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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SF1-HRASLS2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SF1-HRASLS2
FusionPDB ID: 81011
FusionGDB2.0 ID: 81011
HgeneTgene
Gene symbol

SF1

HRASLS2

Gene ID

7536

54979

Gene namesplicing factor 1phospholipase A and acyltransferase 2
SynonymsBBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162HRASLS2|PLA1/2-2|PLAAT-2
Cytomap

11q13.1

11q12.3

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor 1mammalian branch point-binding proteintranscription factor ZFM1zinc finger gene in MEN1 locuszinc finger protein 162phospholipase A and acyltransferase 2HRAS like suppressor 2phospholipase A/acyltransferase-2
Modification date2020031820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST idsENST00000377394, ENST00000433274, 
ENST00000227503, ENST00000334944, 
ENST00000377387, ENST00000377390, 
ENST00000422298, ENST00000489544, 
ENST00000255695, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 11 X 13=30034 X 2 X 3=24
# samples 264
** MAII scorelog2(26/3003*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SF1 [Title/Abstract] AND HRASLS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SF1(64534372)-HRASLS2(63326132), # samples:3
Anticipated loss of major functional domain due to fusion event.SF1-HRASLS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-HRASLS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-HRASLS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-HRASLS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SF1-HRASLS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SF1-HRASLS2 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHRASLS2

GO:0070292

N-acylphosphatidylethanolamine metabolic process

22825852


check buttonFusion gene breakpoints across SF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HRASLS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BB-8596-01ASF1chr11

64534372

-HRASLS2chr11

63326132

-
ChimerDB4HNSCTCGA-BB-8596SF1chr11

64534371

-HRASLS2chr11

63326132

-
ChimerDB4HNSCTCGA-BB-8596SF1chr11

64534372

-HRASLS2chr11

63326132

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377387SF1chr1164534372-ENST00000255695HRASLS2chr1163326132-25992034772404775
ENST00000377390SF1chr1164534372-ENST00000255695HRASLS2chr1163326132-248519203382290650
ENST00000227503SF1chr1164534372-ENST00000255695HRASLS2chr1163326132-250219373552307650
ENST00000334944SF1chr1164534372-ENST00000255695HRASLS2chr1163326132-254119763942346650
ENST00000422298SF1chr1164534372-ENST00000255695HRASLS2chr1163326132-244818834392253604
ENST00000377387SF1chr1164534371-ENST00000255695HRASLS2chr1163326132-25992034772404775
ENST00000377390SF1chr1164534371-ENST00000255695HRASLS2chr1163326132-248519203382290650
ENST00000227503SF1chr1164534371-ENST00000255695HRASLS2chr1163326132-250219373552307650
ENST00000334944SF1chr1164534371-ENST00000255695HRASLS2chr1163326132-254119763942346650
ENST00000422298SF1chr1164534371-ENST00000255695HRASLS2chr1163326132-244818834392253604

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377387ENST00000255695SF1chr1164534372-HRASLS2chr1163326132-0.0125852340.9874148
ENST00000377390ENST00000255695SF1chr1164534372-HRASLS2chr1163326132-0.0129245720.9870754
ENST00000227503ENST00000255695SF1chr1164534372-HRASLS2chr1163326132-0.01282690.9871731
ENST00000334944ENST00000255695SF1chr1164534372-HRASLS2chr1163326132-0.0131491670.9868508
ENST00000422298ENST00000255695SF1chr1164534372-HRASLS2chr1163326132-0.0166155420.9833845
ENST00000377387ENST00000255695SF1chr1164534371-HRASLS2chr1163326132-0.0125852340.9874148
ENST00000377390ENST00000255695SF1chr1164534371-HRASLS2chr1163326132-0.0129245720.9870754
ENST00000227503ENST00000255695SF1chr1164534371-HRASLS2chr1163326132-0.01282690.9871731
ENST00000334944ENST00000255695SF1chr1164534371-HRASLS2chr1163326132-0.0131491670.9868508
ENST00000422298ENST00000255695SF1chr1164534371-HRASLS2chr1163326132-0.0166155420.9833845

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81011_81011_1_SF1-HRASLS2_SF1_chr11_64534371_ENST00000227503_HRASLS2_chr11_63326132_ENST00000255695_length(amino acids)=650AA_BP=0
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSE
GKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGK
GSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSET
RSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMS
TTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQY
LGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLS
ALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYGVSRSDQVTGAVTTVGVAAG

--------------------------------------------------------------

>81011_81011_2_SF1-HRASLS2_SF1_chr11_64534371_ENST00000334944_HRASLS2_chr11_63326132_ENST00000255695_length(amino acids)=650AA_BP=0
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSE
GKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGK
GSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSET
RSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMS
TTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQY
LGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLS
ALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYGVSRSDQVTGAVTTVGVAAG

--------------------------------------------------------------

>81011_81011_3_SF1-HRASLS2_SF1_chr11_64534371_ENST00000377387_HRASLS2_chr11_63326132_ENST00000255695_length(amino acids)=775AA_BP=0
MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLAPGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPP
SPGASYPPPQPPPPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQ
LQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQD
EYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPED
QNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPV
PASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQH
NPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQ
QPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLSALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYS

--------------------------------------------------------------

>81011_81011_4_SF1-HRASLS2_SF1_chr11_64534371_ENST00000377390_HRASLS2_chr11_63326132_ENST00000255695_length(amino acids)=650AA_BP=0
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSE
GKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGK
GSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSET
RSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMS
TTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQY
LGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLS
ALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYGVSRSDQVTGAVTTVGVAAG

--------------------------------------------------------------

>81011_81011_5_SF1-HRASLS2_SF1_chr11_64534371_ENST00000422298_HRASLS2_chr11_63326132_ENST00000255695_length(amino acids)=604AA_BP=1
MEPRHNGTEDSDSRNAYSYSPWTYSRTRKSLYRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRV
SDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNIL
KQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSL
MAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTG
GHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGP
LPPWQQQQQQPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLSALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEE

--------------------------------------------------------------

>81011_81011_6_SF1-HRASLS2_SF1_chr11_64534372_ENST00000227503_HRASLS2_chr11_63326132_ENST00000255695_length(amino acids)=650AA_BP=0
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSE
GKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGK
GSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSET
RSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMS
TTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQY
LGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLS
ALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYGVSRSDQVTGAVTTVGVAAG

--------------------------------------------------------------

>81011_81011_7_SF1-HRASLS2_SF1_chr11_64534372_ENST00000334944_HRASLS2_chr11_63326132_ENST00000255695_length(amino acids)=650AA_BP=0
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSE
GKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGK
GSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSET
RSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMS
TTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQY
LGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLS
ALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYGVSRSDQVTGAVTTVGVAAG

--------------------------------------------------------------

>81011_81011_8_SF1-HRASLS2_SF1_chr11_64534372_ENST00000377387_HRASLS2_chr11_63326132_ENST00000255695_length(amino acids)=775AA_BP=0
MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLAPGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPP
SPGASYPPPQPPPPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQ
LQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQD
EYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPED
QNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPV
PASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQH
NPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQ
QPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLSALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYS

--------------------------------------------------------------

>81011_81011_9_SF1-HRASLS2_SF1_chr11_64534372_ENST00000377390_HRASLS2_chr11_63326132_ENST00000255695_length(amino acids)=650AA_BP=0
MATGANATPLDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSE
GKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGK
GSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSET
RSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMS
TTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQY
LGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLS
ALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYSLTSDNCEHFVNHLRYGVSRSDQVTGAVTTVGVAAG

--------------------------------------------------------------

>81011_81011_10_SF1-HRASLS2_SF1_chr11_64534372_ENST00000422298_HRASLS2_chr11_63326132_ENST00000255695_length(amino acids)=604AA_BP=1
MEPRHNGTEDSDSRNAYSYSPWTYSRTRKSLYRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRV
SDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNIL
KQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSL
MAELGEAPVPASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTG
GHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGP
LPPWQQQQQQPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLSALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64534372/chr11:63326132)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64534371chr11:63326132ENST00000377387-1213324_637652.3333333333334674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534372chr11:63326132ENST00000377387-1213324_637652.3333333333334674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534371chr11:63326132ENST00000227503-1213141_222527.3333333333334549.0DomainKH
HgeneSF1chr11:64534371chr11:63326132ENST00000334944-1214141_222527.3333333333334639.0DomainKH
HgeneSF1chr11:64534371chr11:63326132ENST00000377387-1213141_222652.3333333333334674.0DomainKH
HgeneSF1chr11:64534371chr11:63326132ENST00000377390-1213141_222527.3333333333334640.0DomainKH
HgeneSF1chr11:64534371chr11:63326132ENST00000377394-1213141_222528.6666666666666572.0DomainKH
HgeneSF1chr11:64534371chr11:63326132ENST00000433274-1213141_222501.3333333333333614.0DomainKH
HgeneSF1chr11:64534372chr11:63326132ENST00000227503-1213141_222527.3333333333334549.0DomainKH
HgeneSF1chr11:64534372chr11:63326132ENST00000334944-1214141_222527.3333333333334639.0DomainKH
HgeneSF1chr11:64534372chr11:63326132ENST00000377387-1213141_222652.3333333333334674.0DomainKH
HgeneSF1chr11:64534372chr11:63326132ENST00000377390-1213141_222527.3333333333334640.0DomainKH
HgeneSF1chr11:64534372chr11:63326132ENST00000377394-1213141_222528.6666666666666572.0DomainKH
HgeneSF1chr11:64534372chr11:63326132ENST00000433274-1213141_222501.3333333333333614.0DomainKH
HgeneSF1chr11:64534371chr11:63326132ENST00000227503-121315_19527.3333333333334549.0MotifNuclear localization signal
HgeneSF1chr11:64534371chr11:63326132ENST00000334944-121415_19527.3333333333334639.0MotifNuclear localization signal
HgeneSF1chr11:64534371chr11:63326132ENST00000377387-121315_19652.3333333333334674.0MotifNuclear localization signal
HgeneSF1chr11:64534371chr11:63326132ENST00000377390-121315_19527.3333333333334640.0MotifNuclear localization signal
HgeneSF1chr11:64534371chr11:63326132ENST00000377394-121315_19528.6666666666666572.0MotifNuclear localization signal
HgeneSF1chr11:64534371chr11:63326132ENST00000433274-121315_19501.3333333333333614.0MotifNuclear localization signal
HgeneSF1chr11:64534372chr11:63326132ENST00000227503-121315_19527.3333333333334549.0MotifNuclear localization signal
HgeneSF1chr11:64534372chr11:63326132ENST00000334944-121415_19527.3333333333334639.0MotifNuclear localization signal
HgeneSF1chr11:64534372chr11:63326132ENST00000377387-121315_19652.3333333333334674.0MotifNuclear localization signal
HgeneSF1chr11:64534372chr11:63326132ENST00000377390-121315_19527.3333333333334640.0MotifNuclear localization signal
HgeneSF1chr11:64534372chr11:63326132ENST00000377394-121315_19528.6666666666666572.0MotifNuclear localization signal
HgeneSF1chr11:64534372chr11:63326132ENST00000433274-121315_19501.3333333333333614.0MotifNuclear localization signal
HgeneSF1chr11:64534371chr11:63326132ENST00000227503-1213277_296527.3333333333334549.0Zinc fingerCCHC-type
HgeneSF1chr11:64534371chr11:63326132ENST00000334944-1214277_296527.3333333333334639.0Zinc fingerCCHC-type
HgeneSF1chr11:64534371chr11:63326132ENST00000377387-1213277_296652.3333333333334674.0Zinc fingerCCHC-type
HgeneSF1chr11:64534371chr11:63326132ENST00000377390-1213277_296527.3333333333334640.0Zinc fingerCCHC-type
HgeneSF1chr11:64534371chr11:63326132ENST00000377394-1213277_296528.6666666666666572.0Zinc fingerCCHC-type
HgeneSF1chr11:64534371chr11:63326132ENST00000433274-1213277_296501.3333333333333614.0Zinc fingerCCHC-type
HgeneSF1chr11:64534372chr11:63326132ENST00000227503-1213277_296527.3333333333334549.0Zinc fingerCCHC-type
HgeneSF1chr11:64534372chr11:63326132ENST00000334944-1214277_296527.3333333333334639.0Zinc fingerCCHC-type
HgeneSF1chr11:64534372chr11:63326132ENST00000377387-1213277_296652.3333333333334674.0Zinc fingerCCHC-type
HgeneSF1chr11:64534372chr11:63326132ENST00000377390-1213277_296527.3333333333334640.0Zinc fingerCCHC-type
HgeneSF1chr11:64534372chr11:63326132ENST00000377394-1213277_296528.6666666666666572.0Zinc fingerCCHC-type
HgeneSF1chr11:64534372chr11:63326132ENST00000433274-1213277_296501.3333333333333614.0Zinc fingerCCHC-type
TgeneHRASLS2chr11:64534371chr11:63326132ENST0000025569514155_16239.333333333333336163.0Topological domainLumenal
TgeneHRASLS2chr11:64534372chr11:63326132ENST0000025569514155_16239.333333333333336163.0Topological domainLumenal
TgeneHRASLS2chr11:64534371chr11:63326132ENST0000025569514134_15439.333333333333336163.0TransmembraneHelical
TgeneHRASLS2chr11:64534372chr11:63326132ENST0000025569514134_15439.333333333333336163.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64534371chr11:63326132ENST00000227503-1213324_637527.3333333333334549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534371chr11:63326132ENST00000334944-1214324_637527.3333333333334639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534371chr11:63326132ENST00000377390-1213324_637527.3333333333334640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534371chr11:63326132ENST00000377394-1213324_637528.6666666666666572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534371chr11:63326132ENST00000433274-1213324_637501.3333333333333614.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534372chr11:63326132ENST00000227503-1213324_637527.3333333333334549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534372chr11:63326132ENST00000334944-1214324_637527.3333333333334639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534372chr11:63326132ENST00000377390-1213324_637527.3333333333334640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534372chr11:63326132ENST00000377394-1213324_637528.6666666666666572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64534372chr11:63326132ENST00000433274-1213324_637501.3333333333333614.0Compositional biasNote=Pro-rich
TgeneHRASLS2chr11:64534371chr11:63326132ENST000002556951413_12939.333333333333336163.0DomainLRAT
TgeneHRASLS2chr11:64534372chr11:63326132ENST000002556951413_12939.333333333333336163.0DomainLRAT
TgeneHRASLS2chr11:64534371chr11:63326132ENST00000255695141_13339.333333333333336163.0Topological domainCytoplasmic
TgeneHRASLS2chr11:64534372chr11:63326132ENST00000255695141_13339.333333333333336163.0Topological domainCytoplasmic


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1557_SF1_64534372_HRASLS2_63326132_ranked_0.pdbSF16453437164534372ENST00000255695HRASLS2chr1163326132-
MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLAPGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPP
SPGASYPPPQPPPPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPGMPTVIPPGLTREQERAYIVQ
LQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQD
EYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTANTMENVKKAVEQIRNILKQGIETPED
QNDLRKMQLRELARLNGTLREDDNRILRPWQSSETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPV
PASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQH
NPNGPPPPWMQPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPPWQQQQQ
QPPPPPPPSSSMASSTPLPWQQSEIAGAGAASVLSALTNKAIVKKELLSVVAGGDNYRVNNKHDDRYTPLPSNKIVKRAEELVGQELPYS
775


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SF1_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SF1
HRASLS2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SF1-HRASLS2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SF1-HRASLS2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource