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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ATXN7-SLC25A26

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ATXN7-SLC25A26
FusionPDB ID: 8468
FusionGDB2.0 ID: 8468
HgeneTgene
Gene symbol

ATXN7

SLC25A26

Gene ID

6314

115286

Gene nameataxin 7solute carrier family 25 member 26
SynonymsADCAII|OPCA3|SCA7|SGF73COXPD28|SAMC
Cytomap

3p14.1

3p14.1

Type of geneprotein-codingprotein-coding
Descriptionataxin-7spinocerebellar ataxia type 7 proteinS-adenosylmethionine mitochondrial carrier proteinmitochondrial S-adenosylmethionine transportersolute carrier family 25 (S-adenosylmethionine carrier), member 26solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 26
Modification date2020031320200326
UniProtAcc

Q96GX2

.
Ensembl transtripts involved in fusion geneENST idsENST00000295900, ENST00000398590, 
ENST00000487717, ENST00000538065, 
ENST00000484332, ENST00000488239, 
ENST00000336733, ENST00000354883, 
ENST00000413054, ENST00000536651, 
ENST00000484768, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 6 X 6=25210 X 11 X 8=880
# samples 814
** MAII scorelog2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/880*10)=-2.65207669657969
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ATXN7 [Title/Abstract] AND SLC25A26 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ATXN7(63938159)-SLC25A26(66271168), # samples:2
ATXN7(63938159)-SLC25A26(66293627), # samples:2
Anticipated loss of major functional domain due to fusion event.ATXN7-SLC25A26 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATXN7-SLC25A26 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATXN7-SLC25A26 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATXN7-SLC25A26 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATXN7

GO:0016578

histone deubiquitination

18206972


check buttonFusion gene breakpoints across ATXN7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC25A26 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-FS-A1ZZ-06AATXN7chr3

63938159

-SLC25A26chr3

66271168

+
ChimerDB4SKCMTCGA-FS-A1ZZ-06AATXN7chr3

63938159

+SLC25A26chr3

66271168

+
ChimerDB4UCSTCGA-NA-A4QW-01AATXN7chr3

63938159

-SLC25A26chr3

66293627

+
ChimerDB4UCSTCGA-NA-A4QWATXN7chr3

63938159

+SLC25A26chr3

66293627

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398590ATXN7chr363938159+ENST00000354883SLC25A26chr366293627+280710525531686377
ENST00000295900ATXN7chr363938159+ENST00000354883SLC25A26chr366293627+280410495501683377
ENST00000487717ATXN7chr363938159+ENST00000354883SLC25A26chr366293627+251876301397465
ENST00000538065ATXN7chr363938159+ENST00000354883SLC25A26chr366293627+225449901133377

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398590ENST00000354883ATXN7chr363938159+SLC25A26chr366293627+0.0175118390.9824882
ENST00000295900ENST00000354883ATXN7chr363938159+SLC25A26chr366293627+0.0178579760.9821421
ENST00000487717ENST00000354883ATXN7chr363938159+SLC25A26chr366293627+0.0280960980.971904
ENST00000538065ENST00000354883ATXN7chr363938159+SLC25A26chr366293627+0.0251169670.974883

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8468_8468_1_ATXN7-SLC25A26_ATXN7_chr3_63938159_ENST00000295900_SLC25A26_chr3_66293627_ENST00000354883_length(amino acids)=377AA_BP=166
MSERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRPEDGGPGAASTSAAAMATVGERRPLPSPEVM
LGQSWNLWVEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYAAAFFITYEYVKWF
LHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKA
LWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRITLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLG

--------------------------------------------------------------

>8468_8468_2_ATXN7-SLC25A26_ATXN7_chr3_63938159_ENST00000398590_SLC25A26_chr3_66293627_ENST00000354883_length(amino acids)=377AA_BP=166
MSERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRPEDGGPGAASTSAAAMATVGERRPLPSPEVM
LGQSWNLWVEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYAAAFFITYEYVKWF
LHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKA
LWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRITLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLG

