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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SLAIN2-CWH43

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SLAIN2-CWH43
	FusionPDB ID: 82171
	FusionGDB2.0 ID: 82171
		Hgene	Tgene
	Gene symbol	SLAIN2	CWH43
	Gene ID	57606	80157
	Gene name	SLAIN motif family member 2	cell wall biogenesis 43 C-terminal homolog
	Synonyms	KIAA1458	CWH43-C\|PGAP2IP
	Cytomap	4p11	4p11
	Type of gene	protein-coding	protein-coding
	Description	SLAIN motif-containing protein 2	PGAP2-interacting proteincell wall biogenesis protein 43 C-terminal homolog
	Modification date	20200313	20200313
	UniProtAcc	.	Q9H720
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264313, ENST00000512093, ENST00000506375,	ENST00000226432, ENST00000513409,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 3=48	3 X 6 X 3=54
	# samples	5	4
	** MAII score	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/54*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SLAIN2 [Title/Abstract] AND CWH43 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SLAIN2(48385801)-CWH43(49005752), # samples:2
Anticipated loss of major functional domain due to fusion event.	SLAIN2-CWH43 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLAIN2-CWH43 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLAIN2-CWH43 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLAIN2-CWH43 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SLAIN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CWH43 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CN-4725-01A	SLAIN2	chr4	48385801	+	CWH43	chr4	49005752	+
ChimerDB4	HNSC	TCGA-CN-4725	SLAIN2	chr4	48385801	+	CWH43	chr4	49005751	+
ChimerDB4	HNSC	TCGA-CN-4725	SLAIN2	chr4	48385801	+	CWH43	chr4	49005752	+
ChimerDB4	HNSC	TCGA-CN-4725	SLAIN2	chr4	48385801	+	CWH43	chr4	49009217	+
ChimerDB4	HNSC	TCGA-CN-4725	SLAIN2	chr4	48385801	+	CWH43	chr4	49009218	+
ChimerDB4	HNSC	TCGA-CN-4725	SLAIN2	chr4	48396670	+	CWH43	chr4	49005752	+
ChimerDB4	HNSC	TCGA-CN-4725	SLAIN2	chr4	48396670	+	CWH43	chr4	49009218	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264313	SLAIN2	chr4	48385801	+	ENST00000226432	CWH43	chr4	49005752	+	3265	1778	364	3075	903
ENST00000264313	SLAIN2	chr4	48385801	+	ENST00000513409	CWH43	chr4	49005752	+	3262	1778	364	3075	903
ENST00000512093	SLAIN2	chr4	48385801	+	ENST00000226432	CWH43	chr4	49005752	+	2304	817	36	2114	692
ENST00000512093	SLAIN2	chr4	48385801	+	ENST00000513409	CWH43	chr4	49005752	+	2301	817	36	2114	692
ENST00000264313	SLAIN2	chr4	48385801	+	ENST00000226432	CWH43	chr4	49009217	+	3007	1778	364	2817	817
ENST00000264313	SLAIN2	chr4	48385801	+	ENST00000513409	CWH43	chr4	49009217	+	3004	1778	364	2817	817
ENST00000512093	SLAIN2	chr4	48385801	+	ENST00000226432	CWH43	chr4	49009217	+	2046	817	36	1856	606
ENST00000512093	SLAIN2	chr4	48385801	+	ENST00000513409	CWH43	chr4	49009217	+	2043	817	36	1856	606
ENST00000264313	SLAIN2	chr4	48385801	+	ENST00000226432	CWH43	chr4	49005751	+	3265	1778	364	3075	903
ENST00000264313	SLAIN2	chr4	48385801	+	ENST00000513409	CWH43	chr4	49005751	+	3262	1778	364	3075	903
ENST00000512093	SLAIN2	chr4	48385801	+	ENST00000226432	CWH43	chr4	49005751	+	2304	817	36	2114	692
ENST00000512093	SLAIN2	chr4	48385801	+	ENST00000513409	CWH43	chr4	49005751	+	2301	817	36	2114	692
ENST00000512093	SLAIN2	chr4	48396670	+	ENST00000226432	CWH43	chr4	49005752	+	2382	895	36	2192	718
ENST00000512093	SLAIN2	chr4	48396670	+	ENST00000513409	CWH43	chr4	49005752	+	2379	895	36	2192	718
ENST00000264313	SLAIN2	chr4	48385801	+	ENST00000226432	CWH43	chr4	49009218	+	3007	1778	364	2817	817
ENST00000264313	SLAIN2	chr4	48385801	+	ENST00000513409	CWH43	chr4	49009218	+	3004	1778	364	2817	817
ENST00000512093	SLAIN2	chr4	48385801	+	ENST00000226432	CWH43	chr4	49009218	+	2046	817	36	1856	606
ENST00000512093	SLAIN2	chr4	48385801	+	ENST00000513409	CWH43	chr4	49009218	+	2043	817	36	1856	606
ENST00000512093	SLAIN2	chr4	48396670	+	ENST00000226432	CWH43	chr4	49009218	+	2124	895	36	1934	632
ENST00000512093	SLAIN2	chr4	48396670	+	ENST00000513409	CWH43	chr4	49009218	+	2121	895	36	1934	632

