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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SLC12A2-NRG2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SLC12A2-NRG2
	FusionPDB ID: 82216
	FusionGDB2.0 ID: 82216
		Hgene	Tgene
	Gene symbol	SLC12A2	NRG2
	Gene ID	6558	9542
	Gene name	solute carrier family 12 member 2	neuregulin 2
	Synonyms	BSC\|BSC2\|NKCC1\|PPP1R141	DON1\|HRG2\|NTAK
	Cytomap	5q23.3	5q31.2
	Type of gene	protein-coding	protein-coding
	Description	solute carrier family 12 member 2basolateral Na-K-Cl symporterbumetanide-sensitive sodium-(potassium)-chloride cotransporter 1bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2protein phosphatase 1, regulatory subunit 141solute carrier	pro-neuregulin-2, membrane-bound isoformdivergent of neuregulin-1neural- and thymus-derived activator for ErbB kinasespro-NRG2
	Modification date	20200327	20200313
	UniProtAcc	.	O14511
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262461, ENST00000343225, ENST00000507791,	ENST00000518130, ENST00000394770, ENST00000289409, ENST00000289422, ENST00000340391, ENST00000358522, ENST00000361474, ENST00000541337, ENST00000545385,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 13 X 4=728	3 X 3 X 4=36
	# samples	16	4
	** MAII score	log2(16/728*10)=-2.18586654531133 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SLC12A2 [Title/Abstract] AND NRG2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SLC12A2(127450373)-NRG2(139267098), # samples:5
Anticipated loss of major functional domain due to fusion event.	SLC12A2-NRG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC12A2-NRG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC12A2-NRG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC12A2-NRG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC12A2-NRG2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SLC12A2	GO:0015696	ammonium transport	12946942\|18032481
Hgene	SLC12A2	GO:0030321	transepithelial chloride transport	12946942
Hgene	SLC12A2	GO:0070634	transepithelial ammonium transport	18032481

Fusion gene breakpoints across SLC12A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NRG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	LQ657575	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-
ChiTaRS5.0	N/A	LQ657577	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-
ChiTaRS5.0	N/A	LQ657579	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-
ChiTaRS5.0	N/A	LQ657581	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-
ChiTaRS5.0	N/A	LQ657583	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000262461	SLC12A2	chr5	127450373	+	ENST00000541337	NRG2	chr5	139267098	-	4030	1237	33	2891	952
ENST00000262461	SLC12A2	chr5	127450373	+	ENST00000289422	NRG2	chr5	139267098	-	3382	1237	33	3113	1026
ENST00000262461	SLC12A2	chr5	127450373	+	ENST00000361474	NRG2	chr5	139267098	-	3332	1237	33	3089	1018
ENST00000262461	SLC12A2	chr5	127450373	+	ENST00000545385	NRG2	chr5	139267098	-	3338	1237	33	3095	1020
ENST00000262461	SLC12A2	chr5	127450373	+	ENST00000358522	NRG2	chr5	139267098	-	3096	1237	33	3095	1020
ENST00000262461	SLC12A2	chr5	127450373	+	ENST00000289409	NRG2	chr5	139267098	-	3072	1237	33	3071	1012
ENST00000262461	SLC12A2	chr5	127450373	+	ENST00000340391	NRG2	chr5	139267098	-	3090	1237	33	3089	1018
ENST00000343225	SLC12A2	chr5	127450373	+	ENST00000541337	NRG2	chr5	139267098	-	3948	1155	8	2809	933
ENST00000343225	SLC12A2	chr5	127450373	+	ENST00000289422	NRG2	chr5	139267098	-	3300	1155	8	3031	1007
ENST00000343225	SLC12A2	chr5	127450373	+	ENST00000361474	NRG2	chr5	139267098	-	3250	1155	8	3007	999
ENST00000343225	SLC12A2	chr5	127450373	+	ENST00000545385	NRG2	chr5	139267098	-	3256	1155	8	3013	1001
ENST00000343225	SLC12A2	chr5	127450373	+	ENST00000358522	NRG2	chr5	139267098	-	3014	1155	8	3013	1002
ENST00000343225	SLC12A2	chr5	127450373	+	ENST00000289409	NRG2	chr5	139267098	-	2990	1155	8	2989	994
ENST00000343225	SLC12A2	chr5	127450373	+	ENST00000340391	NRG2	chr5	139267098	-	3008	1155	8	3007	1000

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000262461	ENST00000541337	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.002220037	0.99778
ENST00000262461	ENST00000289422	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.002105498	0.9978946
ENST00000262461	ENST00000361474	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.002516196	0.99748373
ENST00000262461	ENST00000545385	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.002326909	0.9976731
ENST00000262461	ENST00000358522	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.003751666	0.9962483
ENST00000262461	ENST00000289409	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.003825308	0.9961747
ENST00000262461	ENST00000340391	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.004020782	0.9959792
ENST00000343225	ENST00000541337	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.002102833	0.99789715
ENST00000343225	ENST00000289422	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.001984235	0.99801576
ENST00000343225	ENST00000361474	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.002379457	0.9976205
ENST00000343225	ENST00000545385	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.002196424	0.9978035
ENST00000343225	ENST00000358522	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.003573854	0.99642617
ENST00000343225	ENST00000289409	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.003642126	0.99635786
ENST00000343225	ENST00000340391	SLC12A2	chr5	127450373	+	NRG2	chr5	139267098	-	0.003836777	0.99616325

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>82216_82216_1_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000262461_NRG2_chr5_139267098_ENST00000289409_length(amino acids)=1012AA_BP=141
MWPSRLAAARRRRGERLSHLVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTA
VPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEP
AKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTM
DAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRL
SWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRD
IRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKC
PVGYTGDRCQQFAMVNFSKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEI
QMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARAR
RAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLL
RHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSA
GPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHS

--------------------------------------------------------------

>82216_82216_2_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000262461_NRG2_chr5_139267098_ENST00000289422_length(amino acids)=1026AA_BP=141
MWPSRLAAARRRRGERLSHLVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTA
VPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEP
AKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTM
DAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRL
SWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRD
IRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKC
PNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSL
ANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGT
SKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPA
APISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPP
PRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCP

--------------------------------------------------------------

>82216_82216_3_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000262461_NRG2_chr5_139267098_ENST00000340391_length(amino acids)=1018AA_BP=141
MWPSRLAAARRRRGERLSHLVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTA
VPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEP
AKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTM
DAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRL
SWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRD
IRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKC
PNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPR
LDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPAC
VEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLA
EQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGA
SRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYY

--------------------------------------------------------------

>82216_82216_4_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000262461_NRG2_chr5_139267098_ENST00000358522_length(amino acids)=1020AA_BP=141
MWPSRLAAARRRRGERLSHLVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTA
VPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEP
AKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTM
DAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRL
SWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRD
IRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKC
PVGYTGDRCQQFAMVNFSKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSH
PRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSP
ACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYR
LAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRAR
GASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT

--------------------------------------------------------------

>82216_82216_5_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000262461_NRG2_chr5_139267098_ENST00000361474_length(amino acids)=1018AA_BP=141
MWPSRLAAARRRRGERLSHLVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTA
VPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEP
AKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTM
DAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRL
SWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRD
IRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKC
PNGFFGQRCLEKLPLRLYMPDPKQKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPR
LDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPAC
VEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLA
EQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGA
SRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYY

--------------------------------------------------------------

>82216_82216_6_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000262461_NRG2_chr5_139267098_ENST00000541337_length(amino acids)=952AA_BP=141
MWPSRLAAARRRRGERLSHLVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTA
VPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEP
AKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTM
DAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRL
SWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRD
IRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMH
NHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSES
LTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTF
EITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIP
EDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGL

--------------------------------------------------------------

>82216_82216_7_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000262461_NRG2_chr5_139267098_ENST00000545385_length(amino acids)=1020AA_BP=141
MWPSRLAAARRRRGERLSHLVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTA
VPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEP
AKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTM
DAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRL
SWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRD
IRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKC
PVGYTGDRCQQFAMVNFSTRLGGDVEEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSH
PRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSP
ACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYR
LAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRAR
GASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRT

--------------------------------------------------------------

>82216_82216_8_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000343225_NRG2_chr5_139267098_ENST00000289409_length(amino acids)=994AA_BP=122
MVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVR
DEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPA
ASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEK
LLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMA
TVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV
KVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSK
AEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPATDHVIRR
ETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRATAPPYH
DSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPGPGPGPG
ADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGLAAQRAR
AARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPPRAKQDS

--------------------------------------------------------------

>82216_82216_9_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000343225_NRG2_chr5_139267098_ENST00000289422_length(amino acids)=1007AA_BP=122
MVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVR
DEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPA
ASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEK
LLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMA
TVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV
KVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYM
PDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADY
ISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAY
NLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAP
PGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRW
RRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASS

--------------------------------------------------------------

>82216_82216_10_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000343225_NRG2_chr5_139267098_ENST00000340391_length(amino acids)=1000AA_BP=122
MVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVR
DEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPA
ASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEK
LLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMA
TVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV
KVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYM
PDPKQKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPAT
DHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRA
TAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPG
PGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGL
AAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPP

--------------------------------------------------------------

>82216_82216_11_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000343225_NRG2_chr5_139267098_ENST00000358522_length(amino acids)=1002AA_BP=122
MVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVR
DEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPA
ASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEK
LLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMA
TVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV
KVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFSK
HLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVP
ATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERR
RATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPG
PGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLN
GLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGP

--------------------------------------------------------------

>82216_82216_12_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000343225_NRG2_chr5_139267098_ENST00000361474_length(amino acids)=999AA_BP=122
MVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVR
DEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPA
ASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEK
LLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMA
TVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV
KVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPNGFFGQRCLEKLPLRLYM
PDPKQKAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVPAT
DHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERRRA
TAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPGPG
PGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLNGL
AAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGPPP

--------------------------------------------------------------

>82216_82216_13_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000343225_NRG2_chr5_139267098_ENST00000541337_length(amino acids)=933AA_BP=122
MVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVR
DEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPA
ASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEK
LLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMA
TVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV
KVEDAGEYVCEAENILGKDTVRGRLYVNSEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANG
PSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKC
NSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPI
SYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRP
RARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAAD

--------------------------------------------------------------

>82216_82216_14_SLC12A2-NRG2_SLC12A2_chr5_127450373_ENST00000343225_NRG2_chr5_139267098_ENST00000545385_length(amino acids)=1001AA_BP=122
MVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVR
DEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPA
ASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEK
LLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMA
TVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRDIRIKYGNGRKNSRLQFNKV
KVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKCPVGYTGDRCQQFAMVNFST
RLGGDVEEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSLANGPSHPRLDPEEIQMADYISKNVP
ATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGTSKCNSPACVEARARRAAAYNLEERR
RATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPAAPISYRLAEQQPLLRHPAPPGPGPG
PGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPPPRPRARGASRRTSAGPRRWRRSRLN
GLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCPAADSRTYYSLDSHSTRASSRHSRGP

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:127450373/chr5:139267098)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NRG2 O14511
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

188_194

349.3333333333333

1213.0

Compositional bias

Note=Poly-Gly

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

90_122

349.3333333333333

1213.0

Compositional bias

Note=Ala-rich

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

188_194

349.3333333333333

1197.0

Compositional bias

Note=Poly-Gly

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

90_122

349.3333333333333

1197.0

Compositional bias

Note=Ala-rich

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

287_299

349.3333333333333

1213.0

Intramembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

300_307

349.3333333333333

1213.0

Intramembrane

Ontology_term=ECO:0000305

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

308_313

349.3333333333333

1213.0

Intramembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

287_299

349.3333333333333

1197.0

Intramembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

300_307

349.3333333333333

1197.0

Intramembrane

Ontology_term=ECO:0000305

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

308_313

349.3333333333333

1197.0

Intramembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

1_286

349.3333333333333

1213.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

314_321

349.3333333333333

1213.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

1_286

349.3333333333333

1197.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

314_321

349.3333333333333

1197.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

287_313

349.3333333333333

1213.0

Transmembrane

Discontinuously helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

322_343

349.3333333333333

1213.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

287_313

349.3333333333333

1197.0

Transmembrane

Discontinuously helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

322_343

349.3333333333333

1197.0

Transmembrane

Helical

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289409

330_340

233.33333333333334

845.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289409

721_727

233.33333333333334

845.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289422

330_340

233.33333333333334

859.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289422

721_727

233.33333333333334

859.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000340391

330_340

30.333333333333332

648.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000340391

33_47

30.333333333333332

648.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000340391

721_727

30.333333333333332

648.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000340391

87_90

30.333333333333332

648.0

Compositional bias

Note=Poly-Ala

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000358522

330_340

233.33333333333334

853.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000358522

721_727

233.33333333333334

853.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000361474

330_340

233.33333333333334

851.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000361474

721_727

233.33333333333334

851.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000394770

330_340

233.33333333333334

491.0

Compositional bias

Note=Ser/Thr-rich

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000394770

721_727

233.33333333333334

491.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289409

237_332

233.33333333333334

845.0

Domain

Note=Ig-like C2-type

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289409

341_382

233.33333333333334

845.0

Domain

EGF-like

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289422

237_332

233.33333333333334

859.0

Domain

Note=Ig-like C2-type

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289422

341_382

233.33333333333334

859.0

Domain

EGF-like

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000340391

237_332

30.333333333333332

648.0

Domain

Note=Ig-like C2-type

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000340391

341_382

30.333333333333332

648.0

Domain

EGF-like

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000358522

237_332

233.33333333333334

853.0

Domain

Note=Ig-like C2-type

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000358522

341_382

233.33333333333334

853.0

Domain

EGF-like

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000361474

237_332

233.33333333333334

851.0

Domain

Note=Ig-like C2-type

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000361474

341_382

233.33333333333334

851.0

Domain

EGF-like

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000394770

237_332

233.33333333333334

491.0

Domain

Note=Ig-like C2-type

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000394770

341_382

233.33333333333334

491.0

Domain

EGF-like

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000340391

112_405

30.333333333333332

648.0

Topological domain

Extracellular

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289409

406_426

233.33333333333334

845.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289422

406_426

233.33333333333334

859.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000340391

406_426

30.333333333333332

648.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000358522

406_426

233.33333333333334

853.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000361474

406_426

233.33333333333334

851.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000394770

406_426

233.33333333333334

491.0

Transmembrane

Helical%3B Note%3DInternal signal sequence

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

487_498

349.3333333333333

1213.0

Intramembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

499_500

349.3333333333333

1213.0

Intramembrane

Ontology_term=ECO:0000305

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

501_507

349.3333333333333

1213.0

Intramembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

487_498

349.3333333333333

1197.0

Intramembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

499_500

349.3333333333333

1197.0

Intramembrane

Ontology_term=ECO:0000305

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

501_507

349.3333333333333

1197.0

Intramembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

344_361

349.3333333333333

1213.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

398_406

349.3333333333333

1213.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

425_429

349.3333333333333

1213.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

455_486

349.3333333333333

1213.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

508_514

349.3333333333333

1213.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

543_599

349.3333333333333

1213.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

633_653

349.3333333333333

1213.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

669_670

349.3333333333333

1213.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

698_711

349.3333333333333

1213.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

731_731

349.3333333333333

1213.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

752_1212

349.3333333333333

1213.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

344_361

349.3333333333333

1197.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

398_406

349.3333333333333

1197.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

425_429

349.3333333333333

1197.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

455_486

349.3333333333333

1197.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

508_514

349.3333333333333

1197.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

543_599

349.3333333333333

1197.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

633_653

349.3333333333333

1197.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

669_670

349.3333333333333

1197.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

698_711

349.3333333333333

1197.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

731_731

349.3333333333333

1197.0

Topological domain

Extracellular

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

752_1212

349.3333333333333

1197.0

Topological domain

Cytoplasmic

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

407_424

349.3333333333333

1213.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

430_454

349.3333333333333

1213.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

487_507

349.3333333333333

1213.0

Transmembrane

Discontinuously helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

515_542

349.3333333333333

1213.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

600_632

349.3333333333333

1213.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

654_668

349.3333333333333

1213.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000262461

712_730

349.3333333333333

1213.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

407_424

349.3333333333333

1197.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

430_454

349.3333333333333

1197.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

487_507

349.3333333333333

1197.0

Transmembrane

Discontinuously helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

515_542

349.3333333333333

1197.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

600_632

349.3333333333333

1197.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

654_668

349.3333333333333

1197.0

Transmembrane

Helical

Hgene

SLC12A2

chr5:127450373

chr5:139267098

ENST00000343225

712_730

349.3333333333333

1197.0

Transmembrane

Helical

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289409

10_13

233.33333333333334

845.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289409

20_30

233.33333333333334

845.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289409

33_47

233.33333333333334

845.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289409

87_90

233.33333333333334

845.0

Compositional bias

Note=Poly-Ala

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289422

10_13

233.33333333333334

859.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289422

20_30

233.33333333333334

859.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289422

33_47

233.33333333333334

859.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289422

87_90

233.33333333333334

859.0

Compositional bias

Note=Poly-Ala

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000340391

10_13

30.333333333333332

648.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000340391

20_30

30.333333333333332

648.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000358522

10_13

233.33333333333334

853.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000358522

20_30

233.33333333333334

853.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000358522

33_47

233.33333333333334

853.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000358522

87_90

233.33333333333334

853.0

Compositional bias

Note=Poly-Ala

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000361474

10_13

233.33333333333334

851.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000361474

20_30

233.33333333333334

851.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000361474

33_47

233.33333333333334

851.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000361474

87_90

233.33333333333334

851.0

Compositional bias

Note=Poly-Ala

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000394770

10_13

233.33333333333334

491.0

Compositional bias

Note=Poly-Pro

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000394770

20_30

233.33333333333334

491.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000394770

33_47

233.33333333333334

491.0

Compositional bias

Note=Poly-Ser

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000394770

87_90

233.33333333333334

491.0

Compositional bias

Note=Poly-Ala

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289409

112_405

233.33333333333334

845.0

Topological domain

Extracellular

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000289422

112_405

233.33333333333334

859.0

Topological domain

Extracellular

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000358522

112_405

233.33333333333334

853.0

Topological domain

Extracellular

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000361474

112_405

233.33333333333334

851.0

Topological domain

Extracellular

Tgene

NRG2

chr5:127450373

chr5:139267098

ENST00000394770

112_405

233.33333333333334

491.0

Topological domain

Extracellular

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1809_SLC12A2_127450373_NRG2_139267098_ranked_0.pdb	SLC12A2	127450373	127450373	ENST00000340391	NRG2	chr5	139267098	-	MWPSRLAAARRRRGERLSHLVLRLWPPPARGVEGVLPETSAGLCSSAGGRAAMEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTA VPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEP AKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTM DAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRL SWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGATRPKLKKMKSQTGQVGEKQSLKCEAAAGNPQPSYRWFKDGKELNRSRD IRIKYGNGRKNSRLQFNKVKVEDAGEYVCEAENILGKDTVRGRLYVNSVSTTLSSWSGHARKCNETAKSYCVNGGVCYYIEGINQLSCKC PNGFFGQRCLEKLPLRLYMPDPKQKHLGFELKEAEELYQKRVLTITGICVALLVVGIVCVVAYCKTKKQRKQMHNHLRQNMCPAHQNRSL ANGPSHPRLDPEEIQMADYISKNVPATDHVIRRETETTFSGSHSCSPSHHCSTATPTSSHRHESHTWSLERSESLTSDSQSGIMLSSVGT SKCNSPACVEARARRAAAYNLEERRRATAPPYHDSVDSLRDSPHSERYVSALTTPARLSPVDFHYSLATQVPTFEITSPNSAHAVSLPPA APISYRLAEQQPLLRHPAPPGPGPGPGPGPGPGADMQRSYDSYYYPAAGPGPRRGTCALGGSLGSLPASPFRIPEDDEYETTQECAPPPP PRPRARGASRRTSAGPRRWRRSRLNGLAAQRARAARDSLSLSSGSGGGSASASDDDADDADGALAAESTPFLGLRGAHDALRSDSPPLCP	1026

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SLC12A2_pLDDT.png

NRG2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SLC12A2
NRG2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to SLC12A2-NRG2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SLC12A2-NRG2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source