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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SF1-FUS

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SF1-FUS
	FusionPDB ID: 81009
	FusionGDB2.0 ID: 81009
		Hgene	Tgene
	Gene symbol	SF1	FUS
	Gene ID	7536	2521
	Gene name	splicing factor 1	FUS RNA binding protein
	Synonyms	BBP\|D11S636\|MBBP\|ZCCHC25\|ZFM1\|ZNF162	ALS6\|ETM4\|FUS1\|HNRNPP2\|POMP75\|TLS
	Cytomap	11q13.1	16p11.2
	Type of gene	protein-coding	protein-coding
	Description	splicing factor 1mammalian branch point-binding proteintranscription factor ZFM1zinc finger gene in MEN1 locuszinc finger protein 162	RNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma protein
	Modification date	20200318	20200329
	UniProtAcc	.	P35637
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000227503, ENST00000334944, ENST00000377387, ENST00000377390, ENST00000377394, ENST00000433274, ENST00000422298, ENST00000489544,	ENST00000474990, ENST00000254108, ENST00000380244, ENST00000568685,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 11 X 13=3003	20 X 13 X 10=2600
	# samples	26	22
	** MAII score	log2(26/3003*10)=-3.52982094652869 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/2600*10)=-3.56293619439116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SF1 [Title/Abstract] AND FUS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SF1(64543970)-FUS(31199646), # samples:1
Anticipated loss of major functional domain due to fusion event.	SF1-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SF1-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SF1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SF1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SF1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SF1-FUS seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. SF1-FUS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. SF1-FUS seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	FUS	GO:0006355	regulation of transcription, DNA-templated	26124092
Tgene	FUS	GO:0006357	regulation of transcription by RNA polymerase II	25453086
Tgene	FUS	GO:0008380	RNA splicing	26124092
Tgene	FUS	GO:0043484	regulation of RNA splicing	25453086\|27731383
Tgene	FUS	GO:0048255	mRNA stabilization	27378374
Tgene	FUS	GO:0051260	protein homooligomerization	25453086
Tgene	FUS	GO:1905168	positive regulation of double-strand break repair via homologous recombination	10567410

Fusion gene breakpoints across SF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FUS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-BR-7851-11A	SF1	chr11	64543970	-	FUS	chr16	31199646	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000377387	SF1	chr11	64543970	-	ENST00000254108	FUS	chr16	31199646	+	1762	612	77	1393	438
ENST00000377387	SF1	chr11	64543970	-	ENST00000380244	FUS	chr16	31199646	+	1558	612	77	1393	438
ENST00000377387	SF1	chr11	64543970	-	ENST00000568685	FUS	chr16	31199646	+	1534	612	77	1396	439
ENST00000377390	SF1	chr11	64543970	-	ENST00000254108	FUS	chr16	31199646	+	1648	498	338	1279	313
ENST00000377390	SF1	chr11	64543970	-	ENST00000380244	FUS	chr16	31199646	+	1444	498	338	1279	313
ENST00000377390	SF1	chr11	64543970	-	ENST00000568685	FUS	chr16	31199646	+	1420	498	338	1282	314
ENST00000377394	SF1	chr11	64543970	-	ENST00000254108	FUS	chr16	31199646	+	1665	515	355	1296	313
ENST00000377394	SF1	chr11	64543970	-	ENST00000380244	FUS	chr16	31199646	+	1461	515	355	1296	313
ENST00000377394	SF1	chr11	64543970	-	ENST00000568685	FUS	chr16	31199646	+	1437	515	355	1299	314
ENST00000227503	SF1	chr11	64543970	-	ENST00000254108	FUS	chr16	31199646	+	1665	515	355	1296	313
ENST00000227503	SF1	chr11	64543970	-	ENST00000380244	FUS	chr16	31199646	+	1461	515	355	1296	313
ENST00000227503	SF1	chr11	64543970	-	ENST00000568685	FUS	chr16	31199646	+	1437	515	355	1299	314
ENST00000334944	SF1	chr11	64543970	-	ENST00000254108	FUS	chr16	31199646	+	1704	554	394	1335	313
ENST00000334944	SF1	chr11	64543970	-	ENST00000380244	FUS	chr16	31199646	+	1500	554	394	1335	313
ENST00000334944	SF1	chr11	64543970	-	ENST00000568685	FUS	chr16	31199646	+	1476	554	394	1338	314

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377387	ENST00000254108	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.013675669	0.98632437
ENST00000377387	ENST00000380244	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.015733372	0.9842666
ENST00000377387	ENST00000568685	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.022868881	0.9771311
ENST00000377390	ENST00000254108	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.006073725	0.99392635
ENST00000377390	ENST00000380244	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.006587741	0.9934123
ENST00000377390	ENST00000568685	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.007142664	0.99285734
ENST00000377394	ENST00000254108	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.00630196	0.99369806
ENST00000377394	ENST00000380244	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.006915264	0.9930848
ENST00000377394	ENST00000568685	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.007416484	0.9925835
ENST00000227503	ENST00000254108	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.00630196	0.99369806
ENST00000227503	ENST00000380244	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.006915264	0.9930848
ENST00000227503	ENST00000568685	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.007416484	0.9925835
ENST00000334944	ENST00000254108	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.006792611	0.9932074
ENST00000334944	ENST00000380244	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.007466507	0.99253345
ENST00000334944	ENST00000568685	SF1	chr11	64543970	-	FUS	chr16	31199646	+	0.007908016	0.992092

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81009_81009_1_SF1-FUS_SF1_chr11_64543970_ENST00000227503_FUS_chr16_31199646_ENST00000254108_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_2_SF1-FUS_SF1_chr11_64543970_ENST00000227503_FUS_chr16_31199646_ENST00000380244_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_3_SF1-FUS_SF1_chr11_64543970_ENST00000227503_FUS_chr16_31199646_ENST00000568685_length(amino acids)=314AA_BP=170
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVA
DYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPM
GRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRG

--------------------------------------------------------------

>81009_81009_4_SF1-FUS_SF1_chr11_64543970_ENST00000334944_FUS_chr16_31199646_ENST00000254108_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_5_SF1-FUS_SF1_chr11_64543970_ENST00000334944_FUS_chr16_31199646_ENST00000380244_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_6_SF1-FUS_SF1_chr11_64543970_ENST00000334944_FUS_chr16_31199646_ENST00000568685_length(amino acids)=314AA_BP=170
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVA
DYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPM
GRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRG

--------------------------------------------------------------

>81009_81009_7_SF1-FUS_SF1_chr11_64543970_ENST00000377387_FUS_chr16_31199646_ENST00000254108_length(amino acids)=438AA_BP=294
MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLAPGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPP
SPGASYPPPQPPPPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGP
RDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKE
FSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCK

--------------------------------------------------------------

>81009_81009_8_SF1-FUS_SF1_chr11_64543970_ENST00000377387_FUS_chr16_31199646_ENST00000380244_length(amino acids)=438AA_BP=294
MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLAPGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPP
SPGASYPPPQPPPPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGP
RDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKE
FSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCK

--------------------------------------------------------------

>81009_81009_9_SF1-FUS_SF1_chr11_64543970_ENST00000377387_FUS_chr16_31199646_ENST00000568685_length(amino acids)=439AA_BP=295
MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLAPGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPP
SPGASYPPPQPPPPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGP
RDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGK
EFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQC

--------------------------------------------------------------

>81009_81009_10_SF1-FUS_SF1_chr11_64543970_ENST00000377390_FUS_chr16_31199646_ENST00000254108_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_11_SF1-FUS_SF1_chr11_64543970_ENST00000377390_FUS_chr16_31199646_ENST00000380244_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_12_SF1-FUS_SF1_chr11_64543970_ENST00000377390_FUS_chr16_31199646_ENST00000568685_length(amino acids)=314AA_BP=170
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVA
DYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPM
GRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRG

--------------------------------------------------------------

>81009_81009_13_SF1-FUS_SF1_chr11_64543970_ENST00000377394_FUS_chr16_31199646_ENST00000254108_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_14_SF1-FUS_SF1_chr11_64543970_ENST00000377394_FUS_chr16_31199646_ENST00000380244_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_15_SF1-FUS_SF1_chr11_64543970_ENST00000377394_FUS_chr16_31199646_ENST00000568685_length(amino acids)=314AA_BP=170
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVA
DYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPM
GRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRG

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64543970/chr16:31199646)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	FUS P35637
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250\|UniProtKB:P56959, ECO:0000269\|PubMed:10567410, ECO:0000269\|PubMed:24204307, ECO:0000269\|PubMed:26124092, ECO:0000269\|PubMed:27731383}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000227503

15_19

53.333333333333336

549.0

Motif

Nuclear localization signal

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000334944

15_19

53.333333333333336

639.0

Motif

Nuclear localization signal

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377387

15_19

178.33333333333334

674.0

Motif

Nuclear localization signal

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377390

15_19

53.333333333333336

640.0

Motif

Nuclear localization signal

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377394

15_19

53.333333333333336

572.0

Motif

Nuclear localization signal

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000433274

15_19

27.333333333333332

614.0

Motif

Nuclear localization signal

Tgene

FUS

chr11:64543970

chr16:31199646

ENST00000254108

371_526

266.3333333333333

527.0

Compositional bias

Note=Arg/Gly-rich

Tgene

FUS

chr11:64543970

chr16:31199646

ENST00000380244

371_526

265.3333333333333

526.0

Compositional bias

Note=Arg/Gly-rich

Tgene

FUS

chr11:64543970

chr16:31199646

ENST00000254108

285_371

266.3333333333333

527.0

Domain

RRM

Tgene

FUS

chr11:64543970

chr16:31199646

ENST00000380244

285_371

265.3333333333333

526.0

Domain

RRM

Tgene

FUS

chr11:64543970

chr16:31199646

ENST00000254108

422_453

266.3333333333333

527.0

Zinc finger

RanBP2-type

Tgene

FUS

chr11:64543970

chr16:31199646

ENST00000380244

422_453

265.3333333333333

526.0

Zinc finger

RanBP2-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000227503

324_637

53.333333333333336

549.0

Compositional bias

Note=Pro-rich

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000334944

324_637

53.333333333333336

639.0

Compositional bias

Note=Pro-rich

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377387

324_637

178.33333333333334

674.0

Compositional bias

Note=Pro-rich

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377390

324_637

53.333333333333336

640.0

Compositional bias

Note=Pro-rich

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377394

324_637

53.333333333333336

572.0

Compositional bias

Note=Pro-rich

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000433274

324_637

27.333333333333332

614.0

Compositional bias

Note=Pro-rich

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000227503

141_222

53.333333333333336

549.0

Domain

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000334944

141_222

53.333333333333336

639.0

Domain

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377387

141_222

178.33333333333334

674.0

Domain

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377390

141_222

53.333333333333336

640.0

Domain

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377394

141_222

53.333333333333336

572.0

Domain

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000433274

141_222

27.333333333333332

614.0

Domain

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000227503

277_296

53.333333333333336

549.0

Zinc finger

CCHC-type

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000334944

277_296

53.333333333333336

639.0

Zinc finger

CCHC-type

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377387

277_296

178.33333333333334

674.0

Zinc finger

CCHC-type

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377390

277_296

53.333333333333336

640.0

Zinc finger

CCHC-type

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000377394

277_296

53.333333333333336

572.0

Zinc finger

CCHC-type

Hgene

SF1

chr11:64543970

chr16:31199646

ENST00000433274

277_296

27.333333333333332

614.0

Zinc finger

CCHC-type

Tgene

FUS

chr11:64543970

chr16:31199646

ENST00000254108

166_267

266.3333333333333

527.0

Compositional bias

Note=Gly-rich

Tgene

FUS

chr11:64543970

chr16:31199646

ENST00000254108

1_165

266.3333333333333

527.0

Compositional bias

Note=Gln/Gly/Ser/Tyr-rich

Tgene

FUS

chr11:64543970

chr16:31199646

ENST00000380244

166_267

265.3333333333333

526.0

Compositional bias

Note=Gly-rich

Tgene

FUS

chr11:64543970

chr16:31199646

ENST00000380244

1_165

265.3333333333333

526.0

Compositional bias

Note=Gln/Gly/Ser/Tyr-rich

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

FUS

EIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, Mapk13, DGCR8, Pds5a, Shoc2, Ccdc15, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, ECM32, NAM8, SBP1, SKO1, VHR1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, rev, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, DBR1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, HSP104, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6, WDR77, PCBP1, PPIE, YAP1, EFTUD2, AAR2, PIH1D1, NKX2-1, CHD3, CHD4, TNF, HEXIM1, MEPCE, LARP7, RUNX1, PPT1, CTDSPL2, AGR2, RECQL4, CDK9, ARID1A, SMARCA4, SMARCD1, DDIT3, SMARCC2, SMARCC1, SS18, SMARCB1, FLI1, TP53BP1, MDC1, METTL3, METTL14, KIAA1429, RC3H2, ATG16L1, LINC00470, AKT1, ACTC1, RBX1, MYC, MAPT, HIV2gp4, HIV2gp3, NR2C2, UBQLN2, HDAC2, ZFYVE21, XRCC6, DYNLT1, HIST1H4A, SNRNP70, SNRPA, SRSF1, SNRPB, SNRPC, SNRPD1, SNRPD3, RNU1-1, FUS, TRIM28, HNRNPA2B1, HNRNPR, PPP1R10, ILF2, DHX9, PABPC1, DDX3X, SRSF7, HNRNPM, HNRNPUL1, PABPC4, SF3B1, LARP1, PBRM1, THRAP3, MOV10, FAM120A, SKIV2L2, TOX, POLR2A, ELAVL1, SF3B2, STRBP, WDR82, HNRNPCL1, CCNT1, RBM14, U2SURP, DDX20, HIST1H1C, NUMA1, CCBL2, ZFR, ACIN1, CDC73, DDX23, SLTM, SRRT, IGF2BP3, ZC3H18, PRRC2A, HNRNPUL2, THOC1, AKAP8, BCLAF1, SRSF3, CHERP, INTS12, PAF1, PNN, PPFIA1, RBM10, SNRNP200, TOE1, TRA2B, HNRNPC, HNRNPA0, PPP1CC, CCAR1, DDX21, HNRNPAB, INTS6, POLR2B, PRPF6, RALY, RBM25, RBM7, SAFB, THOC5, XRN2, EBNA1BP2, HSPA1A, RBM39, STRAP, TRA2A, YBX3, ZCCHC8, GPATCH8, SMN1, SRSF5, CTR9, EIF4A3, GNL3, HNRNPH3, HP1BP3, NCBP1, PRPF19, RBM17, RRP9, THOC2, ZC3HAV1, EXOSC10, GEMIN6, XAB2, HSPB1, PABPN1, CAPRIN1, CCAR2, GEMIN4, INTS4, KHDRBS1, PLRG1, PRMT5, SRSF6, ZNF326, ADAR, ARID2, GEMIN5, PHF10, PURB, SMU1, TOX4, AQR, ITFG1, ARAF, BIRC3, NFX1, VPS15, VPS34, VPS38, VPS8, PEP3, VPS21, CDC48, UBX3, BRE5, UBP3, SOX2, EP300, CMTR1, ARIH2, PLEKHA4, PINK1, PRMT8, FANCD2, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ADAMTS9-AS2, MDM2, OPTN, PRKD1, HVCN1, CELF1, FUBP3, DUX4, DUX4L9, CIT, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, MKI67, BRD4, NINL, RBM45, UCHL1, Apc2, FBP1, LGALS9, WDR76, EIF3F, CREBBP, vpr, RNF4, OGT, CD274, SPOP, DDRGK1, TP53, DDX39B, HIST1H2BG, USP15, FZR1, WDR5, NUDCD2, CPSF1, NUP43, BTF3, BSG, S, RCHY1, NBR1, BACH2, PDE4B, SIRT6,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SF1
FUS

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to SF1-FUS

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SF1-FUS

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	FUS	C1842675	AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)	5	UNIPROT
Tgene	FUS	C3468114	Juvenile amyotrophic lateral sclerosis	5	ORPHANET
Tgene	FUS	C0002736	Amyotrophic Lateral Sclerosis	2	CTD_human;ORPHANET
Tgene	FUS	C0206634	Liposarcoma, Myxoid	2	CTD_human;ORPHANET
Tgene	FUS	C0393554	Amyotrophic Lateral Sclerosis With Dementia	1	CTD_human
Tgene	FUS	C0497327	Dementia	1	GENOMICS_ENGLAND
Tgene	FUS	C0543859	Amyotrophic Lateral Sclerosis, Guam Form	1	CTD_human
Tgene	FUS	C3539195	TREMOR, HEREDITARY ESSENTIAL, 4	1	CTD_human;UNIPROT
Tgene	FUS	C3888102	Frontotemporal Dementia With Motor Neuron Disease	1	ORPHANET