--------------------------------------------------------------

>8468_8468_3_ATXN7-SLC25A26_ATXN7_chr3_63938159_ENST00000487717_SLC25A26_chr3_66293627_ENST00000354883_length(amino acids)=465AA_BP=254
LPWGRPAGSSIGGCISDFALAPVRGLDVQTSPERAEREGPASGRRRREASPLKGAGRVPPLGRTRGRKEGAGQPGRARGCKRPKGAERMS
ERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRPEDGGPGAASTSAAAMATVGERRPLPSPEVMLG
QSWNLWVEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYAAAFFITYEYVKWFLH
ADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALW
SWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRITLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAY

--------------------------------------------------------------

>8468_8468_4_ATXN7-SLC25A26_ATXN7_chr3_63938159_ENST00000538065_SLC25A26_chr3_66293627_ENST00000354883_length(amino acids)=377AA_BP=166
MSERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRPEDGGPGAASTSAAAMATVGERRPLPSPEVM
LGQSWNLWVEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYAAAFFITYEYVKWF
LHADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKA
LWSWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRITLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:63938159/chr3:66271168)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATXN7

Q96GX2

.
FUNCTION: By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3. {ECO:0000269|PubMed:27601583}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+51316_20166.33333333333334893.0Compositional biasNote=Poly-Ala
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+51323_28166.33333333333334893.0Compositional biasNote=Poly-Ala
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+51330_39166.33333333333334893.0Compositional biasNote=Poly-Gln
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+51330_49166.33333333333334893.0Compositional biasNote=Gln-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+51340_45166.33333333333334893.0Compositional biasNote=Poly-Pro
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+51340_65166.33333333333334893.0Compositional biasNote=Pro-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+51351_55166.33333333333334893.0Compositional biasNote=Poly-Pro
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+51416_20166.33333333333334946.0Compositional biasNote=Poly-Ala
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+51423_28166.33333333333334946.0Compositional biasNote=Poly-Ala
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+51430_39166.33333333333334946.0Compositional biasNote=Poly-Gln
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+51430_49166.33333333333334946.0Compositional biasNote=Gln-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+51440_45166.33333333333334946.0Compositional biasNote=Poly-Pro
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+51440_65166.33333333333334946.0Compositional biasNote=Pro-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+51451_55166.33333333333334946.0Compositional biasNote=Poly-Pro
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+41216_20166.33333333333334893.0Compositional biasNote=Poly-Ala
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+41223_28166.33333333333334893.0Compositional biasNote=Poly-Ala
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+41230_39166.33333333333334893.0Compositional biasNote=Poly-Gln
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+41230_49166.33333333333334893.0Compositional biasNote=Gln-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+41240_45166.33333333333334893.0Compositional biasNote=Poly-Pro
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+41240_65166.33333333333334893.0Compositional biasNote=Pro-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+41251_55166.33333333333334893.0Compositional biasNote=Poly-Pro
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+31216_20166.33333333333334946.0Compositional biasNote=Poly-Ala
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+31223_28166.33333333333334946.0Compositional biasNote=Poly-Ala
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+31230_39166.33333333333334946.0Compositional biasNote=Poly-Gln
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+31230_49166.33333333333334946.0Compositional biasNote=Gln-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+31240_45166.33333333333334946.0Compositional biasNote=Poly-Pro
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+31240_65166.33333333333334946.0Compositional biasNote=Pro-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+31251_55166.33333333333334946.0Compositional biasNote=Poly-Pro
TgeneSLC25A26chr3:63938159chr3:66293627ENST0000033673309177_2650187.0RepeatNote=Solcar 3
TgeneSLC25A26chr3:63938159chr3:66293627ENST00000336733094_770187.0RepeatNote=Solcar 1
TgeneSLC25A26chr3:63938159chr3:66293627ENST000003367330986_1680187.0RepeatNote=Solcar 2
TgeneSLC25A26chr3:63938159chr3:66293627ENST0000033673309142_1620187.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A26chr3:63938159chr3:66293627ENST0000033673309182_2020187.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A26chr3:63938159chr3:66293627ENST0000033673309238_2580187.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A26chr3:63938159chr3:66293627ENST000003367330949_690187.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A26chr3:63938159chr3:66293627ENST00000336733095_250187.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A26chr3:63938159chr3:66293627ENST000003367330985_1050187.0TransmembraneHelical%3B Name%3D3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+513171_174166.33333333333334893.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+513171_219166.33333333333334893.0Compositional biasNote=Ser-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+513213_219166.33333333333334893.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+513402_486166.33333333333334893.0Compositional biasNote=Pro-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+513640_851166.33333333333334893.0Compositional biasNote=Ser-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+513647_654166.33333333333334893.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+513717_730166.33333333333334893.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+513840_845166.33333333333334893.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+514171_174166.33333333333334946.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+514171_219166.33333333333334946.0Compositional biasNote=Ser-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+514213_219166.33333333333334946.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+514402_486166.33333333333334946.0Compositional biasNote=Pro-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+514640_851166.33333333333334946.0Compositional biasNote=Ser-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+514647_654166.33333333333334946.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+514717_730166.33333333333334946.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+514840_845166.33333333333334946.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+1916_200748.0Compositional biasNote=Poly-Ala
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+19171_1740748.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+19171_2190748.0Compositional biasNote=Ser-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+19213_2190748.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+1923_280748.0Compositional biasNote=Poly-Ala
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+1930_390748.0Compositional biasNote=Poly-Gln
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+1930_490748.0Compositional biasNote=Gln-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+19402_4860748.0Compositional biasNote=Pro-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+1940_450748.0Compositional biasNote=Poly-Pro
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+1940_650748.0Compositional biasNote=Pro-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+1951_550748.0Compositional biasNote=Poly-Pro
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+19640_8510748.0Compositional biasNote=Ser-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+19647_6540748.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+19717_7300748.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+19840_8450748.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+412171_174166.33333333333334893.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+412171_219166.33333333333334893.0Compositional biasNote=Ser-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+412213_219166.33333333333334893.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+412402_486166.33333333333334893.0Compositional biasNote=Pro-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+412640_851166.33333333333334893.0Compositional biasNote=Ser-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+412647_654166.33333333333334893.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+412717_730166.33333333333334893.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+412840_845166.33333333333334893.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+312171_174166.33333333333334946.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+312171_219166.33333333333334946.0Compositional biasNote=Ser-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+312213_219166.33333333333334946.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+312402_486166.33333333333334946.0Compositional biasNote=Pro-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+312640_851166.33333333333334946.0Compositional biasNote=Ser-rich
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+312647_654166.33333333333334946.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+312717_730166.33333333333334946.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+312840_845166.33333333333334946.0Compositional biasNote=Poly-Ser
HgeneATXN7chr3:63938159chr3:66293627ENST00000295900+513334_401166.33333333333334893.0DomainSCA7
HgeneATXN7chr3:63938159chr3:66293627ENST00000398590+514334_401166.33333333333334946.0DomainSCA7
HgeneATXN7chr3:63938159chr3:66293627ENST00000484332+19334_4010748.0DomainSCA7
HgeneATXN7chr3:63938159chr3:66293627ENST00000487717+412334_401166.33333333333334893.0DomainSCA7
HgeneATXN7chr3:63938159chr3:66293627ENST00000538065+312334_401166.33333333333334946.0DomainSCA7


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>977_ATXN7_63938159_SLC25A26_66293627_977_ATXN7_63938159_SLC25A26_66293627_ranked_0.pdbATXN76393815963938159ENST00000354883SLC25A26chr366293627+
LPWGRPAGSSIGGCISDFALAPVRGLDVQTSPERAEREGPASGRRRREASPLKGAGRVPPLGRTRGRKEGAGQPGRARGCKRPKGAERMS
ERAADDVRGEPRRAAAAAGGAAAAAARQQQQQQQQQQPPPPQPQRQQHPPPPPRRTRPEDGGPGAASTSAAAMATVGERRPLPSPEVMLG
QSWNLWVEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGFCPAHDDFYLVVCNDCNQVVKPQAFQSHYAAAFFITYEYVKWFLH
ADSSSYLTPMKHMLAASAGEVVACLIRVPSEVVKQRAQVSASTRTFQIFSNILYEEGIQGLYRGYKSTVLREIPFSLVQFPLWESLKALW
SWRQDHVVDSWQSAVCGAFAGGFAAAVTTPLDVAKTRITLAKAGSSTADGNVLSVLHGVWRSQGLAGLFAGVFPRMAAISLGGFIFLGAY
465


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ATXN7_pLDDT.png
all structure
all structure
SLC25A26_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ATXN7
SLC25A26


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ATXN7-SLC25A26


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ATXN7-SLC25A26


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource