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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SLC47A2-FADS2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SLC47A2-FADS2
FusionPDB ID: 83355
FusionGDB2.0 ID: 83355
HgeneTgene
Gene symbol

SLC47A2

FADS2

Gene ID

146802

9415

Gene namesolute carrier family 47 member 2fatty acid desaturase 2
SynonymsMATE2|MATE2-B|MATE2-K|MATE2KD6D|DES6|FADSD6|LLCDL2|SLL0262|TU13
Cytomap

17p11.2

11q12.2

Type of geneprotein-codingprotein-coding
Descriptionmultidrug and toxin extrusion protein 2kidney-specific H(+)/organic cation antiportersolute carrier family 47 (multidrug and toxin extrusion), member 2acyl-CoA 6-desaturasedelta-6 fatty acid desaturasedelta-6-desaturaselinoleoyl-CoA desaturase (delta-6-desaturase)-like 2
Modification date2020032020200313
UniProtAcc.

O95864

Ensembl transtripts involved in fusion geneENST idsENST00000325411, ENST00000350657, 
ENST00000463318, 
ENST00000517839, 
ENST00000522639, ENST00000574708, 
ENST00000257261, ENST00000278840, 
ENST00000521849, ENST00000522056, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 5 X 4=8020 X 10 X 8=1600
# samples 521
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(21/1600*10)=-2.9296106721086
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SLC47A2 [Title/Abstract] AND FADS2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SLC47A2(19605918)-FADS2(61624483), # samples:3
Anticipated loss of major functional domain due to fusion event.SLC47A2-FADS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC47A2-FADS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC47A2-FADS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SLC47A2-FADS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SLC47A2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FADS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-21-1071-01ASLC47A2chr17

19605918

-FADS2chr11

61624483

+
ChimerDB4LUSCTCGA-21-1071SLC47A2chr17

19605918

-FADS2chr11

61624483

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000325411SLC47A2chr1719605918-ENST00000257261FADS2chr1161624483+35791323511913620
ENST00000325411SLC47A2chr1719605918-ENST00000522056FADS2chr1161624483+21821323511913620
ENST00000325411SLC47A2chr1719605918-ENST00000278840FADS2chr1161624483+35791323511913620
ENST00000325411SLC47A2chr1719605918-ENST00000521849FADS2chr1161624483+21711323511739562
ENST00000350657SLC47A2chr1719605918-ENST00000257261FADS2chr1161624483+363713811751971598
ENST00000350657SLC47A2chr1719605918-ENST00000522056FADS2chr1161624483+224013811751971598
ENST00000350657SLC47A2chr1719605918-ENST00000278840FADS2chr1161624483+363713811751971598
ENST00000350657SLC47A2chr1719605918-ENST00000521849FADS2chr1161624483+222913811751797540

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000325411ENST00000257261SLC47A2chr1719605918-FADS2chr1161624483+0.0074805280.9925195
ENST00000325411ENST00000522056SLC47A2chr1719605918-FADS2chr1161624483+0.0102795790.9897204
ENST00000325411ENST00000278840SLC47A2chr1719605918-FADS2chr1161624483+0.0074805280.9925195
ENST00000325411ENST00000521849SLC47A2chr1719605918-FADS2chr1161624483+0.0055749790.99442494
ENST00000350657ENST00000257261SLC47A2chr1719605918-FADS2chr1161624483+0.0070108750.99298906
ENST00000350657ENST00000522056SLC47A2chr1719605918-FADS2chr1161624483+0.010407230.9895928
ENST00000350657ENST00000278840SLC47A2chr1719605918-FADS2chr1161624483+0.0070108750.99298906
ENST00000350657ENST00000521849SLC47A2chr1719605918-FADS2chr1161624483+0.0060966230.99390334

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83355_83355_1_SLC47A2-FADS2_SLC47A2_chr17_19605918_ENST00000325411_FADS2_chr11_61624483_ENST00000257261_length(amino acids)=620AA_BP=424
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSS
ACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWL
KGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLK
KLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAAD
TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICYGKKKLKYLPYNHQHEYFFLIGPPLL
IPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATC

--------------------------------------------------------------

>83355_83355_2_SLC47A2-FADS2_SLC47A2_chr17_19605918_ENST00000325411_FADS2_chr11_61624483_ENST00000278840_length(amino acids)=620AA_BP=424
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSS
ACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWL
KGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLK
KLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAAD
TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICYGKKKLKYLPYNHQHEYFFLIGPPLL
IPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATC

--------------------------------------------------------------

>83355_83355_3_SLC47A2-FADS2_SLC47A2_chr17_19605918_ENST00000325411_FADS2_chr11_61624483_ENST00000521849_length(amino acids)=562AA_BP=424
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSS
ACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWL
KGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLK
KLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAAD
TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICYGKKKLKYLPYNHQHEYFFLIGPPLL
IPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATC

--------------------------------------------------------------

>83355_83355_4_SLC47A2-FADS2_SLC47A2_chr17_19605918_ENST00000325411_FADS2_chr11_61624483_ENST00000522056_length(amino acids)=620AA_BP=424
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSS
ACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWL
KGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLK
KLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAAD
TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICYGKKKLKYLPYNHQHEYFFLIGPPLL
IPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATC

--------------------------------------------------------------

>83355_83355_5_SLC47A2-FADS2_SLC47A2_chr17_19605918_ENST00000350657_FADS2_chr11_61624483_ENST00000257261_length(amino acids)=598AA_BP=402
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSS
ACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKIT
WPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEW
WAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMRHSHRLAYAAHVTRIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVL
GTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDL
AWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHH

--------------------------------------------------------------

>83355_83355_6_SLC47A2-FADS2_SLC47A2_chr17_19605918_ENST00000350657_FADS2_chr11_61624483_ENST00000278840_length(amino acids)=598AA_BP=402
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSS
ACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKIT
WPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEW
WAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMRHSHRLAYAAHVTRIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVL
GTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDL
AWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHH

--------------------------------------------------------------

>83355_83355_7_SLC47A2-FADS2_SLC47A2_chr17_19605918_ENST00000350657_FADS2_chr11_61624483_ENST00000521849_length(amino acids)=540AA_BP=402
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSS
ACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKIT
WPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEW
WAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMRHSHRLAYAAHVTRIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVL
GTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDL
AWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHQ

--------------------------------------------------------------

>83355_83355_8_SLC47A2-FADS2_SLC47A2_chr17_19605918_ENST00000350657_FADS2_chr11_61624483_ENST00000522056_length(amino acids)=598AA_BP=402
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSS
ACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQKIT
WPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLKKLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEW
WAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMRHSHRLAYAAHVTRIPLGLSIGVCVRVGMALGAADTVQAKRSAVSGVLSIVGISLVL
GTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDL
AWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHH

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:19605918/chr11:61624483)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FADS2

O95864

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively (PubMed:12713571). Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function (By similarity). Desaturates hexadecanate (palmitate) to produce 6Z-hexadecenoate (sapienate), a fatty acid unique to humans and major component of human sebum, that has been implicated in the development of acne and may have potent antibacterial activity (PubMed:12713571). It can also desaturate (11E)-octadecenoate (trans-vaccenoate, the predominant trans fatty acid in human milk) at carbon 6 generating (6Z,11E)-octadecadienoate (By similarity). In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates (By similarity). {ECO:0000250|UniProtKB:B8R1K0, ECO:0000250|UniProtKB:Q9Z122, ECO:0000269|PubMed:12713571}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317141_153424.0603.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317175_219424.0603.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-13171_33424.0603.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317241_248424.0603.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317270_289424.0603.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317310_327424.0603.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317349_368424.0603.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317390_402424.0603.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-131755_66424.0603.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-131788_119424.0603.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418141_153402.0581.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418175_219402.0581.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-14181_33402.0581.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418241_248402.0581.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418270_289402.0581.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418310_327402.0581.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418349_368402.0581.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418390_402402.0581.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-141855_66402.0581.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-141888_119402.0581.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317120_140424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317154_174424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317220_240424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317249_269424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317290_309424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317328_348424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-131734_54424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317369_389424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317403_423424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-131767_87424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418120_140402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418154_174402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418220_240402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418249_269402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418290_309402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418328_348402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-141834_54402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418369_389402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-141867_87402.0581.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412382_386226.0423.0MotifNote=Histidine box-3
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412382_386248.0445.0MotifNote=Histidine box-3
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410382_386248.0387.0MotifNote=Histidine box-3
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412286_305226.0423.0Topological domainLumenal
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412327_444226.0423.0Topological domainCytoplasmic
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412286_305248.0445.0Topological domainLumenal
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412327_444248.0445.0Topological domainCytoplasmic
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410286_305248.0387.0Topological domainLumenal
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410327_444248.0387.0Topological domainCytoplasmic
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412265_285226.0423.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412306_326226.0423.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412265_285248.0445.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412306_326248.0445.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410265_285248.0387.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410306_326248.0387.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317508_511424.0603.0Compositional biasNote=Poly-Gln
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418508_511402.0581.0Compositional biasNote=Poly-Gln
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317424_442424.0603.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317464_466424.0603.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317488_578424.0603.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317600_602424.0603.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418424_442402.0581.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418464_466402.0581.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418488_578402.0581.0Topological domainCytoplasmic
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418600_602402.0581.0Topological domainExtracellular
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317443_463424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317467_487424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000325411-1317579_599424.0603.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418403_423402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418443_463402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418467_487402.0581.0TransmembraneHelical
HgeneSLC47A2chr17:19605918chr11:61624483ENST00000350657-1418579_599402.0581.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST0000025726141218_95226.0423.0DomainCytochrome b5 heme-binding
TgeneFADS2chr17:19605918chr11:61624483ENST0000027884041218_95248.0445.0DomainCytochrome b5 heme-binding
TgeneFADS2chr17:19605918chr11:61624483ENST0000052184941018_95248.0387.0DomainCytochrome b5 heme-binding
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412180_184226.0423.0MotifNote=Histidine box-1
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412217_221226.0423.0MotifNote=Histidine box-2
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412180_184248.0445.0MotifNote=Histidine box-1
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412217_221248.0445.0MotifNote=Histidine box-2
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410180_184248.0387.0MotifNote=Histidine box-1
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410217_221248.0387.0MotifNote=Histidine box-2
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412153_157226.0423.0Topological domainLumenal
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412179_264226.0423.0Topological domainCytoplasmic
TgeneFADS2chr17:19605918chr11:61624483ENST000002572614121_131226.0423.0Topological domainCytoplasmic
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412153_157248.0445.0Topological domainLumenal
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412179_264248.0445.0Topological domainCytoplasmic
TgeneFADS2chr17:19605918chr11:61624483ENST000002788404121_131248.0445.0Topological domainCytoplasmic
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410153_157248.0387.0Topological domainLumenal
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410179_264248.0387.0Topological domainCytoplasmic
TgeneFADS2chr17:19605918chr11:61624483ENST000005218494101_131248.0387.0Topological domainCytoplasmic
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412132_152226.0423.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000257261412158_178226.0423.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412132_152248.0445.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000278840412158_178248.0445.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410132_152248.0387.0TransmembraneHelical
TgeneFADS2chr17:19605918chr11:61624483ENST00000521849410158_178248.0387.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1304_SLC47A2_19605918_FADS2_61624483_1304_SLC47A2_19605918_FADS2_61624483_ranked_0.pdbSLC47A21960591819605918ENST00000521849FADS2chr1161624483+
MDSLQDTVALDHGGCCPALSRLVPRGFGTEMWTLFALSGPLFLFQVLTFMIYIVSTVFCGHLGKVELASVTLAVAFVNVCGVSVGVGLSS
ACDTLMSQSFGSPNKKHVGVILQRGALVLLLCCLPCWALFLNTQHILLLFRQDPDVSRLTQDYVMIFIPGLPVIFLYNLLAKYLQNQGWL
KGQEEESPFQTPGLSILHPSHSHLSRASFHLFQKITWPQVLSGVVGNCVNGVANYALVSVLNLGVRGSAYANIISQFAQTVFLLLYIVLK
KLHLETWAGWSSQCLQDWGPFFSLAVPSMLMICVEWWAYEIGSFLMGLLSVVDLSAQAVIYEVATVTYMIPLGLSIGVCVRVGMALGAAD
TVQAKRSAVSGVLSIVGISLVLGTLISILKNQLGHIFTNDEDVIALVSQVLPVYSVFHVFEAICYGKKKLKYLPYNHQHEYFFLIGPPLL
IPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQLTATC
620


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SLC47A2_pLDDT.png
all structure
all structure
FADS2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SLC47A2
FADS2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SLC47A2-FADS2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SLC47A2-FADS2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource