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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC22A23-CAMTA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC22A23-CAMTA1
FusionPDB ID: 82456
FusionGDB2.0 ID: 82456
HgeneTgene
Gene symbol

SLC22A23

CAMTA1

Gene ID

63027

23261

Gene namesolute carrier family 22 member 23calmodulin binding transcription activator 1
SynonymsC6orf85CANPMR
Cytomap

6p25.2

1p36.31-p36.23

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 22 member 23ion transporter proteincalmodulin-binding transcription activator 1
Modification date2020031320200315
UniProtAcc.

Q9Y6Y1

Ensembl transtripts involved in fusion geneENST idsENST00000380298, ENST00000380302, 
ENST00000406686, ENST00000436008, 
ENST00000490273, ENST00000433689, 
ENST00000467404, ENST00000473578, 
ENST00000476163, ENST00000557126, 
ENST00000476864, ENST00000303635, 
ENST00000439411, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 5 X 9=54021 X 19 X 8=3192
# samples 1424
** MAII scorelog2(14/540*10)=-1.94753258010586
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3192*10)=-3.73335434061383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC22A23 [Title/Abstract] AND CAMTA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC22A23(3410422)-CAMTA1(6880241), # samples:3
Anticipated loss of major functional domain due to fusion event.SLC22A23-CAMTA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC22A23-CAMTA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC22A23-CAMTA1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SLC22A23-CAMTA1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
SLC22A23-CAMTA1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SLC22A23-CAMTA1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
SLC22A23-CAMTA1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC22A23 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAMTA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-A632-01ASLC22A23chr6

3410422

-CAMTA1chr1

6880241

+
ChimerDB4PRADTCGA-HC-A632SLC22A23chr6

3410422

-CAMTA1chr1

6880241

+
ChimerDB4PRADTCGA-HC-A632SLC22A23chr6

3410422

-CAMTA1chr1

6885152

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000380302SLC22A23chr63410422-ENST00000303635CAMTA1chr16880241+864645440654301674
ENST00000380302SLC22A23chr63410422-ENST00000439411CAMTA1chr16880241+538945440653881661
ENST00000436008SLC22A23chr63410422-ENST00000303635CAMTA1chr16885152+9498137630762821991
ENST00000436008SLC22A23chr63410422-ENST00000439411CAMTA1chr16885152+6241137630762401978
ENST00000406686SLC22A23chr63410422-ENST00000303635CAMTA1chr16885152+9035913058191939
ENST00000406686SLC22A23chr63410422-ENST00000439411CAMTA1chr16885152+5778913057771925
ENST00000380298SLC22A23chr63410422-ENST00000303635CAMTA1chr16885152+9035913058191939
ENST00000380298SLC22A23chr63410422-ENST00000439411CAMTA1chr16885152+5778913057771925

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000380302ENST00000303635SLC22A23chr63410422-CAMTA1chr16880241+0.0004483790.9995516
ENST00000380302ENST00000439411SLC22A23chr63410422-CAMTA1chr16880241+0.0033098530.99669015
ENST00000436008ENST00000303635SLC22A23chr63410422-CAMTA1chr16885152+0.0009269120.999073
ENST00000436008ENST00000439411SLC22A23chr63410422-CAMTA1chr16885152+0.0057355540.9942644
ENST00000406686ENST00000303635SLC22A23chr63410422-CAMTA1chr16885152+0.0004509810.999549
ENST00000406686ENST00000439411SLC22A23chr63410422-CAMTA1chr16885152+0.0033780120.99662197
ENST00000380298ENST00000303635SLC22A23chr63410422-CAMTA1chr16885152+0.0004509810.999549
ENST00000380298ENST00000439411SLC22A23chr63410422-CAMTA1chr16885152+0.0033780120.99662197

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>82456_82456_1_SLC22A23-CAMTA1_SLC22A23_chr6_3410422_ENST00000380298_CAMTA1_chr1_6885152_ENST00000303635_length(amino acids)=1939AA_BP=305
MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPLGGRAGPGGGAEIQPLPPLHPGGGPHPSCCSAAAAPSLLLLDYDGSVLPFLGG
LGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGG
DTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIF
GLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALHDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWL
TTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPA
IEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSV
HHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISS
GLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLS
MLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMA
KEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSS
LSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETN
GVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPF
TQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSC
LFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMT
GSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTL
IKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQL
GQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTA
LSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVR
PREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYL
ADADCLPSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTA
FRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQ

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>82456_82456_2_SLC22A23-CAMTA1_SLC22A23_chr6_3410422_ENST00000380298_CAMTA1_chr1_6885152_ENST00000439411_length(amino acids)=1925AA_BP=305
MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPLGGRAGPGGGAEIQPLPPLHPGGGPHPSCCSAAAAPSLLLLDYDGSVLPFLGG
LGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGG
DTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIF
GLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALHDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWL
TTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPA
IEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSV
HHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISS
GLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLS
MLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMA
KEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSS
LSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETN
GVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPF
TQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSC
LFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMT
GSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTL
IKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQL
GQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTA
LSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVR
PREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYL
ADADCLPSAAQIRLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQE
VAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQ

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>82456_82456_3_SLC22A23-CAMTA1_SLC22A23_chr6_3410422_ENST00000380302_CAMTA1_chr1_6880241_ENST00000303635_length(amino acids)=1674AA_BP=16
MKDFAWLESFSPCMLYSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEK
HEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHY
LNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLG
AGGSVHHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSP
VSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGS
SESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSF
EQQMAKEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQ
NTHSSLSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYL
QPETNGVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDG
ARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEAS
NNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERR
MAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYAT
LIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRD
EQAQLGQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEK
LLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAA
PSQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSW
LASYLADADCLPSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAAR
LVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRT

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>82456_82456_4_SLC22A23-CAMTA1_SLC22A23_chr6_3410422_ENST00000380302_CAMTA1_chr1_6880241_ENST00000439411_length(amino acids)=1661AA_BP=16
MKDFAWLESFSPCMLYSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEK
HEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHY
LNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLG
AGGSVHHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSP
VSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGS
SESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSF
EQQMAKEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQ
NTHSSLSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYL
QPETNGVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDG
ARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEAS
NNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERR
MAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYAT
LIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRD
EQAQLGQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEK
LLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAA
PSQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSW
LASYLADADCLPSAAQIRLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPL
REQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLT

--------------------------------------------------------------

>82456_82456_5_SLC22A23-CAMTA1_SLC22A23_chr6_3410422_ENST00000406686_CAMTA1_chr1_6885152_ENST00000303635_length(amino acids)=1939AA_BP=305
MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPLGGRAGPGGGAEIQPLPPLHPGGGPHPSCCSAAAAPSLLLLDYDGSVLPFLGG
LGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGG
DTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIF
GLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALHDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWL
TTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPA
IEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSV
HHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISS
GLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLS
MLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMA
KEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSS
LSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETN
GVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPF
TQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSC
LFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMT
GSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTL
IKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQL
GQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTA
LSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVR
PREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYL
ADADCLPSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTA
FRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQ

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>82456_82456_6_SLC22A23-CAMTA1_SLC22A23_chr6_3410422_ENST00000406686_CAMTA1_chr1_6885152_ENST00000439411_length(amino acids)=1925AA_BP=305
MAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPLGGRAGPGGGAEIQPLPPLHPGGGPHPSCCSAAAAPSLLLLDYDGSVLPFLGG
LGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWCRGAGKGTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGG
DTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSKWDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIF
GLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALHDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWL
TTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPA
IEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSV
HHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISS
GLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLS
MLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMA
KEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSS
LSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETN
GVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPF
TQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSC
LFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMT
GSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTL
IKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQL
GQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTA
LSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVR
PREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYL
ADADCLPSAAQIRLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQE
VAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQ

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>82456_82456_7_SLC22A23-CAMTA1_SLC22A23_chr6_3410422_ENST00000436008_CAMTA1_chr1_6885152_ENST00000303635_length(amino acids)=1991AA_BP=357
MTHPEPPSALSRAAGPPRRQRLQAPGPARCARGARGASAALYAPLREPRARAMAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPL
GGRAGPGGGAEIQPLPPLHPGGGPHPSCCSAAAAPSLLLLDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWC
RGAGKGTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSK
WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALHDHG
NSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKT
TREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMF
HGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSVHHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGK
HEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMS
EVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNP
KQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMAKEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLE
QMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSSLSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSL
HLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETNGVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSL
DHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVV
SAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQ
IISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGS
CFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGH
LEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVT
VIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSP
PTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDD
IQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYLADADCLPSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEI
AFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQ
AAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYK

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>82456_82456_8_SLC22A23-CAMTA1_SLC22A23_chr6_3410422_ENST00000436008_CAMTA1_chr1_6885152_ENST00000439411_length(amino acids)=1978AA_BP=357
MTHPEPPSALSRAAGPPRRQRLQAPGPARCARGARGASAALYAPLREPRARAMAIDRRREAAGGGPGRQPAPAEENGSLPPGDAAASAPL
GGRAGPGGGAEIQPLPPLHPGGGPHPSCCSAAAAPSLLLLDYDGSVLPFLGGLGGGYQKTLVLLTWIPALFIGFSQFSDSFLLDQPNFWC
RGAGKGTELAGVTTTGRGGDMGNWTSLPTTPFATAPWEAAGNRSNSSGADGGDTPPLPSPPDKGDNASNCDCRAWDYGIRAGLVQNVVSK
WDLVCDNAWKVHIAKFSLLVGLIFGYLITGCIADWVGRRPVLLFSIIFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILTLYALHDHG
NSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKT
TREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMF
HGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSVHHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGK
HEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMS
EVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNP
KQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMAKEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLE
QMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSSLSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSL
HLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETNGVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSL
DHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVV
SAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQ
IISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGS
CFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGH
LEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVT
VIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSP
PTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDD
IQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYLADADCLPSAAQIRLSPVGSPVSEIAFEKPNLPSAADWS
EFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYE

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:3410422/chr1:6880241)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAMTA1

Q9Y6Y1

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Transcriptional activator. May act as a tumor suppressor. {ECO:0000269|PubMed:11925432, ECO:0000269|PubMed:15709179}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380298-34234_254304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380298-34258_278304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000406686-310234_254304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000406686-310258_278304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380298-34234_254304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380298-34258_278304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000406686-310234_254304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000406686-310258_278304.3333333333333687.0TransmembraneHelical
TgeneCAMTA1chr6:3410422chr1:6880241ENST000003036350231038_104115.01674.0Compositional biasNote=Poly-Val
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000303635023499_50215.01674.0Compositional biasNote=Poly-Gly
TgeneCAMTA1chr6:3410422chr1:6880241ENST000004394110221038_104115.01660.0Compositional biasNote=Poly-Val
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000439411022499_50215.01660.0Compositional biasNote=Poly-Gly
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000473578041038_104115.081.0Compositional biasNote=Poly-Val
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000047357804499_50215.081.0Compositional biasNote=Poly-Gly
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000476864061038_10410.0238.0Compositional biasNote=Poly-Val
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000047686406499_5020.0238.0Compositional biasNote=Poly-Gly
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000557126041038_104115.0102.0Compositional biasNote=Poly-Val
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000055712604499_50215.0102.0Compositional biasNote=Poly-Gly
TgeneCAMTA1chr6:3410422chr1:6885152ENST000003036351231038_104138.3333333333333361674.0Compositional biasNote=Poly-Val
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000303635123499_50238.3333333333333361674.0Compositional biasNote=Poly-Gly
TgeneCAMTA1chr6:3410422chr1:6885152ENST000004394111221038_104138.3333333333333361660.0Compositional biasNote=Poly-Val
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000439411122499_50238.3333333333333361660.0Compositional biasNote=Poly-Gly
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000473578141038_104138.33333333333333681.0Compositional biasNote=Poly-Val
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000047357814499_50238.33333333333333681.0Compositional biasNote=Poly-Gly
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000476864061038_10410.0238.0Compositional biasNote=Poly-Val
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000047686406499_5020.0238.0Compositional biasNote=Poly-Gly
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000557126141038_104138.333333333333336102.0Compositional biasNote=Poly-Val
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000055712614499_50238.333333333333336102.0Compositional biasNote=Poly-Gly
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000030363502363_18815.01674.0DNA bindingCG-1
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000043941102263_18815.01660.0DNA bindingCG-1
TgeneCAMTA1chr6:3410422chr1:6880241ENST000004735780463_18815.081.0DNA bindingCG-1
TgeneCAMTA1chr6:3410422chr1:6880241ENST000004768640663_1880.0238.0DNA bindingCG-1
TgeneCAMTA1chr6:3410422chr1:6880241ENST000005571260463_18815.0102.0DNA bindingCG-1
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000030363512363_18838.3333333333333361674.0DNA bindingCG-1
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000043941112263_18838.3333333333333361660.0DNA bindingCG-1
TgeneCAMTA1chr6:3410422chr1:6885152ENST000004735781463_18838.33333333333333681.0DNA bindingCG-1
TgeneCAMTA1chr6:3410422chr1:6885152ENST000004768640663_1880.0238.0DNA bindingCG-1
TgeneCAMTA1chr6:3410422chr1:6885152ENST000005571261463_18838.333333333333336102.0DNA bindingCG-1
TgeneCAMTA1chr6:3410422chr1:6880241ENST000003036350231547_157615.01674.0DomainIQ 1
TgeneCAMTA1chr6:3410422chr1:6880241ENST000003036350231577_159915.01674.0DomainIQ 2
TgeneCAMTA1chr6:3410422chr1:6880241ENST000003036350231600_162215.01674.0DomainIQ 3
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000303635023873_95315.01674.0DomainNote=IPT/TIG
TgeneCAMTA1chr6:3410422chr1:6880241ENST000004394110221547_157615.01660.0DomainIQ 1
TgeneCAMTA1chr6:3410422chr1:6880241ENST000004394110221577_159915.01660.0DomainIQ 2
TgeneCAMTA1chr6:3410422chr1:6880241ENST000004394110221600_162215.01660.0DomainIQ 3
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000439411022873_95315.01660.0DomainNote=IPT/TIG
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000473578041547_157615.081.0DomainIQ 1
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000473578041577_159915.081.0DomainIQ 2
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000473578041600_162215.081.0DomainIQ 3
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000047357804873_95315.081.0DomainNote=IPT/TIG
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000476864061547_15760.0238.0DomainIQ 1
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000476864061577_15990.0238.0DomainIQ 2
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000476864061600_16220.0238.0DomainIQ 3
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000047686406873_9530.0238.0DomainNote=IPT/TIG
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000557126041547_157615.0102.0DomainIQ 1
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000557126041577_159915.0102.0DomainIQ 2
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000557126041600_162215.0102.0DomainIQ 3
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000055712604873_95315.0102.0DomainNote=IPT/TIG
TgeneCAMTA1chr6:3410422chr1:6885152ENST000003036351231547_157638.3333333333333361674.0DomainIQ 1
TgeneCAMTA1chr6:3410422chr1:6885152ENST000003036351231577_159938.3333333333333361674.0DomainIQ 2
TgeneCAMTA1chr6:3410422chr1:6885152ENST000003036351231600_162238.3333333333333361674.0DomainIQ 3
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000303635123873_95338.3333333333333361674.0DomainNote=IPT/TIG
TgeneCAMTA1chr6:3410422chr1:6885152ENST000004394111221547_157638.3333333333333361660.0DomainIQ 1
TgeneCAMTA1chr6:3410422chr1:6885152ENST000004394111221577_159938.3333333333333361660.0DomainIQ 2
TgeneCAMTA1chr6:3410422chr1:6885152ENST000004394111221600_162238.3333333333333361660.0DomainIQ 3
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000439411122873_95338.3333333333333361660.0DomainNote=IPT/TIG
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000473578141547_157638.33333333333333681.0DomainIQ 1
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000473578141577_159938.33333333333333681.0DomainIQ 2
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000473578141600_162238.33333333333333681.0DomainIQ 3
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000047357814873_95338.33333333333333681.0DomainNote=IPT/TIG
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000476864061547_15760.0238.0DomainIQ 1
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000476864061577_15990.0238.0DomainIQ 2
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000476864061600_16220.0238.0DomainIQ 3
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000047686406873_9530.0238.0DomainNote=IPT/TIG
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000557126141547_157638.333333333333336102.0DomainIQ 1
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000557126141577_159938.333333333333336102.0DomainIQ 2
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000557126141600_162238.333333333333336102.0DomainIQ 3
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000055712614873_95338.333333333333336102.0DomainNote=IPT/TIG
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000303635023112_11915.01674.0MotifNuclear localization signal
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000439411022112_11915.01660.0MotifNuclear localization signal
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000047357804112_11915.081.0MotifNuclear localization signal
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000047686406112_1190.0238.0MotifNuclear localization signal
TgeneCAMTA1chr6:3410422chr1:6880241ENST0000055712604112_11915.0102.0MotifNuclear localization signal
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000303635123112_11938.3333333333333361674.0MotifNuclear localization signal
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000439411122112_11938.3333333333333361660.0MotifNuclear localization signal
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000047357814112_11938.33333333333333681.0MotifNuclear localization signal
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000047686406112_1190.0238.0MotifNuclear localization signal
TgeneCAMTA1chr6:3410422chr1:6885152ENST0000055712614112_11938.333333333333336102.0MotifNuclear localization signal
TgeneCAMTA1chr6:3410422chr1:6880241ENST000003036350231064_109315.01674.0RepeatNote=ANK 1
TgeneCAMTA1chr6:3410422chr1:6880241ENST000003036350231109_112915.01674.0RepeatNote=ANK 2
TgeneCAMTA1chr6:3410422chr1:6880241ENST000003036350231143_117215.01674.0RepeatNote=ANK 3
TgeneCAMTA1chr6:3410422chr1:6880241ENST000004394110221064_109315.01660.0RepeatNote=ANK 1
TgeneCAMTA1chr6:3410422chr1:6880241ENST000004394110221109_112915.01660.0RepeatNote=ANK 2
TgeneCAMTA1chr6:3410422chr1:6880241ENST000004394110221143_117215.01660.0RepeatNote=ANK 3
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000473578041064_109315.081.0RepeatNote=ANK 1
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000473578041109_112915.081.0RepeatNote=ANK 2
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000473578041143_117215.081.0RepeatNote=ANK 3
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000476864061064_10930.0238.0RepeatNote=ANK 1
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000476864061109_11290.0238.0RepeatNote=ANK 2
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000476864061143_11720.0238.0RepeatNote=ANK 3
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000557126041064_109315.0102.0RepeatNote=ANK 1
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000557126041109_112915.0102.0RepeatNote=ANK 2
TgeneCAMTA1chr6:3410422chr1:6880241ENST00000557126041143_117215.0102.0RepeatNote=ANK 3
TgeneCAMTA1chr6:3410422chr1:6885152ENST000003036351231064_109338.3333333333333361674.0RepeatNote=ANK 1
TgeneCAMTA1chr6:3410422chr1:6885152ENST000003036351231109_112938.3333333333333361674.0RepeatNote=ANK 2
TgeneCAMTA1chr6:3410422chr1:6885152ENST000003036351231143_117238.3333333333333361674.0RepeatNote=ANK 3
TgeneCAMTA1chr6:3410422chr1:6885152ENST000004394111221064_109338.3333333333333361660.0RepeatNote=ANK 1
TgeneCAMTA1chr6:3410422chr1:6885152ENST000004394111221109_112938.3333333333333361660.0RepeatNote=ANK 2
TgeneCAMTA1chr6:3410422chr1:6885152ENST000004394111221143_117238.3333333333333361660.0RepeatNote=ANK 3
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000473578141064_109338.33333333333333681.0RepeatNote=ANK 1
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000473578141109_112938.33333333333333681.0RepeatNote=ANK 2
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000473578141143_117238.33333333333333681.0RepeatNote=ANK 3
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000476864061064_10930.0238.0RepeatNote=ANK 1
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000476864061109_11290.0238.0RepeatNote=ANK 2
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000476864061143_11720.0238.0RepeatNote=ANK 3
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000557126141064_109338.333333333333336102.0RepeatNote=ANK 1
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000557126141109_112938.333333333333336102.0RepeatNote=ANK 2
TgeneCAMTA1chr6:3410422chr1:6885152ENST00000557126141143_117238.333333333333336102.0RepeatNote=ANK 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380298-34288_308304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380298-34315_335304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380298-34344_364304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380298-34467_487304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380298-34494_514304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380298-34538_558304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380298-34569_589304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380298-34598_618304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380302-310234_25423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380302-310258_27823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380302-310288_30823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380302-310315_33523.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380302-310344_36423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380302-310467_48723.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380302-310494_51423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380302-310538_55823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380302-310569_58923.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000380302-310598_61823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000406686-310288_308304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000406686-310315_335304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000406686-310344_364304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000406686-310467_487304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000406686-310494_514304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000406686-310538_558304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000406686-310569_589304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000406686-310598_618304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000490273-411234_25423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000490273-411258_27823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000490273-411288_30823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000490273-411315_33523.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000490273-411344_36423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000490273-411467_48723.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000490273-411494_51423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000490273-411538_55823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000490273-411569_58923.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6880241ENST00000490273-411598_61823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380298-34288_308304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380298-34315_335304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380298-34344_364304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380298-34467_487304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380298-34494_514304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380298-34538_558304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380298-34569_589304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380298-34598_618304.3333333333333362.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380302-310234_25423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380302-310258_27823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380302-310288_30823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380302-310315_33523.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380302-310344_36423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380302-310467_48723.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380302-310494_51423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380302-310538_55823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380302-310569_58923.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000380302-310598_61823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000406686-310288_308304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000406686-310315_335304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000406686-310344_364304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000406686-310467_487304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000406686-310494_514304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000406686-310538_558304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000406686-310569_589304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000406686-310598_618304.3333333333333687.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000490273-411234_25423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000490273-411258_27823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000490273-411288_30823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000490273-411315_33523.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000490273-411344_36423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000490273-411467_48723.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000490273-411494_51423.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000490273-411538_55823.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000490273-411569_58923.333333333333332406.0TransmembraneHelical
HgeneSLC22A23chr6:3410422chr1:6885152ENST00000490273-411598_61823.333333333333332406.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SLC22A23_pLDDT.png
all structure
all structure
CAMTA1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC22A23
CAMTA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLC22A23-CAMTA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC22A23-CAMTA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource