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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ATP6V0A1-STAT3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ATP6V0A1-STAT3
	FusionPDB ID: 8093
	FusionGDB2.0 ID: 8093
		Hgene	Tgene
	Gene symbol	ATP6V0A1	STAT3
	Gene ID	535	6774
	Gene name	ATPase H+ transporting V0 subunit a1	signal transducer and activator of transcription 3
	Synonyms	ATP6N1\|ATP6N1A\|Stv1\|VPP1\|Vph1\|a1	ADMIO\|ADMIO1\|APRF\|HIES
	Cytomap	17q21.2	17q21.2
	Type of gene	protein-coding	protein-coding
	Description	V-type proton ATPase 116 kDa subunit a isoform 1V-type proton ATPase 116 kDa subunit aATPase, H+ transporting, lysosomal V0 subunit a1ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD)H(+)-transporting two-sector ATPase,	signal transducer and activator of transcription 3DNA-binding protein APRFacute-phase response factor
	Modification date	20200324	20200329
	UniProtAcc	Q93050	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264649, ENST00000343619, ENST00000393829, ENST00000537728, ENST00000544137, ENST00000546249, ENST00000585525, ENST00000587797,	ENST00000389272, ENST00000404395, ENST00000588969, ENST00000590776, ENST00000264657, ENST00000585517,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	20 X 17 X 9=3060	17 X 21 X 8=2856
	# samples	22	21
	** MAII score	log2(22/3060*10)=-3.79795622405535 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/2856*10)=-3.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ATP6V0A1 [Title/Abstract] AND STAT3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ATP6V0A1(40666478)-STAT3(40498731), # samples:2
Anticipated loss of major functional domain due to fusion event.	ATP6V0A1-STAT3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATP6V0A1-STAT3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	STAT3	GO:0006355	regulation of transcription, DNA-templated	15664994\|17344214
Tgene	STAT3	GO:0006606	protein import into nucleus	18234692
Tgene	STAT3	GO:0010507	negative regulation of autophagy	26962683
Tgene	STAT3	GO:0010628	positive regulation of gene expression	23820254
Tgene	STAT3	GO:0030522	intracellular receptor signaling pathway	17324931
Tgene	STAT3	GO:0032355	response to estradiol	12552091
Tgene	STAT3	GO:0032870	cellular response to hormone stimulus	12552091
Tgene	STAT3	GO:0033210	leptin-mediated signaling pathway	17344214
Tgene	STAT3	GO:0035278	miRNA mediated inhibition of translation	23820254
Tgene	STAT3	GO:0044320	cellular response to leptin stimulus	17344214
Tgene	STAT3	GO:0044321	response to leptin	17344214
Tgene	STAT3	GO:0045893	positive regulation of transcription, DNA-templated	19390056
Tgene	STAT3	GO:0045944	positive regulation of transcription by RNA polymerase II	17324931\|27050391\|31462771
Tgene	STAT3	GO:0051726	regulation of cell cycle	17344214
Tgene	STAT3	GO:0060396	growth hormone receptor signaling pathway	10925297
Tgene	STAT3	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway	12552091
Tgene	STAT3	GO:0070102	interleukin-6-mediated signaling pathway	12359225\|12552091\|17324931\|24429361
Tgene	STAT3	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	19390056\|23820254
Tgene	STAT3	GO:2000637	positive regulation of gene silencing by miRNA	23820254

Fusion gene breakpoints across ATP6V0A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STAT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A8NH-01A	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-
ChimerDB4	ESCA	TCGA-L5-A8NH	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393829	ATP6V0A1	chr17	40666478	+	ENST00000264657	STAT3	chr17	40498731	-	7175	2569	74	4753	1559
ENST00000393829	ATP6V0A1	chr17	40666478	+	ENST00000585517	STAT3	chr17	40498731	-	5595	2569	74	4609	1511
ENST00000546249	ATP6V0A1	chr17	40666478	+	ENST00000264657	STAT3	chr17	40498731	-	7193	2587	74	4771	1565
ENST00000546249	ATP6V0A1	chr17	40666478	+	ENST00000585517	STAT3	chr17	40498731	-	5613	2587	74	4627	1517
ENST00000537728	ATP6V0A1	chr17	40666478	+	ENST00000264657	STAT3	chr17	40498731	-	7012	2406	40	4590	1516
ENST00000537728	ATP6V0A1	chr17	40666478	+	ENST00000585517	STAT3	chr17	40498731	-	5432	2406	40	4446	1468
ENST00000264649	ATP6V0A1	chr17	40666478	+	ENST00000264657	STAT3	chr17	40498731	-	7160	2554	38	4738	1566
ENST00000264649	ATP6V0A1	chr17	40666478	+	ENST00000585517	STAT3	chr17	40498731	-	5580	2554	38	4594	1518
ENST00000585525	ATP6V0A1	chr17	40666478	+	ENST00000264657	STAT3	chr17	40498731	-	7020	2414	30	4598	1522
ENST00000585525	ATP6V0A1	chr17	40666478	+	ENST00000585517	STAT3	chr17	40498731	-	5440	2414	30	4454	1474
ENST00000343619	ATP6V0A1	chr17	40666478	+	ENST00000264657	STAT3	chr17	40498731	-	7149	2543	30	4727	1565
ENST00000343619	ATP6V0A1	chr17	40666478	+	ENST00000585517	STAT3	chr17	40498731	-	5569	2543	30	4583	1517
ENST00000544137	ATP6V0A1	chr17	40666478	+	ENST00000264657	STAT3	chr17	40498731	-	6101	1495	14	3679	1221
ENST00000544137	ATP6V0A1	chr17	40666478	+	ENST00000585517	STAT3	chr17	40498731	-	4521	1495	14	3535	1173

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393829	ENST00000264657	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.000612246	0.99938774
ENST00000393829	ENST00000585517	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.001603685	0.99839634
ENST00000546249	ENST00000264657	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.000375266	0.9996247
ENST00000546249	ENST00000585517	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.000705942	0.99929404
ENST00000537728	ENST00000264657	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.000538729	0.99946123
ENST00000537728	ENST00000585517	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.001433655	0.9985663
ENST00000264649	ENST00000264657	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.000622212	0.9993777
ENST00000264649	ENST00000585517	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.001641209	0.9983588
ENST00000585525	ENST00000264657	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.000333527	0.99966645
ENST00000585525	ENST00000585517	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.000608305	0.9993917
ENST00000343619	ENST00000264657	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.00036105	0.9996389
ENST00000343619	ENST00000585517	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.000658927	0.9993411
ENST00000544137	ENST00000264657	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.000368224	0.99963176
ENST00000544137	ENST00000585517	ATP6V0A1	chr17	40666478	+	STAT3	chr17	40498731	-	0.000828147	0.99917185

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8093_8093_1_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000264649_STAT3_chr17_40498731_ENST00000264657_length(amino acids)=1566AA_BP=839
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQM
ADPDLLEESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNR
VKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAE
VWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGH
GILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQL
NPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFY
KWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGP
TEEDAEIIQHDQLSTHSEDADEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFF
FTAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARI
VARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQS
VTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKL
EELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGD
VAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVI
SNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENM
AGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQ
LNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSL

--------------------------------------------------------------

>8093_8093_2_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000264649_STAT3_chr17_40498731_ENST00000585517_length(amino acids)=1518AA_BP=839
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQM
ADPDLLEESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNR
VKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAE
VWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGH
GILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQL
NPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFY
KWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGP
TEEDAEIIQHDQLSTHSEDADEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFF
FTAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARI
VARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQS
VTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKL
EELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGD
VAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVI
SNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENM
AGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQ

--------------------------------------------------------------

>8093_8093_3_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000343619_STAT3_chr17_40498731_ENST00000264657_length(amino acids)=1565AA_BP=838
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLE
ESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEG
FRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTD
LDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLF
AVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGV
FGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDA
HTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEI
IQHDQLSTHSEDADEPSEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFF
TAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIV
ARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSV
TRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLE
ELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDV
AALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVIS
NICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMA
GKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQL
NNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLM

--------------------------------------------------------------

>8093_8093_4_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000343619_STAT3_chr17_40498731_ENST00000585517_length(amino acids)=1517AA_BP=838
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLE
ESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEG
FRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTD
LDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLF
AVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGV
FGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDA
HTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEI
IQHDQLSTHSEDADEPSEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFF
TAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIV
ARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSV
TRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLE
ELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDV
AALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVIS
NICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMA
GKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQL

--------------------------------------------------------------

>8093_8093_5_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000393829_STAT3_chr17_40498731_ENST00000264657_length(amino acids)=1559AA_BP=832
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLE
ESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEG
FRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTD
LDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLF
AVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGV
FGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDA
HTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEI
IQHDQLSTHSEDADEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATL
TVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWE
ESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQ
QLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKV
SYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGS
RKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMP
NAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSF
WVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFA
EIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNG

--------------------------------------------------------------

>8093_8093_6_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000393829_STAT3_chr17_40498731_ENST00000585517_length(amino acids)=1511AA_BP=832
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLE
ESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEG
FRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTD
LDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLF
AVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGV
FGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDA
HTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEI
IQHDQLSTHSEDADEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATL
TVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWE
ESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQ
QLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKV
SYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGS
RKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMP
NAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSF
WVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFA

--------------------------------------------------------------

>8093_8093_7_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000537728_STAT3_chr17_40498731_ENST00000264657_length(amino acids)=1516AA_BP=789
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEMADPDLLEESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCR
GNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRV
LQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTY
GFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGL
IYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGV
SLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVV
ALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDADEFDFGDTMVHQAIHTIEYCLGCISNTASY
LRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEI
DQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKR
VQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWK
RRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPD
RPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRA
NCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSS
TTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPG
TFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEH

--------------------------------------------------------------

>8093_8093_8_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000537728_STAT3_chr17_40498731_ENST00000585517_length(amino acids)=1468AA_BP=789
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEMADPDLLEESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCR
GNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRV
LQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTY
GFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGL
IYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGV
SLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVV
ALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDADEFDFGDTMVHQAIHTIEYCLGCISNTASY
LRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEI
DQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKR
VQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWK
RRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPD
RPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRA
NCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSS
TTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPG
TFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEH

--------------------------------------------------------------

>8093_8093_9_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000544137_STAT3_chr17_40498731_ENST00000264657_length(amino acids)=1221AA_BP=494
MAAVVSVAVAVAEFGGWREIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLF
AVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEET
LRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLF
GYLVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNF
GGIRVGNGPTEEDAEIIQHDQLSTHSEDADEPSEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIG
LSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQF
LQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTL
KSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITS
LAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELN
YQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQG
LKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNY
SGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDIS
GKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCS

--------------------------------------------------------------

>8093_8093_10_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000544137_STAT3_chr17_40498731_ENST00000585517_length(amino acids)=1173AA_BP=494
MAAVVSVAVAVAEFGGWREIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLF
AVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEET
LRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLF
GYLVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNF
GGIRVGNGPTEEDAEIIQHDQLSTHSEDADEPSEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIG
LSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQF
LQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTL
KSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITS
LAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELN
YQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQG
LKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNY
SGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDIS
GKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPFIDA

--------------------------------------------------------------

>8093_8093_11_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000546249_STAT3_chr17_40498731_ENST00000264657_length(amino acids)=1565AA_BP=838
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLE
ESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEG
FRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTD
LDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLF
AVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGV
FGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDA
HTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEI
IQHDQLSTHSEDADEPSTSGQFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFF
TAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIV
ARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSV
TRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLE
ELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDV
AALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVIS
NICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMA
GKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQL
NNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLM

--------------------------------------------------------------

>8093_8093_12_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000546249_STAT3_chr17_40498731_ENST00000585517_length(amino acids)=1517AA_BP=838
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLE
ESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEG
FRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTD
LDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLF
AVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGV
FGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDA
HTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEI
IQHDQLSTHSEDADEPSTSGQFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFF
TAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIV
ARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSV
TRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLE
ELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDV
AALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVIS
NICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMA
GKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQL

--------------------------------------------------------------

>8093_8093_13_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000585525_STAT3_chr17_40498731_ENST00000264657_length(amino acids)=1522AA_BP=795
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEMADPDLLEESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCR
GNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRV
LQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTY
GFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGL
IYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGV
SLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVV
ALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDADEPSEDEVFDFGDTMVHQAIHTIEYCLGCI
SNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFH
NLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHL
QDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDE
ELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPC
MPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRC
GNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVL
SWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAIL
STKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCR

--------------------------------------------------------------

>8093_8093_14_ATP6V0A1-STAT3_ATP6V0A1_chr17_40666478_ENST00000585525_STAT3_chr17_40498731_ENST00000585517_length(amino acids)=1474AA_BP=795
MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE
EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEMADPDLLEESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCR
GNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRV
LQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTY
GFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGL
IYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQLNPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGV
SLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFYKWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVV
ALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDADEPSEDEVFDFGDTMVHQAIHTIEYCLGCI
SNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFFFTAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFH
NLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHL
QDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDE
ELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPC
MPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRC
GNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVL
SWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAIL
STKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:40666478/chr17:40498731)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATP6V0A1 Q93050	.
FUNCTION: Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). {ECO:0000250}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

1_388

807.6666666666666

839.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

408_409

807.6666666666666

839.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

427_441

807.6666666666666

839.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

472_534

807.6666666666666

839.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

555_572

807.6666666666666

839.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

594_638

807.6666666666666

839.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

659_724

807.6666666666666

839.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

750_770

807.6666666666666

839.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

1_388

806.6666666666666

838.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

408_409

806.6666666666666

838.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

427_441

806.6666666666666

838.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

472_534

806.6666666666666

838.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

555_572

806.6666666666666

838.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

594_638

806.6666666666666

838.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

659_724

806.6666666666666

838.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

750_770

806.6666666666666

838.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

1_388

800.6666666666666

832.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

408_409

800.6666666666666

832.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

427_441

800.6666666666666

832.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

472_534

800.6666666666666

832.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

555_572

800.6666666666666

832.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

594_638

800.6666666666666

832.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

659_724

800.6666666666666

832.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

750_770

800.6666666666666

832.0

Topological domain

Vacuolar

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

389_407

807.6666666666666

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

410_426

807.6666666666666

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

442_471

807.6666666666666

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

535_554

807.6666666666666

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

573_593

807.6666666666666

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

639_658

807.6666666666666

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

725_749

807.6666666666666

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

771_809

807.6666666666666

839.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

389_407

806.6666666666666

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

410_426

806.6666666666666

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

442_471

806.6666666666666

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

535_554

806.6666666666666

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

573_593

806.6666666666666

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

639_658

806.6666666666666

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

725_749

806.6666666666666

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

771_809

806.6666666666666

838.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

389_407

800.6666666666666

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

410_426

800.6666666666666

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

442_471

800.6666666666666

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

535_554

800.6666666666666

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

573_593

800.6666666666666

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

639_658

800.6666666666666

832.0

Transmembrane

Helical

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

725_749

800.6666666666666

832.0

Transmembrane

Helical

Tgene

STAT3

chr17:40666478

chr17:40498731

ENST00000264657

580_670

42.666666666666664

771.0

Domain

SH2

Tgene

STAT3

chr17:40666478

chr17:40498731

ENST00000404395

580_670

42.666666666666664

770.0

Domain

SH2

Tgene

STAT3

chr17:40666478

chr17:40498731

ENST00000588969

580_670

42.666666666666664

771.0

Domain

SH2

Tgene

STAT3

chr17:40666478

chr17:40498731

ENST00000264657

150_162

42.666666666666664

771.0

Motif

Note=Essential for nuclear import

Tgene

STAT3

chr17:40666478

chr17:40498731

ENST00000404395

150_162

42.666666666666664

770.0

Motif

Note=Essential for nuclear import

Tgene

STAT3

chr17:40666478

chr17:40498731

ENST00000588969

150_162

42.666666666666664

771.0

Motif

Note=Essential for nuclear import

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000264649

810_837

807.6666666666666

839.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000343619

810_837

806.6666666666666

838.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

810_837

800.6666666666666

832.0

Topological domain

Cytoplasmic

Hgene

ATP6V0A1

chr17:40666478

chr17:40498731

ENST00000393829

771_809

800.6666666666666

832.0

Transmembrane

Helical

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>2088_ATP6V0A1_40666478_STAT3_40498731_ranked_0.pdb	ATP6V0A1	40666478	40666478	ENST00000585517	STAT3	chr17	40498731	-	MAAVVSVAVAVAEFGGWREIQVLTRLVPSATMGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCE EMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQM ADPDLLEESSSLLEPSEMGRGTPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNR VKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAE VWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTYGFQNIVDAYGIGTYREINPAPYTIITFPFLFAVMFGDFGH GILMTLFAVWMVLRESRILSQKNENEMFSTVFSGRYIILLMGVFSMYTGLIYNDCFSKSLNIFGSSWSVRPMFTYNWTEETLRGNPVLQL NPALPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMTSLFGYLVILIFY KWTAYDAHTSENAPSLLIHFINMFLFSYPESGYSMLYSGQKGIQCFLVVVALLCVPWMLLFKPLVLRRQYLRRKHLGTLNFGGIRVGNGP TEEDAEIIQHDQLSTHSEDADEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLSVKSLAGGLVLFFF FTAFATLTVAILLIMEGLSAFLHALRLHWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARI VARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQS VTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKL EELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGD VAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVI SNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENM AGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQ LNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSL	1566

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ATP6V0A1_pLDDT.png

STAT3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ATP6V0A1
STAT3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ATP6V0A1-STAT3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ATP6V0A1-STAT3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source