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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SMARCAD1-GRID2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SMARCAD1-GRID2
FusionPDB ID: 83916
FusionGDB2.0 ID: 83916
HgeneTgene
Gene symbol

SMARCAD1

GRID2

Gene ID

56916

2895

Gene nameSWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1glutamate ionotropic receptor delta type subunit 2
SynonymsADERM|BASNS|ETL1|HEL1|HRZGluD2|SCAR18
Cytomap

4q22.3

4q22.1-q22.2

Type of geneprotein-codingprotein-coding
DescriptionSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1ATP-dependent helicase 1glutamate receptor ionotropic, delta-2gluR delta-2 subunitglutamate receptor delta-2 subunitglutamate receptor, ionotropic, delta 2
Modification date2020031320200313
UniProtAcc.

A4D2P6

Ensembl transtripts involved in fusion geneENST idsENST00000354268, ENST00000457823, 
ENST00000509418, 		ENST00000505687, 
ENST00000510992, ENST00000282020, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score3 X 4 X 4=4812 X 15 X 7=1260
# samples 413
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1260*10)=-3.27684020535882
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SMARCAD1 [Title/Abstract] AND GRID2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SMARCAD1(95174158)-GRID2(94128554), # samples:2
SMARCAD1(95174158)-GRID2(94547420), # samples:2
Anticipated loss of major functional domain due to fusion event.SMARCAD1-GRID2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCAD1-GRID2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCAD1-GRID2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SMARCAD1-GRID2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SMARCAD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRID2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-LN-A4A1SMARCAD1chr4

95174158

+GRID2chr4

94128554

+
ChimerDB4ESCATCGA-LN-A4A1SMARCAD1chr4

95174158

+GRID2chr4

94128555

+
ChimerDB4ESCATCGA-LN-A4A1SMARCAD1chr4

95174822

+GRID2chr4

94128554

+
ChimerDB4LGGTCGA-DU-A7TD-01ASMARCAD1chr4

95174158

-GRID2chr4

94547420

+
ChimerDB4LGGTCGA-DU-A7TDSMARCAD1chr4

95174158

+GRID2chr4

94547419

+
ChimerDB4LGGTCGA-DU-A7TDSMARCAD1chr4

95174158

+GRID2chr4

94547420

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457823SMARCAD1chr495174158+ENST00000282020GRID2chr494128554+5903155627538441189
ENST00000354268SMARCAD1chr495174158+ENST00000282020GRID2chr494128554+570113547336421189
ENST00000457823SMARCAD1chr495174158+ENST00000282020GRID2chr494547419+444515562752386703
ENST00000354268SMARCAD1chr495174158+ENST00000282020GRID2chr494547419+42431354732184703
ENST00000457823SMARCAD1chr495174158+ENST00000282020GRID2chr494128555+5903155627538441189
ENST00000354268SMARCAD1chr495174158+ENST00000282020GRID2chr494128555+570113547336421189
ENST00000457823SMARCAD1chr495174158+ENST00000282020GRID2chr494547420+444515562752386703
ENST00000354268SMARCAD1chr495174158+ENST00000282020GRID2chr494547420+42431354732184703

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457823ENST00000282020SMARCAD1chr495174158+GRID2chr494128554+0.0001934590.9998066
ENST00000354268ENST00000282020SMARCAD1chr495174158+GRID2chr494128554+0.0001498050.99985015
ENST00000457823ENST00000282020SMARCAD1chr495174158+GRID2chr494547419+0.0005497960.99945015
ENST00000354268ENST00000282020SMARCAD1chr495174158+GRID2chr494547419+0.0005180890.999482
ENST00000457823ENST00000282020SMARCAD1chr495174158+GRID2chr494128555+0.0001934590.9998066
ENST00000354268ENST00000282020SMARCAD1chr495174158+GRID2chr494128555+0.0001498050.99985015
ENST00000457823ENST00000282020SMARCAD1chr495174158+GRID2chr494547420+0.0005497960.99945015
ENST00000354268ENST00000282020SMARCAD1chr495174158+GRID2chr494547420+0.0005180890.999482

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>83916_83916_1_SMARCAD1-GRID2_SMARCAD1_chr4_95174158_ENST00000354268_GRID2_chr4_94128554_ENST00000282020_length(amino acids)=1189AA_BP=427
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQ
YIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKL
IESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQE
LREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEY
DSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALVVETNLVAFDCHWIIINEEINDV
DVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRK
NSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTV
LEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTT
RYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTL
ATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGS
ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKN
GQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTS
SIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQ

--------------------------------------------------------------

>83916_83916_2_SMARCAD1-GRID2_SMARCAD1_chr4_95174158_ENST00000354268_GRID2_chr4_94128555_ENST00000282020_length(amino acids)=1189AA_BP=427
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQ
YIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKL
IESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQE
LREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEY
DSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALVVETNLVAFDCHWIIINEEINDV
DVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRK
NSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTV
LEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTT
RYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTL
ATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGS
ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKN
GQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTS
SIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQ

--------------------------------------------------------------

>83916_83916_3_SMARCAD1-GRID2_SMARCAD1_chr4_95174158_ENST00000354268_GRID2_chr4_94547419_ENST00000282020_length(amino acids)=703AA_BP=427
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQ
YIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKL
IESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQE
LREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEY
DSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALVKYGNYAFVWDAAVLEYVAINDP
DCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVL
SCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIP

--------------------------------------------------------------

>83916_83916_4_SMARCAD1-GRID2_SMARCAD1_chr4_95174158_ENST00000354268_GRID2_chr4_94547420_ENST00000282020_length(amino acids)=703AA_BP=427
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQ
YIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKL
IESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQE
LREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEY
DSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALVKYGNYAFVWDAAVLEYVAINDP
DCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVL
SCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIP

--------------------------------------------------------------

>83916_83916_5_SMARCAD1-GRID2_SMARCAD1_chr4_95174158_ENST00000457823_GRID2_chr4_94128554_ENST00000282020_length(amino acids)=1189AA_BP=427
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQ
YIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKL
IESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQE
LREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEY
DSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALVVETNLVAFDCHWIIINEEINDV
DVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRK
NSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTV
LEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTT
RYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTL
ATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGS
ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKN
GQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTS
SIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQ

--------------------------------------------------------------

>83916_83916_6_SMARCAD1-GRID2_SMARCAD1_chr4_95174158_ENST00000457823_GRID2_chr4_94128555_ENST00000282020_length(amino acids)=1189AA_BP=427
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQ
YIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKL
IESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQE
LREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEY
DSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALVVETNLVAFDCHWIIINEEINDV
DVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRK
NSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGVVLRVVTV
LEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTT
RYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTL
ATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSNGS
ENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKN
GQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTS
SIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQ

--------------------------------------------------------------

>83916_83916_7_SMARCAD1-GRID2_SMARCAD1_chr4_95174158_ENST00000457823_GRID2_chr4_94547419_ENST00000282020_length(amino acids)=703AA_BP=427
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQ
YIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKL
IESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQE
LREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEY
DSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALVKYGNYAFVWDAAVLEYVAINDP
DCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVL
SCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIP

--------------------------------------------------------------

>83916_83916_8_SMARCAD1-GRID2_SMARCAD1_chr4_95174158_ENST00000457823_GRID2_chr4_94547420_ENST00000282020_length(amino acids)=703AA_BP=427
MNLFNLDRFRFEKRNKIEEAPEATPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQ
YIDLSSDSEDVVSPNCSNTVQEKTFNKDTVIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQTLKELFPQRSDNDLLKL
IESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTRLDHGEESNESAESSSNWEKQESIVLKLQKEFPNFDKQE
LREVLKEHEWMYTEALESLKVFAEDQDMQYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQKFSMKAQNGFNKKRKKNVFNPKRVVEDSEY
DSGSDVGSSLDEDYSSGEEVMEDGYKGKILHFLQDASIGELTLIPQCSQKKAQKITELRPFNSWEALVKYGNYAFVWDAAVLEYVAINDP
DCSFYTIGNTVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVL
SCFIAMLETWWNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFIP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:95174158/chr4:94128554)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GRID2

A4D2P6

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000354268+924157_199427.01027.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000354268+924251_294427.01027.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000457823+924157_199427.01029.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000457823+924251_294427.01029.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000354268+924157_199427.01027.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000354268+924251_294427.01027.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000457823+924157_199427.01029.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000457823+924251_294427.01029.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000354268+924157_199427.01027.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000354268+924251_294427.01027.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000457823+924157_199427.01029.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000457823+924251_294427.01029.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924157_199427.01027.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924251_294427.01027.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924157_199427.01029.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924251_294427.01029.0DomainCUE 2
TgeneGRID2chr4:95174158chr4:94128554ENST000002820203161005_1007245.01008.0MotifPDZ-binding
TgeneGRID2chr4:95174158chr4:94128555ENST000002820203161005_1007245.01008.0MotifPDZ-binding
TgeneGRID2chr4:95174158chr4:94547419ENST0000028202012161005_1007731.01008.0MotifPDZ-binding
TgeneGRID2chr4:95174158chr4:94547420ENST0000028202012161005_1007731.01008.0MotifPDZ-binding
TgeneGRID2chr4:95174158chr4:94128554ENST00000282020316588_635245.01008.0Topological domainCytoplasmic
TgeneGRID2chr4:95174158chr4:94128554ENST00000282020316657_830245.01008.0Topological domainExtracellular
TgeneGRID2chr4:95174158chr4:94128554ENST00000282020316852_1007245.01008.0Topological domainCytoplasmic
TgeneGRID2chr4:95174158chr4:94128555ENST00000282020316588_635245.01008.0Topological domainCytoplasmic
TgeneGRID2chr4:95174158chr4:94128555ENST00000282020316657_830245.01008.0Topological domainExtracellular
TgeneGRID2chr4:95174158chr4:94128555ENST00000282020316852_1007245.01008.0Topological domainCytoplasmic
TgeneGRID2chr4:95174158chr4:94547419ENST000002820201216852_1007731.01008.0Topological domainCytoplasmic
TgeneGRID2chr4:95174158chr4:94547420ENST000002820201216852_1007731.01008.0Topological domainCytoplasmic
TgeneGRID2chr4:95174158chr4:94128554ENST00000282020316567_587245.01008.0TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94128554ENST00000282020316636_656245.01008.0TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94128554ENST00000282020316831_851245.01008.0TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94128555ENST00000282020316567_587245.01008.0TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94128555ENST00000282020316636_656245.01008.0TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94128555ENST00000282020316831_851245.01008.0TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94547419ENST000002820201216831_851731.01008.0TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94547420ENST000002820201216831_851731.01008.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000354268+924509_677427.01027.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000354268+924858_1010427.01027.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000457823+924509_677427.01029.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000457823+924858_1010427.01029.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000509418+116157_1990597.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000509418+116251_2940597.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000509418+116509_6770597.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000509418+116858_10100597.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000354268+924509_677427.01027.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000354268+924858_1010427.01027.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000457823+924509_677427.01029.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000457823+924858_1010427.01029.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000509418+116157_1990597.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000509418+116251_2940597.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000509418+116509_6770597.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000509418+116858_10100597.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000354268+924509_677427.01027.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000354268+924858_1010427.01027.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000457823+924509_677427.01029.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000457823+924858_1010427.01029.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000509418+116157_1990597.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000509418+116251_2940597.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000509418+116509_6770597.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000509418+116858_10100597.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924509_677427.01027.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924858_1010427.01027.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924509_677427.01029.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924858_1010427.01029.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116157_1990597.0DomainCUE 1
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116251_2940597.0DomainCUE 2
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116509_6770597.0DomainHelicase ATP-binding
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116858_10100597.0DomainHelicase C-terminal
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000354268+9241005_1008427.01027.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000354268+924628_631427.01027.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000354268+924721_738427.01027.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000457823+9241005_1008427.01029.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000457823+924628_631427.01029.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000457823+924721_738427.01029.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000509418+1161005_10080597.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000509418+116628_6310597.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000509418+116721_7380597.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000354268+9241005_1008427.01027.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000354268+924628_631427.01027.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000354268+924721_738427.01027.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000457823+9241005_1008427.01029.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000457823+924628_631427.01029.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000457823+924721_738427.01029.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000509418+1161005_10080597.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000509418+116628_6310597.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000509418+116721_7380597.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000354268+9241005_1008427.01027.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000354268+924628_631427.01027.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000354268+924721_738427.01027.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000457823+9241005_1008427.01029.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000457823+924628_631427.01029.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000457823+924721_738427.01029.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000509418+1161005_10080597.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000509418+116628_6310597.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000509418+116721_7380597.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+9241005_1008427.01027.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924628_631427.01027.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924721_738427.01027.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+9241005_1008427.01029.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924628_631427.01029.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924721_738427.01029.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+1161005_10080597.0MotifNote=DEGD box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116628_6310597.0MotifNote=DEGH box
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116721_7380597.0MotifNuclear localization signal
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000354268+924521_529427.01027.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000354268+924897_904427.01027.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000457823+924521_529427.01029.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000457823+924897_904427.01029.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000509418+116521_5290597.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128554ENST00000509418+116897_9040597.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000354268+924521_529427.01027.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000354268+924897_904427.01027.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000457823+924521_529427.01029.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000457823+924897_904427.01029.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000509418+116521_5290597.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94128555ENST00000509418+116897_9040597.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000354268+924521_529427.01027.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000354268+924897_904427.01027.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000457823+924521_529427.01029.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000457823+924897_904427.01029.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000509418+116521_5290597.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547419ENST00000509418+116897_9040597.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924521_529427.01027.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000354268+924897_904427.01027.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924521_529427.01029.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000457823+924897_904427.01029.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116521_5290597.0Nucleotide bindingATP
HgeneSMARCAD1chr4:95174158chr4:94547420ENST00000509418+116897_9040597.0Nucleotide bindingATP
TgeneGRID2chr4:95174158chr4:94128554ENST0000028202031624_566245.01008.0Topological domainExtracellular
TgeneGRID2chr4:95174158chr4:94128555ENST0000028202031624_566245.01008.0Topological domainExtracellular
TgeneGRID2chr4:95174158chr4:94547419ENST00000282020121624_566731.01008.0Topological domainExtracellular
TgeneGRID2chr4:95174158chr4:94547419ENST000002820201216588_635731.01008.0Topological domainCytoplasmic
TgeneGRID2chr4:95174158chr4:94547419ENST000002820201216657_830731.01008.0Topological domainExtracellular
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020121624_566731.01008.0Topological domainExtracellular
TgeneGRID2chr4:95174158chr4:94547420ENST000002820201216588_635731.01008.0Topological domainCytoplasmic
TgeneGRID2chr4:95174158chr4:94547420ENST000002820201216657_830731.01008.0Topological domainExtracellular
TgeneGRID2chr4:95174158chr4:94547419ENST000002820201216567_587731.01008.0TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94547419ENST000002820201216636_656731.01008.0TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94547420ENST000002820201216567_587731.01008.0TransmembraneHelical
TgeneGRID2chr4:95174158chr4:94547420ENST000002820201216636_656731.01008.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
SMARCAD1_pLDDT.png
all structure
all structure
GRID2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SMARCAD1
GRID2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneGRID2chr4:95174158chr4:94128554ENST0000028202031624_345245.01008.0CBLN1 homotrimer
TgeneGRID2chr4:95174158chr4:94128555ENST0000028202031624_345245.01008.0CBLN1 homotrimer
TgeneGRID2chr4:95174158chr4:94547419ENST00000282020121624_345731.01008.0CBLN1 homotrimer
TgeneGRID2chr4:95174158chr4:94547420ENST00000282020121624_345731.01008.0CBLN1 homotrimer


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Related Drugs to SMARCAD1-GRID2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SMARCAD1-GRID2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource