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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AURKA-SOGA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AURKA-SOGA1
FusionPDB ID: 8490
FusionGDB2.0 ID: 8490
HgeneTgene
Gene symbol

AURKA

SOGA1

Gene ID

6790

140710

Gene nameaurora kinase Asuppressor of glucose, autophagy associated 1
SynonymsAIK|ARK1|AURA|BTAK|PPP1R47|STK15|STK6|STK7C20orf117|KIAA0889|SOGA
Cytomap

20q13.2

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionaurora kinase Aaurora 2aurora/IPL1-like kinaseaurora/IPL1-related kinase 1breast tumor-amplified kinaseprotein phosphatase 1, regulatory subunit 47serine/threonine protein kinase 15serine/threonine-protein kinase 6serine/threonine-protein kinase aprotein SOGA1SOGA family member 1suppressor of glucose by autophagysuppressor of glucose from autophagysuppressor of glucose, autophagy-associated protein 1
Modification date2020032920200313
UniProtAcc

Q9NWT8

O94964

Ensembl transtripts involved in fusion geneENST idsENST00000312783, ENST00000347343, 
ENST00000371356, ENST00000395907, 
ENST00000395909, ENST00000395911, 
ENST00000395913, ENST00000395914, 
ENST00000395915, 		ENST00000357779, 
ENST00000456801, ENST00000237536, 
ENST00000279034, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 8 X 3=14410 X 10 X 4=400
# samples 812
** MAII scorelog2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/400*10)=-1.73696559416621
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AURKA [Title/Abstract] AND SOGA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AURKA(54956489)-SOGA1(35445872), # samples:2
Anticipated loss of major functional domain due to fusion event.AURKA-SOGA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AURKA-SOGA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AURKA-SOGA1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
AURKA-SOGA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AURKA-SOGA1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AURKA-SOGA1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
AURKA-SOGA1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAURKA

GO:0006468

protein phosphorylation

21600873|21820309

HgeneAURKA

GO:0009611

response to wounding

19435814

HgeneAURKA

GO:0032091

negative regulation of protein binding

21820309

HgeneAURKA

GO:0097421

liver regeneration

19435814


check buttonFusion gene breakpoints across AURKA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SOGA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1728-01AAURKAchr20

54956489

-SOGA1chr20

35445872

-
ChimerDB4OVTCGA-61-1728AURKAchr20

54956488

-SOGA1chr20

35445872

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371356AURKAchr2054956489-ENST00000237536SOGA1chr2035445872-137958371847511577
ENST00000371356AURKAchr2054956489-ENST00000279034SOGA1chr2035445872-38568371835301170
ENST00000312783AURKAchr2054956489-ENST00000237536SOGA1chr2035445872-1390694824348621539
ENST00000312783AURKAchr2054956489-ENST00000279034SOGA1chr2035445872-396794824336411132
ENST00000395913AURKAchr2054956489-ENST00000237536SOGA1chr2035445872-1385289415948081549
ENST00000395913AURKAchr2054956489-ENST00000279034SOGA1chr2035445872-391389415935871142
ENST00000371356AURKAchr2054956488-ENST00000237536SOGA1chr2035445872-137958371847511577
ENST00000371356AURKAchr2054956488-ENST00000279034SOGA1chr2035445872-38568371835301170
ENST00000312783AURKAchr2054956488-ENST00000237536SOGA1chr2035445872-1390694824348621539
ENST00000312783AURKAchr2054956488-ENST00000279034SOGA1chr2035445872-396794824336411132
ENST00000395913AURKAchr2054956488-ENST00000237536SOGA1chr2035445872-1385289415948081549
ENST00000395913AURKAchr2054956488-ENST00000279034SOGA1chr2035445872-391389415935871142

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371356ENST00000237536AURKAchr2054956489-SOGA1chr2035445872-0.0009886440.9990113
ENST00000371356ENST00000279034AURKAchr2054956489-SOGA1chr2035445872-0.0083886760.9916113
ENST00000312783ENST00000237536AURKAchr2054956489-SOGA1chr2035445872-0.001144840.9988551
ENST00000312783ENST00000279034AURKAchr2054956489-SOGA1chr2035445872-0.0098925890.9901074
ENST00000395913ENST00000237536AURKAchr2054956489-SOGA1chr2035445872-0.0010568320.99894315
ENST00000395913ENST00000279034AURKAchr2054956489-SOGA1chr2035445872-0.0090108210.99098915
ENST00000371356ENST00000237536AURKAchr2054956488-SOGA1chr2035445872-0.0009886440.9990113
ENST00000371356ENST00000279034AURKAchr2054956488-SOGA1chr2035445872-0.0083886760.9916113
ENST00000312783ENST00000237536AURKAchr2054956488-SOGA1chr2035445872-0.001144840.9988551
ENST00000312783ENST00000279034AURKAchr2054956488-SOGA1chr2035445872-0.0098925890.9901074
ENST00000395913ENST00000237536AURKAchr2054956488-SOGA1chr2035445872-0.0010568320.99894315
ENST00000395913ENST00000279034AURKAchr2054956488-SOGA1chr2035445872-0.0090108210.99098915

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>8490_8490_1_AURKA-SOGA1_AURKA_chr20_54956488_ENST00000312783_SOGA1_chr20_35445872_ENST00000237536_length(amino acids)=1539AA_BP=235
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSR
PLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAK
EESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMK
DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEE
LAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAAL
VSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPL
GSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLS
QERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSE
GDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAE
LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLS
QLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSS
EPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPVVHDKEGKIIIEPGFLFTTAKPKESAE
ADGLAESSYGRWLCNFSRQRLDGGSAGSPSAAGPGFPAALHDFEMSGNMSDDMKEITNCVRQAMRSGSLERKVKSTSSQTVGLASVGTQT
IRTVSVGLQTDPPRSSLHGKAWSPRSSSLVSVRSKQISSSLDKVHSRIERPCCSPKYGSPKLQRRSVSKLDSSKDRSLWNLHQGKQNGSA
WARSTTTRDSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSETRAKPEPPKYGIVQEFFRNVCGRAPSPTSSAGEEGTKKPEPLSPASY
HQPEGVARILNKKAAKLGSSEEVRLTMLPQVGKDGVLRDGDGAVVLPNEDAVCDCSTQSLTSCFARSSRSAIRHSPSKCRLHPSESSWGG

--------------------------------------------------------------

>8490_8490_2_AURKA-SOGA1_AURKA_chr20_54956488_ENST00000312783_SOGA1_chr20_35445872_ENST00000279034_length(amino acids)=1132AA_BP=235
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSR
PLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAK
EESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMK
DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEE
LAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAAL
VSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPL
GSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLS
QERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSE
GDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAE
LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLS
QLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSS

--------------------------------------------------------------

>8490_8490_3_AURKA-SOGA1_AURKA_chr20_54956488_ENST00000371356_SOGA1_chr20_35445872_ENST00000237536_length(amino acids)=1577AA_BP=3
MGRRLECNGVISAHCNLCFLGLSDSPASASRVAGITGIMDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSN
SSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKG
KFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQR
TATHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRET
ELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELE
DQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGD
SAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAIL
VRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRS
FRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQE
KNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADM
KVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQ
LQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKS
VSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSSEPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGRQMQRSYTAPDKTGIRVYY
SPPVARRLGVPVVHDKEGKIIIEPGFLFTTAKPKESAEADGLAESSYGRWLCNFSRQRLDGGSAGSPSAAGPGFPAALHDFEMSGNMSDD
MKEITNCVRQAMRSGSLERKVKSTSSQTVGLASVGTQTIRTVSVGLQTDPPRSSLHGKAWSPRSSSLVSVRSKQISSSLDKVHSRIERPC
CSPKYGSPKLQRRSVSKLDSSKDRSLWNLHQGKQNGSAWARSTTTRDSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSETRAKPEPPK
YGIVQEFFRNVCGRAPSPTSSAGEEGTKKPEPLSPASYHQPEGVARILNKKAAKLGSSEEVRLTMLPQVGKDGVLRDGDGAVVLPNEDAV

