingATP
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000265026614174_182426.0967.0Nucleotide bindingATP
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000424227715174_182426.0967.0Nucleotide bindingATP
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000443863614174_182282.0823.0Nucleotide bindingATP
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000446828513174_182219.0760.0Nucleotide bindingATP
TgeneMAP3K13chr3:185344181chr3:185181338ENST00000535426513174_182282.0823.0Nucleotide bindingATP
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000265026914433_454547.6666666666666967.0RegionNote=Leucine-zipper 1
TgeneMAP3K13chr3:185304302chr3:185190763ENST00000265026914486_507547.6666666666666967.0RegionNote=Leucine-zipper 2
TgeneMAP3K13chr3:185304302chr3:185190763ENST000004242271015433_454547.6666666666666967.0RegionNote=Leucine-zipper 1
TgeneMAP3K13chr3:185304302chr3:185190763ENST000004242271015486_507547.6666666666666967.0RegionNote=Leucine-zipper 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1923_SENP2_185344181_MAP3K13_185181338_ranked_0.pdbSENP2185344181185344181ENST00000265026MAP3K13chr3185181338+
MRMELSGRAGGGDVRSGGGRGPLVALGTLYLWALESRHKSATELWRWWLRRRRRQRRRQLWGLRLGVCRPPLLLGPGMYRWLVRILGTIF
RFCDRSVPPARALLKRRRSDSTLFSTVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVTSACNGTRNVAPSGEVFSNSS
SCELTGSGSWNNMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLNSEGCNRRPGGRRHSKGNPESSLMWKPQEQAVTEMISEES
GKGLRRPHCTVEEGVQKEEREKYRKLLERLKESGHGNSVCPVTSNYHSSQRSQMDTLKTKGWGEEQNHGVKTTQFVPKQYRLVETRGPLC
SLRSEKRCSKGKITDTETMVGIRFENESRRGYQLEPDLSEEVSARLRLGSGSNGLLRRKVSIIETKEKNCSGKERDRRTDDLLELTEDME
KEISNALGHGPQDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERNKKQGYPALHVFSTFFYPKLKSGGYQAVKRWTKGVNL
FEQEIILVPIHRKVHWSLVVIDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNSDLNLLEWTHHSMKPHEIPQQLNGSDCGMFTC
KYADYISRDKPITFTQAEWREEVKKHFEKIKSEGTCIHRLDEELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKEL
IKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTASPLSGSPKMSTSSSKSRYRSKPRH
RRGNSRGSHSDFAAILKNQPAQENSPHPTYLHQAQSQYPSLHHHNSLQQQYQQPPPAMSQSHHPRLNMHGQDIATCANNLRYFGPAAALR
SPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADAYDPCLQCRPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLENA
QSSEKTEENEFSGCRSESSLGTSHLGTPPALPRKTRPLQKSGDDSSEEEEGEVDSEVEFPRRQRPHRCISSCQSYSTFSSENFSVSDGEE
GNTSDHSNSPDELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPMQFEESDCDSSDGEC
1186


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SENP2_pLDDT.png
all structure
all structure
MAP3K13_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SENP2
MAP3K13


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SENP2-MAP3K13


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SENP2-MAP3K13


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource