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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC26A6-CYP2C8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC26A6-CYP2C8
FusionPDB ID: 82761
FusionGDB2.0 ID: 82761
HgeneTgene
Gene symbol

SLC26A6

CYP2C8

Gene ID

65010

1558

Gene namesolute carrier family 26 member 6cytochrome P450 family 2 subfamily C member 8
Synonyms-CPC8|CYP2C8DM|CYPIIC8|MP-12/MP-20
Cytomap

3p21.31

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionsolute carrier family 26 member 6anion exchange transporteranion transporter 1pendrin L1solute carrier family 26 (anion exchanger), member 6sulfate anion transportercytochrome P450 2C8P450 form 1cytochrome P450 IIC2cytochrome P450 MP-12cytochrome P450 MP-20cytochrome P450 form 1cytochrome P450, family 2, subfamily C, polypeptide 8cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8flavopr
Modification date2020032920200320
UniProtAcc

Q9BXS9

P10632

Ensembl transtripts involved in fusion geneENST idsENST00000337000, ENST00000383733, 
ENST00000395550, ENST00000420764, 
ENST00000455886, ENST00000358747, 
ENST00000482282, 		ENST00000539050, 
ENST00000371270, ENST00000535898, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 2 X 2=86 X 2 X 5=60
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/60*10)=0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC26A6 [Title/Abstract] AND CYP2C8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC26A6(48672804)-CYP2C8(96798795), # samples:3
Anticipated loss of major functional domain due to fusion event.SLC26A6-CYP2C8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC26A6-CYP2C8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLC26A6

GO:0071346

cellular response to interferon-gamma

18655181

TgeneCYP2C8

GO:0002933

lipid hydroxylation

14559847

TgeneCYP2C8

GO:0006082

organic acid metabolic process

19651758

TgeneCYP2C8

GO:0008202

steroid metabolic process

14559847

TgeneCYP2C8

GO:0008210

estrogen metabolic process

12865317|14559847

TgeneCYP2C8

GO:0017144

drug metabolic process

19651758

TgeneCYP2C8

GO:0019373

epoxygenase P450 pathway

7574697

TgeneCYP2C8

GO:0042573

retinoic acid metabolic process

11093772

TgeneCYP2C8

GO:0042738

exogenous drug catabolic process

18619574

TgeneCYP2C8

GO:0046456

icosanoid biosynthetic process

15766564

TgeneCYP2C8

GO:0055114

oxidation-reduction process

19651758

TgeneCYP2C8

GO:0070989

oxidative demethylation

18619574


check buttonFusion gene breakpoints across SLC26A6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CYP2C8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3IA-01ASLC26A6chr3

48672804

-CYP2C8chr10

96798795

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420764SLC26A6chr348672804-ENST00000371270CYP2C8chr1096798795-792113570232112
ENST00000420764SLC26A6chr348672804-ENST00000535898CYP2C8chr1096798795-581113570232112
ENST00000395550SLC26A6chr348672804-ENST00000371270CYP2C8chr1096798795-75071528190112
ENST00000395550SLC26A6chr348672804-ENST00000535898CYP2C8chr1096798795-53971528190112
ENST00000383733SLC26A6chr348672804-ENST00000371270CYP2C8chr1096798795-76384541203112
ENST00000383733SLC26A6chr348672804-ENST00000535898CYP2C8chr1096798795-55284541203112
ENST00000337000SLC26A6chr348672804-ENST00000371270CYP2C8chr1096798795-802123580242112
ENST00000337000SLC26A6chr348672804-ENST00000535898CYP2C8chr1096798795-591123580242112
ENST00000455886SLC26A6chr348672804-ENST00000371270CYP2C8chr1096798795-75071528190112
ENST00000455886SLC26A6chr348672804-ENST00000535898CYP2C8chr1096798795-53971528190112

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420764ENST00000371270SLC26A6chr348672804-CYP2C8chr1096798795-0.0158692260.9841308
ENST00000420764ENST00000535898SLC26A6chr348672804-CYP2C8chr1096798795-0.0060978250.9939022
ENST00000395550ENST00000371270SLC26A6chr348672804-CYP2C8chr1096798795-0.0210647550.9789353
ENST00000395550ENST00000535898SLC26A6chr348672804-CYP2C8chr1096798795-0.0100743820.9899256
ENST00000383733ENST00000371270SLC26A6chr348672804-CYP2C8chr1096798795-0.0211366620.9788633
ENST00000383733ENST00000535898SLC26A6chr348672804-CYP2C8chr1096798795-0.0085717930.9914282
ENST00000337000ENST00000371270SLC26A6chr348672804-CYP2C8chr1096798795-0.0196195520.9803805
ENST00000337000ENST00000535898SLC26A6chr348672804-CYP2C8chr1096798795-0.0102093480.9897906
ENST00000455886ENST00000371270SLC26A6chr348672804-CYP2C8chr1096798795-0.0210647550.9789353
ENST00000455886ENST00000535898SLC26A6chr348672804-CYP2C8chr1096798795-0.0100743820.9899256

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>82761_82761_1_SLC26A6-CYP2C8_SLC26A6_chr3_48672804_ENST00000337000_CYP2C8_chr10_96798795_ENST00000371270_length(amino acids)=112AA_BP=
MDAYGILSEWEDLMRGQRRHNSGNVLDKKRVAGDSRSAARWASILQTGMKQIWYEGGRETIPLVTAVVLRFFKSSTDFRLKFCKIVVRNK

--------------------------------------------------------------

>82761_82761_2_SLC26A6-CYP2C8_SLC26A6_chr3_48672804_ENST00000337000_CYP2C8_chr10_96798795_ENST00000535898_length(amino acids)=112AA_BP=
MDAYGILSEWEDLMRGQRRHNSGNVLDKKRVAGDSRSAARWASILQTGMKQIWYEGGRETIPLVTAVVLRFFKSSTDFRLKFCKIVVRNK

--------------------------------------------------------------

>82761_82761_3_SLC26A6-CYP2C8_SLC26A6_chr3_48672804_ENST00000383733_CYP2C8_chr10_96798795_ENST00000371270_length(amino acids)=112AA_BP=
MDAYGILSEWEDLMRGQRRHNSGNVLDKKRVAGDSRSAARWASILQTGMKQIWYEGGRETIPLVTAVVLRFFKSSTDFRLKFCKIVVRNK

--------------------------------------------------------------

>82761_82761_4_SLC26A6-CYP2C8_SLC26A6_chr3_48672804_ENST00000383733_CYP2C8_chr10_96798795_ENST00000535898_length(amino acids)=112AA_BP=
MDAYGILSEWEDLMRGQRRHNSGNVLDKKRVAGDSRSAARWASILQTGMKQIWYEGGRETIPLVTAVVLRFFKSSTDFRLKFCKIVVRNK

--------------------------------------------------------------

>82761_82761_5_SLC26A6-CYP2C8_SLC26A6_chr3_48672804_ENST00000395550_CYP2C8_chr10_96798795_ENST00000371270_length(amino acids)=112AA_BP=
MDAYGILSEWEDLMRGQRRHNSGNVLDKKRVAGDSRSAARWASILQTGMKQIWYEGGRETIPLVTAVVLRFFKSSTDFRLKFCKIVVRNK

--------------------------------------------------------------

>82761_82761_6_SLC26A6-CYP2C8_SLC26A6_chr3_48672804_ENST00000395550_CYP2C8_chr10_96798795_ENST00000535898_length(amino acids)=112AA_BP=
MDAYGILSEWEDLMRGQRRHNSGNVLDKKRVAGDSRSAARWASILQTGMKQIWYEGGRETIPLVTAVVLRFFKSSTDFRLKFCKIVVRNK

--------------------------------------------------------------

>82761_82761_7_SLC26A6-CYP2C8_SLC26A6_chr3_48672804_ENST00000420764_CYP2C8_chr10_96798795_ENST00000371270_length(amino acids)=112AA_BP=
MDAYGILSEWEDLMRGQRRHNSGNVLDKKRVAGDSRSAARWASILQTGMKQIWYEGGRETIPLVTAVVLRFFKSSTDFRLKFCKIVVRNK

--------------------------------------------------------------

>82761_82761_8_SLC26A6-CYP2C8_SLC26A6_chr3_48672804_ENST00000420764_CYP2C8_chr10_96798795_ENST00000535898_length(amino acids)=112AA_BP=
MDAYGILSEWEDLMRGQRRHNSGNVLDKKRVAGDSRSAARWASILQTGMKQIWYEGGRETIPLVTAVVLRFFKSSTDFRLKFCKIVVRNK

--------------------------------------------------------------

>82761_82761_9_SLC26A6-CYP2C8_SLC26A6_chr3_48672804_ENST00000455886_CYP2C8_chr10_96798795_ENST00000371270_length(amino acids)=112AA_BP=
MDAYGILSEWEDLMRGQRRHNSGNVLDKKRVAGDSRSAARWASILQTGMKQIWYEGGRETIPLVTAVVLRFFKSSTDFRLKFCKIVVRNK

--------------------------------------------------------------

>82761_82761_10_SLC26A6-CYP2C8_SLC26A6_chr3_48672804_ENST00000455886_CYP2C8_chr10_96798795_ENST00000535898_length(amino acids)=112AA_BP=
MDAYGILSEWEDLMRGQRRHNSGNVLDKKRVAGDSRSAARWASILQTGMKQIWYEGGRETIPLVTAVVLRFFKSSTDFRLKFCKIVVRNK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:48672804/chr10:96798795)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SLC26A6

Q9BXS9

CYP2C8

P10632

FUNCTION: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH.; FUNCTION: [Isoform 4]: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site.FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond (PubMed:7574697, PubMed:15766564, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772). Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1) (PubMed:14559847). Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) (PubMed:26427316). {ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15766564, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:26427316, ECO:0000269|PubMed:7574697}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120530_7420739.0DomainSTAS
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120530_7427.666666666666667741.0DomainSTAS
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121530_7427.666666666666667760.0DomainSTAS
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121530_7427.666666666666667759.0DomainSTAS
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120137_1860739.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-1201_1150739.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120208_2630739.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120285_2930739.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120315_3470739.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120369_3790739.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120401_4160739.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120438_4840739.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120506_7590739.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120137_1867.666666666666667741.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-1201_1157.666666666666667741.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120208_2637.666666666666667741.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120285_2937.666666666666667741.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120315_3477.666666666666667741.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120369_3797.666666666666667741.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120401_4167.666666666666667741.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120438_4847.666666666666667741.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120506_7597.666666666666667741.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121137_1867.666666666666667760.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-1211_1157.666666666666667760.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121208_2637.666666666666667760.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121285_2937.666666666666667760.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121315_3477.666666666666667760.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121369_3797.666666666666667760.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121401_4167.666666666666667760.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121438_4847.666666666666667760.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121506_7597.666666666666667760.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121137_1867.666666666666667759.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-1211_1157.666666666666667759.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121208_2637.666666666666667759.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121285_2937.666666666666667759.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121315_3477.666666666666667759.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121369_3797.666666666666667759.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121401_4167.666666666666667759.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121438_4847.666666666666667759.0Topological domainExtracellular
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121506_7597.666666666666667759.0Topological domainCytoplasmic
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120116_1360739.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120187_2070739.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120264_2840739.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120294_3140739.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120348_3680739.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120380_4000739.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120417_4370739.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000358747-120485_5050739.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120116_1367.666666666666667741.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120187_2077.666666666666667741.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120264_2847.666666666666667741.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120294_3147.666666666666667741.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120348_3687.666666666666667741.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120380_4007.666666666666667741.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120417_4377.666666666666667741.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000383733-120485_5057.666666666666667741.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121116_1367.666666666666667760.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121187_2077.666666666666667760.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121264_2847.666666666666667760.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121294_3147.666666666666667760.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121348_3687.666666666666667760.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121380_4007.666666666666667760.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121417_4377.666666666666667760.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000395550-121485_5057.666666666666667760.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121116_1367.666666666666667759.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121187_2077.666666666666667759.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121264_2847.666666666666667759.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121294_3147.666666666666667759.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121348_3687.666666666666667759.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121380_4007.666666666666667759.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121417_4377.666666666666667759.0TransmembraneHelical
HgeneSLC26A6chr3:48672804chr10:96798795ENST00000420764-121485_5057.666666666666667759.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SLC26A6LGALS9C, NT5E, FLOT2, ENPP6, FAF2, IRGC, VAC14, PPP6R2, ATP2B2, SLC15A1, P2RX2, PMEL, LRP1, TMCO3, CD79A, PDCD1, TNFSF8, HRAS, KRAS, TF, BET1, CD81, PLP1, APOL2, TMEM128, C14orf1, AQP2, C2orf82, TMEM201, LAT, SLC26A6, RAN, M, nsp4, ORF7b, S, LDLR, TP53, ARF6, LAMP3, RAB35, RHOB, TSPAN10, SLC25A46, PKNOX2, SLC26A2, LPCAT3, SLC6A8, LMBRD2, ABHD17B, MFSD12, ARL8B, SCPEP1, PTPLB, ND1, ARHGDIB, MTX1, TNFRSF10C, LGALS3, ABCB8, PXMP2, ORMDL2, SLC7A3, SLC25A17, KRTCAP2,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC26A6all structure
CYP2C8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLC26A6-CYP2C8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC26A6-CYP2C8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSLC26A6C2239176Liver carcinoma1CTD_human