UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SETDB1-GABPB2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SETDB1-GABPB2
	FusionPDB ID: 80941
	FusionGDB2.0 ID: 80941
		Hgene	Tgene
	Gene symbol	SETDB1	GABPB2
	Gene ID	9869	126626
	Gene name	SET domain bifurcated histone lysine methyltransferase 1	GA binding protein transcription factor subunit beta 2
	Synonyms	ESET\|H3-K9-HMTase4\|KG1T\|KMT1E\|TDRD21	GABPB-2
	Cytomap	1q21.3	1q21.3
	Type of gene	protein-coding	protein-coding
	Description	histone-lysine N-methyltransferase SETDB1ERG-associated protein with a SET domain, ESETSET domain bifurcated 1histone H3-K9 methyltransferase 4histone-lysine N-methyltransferase, H3lysine-9 specific 4lysine N-methyltransferase 1Etudor domain contain	GA-binding protein subunit beta-2GA binding protein transcription factor beta subunit 2GABP subunit beta-2
	Modification date	20200313	20200313
	UniProtAcc	.	Q8TAK5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000459773, ENST00000271640, ENST00000368962, ENST00000368963, ENST00000368969,	ENST00000368916, ENST00000368917, ENST00000368918, ENST00000467551,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 7 X 6=336	5 X 4 X 4=80
	# samples	8	5
	** MAII score	log2(8/336*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SETDB1 [Title/Abstract] AND GABPB2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SETDB1(150902594)-GABPB2(151089868), # samples:1
Anticipated loss of major functional domain due to fusion event.	SETDB1-GABPB2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SETDB1-GABPB2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GABPB2	GO:0045944	positive regulation of transcription by RNA polymerase II	9857059

Fusion gene breakpoints across SETDB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GABPB2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-GJ-A6C0-01A	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000271640	SETDB1	chr1	150902594	+	ENST00000368917	GABPB2	chr1	151089868	+	2691	602	190	1026	278
ENST00000271640	SETDB1	chr1	150902594	+	ENST00000368918	GABPB2	chr1	151089868	+	8313	602	190	1026	278
ENST00000271640	SETDB1	chr1	150902594	+	ENST00000368916	GABPB2	chr1	151089868	+	1442	602	190	1026	278
ENST00000368962	SETDB1	chr1	150902594	+	ENST00000368917	GABPB2	chr1	151089868	+	2627	538	126	962	278
ENST00000368962	SETDB1	chr1	150902594	+	ENST00000368918	GABPB2	chr1	151089868	+	8249	538	126	962	278
ENST00000368962	SETDB1	chr1	150902594	+	ENST00000368916	GABPB2	chr1	151089868	+	1378	538	126	962	278
ENST00000368969	SETDB1	chr1	150902594	+	ENST00000368917	GABPB2	chr1	151089868	+	2618	529	117	953	278
ENST00000368969	SETDB1	chr1	150902594	+	ENST00000368918	GABPB2	chr1	151089868	+	8240	529	117	953	278
ENST00000368969	SETDB1	chr1	150902594	+	ENST00000368916	GABPB2	chr1	151089868	+	1369	529	117	953	278
ENST00000368963	SETDB1	chr1	150902594	+	ENST00000368917	GABPB2	chr1	151089868	+	2606	517	105	941	278
ENST00000368963	SETDB1	chr1	150902594	+	ENST00000368918	GABPB2	chr1	151089868	+	8228	517	105	941	278
ENST00000368963	SETDB1	chr1	150902594	+	ENST00000368916	GABPB2	chr1	151089868	+	1357	517	105	941	278

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000271640	ENST00000368917	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000663856	0.99933606
ENST00000271640	ENST00000368918	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000325712	0.9996743
ENST00000271640	ENST00000368916	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000566466	0.99943346
ENST00000368962	ENST00000368917	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000676569	0.9993235
ENST00000368962	ENST00000368918	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000319379	0.99968064
ENST00000368962	ENST00000368916	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000569137	0.99943084
ENST00000368969	ENST00000368917	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000736454	0.9992636
ENST00000368969	ENST00000368918	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.0003291	0.99967086
ENST00000368969	ENST00000368916	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000663245	0.9993368
ENST00000368963	ENST00000368917	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000857177	0.99914277
ENST00000368963	ENST00000368918	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000327351	0.99967265
ENST00000368963	ENST00000368916	SETDB1	chr1	150902594	+	GABPB2	chr1	151089868	+	0.000683745	0.9993162

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>80941_80941_1_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000271640_GABPB2_chr1_151089868_ENST00000368916_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_2_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000271640_GABPB2_chr1_151089868_ENST00000368917_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_3_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000271640_GABPB2_chr1_151089868_ENST00000368918_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_4_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000368962_GABPB2_chr1_151089868_ENST00000368916_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_5_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000368962_GABPB2_chr1_151089868_ENST00000368917_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_6_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000368962_GABPB2_chr1_151089868_ENST00000368918_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_7_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000368963_GABPB2_chr1_151089868_ENST00000368916_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_8_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000368963_GABPB2_chr1_151089868_ENST00000368917_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_9_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000368963_GABPB2_chr1_151089868_ENST00000368918_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_10_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000368969_GABPB2_chr1_151089868_ENST00000368916_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_11_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000368969_GABPB2_chr1_151089868_ENST00000368917_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

>80941_80941_12_SETDB1-GABPB2_SETDB1_chr1_150902594_ENST00000368969_GABPB2_chr1_151089868_ENST00000368918_length(amino acids)=278AA_BP=0
MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFIDEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVT
NCESLVKDFYSKLGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSVLTVPAGKVAEETVIKEEEEEKLPLTKKPRIGEKTNSVEESKE
GNERELLQQQLQEANRRAQEYRHQLLKKEQEAEQYRLKLEAIARQQPNGVDFTMVEEVAEVDAVVVTEGELEERETKVTGSAGTTEPHTR

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:150902594/chr1:151089868)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	GABPB2 Q8TAK5
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: May function as transcription factor capable of interacting with purine rich repeats (GA repeats). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000271640

18_64

137.33333333333334

1292.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368962

18_64

137.33333333333334

398.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368969

18_64

137.33333333333334

1291.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

GABPB2

chr1:150902594

chr1:151089868

ENST00000368918

345_395

307.3333333333333

449.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000271640

1275_1291

137.33333333333334

1292.0

Domain

Post-SET

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000271640

257_320

137.33333333333334

1292.0

Domain

Note=Tudor 1

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000271640

347_403

137.33333333333334

1292.0

Domain

Note=Tudor 2

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000271640

594_665

137.33333333333334

1292.0

Domain

MBD

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000271640

727_800

137.33333333333334

1292.0

Domain

Pre-SET

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000271640

803_1266

137.33333333333334

1292.0

Domain

SET

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368962

1275_1291

137.33333333333334

398.0

Domain

Post-SET

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368962

257_320

137.33333333333334

398.0

Domain

Note=Tudor 1

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368962

347_403

137.33333333333334

398.0

Domain

Note=Tudor 2

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368962

594_665

137.33333333333334

398.0

Domain

MBD

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368962

727_800

137.33333333333334

398.0

Domain

Pre-SET

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368962

803_1266

137.33333333333334

398.0

Domain

SET

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368969

1275_1291

137.33333333333334

1291.0

Domain

Post-SET

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368969

257_320

137.33333333333334

1291.0

Domain

Note=Tudor 1

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368969

347_403

137.33333333333334

1291.0

Domain

Note=Tudor 2

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368969

594_665

137.33333333333334

1291.0

Domain

MBD

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368969

727_800

137.33333333333334

1291.0

Domain

Pre-SET

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368969

803_1266

137.33333333333334

1291.0

Domain

SET

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000271640

1223_1224

137.33333333333334

1292.0

Region

S-adenosyl-L-methionine binding

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000271640

813_815

137.33333333333334

1292.0

Region

S-adenosyl-L-methionine binding

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368962

1223_1224

137.33333333333334

398.0

Region

S-adenosyl-L-methionine binding

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368962

813_815

137.33333333333334

398.0

Region

S-adenosyl-L-methionine binding

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368969

1223_1224

137.33333333333334

1291.0

Region

S-adenosyl-L-methionine binding

Hgene

SETDB1

chr1:150902594

chr1:151089868

ENST00000368969

813_815

137.33333333333334

1291.0

Region

S-adenosyl-L-methionine binding

Tgene

GABPB2

chr1:150902594

chr1:151089868

ENST00000368918

103_132

307.3333333333333

449.0

Repeat

Note=ANK 4

Tgene

GABPB2

chr1:150902594

chr1:151089868

ENST00000368918

136_166

307.3333333333333

449.0

Repeat

Note=ANK 5

Tgene

GABPB2

chr1:150902594

chr1:151089868

ENST00000368918

37_66

307.3333333333333

449.0

Repeat

Note=ANK 2

Tgene

GABPB2

chr1:150902594

chr1:151089868

ENST00000368918

5_34

307.3333333333333

449.0

Repeat

Note=ANK 1

Tgene

GABPB2

chr1:150902594

chr1:151089868

ENST00000368918

70_99

307.3333333333333

449.0

Repeat

Note=ANK 3

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SETDB1
GABPB2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to SETDB1-GABPB2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SETDB1-GABPB2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source