--------------------------------------------------------------

>8490_8490_4_AURKA-SOGA1_AURKA_chr20_54956488_ENST00000371356_SOGA1_chr20_35445872_ENST00000279034_length(amino acids)=1170AA_BP=3
MGRRLECNGVISAHCNLCFLGLSDSPASASRVAGITGIMDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSN
SSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKG
KFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQR
TATHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRET
ELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELE
DQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGD
SAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAIL
VRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRS
FRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQE
KNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADM
KVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQ
LQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKS
VSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSSEPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGSQKLPFLLILAPPQPPPIL

--------------------------------------------------------------

>8490_8490_5_AURKA-SOGA1_AURKA_chr20_54956488_ENST00000395913_SOGA1_chr20_35445872_ENST00000237536_length(amino acids)=1549AA_BP=245
MGRRWEPTGIMDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQ
ATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE
KAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATHSLKKRGTRSLGKADKKTLVQEDSA
DLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENR
GLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSC
SVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEV
LPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQ
QESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHD
SLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKR
WRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKA
KATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQ
QVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLP
NNPAFGFVSSEPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPVVHDKEGKIIIEPGFLF
TTAKPKESAEADGLAESSYGRWLCNFSRQRLDGGSAGSPSAAGPGFPAALHDFEMSGNMSDDMKEITNCVRQAMRSGSLERKVKSTSSQT
VGLASVGTQTIRTVSVGLQTDPPRSSLHGKAWSPRSSSLVSVRSKQISSSLDKVHSRIERPCCSPKYGSPKLQRRSVSKLDSSKDRSLWN
LHQGKQNGSAWARSTTTRDSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSETRAKPEPPKYGIVQEFFRNVCGRAPSPTSSAGEEGTK
KPEPLSPASYHQPEGVARILNKKAAKLGSSEEVRLTMLPQVGKDGVLRDGDGAVVLPNEDAVCDCSTQSLTSCFARSSRSAIRHSPSKCR

--------------------------------------------------------------

>8490_8490_6_AURKA-SOGA1_AURKA_chr20_54956488_ENST00000395913_SOGA1_chr20_35445872_ENST00000279034_length(amino acids)=1142AA_BP=245
MGRRWEPTGIMDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQ
ATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE
KAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATHSLKKRGTRSLGKADKKTLVQEDSA
DLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENR
GLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSC
SVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEV
LPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQ
QESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHD
SLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKR
WRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKA
KATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQ
QVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLP

--------------------------------------------------------------

>8490_8490_7_AURKA-SOGA1_AURKA_chr20_54956489_ENST00000312783_SOGA1_chr20_35445872_ENST00000237536_length(amino acids)=1539AA_BP=235
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSR
PLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAK
EESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMK
DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEE
LAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAAL
VSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPL
GSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLS
QERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSE
GDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAE
LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLS
QLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSS
EPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPVVHDKEGKIIIEPGFLFTTAKPKESAE
ADGLAESSYGRWLCNFSRQRLDGGSAGSPSAAGPGFPAALHDFEMSGNMSDDMKEITNCVRQAMRSGSLERKVKSTSSQTVGLASVGTQT
IRTVSVGLQTDPPRSSLHGKAWSPRSSSLVSVRSKQISSSLDKVHSRIERPCCSPKYGSPKLQRRSVSKLDSSKDRSLWNLHQGKQNGSA
WARSTTTRDSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSETRAKPEPPKYGIVQEFFRNVCGRAPSPTSSAGEEGTKKPEPLSPASY
HQPEGVARILNKKAAKLGSSEEVRLTMLPQVGKDGVLRDGDGAVVLPNEDAVCDCSTQSLTSCFARSSRSAIRHSPSKCRLHPSESSWGG

--------------------------------------------------------------

>8490_8490_8_AURKA-SOGA1_AURKA_chr20_54956489_ENST00000312783_SOGA1_chr20_35445872_ENST00000279034_length(amino acids)=1132AA_BP=235
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSR
PLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAK
EESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMK
DHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEE
LAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAAL
VSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPL
GSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLS
QERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSE
GDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAE
LKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLS
QLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSS

--------------------------------------------------------------

>8490_8490_9_AURKA-SOGA1_AURKA_chr20_54956489_ENST00000371356_SOGA1_chr20_35445872_ENST00000237536_length(amino acids)=1577AA_BP=3
MGRRLECNGVISAHCNLCFLGLSDSPASASRVAGITGIMDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSN
SSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKG
KFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQR
TATHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRET
ELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELE
DQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGD
SAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAIL
VRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRS
FRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQE
KNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADM
KVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQ
LQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKS
VSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSSEPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGRQMQRSYTAPDKTGIRVYY
SPPVARRLGVPVVHDKEGKIIIEPGFLFTTAKPKESAEADGLAESSYGRWLCNFSRQRLDGGSAGSPSAAGPGFPAALHDFEMSGNMSDD
MKEITNCVRQAMRSGSLERKVKSTSSQTVGLASVGTQTIRTVSVGLQTDPPRSSLHGKAWSPRSSSLVSVRSKQISSSLDKVHSRIERPC
CSPKYGSPKLQRRSVSKLDSSKDRSLWNLHQGKQNGSAWARSTTTRDSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSETRAKPEPPK
YGIVQEFFRNVCGRAPSPTSSAGEEGTKKPEPLSPASYHQPEGVARILNKKAAKLGSSEEVRLTMLPQVGKDGVLRDGDGAVVLPNEDAV

--------------------------------------------------------------

>8490_8490_10_AURKA-SOGA1_AURKA_chr20_54956489_ENST00000371356_SOGA1_chr20_35445872_ENST00000279034_length(amino acids)=1170AA_BP=3
MGRRLECNGVISAHCNLCFLGLSDSPASASRVAGITGIMDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSN
SSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKG
KFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQR
TATHSLKKRGTRSLGKADKKTLVQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRET
ELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELE
DQNKLLLNELAKFRSEHELDVALSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGD
SAQCVPAPLGETHESHAVRLCRAREAEVLPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAIL
VRLSVLQQELNAFTRKADAVLGCSVKEQQESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRS
FRPYRAEDNDSYASEIKELQLVLAEAHDSLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQE
KNMLVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADM
KVTLKELCWLLRDERRGLTELQQQFAKAKATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQ
LQISERNWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKS
VSSMSEFESLLDCSPYLAGGDARGKKLPNNPAFGFVSSEPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGSQKLPFLLILAPPQPPPIL

--------------------------------------------------------------

>8490_8490_11_AURKA-SOGA1_AURKA_chr20_54956489_ENST00000395913_SOGA1_chr20_35445872_ENST00000237536_length(amino acids)=1549AA_BP=245
MGRRWEPTGIMDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQ
ATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE
KAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATHSLKKRGTRSLGKADKKTLVQEDSA
DLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENR
GLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSC
SVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEV
LPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQ
QESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHD
SLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKR
WRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKA
KATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQ
QVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLP
NNPAFGFVSSEPGDPEKDTKEKPGLSSRDCNHLGALACQDPPGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPVVHDKEGKIIIEPGFLF
TTAKPKESAEADGLAESSYGRWLCNFSRQRLDGGSAGSPSAAGPGFPAALHDFEMSGNMSDDMKEITNCVRQAMRSGSLERKVKSTSSQT
VGLASVGTQTIRTVSVGLQTDPPRSSLHGKAWSPRSSSLVSVRSKQISSSLDKVHSRIERPCCSPKYGSPKLQRRSVSKLDSSKDRSLWN
LHQGKQNGSAWARSTTTRDSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSETRAKPEPPKYGIVQEFFRNVCGRAPSPTSSAGEEGTK
KPEPLSPASYHQPEGVARILNKKAAKLGSSEEVRLTMLPQVGKDGVLRDGDGAVVLPNEDAVCDCSTQSLTSCFARSSRSAIRHSPSKCR

--------------------------------------------------------------

>8490_8490_12_AURKA-SOGA1_AURKA_chr20_54956489_ENST00000395913_SOGA1_chr20_35445872_ENST00000279034_length(amino acids)=1142AA_BP=245
MGRRWEPTGIMDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQ
ATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLE
KAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATHSLKKRGTRSLGKADKKTLVQEDSA
DLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDSALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENR
GLRAEMDDMKDHGGGCGGPEARLAFSALGGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKFRSEHELDVALSEDSC
SVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETHESHAVRLCRAREAEV
LPGLREQAALVSKAIDVLVADANGFTAGLRLCLDNECADFRLHEAPDNSEGPRDTKLIHAILVRLSVLQQELNAFTRKADAVLGCSVKEQ
QESFSSLPPLGSQGLSKEILLAKDLGSDFQPPDFRDLPEWEPRIREAFRTGDLDSKPDPSRSFRPYRAEDNDSYASEIKELQLVLAEAHD
SLRGLQEQLSQERQLRKEEADNFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNMLVQESQQFKHNFLLLFMKLRWFLKR
WRQGKVLPSEGDDFLEVNSMKELYLLMEEEEINAQHSDNKACTGDSWTQNTPNEYIKTLADMKVTLKELCWLLRDERRGLTELQQQFAKA
KATWETERAELKGHTSQMELKTGKGAGERAGPDWKAALQREREEQQHLLAESYSAVMELTRQLQISERNWSQEKLQLVERLQGEKQQVEQ
QVKELQNRLSQLQKAADPWVLKHSELEKQDNSWKETRSEKIHDKEAVSEVELGGNGLKRTKSVSSMSEFESLLDCSPYLAGGDARGKKLP

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Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:54956489/chr20:35445872)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AURKA

Q9NWT8

SOGA1

O94964

FUNCTION: May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.FUNCTION: Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAURKAchr20:54956488chr20:35445872ENST00000312783-710211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000347343-69211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000371356-710211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000395909-811211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000395911-710211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000395913-69211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000395914-710211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000395915-69211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000312783-710211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000347343-69211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000371356-710211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000395909-811211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000395911-710211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000395913-69211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000395914-710211_213235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000395915-69211_213235.0404.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAURKAchr20:54956488chr20:35445872ENST00000312783-710133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956488chr20:35445872ENST00000347343-69133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956488chr20:35445872ENST00000371356-710133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956488chr20:35445872ENST00000395909-811133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956488chr20:35445872ENST00000395911-710133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956488chr20:35445872ENST00000395913-69133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956488chr20:35445872ENST00000395914-710133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956488chr20:35445872ENST00000395915-69133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956489chr20:35445872ENST00000312783-710133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956489chr20:35445872ENST00000347343-69133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956489chr20:35445872ENST00000371356-710133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956489chr20:35445872ENST00000395909-811133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956489chr20:35445872ENST00000395911-710133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956489chr20:35445872ENST00000395913-69133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956489chr20:35445872ENST00000395914-710133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956489chr20:35445872ENST00000395915-69133_383235.0404.0DomainProtein kinase
HgeneAURKAchr20:54956488chr20:35445872ENST00000312783-710260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000347343-69260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000371356-710260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000395909-811260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000395911-710260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000395913-69260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000395914-710260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000395915-69260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000312783-710260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000347343-69260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000371356-710260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000395909-811260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000395911-710260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000395913-69260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000395914-710260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956489chr20:35445872ENST00000395915-69260_261235.0404.0Nucleotide bindingATP
HgeneAURKAchr20:54956488chr20:35445872ENST00000312783-710280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956488chr20:35445872ENST00000347343-69280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956488chr20:35445872ENST00000371356-710280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956488chr20:35445872ENST00000395909-811280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956488chr20:35445872ENST00000395911-710280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956488chr20:35445872ENST00000395913-69280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956488chr20:35445872ENST00000395914-710280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956488chr20:35445872ENST00000395915-69280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956489chr20:35445872ENST00000312783-710280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956489chr20:35445872ENST00000347343-69280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956489chr20:35445872ENST00000371356-710280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956489chr20:35445872ENST00000395909-811280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956489chr20:35445872ENST00000395911-710280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956489chr20:35445872ENST00000395913-69280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956489chr20:35445872ENST00000395914-710280_293235.0404.0RegionActivation segment
HgeneAURKAchr20:54956489chr20:35445872ENST00000395915-69280_293235.0404.0RegionActivation segment


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AURKA
SOGA1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to AURKA-SOGA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AURKA-SOGA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource