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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SH3TC1-FNBP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SH3TC1-FNBP1
FusionPDB ID: 81534
FusionGDB2.0 ID: 81534
HgeneTgene
Gene symbol

SH3TC1

FNBP1

Gene ID

54436

23048

Gene nameSH3 domain and tetratricopeptide repeats 1formin binding protein 1
Synonyms-FBP17
Cytomap

4p16.1

9q34.11

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain and tetratricopeptide repeat-containing protein 1SH3 domain and tetratricopeptide repeats-containing protein 1formin-binding protein 1formin-binding protein 17
Modification date2020031320200313
UniProtAcc.

Q5T0N5

Ensembl transtripts involved in fusion geneENST idsENST00000245105, ENST00000539824, 
ENST00000382521, ENST00000514274, 
ENST00000478129, ENST00000355681, 
ENST00000420781, ENST00000443566, 
ENST00000446176, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 2=824 X 24 X 8=4608
# samples 226
** MAII scorelog2(2/8*10)=1.32192809488736log2(26/4608*10)=-4.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SH3TC1 [Title/Abstract] AND FNBP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SH3TC1(8216307)-FNBP1(132658275), # samples:1
Anticipated loss of major functional domain due to fusion event.SH3TC1-FNBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SH3TC1-FNBP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SH3TC1-FNBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SH3TC1-FNBP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SH3TC1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FNBP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-5798-01ASH3TC1chr4

8216307

+FNBP1chr9

132658275

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000245105SH3TC1chr48216307+ENST00000446176FNBP1chr9132658275-406754858714218
ENST00000245105SH3TC1chr48216307+ENST00000420781FNBP1chr9132658275-406754858714218
ENST00000245105SH3TC1chr48216307+ENST00000355681FNBP1chr9132658275-73354858726222
ENST00000245105SH3TC1chr48216307+ENST00000443566FNBP1chr9132658275-86954858714218
ENST00000539824SH3TC1chr48216307+ENST00000446176FNBP1chr9132658275-414662713461984212
ENST00000539824SH3TC1chr48216307+ENST00000420781FNBP1chr9132658275-414662713461984212
ENST00000539824SH3TC1chr48216307+ENST00000355681FNBP1chr9132658275-812627188805205
ENST00000539824SH3TC1chr48216307+ENST00000443566FNBP1chr9132658275-948627188793201

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000245105ENST00000446176SH3TC1chr48216307+FNBP1chr9132658275-0.0066145090.9933855
ENST00000245105ENST00000420781SH3TC1chr48216307+FNBP1chr9132658275-0.0066145090.9933855
ENST00000245105ENST00000355681SH3TC1chr48216307+FNBP1chr9132658275-0.0077340890.9922659
ENST00000245105ENST00000443566SH3TC1chr48216307+FNBP1chr9132658275-0.0115119850.988488
ENST00000539824ENST00000446176SH3TC1chr48216307+FNBP1chr9132658275-0.621085940.378914
ENST00000539824ENST00000420781SH3TC1chr48216307+FNBP1chr9132658275-0.621085940.378914
ENST00000539824ENST00000355681SH3TC1chr48216307+FNBP1chr9132658275-0.0119951040.98800486
ENST00000539824ENST00000443566SH3TC1chr48216307+FNBP1chr9132658275-0.0152684390.98473155

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>81534_81534_1_SH3TC1-FNBP1_SH3TC1_chr4_8216307_ENST00000245105_FNBP1_chr9_132658275_ENST00000355681_length(amino acids)=222AA_BP=163
MRVMENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEAPPARVAGPAAGTPPCQMGVYPTDLTLQ
LLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYV

--------------------------------------------------------------

>81534_81534_2_SH3TC1-FNBP1_SH3TC1_chr4_8216307_ENST00000245105_FNBP1_chr9_132658275_ENST00000420781_length(amino acids)=218AA_BP=163
MRVMENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEAPPARVAGPAAGTPPCQMGVYPTDLTLQ
LLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYV

--------------------------------------------------------------

>81534_81534_3_SH3TC1-FNBP1_SH3TC1_chr4_8216307_ENST00000245105_FNBP1_chr9_132658275_ENST00000443566_length(amino acids)=218AA_BP=163
MRVMENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEAPPARVAGPAAGTPPCQMGVYPTDLTLQ
LLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYV

--------------------------------------------------------------

>81534_81534_4_SH3TC1-FNBP1_SH3TC1_chr4_8216307_ENST00000245105_FNBP1_chr9_132658275_ENST00000446176_length(amino acids)=218AA_BP=163
MRVMENLPAVTTEEPTPMGRGPVGPSGGGSTRDQVRTVVMRPSVSWEKAGPEEAKAPVRGDEAPPARVAGPAAGTPPCQMGVYPTDLTLQ
LLAVRRKSRLRDPGLQQTLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYV

--------------------------------------------------------------

>81534_81534_5_SH3TC1-FNBP1_SH3TC1_chr4_8216307_ENST00000539824_FNBP1_chr9_132658275_ENST00000355681_length(amino acids)=205AA_BP=146
MGESGARGGQGASERRETWSVWRLQRSQAFAWSPLILGTCCVADEAPPARVAGPAAGTPPCQMGVYPTDLTLQLLAVRRKSRLRDPGLQQ
TLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNED

--------------------------------------------------------------

>81534_81534_6_SH3TC1-FNBP1_SH3TC1_chr4_8216307_ENST00000539824_FNBP1_chr9_132658275_ENST00000420781_length(amino acids)=212AA_BP=20
MHLILNIDPFTMPSTWEHLAGRGAGTHTPTGTPTSTHACAYTHFGLTPCFQWPGEVHTGSRIPARLVDSPVSTGHEEPTPVLPITFLSLR
TVDHALVSEALPSAPAHCKANILSFPGAPGLASEKGSTSFFVVVFFFFLRRESRSIVQTGVQWHDLGSLQPPPPGFQRFSCLSLPNSCDY

--------------------------------------------------------------

>81534_81534_7_SH3TC1-FNBP1_SH3TC1_chr4_8216307_ENST00000539824_FNBP1_chr9_132658275_ENST00000443566_length(amino acids)=201AA_BP=146
MGESGARGGQGASERRETWSVWRLQRSQAFAWSPLILGTCCVADEAPPARVAGPAAGTPPCQMGVYPTDLTLQLLAVRRKSRLRDPGLQQ
TLRGQLRLLENDSREMARVLGELSARLLSIHSDQDRIVVTFKTFEEIWKFSTYHALGQNEGTISVVEGETLYVIEEDKGDGWTRIRRNED

--------------------------------------------------------------

>81534_81534_8_SH3TC1-FNBP1_SH3TC1_chr4_8216307_ENST00000539824_FNBP1_chr9_132658275_ENST00000446176_length(amino acids)=212AA_BP=20
MHLILNIDPFTMPSTWEHLAGRGAGTHTPTGTPTSTHACAYTHFGLTPCFQWPGEVHTGSRIPARLVDSPVSTGHEEPTPVLPITFLSLR
TVDHALVSEALPSAPAHCKANILSFPGAPGLASEKGSTSFFVVVFFFFLRRESRSIVQTGVQWHDLGSLQPPPPGFQRFSCLSLPNSCDY

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:8216307/chr9:132658275)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FNBP1

Q5T0N5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416550_611533.3333333333334593.0DomainSH3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518305_368160.333333333333341337.0DomainSH3
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+5181027_1063160.333333333333341337.0RepeatNote=TPR 7
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+5181192_1225160.333333333333341337.0RepeatNote=TPR 8
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+5181277_1311160.333333333333341337.0RepeatNote=TPR 9
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518560_593160.333333333333341337.0RepeatNote=TPR 1
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518601_634160.333333333333341337.0RepeatNote=TPR 2
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518665_698160.333333333333341337.0RepeatNote=TPR 3
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518786_819160.333333333333341337.0RepeatNote=TPR 4
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518863_896160.333333333333341337.0RepeatNote=TPR 5
HgeneSH3TC1chr4:8216307chr9:132658275ENST00000245105+518946_979160.333333333333341337.0RepeatNote=TPR 6
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416398_490533.3333333333334593.0Coiled coilOntology_term=ECO:0000250
TgeneFNBP1chr4:8216307chr9:132658275ENST00000355681141667_259533.3333333333334593.0Coiled coilOntology_term=ECO:0000269
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417398_490562.3333333333334618.0Coiled coilOntology_term=ECO:0000250
TgeneFNBP1chr4:8216307chr9:132658275ENST00000446176141767_259562.3333333333334618.0Coiled coilOntology_term=ECO:0000269
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416340_345533.3333333333334593.0Compositional biasNote=Poly-Pro
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417340_345562.3333333333334618.0Compositional biasNote=Poly-Pro
TgeneFNBP1chr4:8216307chr9:132658275ENST0000035568114161_264533.3333333333334593.0DomainF-BAR
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416404_481533.3333333333334593.0DomainREM-1
TgeneFNBP1chr4:8216307chr9:132658275ENST0000044617614171_264562.3333333333334618.0DomainF-BAR
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417404_481562.3333333333334618.0DomainREM-1
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417550_611562.3333333333334618.0DomainSH3
TgeneFNBP1chr4:8216307chr9:132658275ENST0000035568114161_79533.3333333333334593.0RegionNote=Required for self-association and induction of membrane tubulation
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416251_617533.3333333333334593.0RegionNote=Required for self-association and induction of membrane tubulation
TgeneFNBP1chr4:8216307chr9:132658275ENST0000044617614171_79562.3333333333334618.0RegionNote=Required for self-association and induction of membrane tubulation
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417251_617562.3333333333334618.0RegionNote=Required for self-association and induction of membrane tubulation


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SH3TC1
FNBP1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417550_617562.3333333333334618.0ARHGAP17%2C DAAM1%2C DIAPH1 and DIAPH2
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417535_617562.3333333333334618.0DNM1 and DNM3
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417553_609562.3333333333334618.0DNM2 and WASL
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417553_610562.3333333333334618.0FASLG
TgeneFNBP1chr4:8216307chr9:132658275ENST0000035568114161_335533.3333333333334593.0microtubules
TgeneFNBP1chr4:8216307chr9:132658275ENST0000044617614171_335562.3333333333334618.0microtubules
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416495_617533.3333333333334593.0PDE6G
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417495_617562.3333333333334618.0PDE6G
TgeneFNBP1chr4:8216307chr9:132658275ENST000003556811416400_552533.3333333333334593.0RND2
TgeneFNBP1chr4:8216307chr9:132658275ENST000004461761417400_552562.3333333333334618.0RND2


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Related Drugs to SH3TC1-FNBP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SH3TC1-FNBP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource