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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATP8A1-PDS5A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATP8A1-PDS5A
FusionPDB ID: 8235
FusionGDB2.0 ID: 8235
HgeneTgene
Gene symbol

ATP8A1

PDS5A

Gene ID

10396

23244

Gene nameATPase phospholipid transporting 8A1PDS5 cohesin associated factor A
SynonymsATPASEII|ATPIA|ATPP2PIG54|SCC-112|SCC112
Cytomap

4p13

4p14

Type of geneprotein-codingprotein-coding
Descriptionphospholipid-transporting ATPase IAATPase IIATPase class I type 8A member 1ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1P4-ATPase flippase complex alpha subunit ATP8A1aminophospholipid translocasechromaffin granule ATPase sister chromatid cohesion protein PDS5 homolog APDS5, regulator of cohesion maintenance, homolog Acell proliferation-inducing gene 54 proteinsister chromatid cohesion protein 112
Modification date2020032920200327
UniProtAcc

Q9Y2Q0

Q29RF7

Ensembl transtripts involved in fusion geneENST idsENST00000264449, ENST00000381668, 
ENST00000510289, 		ENST00000503396, 
ENST00000303538, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 13 X 7=81921 X 21 X 8=3528
# samples 1326
** MAII scorelog2(13/819*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/3528*10)=-3.76226703252907
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATP8A1 [Title/Abstract] AND PDS5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATP8A1(42551030)-PDS5A(39865079), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ATP8A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PDS5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8536-01AATP8A1chr4

42551030

-PDS5Achr4

39865079

-
ChimerDB4STADTCGA-CD-8536ATP8A1chr4

42551029

-PDS5Achr4

39865079

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381668ATP8A1chr442551030-ENST00000303538PDS5Achr439865079-5878188423232551007
ENST00000264449ATP8A1chr442551030-ENST00000303538PDS5Achr439865079-582118272203198992
ENST00000381668ATP8A1chr442551029-ENST00000303538PDS5Achr439865079-5878188423232551007
ENST00000264449ATP8A1chr442551029-ENST00000303538PDS5Achr439865079-582118272203198992

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381668ENST00000303538ATP8A1chr442551030-PDS5Achr439865079-0.0003446840.99965537
ENST00000264449ENST00000303538ATP8A1chr442551030-PDS5Achr439865079-0.0001544540.9998455
ENST00000381668ENST00000303538ATP8A1chr442551029-PDS5Achr439865079-0.0003446840.99965537
ENST00000264449ENST00000303538ATP8A1chr442551029-PDS5Achr439865079-0.0001544540.9998455

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8235_8235_1_ATP8A1-PDS5A_ATP8A1_chr4_42551029_ENST00000264449_PDS5A_chr4_39865079_ENST00000303538_length(amino acids)=992AA_BP=535
MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQI
PDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVNVGDIVIIKGKEYIPADTVLLSSSEPQAM
CYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYT
GHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLL
VTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGQNSQFGDEKTFSDSSLLE
NLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSKSDM
SRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLLKN
ISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQS
PDESKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPAGVLGAVNKPLSATGRKP
YVRSTGTETGSNINVNSELNPSTGNRSREQSSEAAETGVSENEENPVRIISVTPVKNIDPVKNKEINSDQATQGNISSDRGKKRTVTAAG
AENIQQKTDEKVDESGPPAPSKPRRGRRPKSESQGNATKNDDLNKPINKGRKRAAVGQESPGGLEAGNAKAPKLQDLAKKAAPAERQIDL

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>8235_8235_2_ATP8A1-PDS5A_ATP8A1_chr4_42551029_ENST00000381668_PDS5A_chr4_39865079_ENST00000303538_length(amino acids)=1007AA_BP=550
MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQI
PDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAM
CYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYT
GHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLL
VTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQNS
QFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEER
YELLNVLEFTSKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDP
VKERRAHARQCLLKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFM
KKMAENIKLTRDAQSPDESKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPAGV
LGAVNKPLSATGRKPYVRSTGTETGSNINVNSELNPSTGNRSREQSSEAAETGVSENEENPVRIISVTPVKNIDPVKNKEINSDQATQGN
ISSDRGKKRTVTAAGAENIQQKTDEKVDESGPPAPSKPRRGRRPKSESQGNATKNDDLNKPINKGRKRAAVGQESPGGLEAGNAKAPKLQ

--------------------------------------------------------------

>8235_8235_3_ATP8A1-PDS5A_ATP8A1_chr4_42551030_ENST00000264449_PDS5A_chr4_39865079_ENST00000303538_length(amino acids)=992AA_BP=535
MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQI
PDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVNVGDIVIIKGKEYIPADTVLLSSSEPQAM
CYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYT
GHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLL
VTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGQNSQFGDEKTFSDSSLLE
NLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSKSDM
SRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDPVKERRAHARQCLLKN
ISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFMKKMAENIKLTRDAQS
PDESKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPAGVLGAVNKPLSATGRKP
YVRSTGTETGSNINVNSELNPSTGNRSREQSSEAAETGVSENEENPVRIISVTPVKNIDPVKNKEINSDQATQGNISSDRGKKRTVTAAG
AENIQQKTDEKVDESGPPAPSKPRRGRRPKSESQGNATKNDDLNKPINKGRKRAAVGQESPGGLEAGNAKAPKLQDLAKKAAPAERQIDL

--------------------------------------------------------------

>8235_8235_4_ATP8A1-PDS5A_ATP8A1_chr4_42551030_ENST00000381668_PDS5A_chr4_39865079_ENST00000303538_length(amino acids)=1007AA_BP=550
MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQI
PDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIVKVTNGEHLPADLISLSSSEPQAM
CYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYT
GHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFIILFNNLIPISLL
VTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQNS
QFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEER
YELLNVLEFTSKSDMSRLRLAAGSAIMKLAQEPCYHEIITPEQFQLCALVINDECYQVRQIFAQKLHKALVKLLLPLEYMAIFALCAKDP
VKERRAHARQCLLKNISIRREYIKQNPMATEKLLSLLPEYVVPYMIHLLAHDPDFTRSQDVDQLRDIKECLWFMLEVLMTKNENNSHAFM
KKMAENIKLTRDAQSPDESKTNEKLYTVCDVALCVINSKSALCNADSPKDPVLPMKFFTQPEKDFCNDKSYISEETRVLLLTGKPKPAGV
LGAVNKPLSATGRKPYVRSTGTETGSNINVNSELNPSTGNRSREQSSEAAETGVSENEENPVRIISVTPVKNIDPVKNKEINSDQATQGN
ISSDRGKKRTVTAAGAENIQQKTDEKVDESGPPAPSKPRRGRRPKSESQGNATKNDDLNKPINKGRKRAAVGQESPGGLEAGNAKAPKLQ

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:42551030/chr4:39865079)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP8A1

Q9Y2Q0

PDS5A

Q29RF7

FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:31416931). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (PubMed:31416931). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane (By similarity). Acts as aminophospholipid translocase at the plasma membrane in neuronal cells (By similarity). {ECO:0000250|UniProtKB:P70704, ECO:0000269|PubMed:31416931}.FUNCTION: Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. {ECO:0000269|PubMed:15855230, ECO:0000269|PubMed:19907496}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836409_411535.66666666666661150.0Nucleotide bindingATP
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937409_411550.66666666666661165.0Nucleotide bindingATP
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836409_411535.66666666666661150.0Nucleotide bindingATP
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937409_411550.66666666666661165.0Nucleotide bindingATP
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836116_297535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-18361_65535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836320_344535.66666666666661150.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-183687_92535.66666666666661150.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937116_297550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-19371_65550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937320_344550.66666666666661165.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-193787_92550.66666666666661165.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836116_297535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-18361_65535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836320_344535.66666666666661150.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-183687_92535.66666666666661150.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937116_297550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-19371_65550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937320_344550.66666666666661165.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-193787_92550.66666666666661165.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836298_319535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836345_366535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-183666_86535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-183693_115535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937298_319550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937345_366550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-193766_86550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-193793_115550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836298_319535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836345_366535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-183666_86535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-183693_115535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937298_319550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937345_366550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-193766_86550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-193793_115550.66666666666661165.0TransmembraneHelical
TgenePDS5Achr4:42551029chr4:39865079ENST00000503396016393_4290601.0RepeatHEAT
TgenePDS5Achr4:42551030chr4:39865079ENST00000503396016393_4290601.0RepeatHEAT

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-18361095_1102535.66666666666661150.0Nucleotide bindingATP
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836741_748535.66666666666661150.0Nucleotide bindingATP
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836804_805535.66666666666661150.0Nucleotide bindingATP
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-19371095_1102550.66666666666661165.0Nucleotide bindingATP
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937741_748550.66666666666661165.0Nucleotide bindingATP
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937804_805550.66666666666661165.0Nucleotide bindingATP
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-18361095_1102535.66666666666661150.0Nucleotide bindingATP
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836741_748535.66666666666661150.0Nucleotide bindingATP
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836804_805535.66666666666661150.0Nucleotide bindingATP
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-19371095_1102550.66666666666661165.0Nucleotide bindingATP
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937741_748550.66666666666661165.0Nucleotide bindingATP
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937804_805550.66666666666661165.0Nucleotide bindingATP
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-18361000_1005535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-18361027_1044535.66666666666661150.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-18361071_1164535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836367_857535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836879_890535.66666666666661150.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836911_940535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836963_976535.66666666666661150.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-19371000_1005550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-19371027_1044550.66666666666661165.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-19371071_1164550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937367_857550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937879_890550.66666666666661165.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937911_940550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937963_976550.66666666666661165.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-18361000_1005535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-18361027_1044535.66666666666661150.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-18361071_1164535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836367_857535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836879_890535.66666666666661150.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836911_940535.66666666666661150.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836963_976535.66666666666661150.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-19371000_1005550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-19371027_1044550.66666666666661165.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-19371071_1164550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937367_857550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937879_890550.66666666666661165.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937911_940550.66666666666661165.0Topological domainCytoplasmic
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937963_976550.66666666666661165.0Topological domainExoplasmic loop
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-18361006_1026535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-18361045_1070535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836858_878535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836891_910535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000264449-1836941_962535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-19371006_1026550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-19371045_1070550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937858_878550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937891_910550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551029chr4:39865079ENST00000381668-1937941_962550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-18361006_1026535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-18361045_1070535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836858_878535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836891_910535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000264449-1836941_962535.66666666666661150.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-19371006_1026550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-19371045_1070550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937858_878550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937891_910550.66666666666661165.0TransmembraneHelical
HgeneATP8A1chr4:42551030chr4:39865079ENST00000381668-1937941_962550.66666666666661165.0TransmembraneHelical
TgenePDS5Achr4:42551029chr4:39865079ENST000003035382233393_429880.66666666666661338.0RepeatHEAT
TgenePDS5Achr4:42551030chr4:39865079ENST000003035382233393_429880.66666666666661338.0RepeatHEAT


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATP8A1
PDS5Aall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATP8A1-PDS5A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATP8A1-PDS5A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePDS5AC0033578Prostatic Neoplasms1CTD_human
TgenePDS5AC0376358Malignant neoplasm of prostate1CTD_human