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264313	ENST00000226432	SLAIN2	chr4	48385801	+	CWH43	chr4	49005752	+	0.00086649	0.9991335
ENST00000264313	ENST00000513409	SLAIN2	chr4	48385801	+	CWH43	chr4	49005752	+	0.000888843	0.9991111
ENST00000512093	ENST00000226432	SLAIN2	chr4	48385801	+	CWH43	chr4	49005752	+	0.000738581	0.99926144
ENST00000512093	ENST00000513409	SLAIN2	chr4	48385801	+	CWH43	chr4	49005752	+	0.000751866	0.9992481
ENST00000264313	ENST00000226432	SLAIN2	chr4	48385801	+	CWH43	chr4	49009217	+	0.00172705	0.9982729
ENST00000264313	ENST00000513409	SLAIN2	chr4	48385801	+	CWH43	chr4	49009217	+	0.00178389	0.9982161
ENST00000512093	ENST00000226432	SLAIN2	chr4	48385801	+	CWH43	chr4	49009217	+	0.000710565	0.9992894
ENST00000512093	ENST00000513409	SLAIN2	chr4	48385801	+	CWH43	chr4	49009217	+	0.00073342	0.99926656
ENST00000264313	ENST00000226432	SLAIN2	chr4	48385801	+	CWH43	chr4	49005751	+	0.00086649	0.9991335
ENST00000264313	ENST00000513409	SLAIN2	chr4	48385801	+	CWH43	chr4	49005751	+	0.000888843	0.9991111
ENST00000512093	ENST00000226432	SLAIN2	chr4	48385801	+	CWH43	chr4	49005751	+	0.000738581	0.99926144
ENST00000512093	ENST00000513409	SLAIN2	chr4	48385801	+	CWH43	chr4	49005751	+	0.000751866	0.9992481
ENST00000512093	ENST00000226432	SLAIN2	chr4	48396670	+	CWH43	chr4	49005752	+	0.000756305	0.99924374
ENST00000512093	ENST00000513409	SLAIN2	chr4	48396670	+	CWH43	chr4	49005752	+	0.00077389	0.9992261
ENST00000264313	ENST00000226432	SLAIN2	chr4	48385801	+	CWH43	chr4	49009218	+	0.00172705	0.9982729
ENST00000264313	ENST00000513409	SLAIN2	chr4	48385801	+	CWH43	chr4	49009218	+	0.00178389	0.9982161
ENST00000512093	ENST00000226432	SLAIN2	chr4	48385801	+	CWH43	chr4	49009218	+	0.000710565	0.9992894
ENST00000512093	ENST00000513409	SLAIN2	chr4	48385801	+	CWH43	chr4	49009218	+	0.00073342	0.99926656
ENST00000512093	ENST00000226432	SLAIN2	chr4	48396670	+	CWH43	chr4	49009218	+	0.000839307	0.99916065
ENST00000512093	ENST00000513409	SLAIN2	chr4	48396670	+	CWH43	chr4	49009218	+	0.000864879	0.9991352

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>82171_82171_1_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000264313_CWH43_chr4_49005751_ENST00000226432_length(amino acids)=903AA_BP=1
MSLRERAGGGGGGGGGAGMEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLS
AKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPD
VECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSI
DSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRF
SPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSR
SDSNFQVPNGGIPRMQPQASARTASAAGLLYLHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAF
KFVPGGVYARERSDVLLGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTK
EVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSE
HHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDST
DHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTPK

--------------------------------------------------------------

>82171_82171_2_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000264313_CWH43_chr4_49005751_ENST00000513409_length(amino acids)=903AA_BP=1
MSLRERAGGGGGGGGGAGMEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLS
AKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPD
VECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSI
DSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRF
SPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSR
SDSNFQVPNGGIPRMQPQASARTASAAGLLYLHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAF
KFVPGGVYARERSDVLLGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTK
EVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSE
HHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDST
DHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTPK

--------------------------------------------------------------

>82171_82171_3_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000264313_CWH43_chr4_49005752_ENST00000226432_length(amino acids)=903AA_BP=1
MSLRERAGGGGGGGGGAGMEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLS
AKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPD
VECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSI
DSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRF
SPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSR
SDSNFQVPNGGIPRMQPQASARTASAAGLLYLHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAF
KFVPGGVYARERSDVLLGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTK
EVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSE
HHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDST
DHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTPK

--------------------------------------------------------------

>82171_82171_4_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000264313_CWH43_chr4_49005752_ENST00000513409_length(amino acids)=903AA_BP=1
MSLRERAGGGGGGGGGAGMEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLS
AKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPD
VECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSI
DSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRF
SPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSR
SDSNFQVPNGGIPRMQPQASARTASAAGLLYLHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAF
KFVPGGVYARERSDVLLGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTK
EVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSE
HHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDST
DHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTPK

--------------------------------------------------------------

>82171_82171_5_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000264313_CWH43_chr4_49009217_ENST00000226432_length(amino acids)=817AA_BP=1
MSLRERAGGGGGGGGGAGMEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLS
AKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPD
VECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSI
DSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRF
SPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSR
SDSNFQVPNGGIPRMQPQASARTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKV
APTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPI
VKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKD
IDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHM

--------------------------------------------------------------

>82171_82171_6_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000264313_CWH43_chr4_49009217_ENST00000513409_length(amino acids)=817AA_BP=1
MSLRERAGGGGGGGGGAGMEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLS
AKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPD
VECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSI
DSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRF
SPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSR
SDSNFQVPNGGIPRMQPQASARTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKV
APTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPI
VKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKD
IDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHM

--------------------------------------------------------------

>82171_82171_7_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000264313_CWH43_chr4_49009218_ENST00000226432_length(amino acids)=817AA_BP=1
MSLRERAGGGGGGGGGAGMEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLS
AKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPD
VECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSI
DSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRF
SPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSR
SDSNFQVPNGGIPRMQPQASARTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKV
APTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPI
VKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKD
IDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHM

--------------------------------------------------------------

>82171_82171_8_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000264313_CWH43_chr4_49009218_ENST00000513409_length(amino acids)=817AA_BP=1
MSLRERAGGGGGGGGGAGMEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLS
AKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPD
VECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSI
DSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRF
SPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSR
SDSNFQVPNGGIPRMQPQASARTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKV
APTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPI
VKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKD
IDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHM

--------------------------------------------------------------

>82171_82171_9_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000512093_CWH43_chr4_49005751_ENST00000226432_length(amino acids)=692AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASARTASAAGLLY
LHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAFKFVPGGVYARERSDVLLGTMMLIIGLNMLFG
PKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNET
GADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVT
HFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSE

--------------------------------------------------------------

>82171_82171_10_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000512093_CWH43_chr4_49005751_ENST00000513409_length(amino acids)=692AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASARTASAAGLLY
LHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAFKFVPGGVYARERSDVLLGTMMLIIGLNMLFG
PKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNET
GADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVT
HFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSE

--------------------------------------------------------------

>82171_82171_11_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000512093_CWH43_chr4_49005752_ENST00000226432_length(amino acids)=692AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASARTASAAGLLY
LHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAFKFVPGGVYARERSDVLLGTMMLIIGLNMLFG
PKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNET
GADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVT
HFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSE

--------------------------------------------------------------

>82171_82171_12_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000512093_CWH43_chr4_49005752_ENST00000513409_length(amino acids)=692AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASARTASAAGLLY
LHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAFKFVPGGVYARERSDVLLGTMMLIIGLNMLFG
PKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHLLNET
GADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVDFVVT
HFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLGYARISHAELSDSE

--------------------------------------------------------------

>82171_82171_13_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000512093_CWH43_chr4_49009217_ENST00000226432_length(amino acids)=606AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASARTMMLIIGLN
MLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHL
LNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVD
FVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLGYARISHAEL

--------------------------------------------------------------

>82171_82171_14_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000512093_CWH43_chr4_49009217_ENST00000513409_length(amino acids)=606AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASARTMMLIIGLN
MLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHL
LNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVD
FVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLGYARISHAEL

--------------------------------------------------------------

>82171_82171_15_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000512093_CWH43_chr4_49009218_ENST00000226432_length(amino acids)=606AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASARTMMLIIGLN
MLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHL
LNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVD
FVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLGYARISHAEL

--------------------------------------------------------------

>82171_82171_16_SLAIN2-CWH43_SLAIN2_chr4_48385801_ENST00000512093_CWH43_chr4_49009218_ENST00000513409_length(amino acids)=606AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASARTMMLIIGLN
MLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAAIWPFRFGYDNEGWSSLERSAHL
LNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLPSPEGEIAPAITLTVNISGKLVD
FVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRWCEYIMYRGLIRLGYARISHAEL

--------------------------------------------------------------

>82171_82171_17_SLAIN2-CWH43_SLAIN2_chr4_48396670_ENST00000512093_CWH43_chr4_49005752_ENST00000226432_length(amino acids)=718AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASATSQRLKNLPR
TSLKAKQLLQTSSTKRGTASAAGLLYLHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAFKFVPG
GVYARERSDVLLGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAA
IWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLP
SPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRW

--------------------------------------------------------------

>82171_82171_18_SLAIN2-CWH43_SLAIN2_chr4_48396670_ENST00000512093_CWH43_chr4_49005752_ENST00000513409_length(amino acids)=718AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASATSQRLKNLPR
TSLKAKQLLQTSSTKRGTASAAGLLYLHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAFKFVPG
GVYARERSDVLLGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKEVSAA
IWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEHHLLP
SPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTDHDRW

--------------------------------------------------------------

>82171_82171_19_SLAIN2-CWH43_SLAIN2_chr4_48396670_ENST00000512093_CWH43_chr4_49009218_ENST00000226432_length(amino acids)=632AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASATSQRLKNLPR
TSLKAKQLLQTSSTKRGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKE
VSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEH
HLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTD
HDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTPKY

--------------------------------------------------------------

>82171_82171_20_SLAIN2-CWH43_SLAIN2_chr4_48396670_ENST00000512093_CWH43_chr4_49009218_ENST00000513409_length(amino acids)=632AA_BP=0
MSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSIDSELSASELDEDSIGSNYKLNDVTDVQILAR
MQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRFSPSPRNSPRPSPKQSPRNSPRSRSPARGIEY
SRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSRSDSNFQVPNGGIPRMQPQASATSQRLKNLPR
TSLKAKQLLQTSSTKRGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTKE
VSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSEH
HLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDSTD
HDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTPKY

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:48385801/chr4:49005752)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CWH43 Q9H720
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Involved in lipid remodeling during GPI-anchor maturation. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLAIN2

chr4:48385801

chr4:49005751

ENST00000264313

4_39

453.3333333333333

582.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

SLAIN2

chr4:48385801

chr4:49005752

ENST00000264313

4_39

453.3333333333333

582.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

SLAIN2

chr4:48385801

chr4:49009217

ENST00000264313

4_39

453.3333333333333

582.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

SLAIN2

chr4:48385801

chr4:49009218

ENST00000264313

4_39

453.3333333333333

582.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

SLAIN2

chr4:48385801

chr4:49005751

ENST00000264313

124_128

453.3333333333333

582.0

Compositional bias

Note=Poly-Glu

Hgene

SLAIN2

chr4:48385801

chr4:49005752

ENST00000264313

124_128

453.3333333333333

582.0

Compositional bias

Note=Poly-Glu

Hgene

SLAIN2

chr4:48385801

chr4:49009217

ENST00000264313

124_128

453.3333333333333

582.0

Compositional bias

Note=Poly-Glu

Hgene

SLAIN2

chr4:48385801

chr4:49009218

ENST00000264313

124_128

453.3333333333333

582.0

Compositional bias

Note=Poly-Glu

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

607_627

267.3333333333333

700.0

Region

Required for function in lipid remodeling

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

607_627

267.3333333333333

700.0

Region

Required for function in lipid remodeling

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

607_627

353.3333333333333

700.0

Region

Required for function in lipid remodeling

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

607_627

353.3333333333333

700.0

Region

Required for function in lipid remodeling

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

607_627

267.3333333333333

700.0

Region

Required for function in lipid remodeling

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

607_627

353.3333333333333

700.0

Region

Required for function in lipid remodeling

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

273_293

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

316_336

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

349_369

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

390_410

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

273_293

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

316_336

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

349_369

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

390_410

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

390_410

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

390_410

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

273_293

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

316_336

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

349_369

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

390_410

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

390_410

353.3333333333333

700.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLAIN2

chr4:48396670

chr4:49005752

ENST00000264313

4_39

582.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

SLAIN2

chr4:48396670

chr4:49009218

ENST00000264313

4_39

582.0

Coiled coil

Ontology_term=ECO:0000269

Hgene

SLAIN2

chr4:48396670

chr4:49005752

ENST00000264313

124_128

582.0

Compositional bias

Note=Poly-Glu

Hgene

SLAIN2

chr4:48396670

chr4:49009218

ENST00000264313

124_128

582.0

Compositional bias

Note=Poly-Glu

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

123_143

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

13_33

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

196_216

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

237_257

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

41_61

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005751

ENST00000226432

93_113

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

123_143

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

13_33

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

196_216

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

237_257

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

41_61

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49005752

ENST00000226432

93_113

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

123_143

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

13_33

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

196_216

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

237_257

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

273_293

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

316_336

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

349_369

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

41_61

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009217

ENST00000226432

93_113

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

123_143

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

13_33

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

196_216

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

237_257

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

273_293

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

316_336

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

349_369

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

41_61

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48385801

chr4:49009218

ENST00000226432

93_113

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

123_143

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

13_33

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

196_216

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

237_257

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

41_61

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49005752

ENST00000226432

93_113

267.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

123_143

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

13_33

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

196_216

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

237_257

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

273_293

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

316_336

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

349_369

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

41_61

353.3333333333333

700.0

Transmembrane

Helical

Tgene

CWH43

chr4:48396670

chr4:49009218

ENST00000226432

93_113

353.3333333333333

700.0

Transmembrane

Helical

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1697_SLAIN2_48385801_CWH43_49005752_ranked_0.pdb	SLAIN2	48396670	48385801	ENST00000513409	CWH43	chr4	49005752	+	MSLRERAGGGGGGGGGAGMEDVNSNVNADQEVRKLQELVKKLEKQNEQLRSRSGAVQGAGSLGPGSPVRAGASIPSSGAASPRGFPLGLS AKSGGGPGSGPRRTSSEELRDATSLLAAGEGGLLDEVEPLRPDELERLSGWEEEEESWLYSSPKKKLTPMQKSVSPLVWCRQVLDYPSPD VECAKKSLIHKLDQTMSALKRQNLYNNPFNSMSYTSPYSPNASSPYSSGFNSPSSTPVRPPIVKQLILPGNSGNLKSSDRNPPLSPQSSI DSELSASELDEDSIGSNYKLNDVTDVQILARMQEESLRQEYAATTSRRSSGSSCNSTRRGTFSDQELDAQSLDDEDDNMHHAVYPAVNRF SPSPRNSPRPSPKQSPRNSPRSRSPARGIEYSRVSPQPMISRLQQPRLSLQGHPTDLQTSNVKNEEKLRRSLPNLSRTSNTQVDSVKSSR SDSNFQVPNGGIPRMQPQASARTASAAGLLYLHTWAAAVSGCVFAIFTASMWPQTLGHLINSGTNPGKTMTIAMIFYLLEIFFCAWCTAF KFVPGGVYARERSDVLLGTMMLIIGLNMLFGPKKNLDLLLQTKNSSKVLFRKSEKYMKLFLWLLVGVGLLGLGLRHKAYERKLGKVAPTK EVSAAIWPFRFGYDNEGWSSLERSAHLLNETGADFITILESDASKPYMGNNDLTMWLGEKLGFYTDFGPSTRYHTWGIMALSRYPIVKSE HHLLPSPEGEIAPAITLTVNISGKLVDFVVTHFGNHEDDLDRKLQAIAVSKLLKSSSNQVIFLGYITSAPGSRDYLQLTEHGNVKDIDST DHDRWCEYIMYRGLIRLGYARISHAELSDSEIQMAKFRIPDDPTNYRDNQKVVIDHREVSEKIHFNPRFGSYKEGHNYENNHHFHMNTPK	903

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SLAIN2_pLDDT.png

CWH43_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SLAIN2
CWH43

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to SLAIN2-CWH43

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SLAIN2-CWH43

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source