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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SF1-FUS

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SF1-FUS
FusionPDB ID: 81009
FusionGDB2.0 ID: 81009
HgeneTgene
Gene symbol

SF1

FUS

Gene ID

7536

2521

Gene namesplicing factor 1FUS RNA binding protein
SynonymsBBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162ALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS
Cytomap

11q13.1

16p11.2

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor 1mammalian branch point-binding proteintranscription factor ZFM1zinc finger gene in MEN1 locuszinc finger protein 162RNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma protein
Modification date2020031820200329
UniProtAcc.

P35637

Ensembl transtripts involved in fusion geneENST idsENST00000227503, ENST00000334944, 
ENST00000377387, ENST00000377390, 
ENST00000377394, ENST00000433274, 
ENST00000422298, ENST00000489544, 
ENST00000474990, ENST00000254108, 
ENST00000380244, ENST00000568685, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 11 X 13=300320 X 13 X 10=2600
# samples 2622
** MAII scorelog2(26/3003*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(22/2600*10)=-3.56293619439116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SF1 [Title/Abstract] AND FUS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SF1(64543970)-FUS(31199646), # samples:1
Anticipated loss of major functional domain due to fusion event.SF1-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SF1-FUS seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SF1-FUS seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SF1-FUS seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

TgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

TgeneFUS

GO:0008380

RNA splicing

26124092

TgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

TgeneFUS

GO:0048255

mRNA stabilization

27378374

TgeneFUS

GO:0051260

protein homooligomerization

25453086

TgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410


check buttonFusion gene breakpoints across SF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FUS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-BR-7851-11ASF1chr11

64543970

-FUSchr16

31199646

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000377387SF1chr1164543970-ENST00000254108FUSchr1631199646+1762612771393438
ENST00000377387SF1chr1164543970-ENST00000380244FUSchr1631199646+1558612771393438
ENST00000377387SF1chr1164543970-ENST00000568685FUSchr1631199646+1534612771396439
ENST00000377390SF1chr1164543970-ENST00000254108FUSchr1631199646+16484983381279313
ENST00000377390SF1chr1164543970-ENST00000380244FUSchr1631199646+14444983381279313
ENST00000377390SF1chr1164543970-ENST00000568685FUSchr1631199646+14204983381282314
ENST00000377394SF1chr1164543970-ENST00000254108FUSchr1631199646+16655153551296313
ENST00000377394SF1chr1164543970-ENST00000380244FUSchr1631199646+14615153551296313
ENST00000377394SF1chr1164543970-ENST00000568685FUSchr1631199646+14375153551299314
ENST00000227503SF1chr1164543970-ENST00000254108FUSchr1631199646+16655153551296313
ENST00000227503SF1chr1164543970-ENST00000380244FUSchr1631199646+14615153551296313
ENST00000227503SF1chr1164543970-ENST00000568685FUSchr1631199646+14375153551299314
ENST00000334944SF1chr1164543970-ENST00000254108FUSchr1631199646+17045543941335313
ENST00000334944SF1chr1164543970-ENST00000380244FUSchr1631199646+15005543941335313
ENST00000334944SF1chr1164543970-ENST00000568685FUSchr1631199646+14765543941338314

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377387ENST00000254108SF1chr1164543970-FUSchr1631199646+0.0136756690.98632437
ENST00000377387ENST00000380244SF1chr1164543970-FUSchr1631199646+0.0157333720.9842666
ENST00000377387ENST00000568685SF1chr1164543970-FUSchr1631199646+0.0228688810.9771311
ENST00000377390ENST00000254108SF1chr1164543970-FUSchr1631199646+0.0060737250.99392635
ENST00000377390ENST00000380244SF1chr1164543970-FUSchr1631199646+0.0065877410.9934123
ENST00000377390ENST00000568685SF1chr1164543970-FUSchr1631199646+0.0071426640.99285734
ENST00000377394ENST00000254108SF1chr1164543970-FUSchr1631199646+0.006301960.99369806
ENST00000377394ENST00000380244SF1chr1164543970-FUSchr1631199646+0.0069152640.9930848
ENST00000377394ENST00000568685SF1chr1164543970-FUSchr1631199646+0.0074164840.9925835
ENST00000227503ENST00000254108SF1chr1164543970-FUSchr1631199646+0.006301960.99369806
ENST00000227503ENST00000380244SF1chr1164543970-FUSchr1631199646+0.0069152640.9930848
ENST00000227503ENST00000568685SF1chr1164543970-FUSchr1631199646+0.0074164840.9925835
ENST00000334944ENST00000254108SF1chr1164543970-FUSchr1631199646+0.0067926110.9932074
ENST00000334944ENST00000380244SF1chr1164543970-FUSchr1631199646+0.0074665070.99253345
ENST00000334944ENST00000568685SF1chr1164543970-FUSchr1631199646+0.0079080160.992092

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81009_81009_1_SF1-FUS_SF1_chr11_64543970_ENST00000227503_FUS_chr16_31199646_ENST00000254108_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_2_SF1-FUS_SF1_chr11_64543970_ENST00000227503_FUS_chr16_31199646_ENST00000380244_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_3_SF1-FUS_SF1_chr11_64543970_ENST00000227503_FUS_chr16_31199646_ENST00000568685_length(amino acids)=314AA_BP=170
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVA
DYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPM
GRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRG

--------------------------------------------------------------

>81009_81009_4_SF1-FUS_SF1_chr11_64543970_ENST00000334944_FUS_chr16_31199646_ENST00000254108_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_5_SF1-FUS_SF1_chr11_64543970_ENST00000334944_FUS_chr16_31199646_ENST00000380244_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_6_SF1-FUS_SF1_chr11_64543970_ENST00000334944_FUS_chr16_31199646_ENST00000568685_length(amino acids)=314AA_BP=170
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVA
DYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPM
GRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRG

--------------------------------------------------------------

>81009_81009_7_SF1-FUS_SF1_chr11_64543970_ENST00000377387_FUS_chr16_31199646_ENST00000254108_length(amino acids)=438AA_BP=294
MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLAPGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPP
SPGASYPPPQPPPPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGP
RDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKE
FSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCK

--------------------------------------------------------------

>81009_81009_8_SF1-FUS_SF1_chr11_64543970_ENST00000377387_FUS_chr16_31199646_ENST00000380244_length(amino acids)=438AA_BP=294
MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLAPGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPP
SPGASYPPPQPPPPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGP
RDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKE
FSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCK

--------------------------------------------------------------

>81009_81009_9_SF1-FUS_SF1_chr11_64543970_ENST00000377387_FUS_chr16_31199646_ENST00000568685_length(amino acids)=439AA_BP=295
MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLAPGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPP
SPGASYPPPQPPPPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGP
RDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGK
EFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQC

--------------------------------------------------------------

>81009_81009_10_SF1-FUS_SF1_chr11_64543970_ENST00000377390_FUS_chr16_31199646_ENST00000254108_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_11_SF1-FUS_SF1_chr11_64543970_ENST00000377390_FUS_chr16_31199646_ENST00000380244_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_12_SF1-FUS_SF1_chr11_64543970_ENST00000377390_FUS_chr16_31199646_ENST00000568685_length(amino acids)=314AA_BP=170
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVA
DYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPM
GRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRG

--------------------------------------------------------------

>81009_81009_13_SF1-FUS_SF1_chr11_64543970_ENST00000377394_FUS_chr16_31199646_ENST00000254108_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_14_SF1-FUS_SF1_chr11_64543970_ENST00000377394_FUS_chr16_31199646_ENST00000380244_length(amino acids)=313AA_BP=169
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVAD
YFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMG
RGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGG

--------------------------------------------------------------

>81009_81009_15_SF1-FUS_SF1_chr11_64543970_ENST00000377394_FUS_chr16_31199646_ENST00000568685_length(amino acids)=314AA_BP=170
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVA
DYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPM
GRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64543970/chr16:31199646)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FUS

P35637

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64543970chr16:31199646ENST00000227503-21315_1953.333333333333336549.0MotifNuclear localization signal
HgeneSF1chr11:64543970chr16:31199646ENST00000334944-21415_1953.333333333333336639.0MotifNuclear localization signal
HgeneSF1chr11:64543970chr16:31199646ENST00000377387-21315_19178.33333333333334674.0MotifNuclear localization signal
HgeneSF1chr11:64543970chr16:31199646ENST00000377390-21315_1953.333333333333336640.0MotifNuclear localization signal
HgeneSF1chr11:64543970chr16:31199646ENST00000377394-21315_1953.333333333333336572.0MotifNuclear localization signal
HgeneSF1chr11:64543970chr16:31199646ENST00000433274-21315_1927.333333333333332614.0MotifNuclear localization signal
TgeneFUSchr11:64543970chr16:31199646ENST00000254108615371_526266.3333333333333527.0Compositional biasNote=Arg/Gly-rich
TgeneFUSchr11:64543970chr16:31199646ENST00000380244615371_526265.3333333333333526.0Compositional biasNote=Arg/Gly-rich
TgeneFUSchr11:64543970chr16:31199646ENST00000254108615285_371266.3333333333333527.0DomainRRM
TgeneFUSchr11:64543970chr16:31199646ENST00000380244615285_371265.3333333333333526.0DomainRRM
TgeneFUSchr11:64543970chr16:31199646ENST00000254108615422_453266.3333333333333527.0Zinc fingerRanBP2-type
TgeneFUSchr11:64543970chr16:31199646ENST00000380244615422_453265.3333333333333526.0Zinc fingerRanBP2-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64543970chr16:31199646ENST00000227503-213324_63753.333333333333336549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr16:31199646ENST00000334944-214324_63753.333333333333336639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr16:31199646ENST00000377387-213324_637178.33333333333334674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr16:31199646ENST00000377390-213324_63753.333333333333336640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr16:31199646ENST00000377394-213324_63753.333333333333336572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr16:31199646ENST00000433274-213324_63727.333333333333332614.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543970chr16:31199646ENST00000227503-213141_22253.333333333333336549.0DomainKH
HgeneSF1chr11:64543970chr16:31199646ENST00000334944-214141_22253.333333333333336639.0DomainKH
HgeneSF1chr11:64543970chr16:31199646ENST00000377387-213141_222178.33333333333334674.0DomainKH
HgeneSF1chr11:64543970chr16:31199646ENST00000377390-213141_22253.333333333333336640.0DomainKH
HgeneSF1chr11:64543970chr16:31199646ENST00000377394-213141_22253.333333333333336572.0DomainKH
HgeneSF1chr11:64543970chr16:31199646ENST00000433274-213141_22227.333333333333332614.0DomainKH
HgeneSF1chr11:64543970chr16:31199646ENST00000227503-213277_29653.333333333333336549.0Zinc fingerCCHC-type
HgeneSF1chr11:64543970chr16:31199646ENST00000334944-214277_29653.333333333333336639.0Zinc fingerCCHC-type
HgeneSF1chr11:64543970chr16:31199646ENST00000377387-213277_296178.33333333333334674.0Zinc fingerCCHC-type
HgeneSF1chr11:64543970chr16:31199646ENST00000377390-213277_29653.333333333333336640.0Zinc fingerCCHC-type
HgeneSF1chr11:64543970chr16:31199646ENST00000377394-213277_29653.333333333333336572.0Zinc fingerCCHC-type
HgeneSF1chr11:64543970chr16:31199646ENST00000433274-213277_29627.333333333333332614.0Zinc fingerCCHC-type
TgeneFUSchr11:64543970chr16:31199646ENST00000254108615166_267266.3333333333333527.0Compositional biasNote=Gly-rich
TgeneFUSchr11:64543970chr16:31199646ENST000002541086151_165266.3333333333333527.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgeneFUSchr11:64543970chr16:31199646ENST00000380244615166_267265.3333333333333526.0Compositional biasNote=Gly-rich
TgeneFUSchr11:64543970chr16:31199646ENST000003802446151_165265.3333333333333526.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
FUSEIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, Mapk13, DGCR8, Pds5a, Shoc2, Ccdc15, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, ECM32, NAM8, SBP1, SKO1, VHR1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, rev, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, DBR1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, HSP104, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6, WDR77, PCBP1, PPIE, YAP1, EFTUD2, AAR2, PIH1D1, NKX2-1, CHD3, CHD4, TNF, HEXIM1, MEPCE, LARP7, RUNX1, PPT1, CTDSPL2, AGR2, RECQL4, CDK9, ARID1A, SMARCA4, SMARCD1, DDIT3, SMARCC2, SMARCC1, SS18, SMARCB1, FLI1, TP53BP1, MDC1, METTL3, METTL14, KIAA1429, RC3H2, ATG16L1, LINC00470, AKT1, ACTC1, RBX1, MYC, MAPT, HIV2gp4, HIV2gp3, NR2C2, UBQLN2, HDAC2, ZFYVE21, XRCC6, DYNLT1, HIST1H4A, SNRNP70, SNRPA, SRSF1, SNRPB, SNRPC, SNRPD1, SNRPD3, RNU1-1, FUS, TRIM28, HNRNPA2B1, HNRNPR, PPP1R10, ILF2, DHX9, PABPC1, DDX3X, SRSF7, HNRNPM, HNRNPUL1, PABPC4, SF3B1, LARP1, PBRM1, THRAP3, MOV10, FAM120A, SKIV2L2, TOX, POLR2A, ELAVL1, SF3B2, STRBP, WDR82, HNRNPCL1, CCNT1, RBM14, U2SURP, DDX20, HIST1H1C, NUMA1, CCBL2, ZFR, ACIN1, CDC73, DDX23, SLTM, SRRT, IGF2BP3, ZC3H18, PRRC2A, HNRNPUL2, THOC1, AKAP8, BCLAF1, SRSF3, CHERP, INTS12, PAF1, PNN, PPFIA1, RBM10, SNRNP200, TOE1, TRA2B, HNRNPC, HNRNPA0, PPP1CC, CCAR1, DDX21, HNRNPAB, INTS6, POLR2B, PRPF6, RALY, RBM25, RBM7, SAFB, THOC5, XRN2, EBNA1BP2, HSPA1A, RBM39, STRAP, TRA2A, YBX3, ZCCHC8, GPATCH8, SMN1, SRSF5, CTR9, EIF4A3, GNL3, HNRNPH3, HP1BP3, NCBP1, PRPF19, RBM17, RRP9, THOC2, ZC3HAV1, EXOSC10, GEMIN6, XAB2, HSPB1, PABPN1, CAPRIN1, CCAR2, GEMIN4, INTS4, KHDRBS1, PLRG1, PRMT5, SRSF6, ZNF326, ADAR, ARID2, GEMIN5, PHF10, PURB, SMU1, TOX4, AQR, ITFG1, ARAF, BIRC3, NFX1, VPS15, VPS34, VPS38, VPS8, PEP3, VPS21, CDC48, UBX3, BRE5, UBP3, SOX2, EP300, CMTR1, ARIH2, PLEKHA4, PINK1, PRMT8, FANCD2, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ADAMTS9-AS2, MDM2, OPTN, PRKD1, HVCN1, CELF1, FUBP3, DUX4, DUX4L9, CIT, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, MKI67, BRD4, NINL, RBM45, UCHL1, Apc2, FBP1, LGALS9, WDR76, EIF3F, CREBBP, vpr, RNF4, OGT, CD274, SPOP, DDRGK1, TP53, DDX39B, HIST1H2BG, USP15, FZR1, WDR5, NUDCD2, CPSF1, NUP43, BTF3, BSG, S, RCHY1, NBR1, BACH2, PDE4B, SIRT6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SF1
FUSall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SF1-FUS


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SF1-FUS


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)5UNIPROT
TgeneFUSC3468114Juvenile amyotrophic lateral sclerosis5ORPHANET
TgeneFUSC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
TgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
TgeneFUSC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneFUSC0497327Dementia1GENOMICS_ENGLAND
TgeneFUSC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41CTD_human;UNIPROT
TgeneFUSC3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET