UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level1

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SNX31-PABPC1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SNX31-PABPC1
	FusionPDB ID: 84990
	FusionGDB2.0 ID: 84990
		Hgene	Tgene
	Gene symbol	SNX31	PABPC1
	Gene ID	169166	26986
	Gene name	sorting nexin 31	poly(A) binding protein cytoplasmic 1
	Synonyms	-	PAB1\|PABP\|PABP1\|PABPC2\|PABPL1
	Cytomap	8q22.3	8q22.3
	Type of gene	protein-coding	protein-coding
	Description	sorting nexin-31	polyadenylate-binding protein 1poly(A) binding protein, cytoplasmic 2
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000311812, ENST00000428383, ENST00000519521,	ENST00000519596, ENST00000318607, ENST00000519004, ENST00000522387,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 2 X 1=4	28 X 33 X 9=8316
	# samples	3	35
	** MAII score	log2(3/4*10)=2.90689059560852	log2(35/8316*10)=-4.57046293102604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SNX31 [Title/Abstract] AND PABPC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SNX31(101608867)-PABPC1(101725017), # samples:1 SNX31(101608867)-PABPC1(101724685), # samples:1 SNX31(101642555)-PABPC1(101698522), # samples:1
Anticipated loss of major functional domain due to fusion event.	SNX31-PABPC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SNX31-PABPC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SNX31-PABPC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SNX31-PABPC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PABPC1	GO:2000623	negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	18447585

Fusion gene breakpoints across SNX31 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PABPC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-E7-A5KE-01A	SNX31	chr8	101608867	-	PABPC1	chr8	101724685	-
ChimerDB4	BLCA	TCGA-E7-A5KE-01A	SNX31	chr8	101608867	-	PABPC1	chr8	101725017	-
ChimerDB4	BLCA	TCGA-G2-A3VY-01A	SNX31	chr8	101642555	-	PABPC1	chr8	101698522	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000311812	SNX31	chr8	101608867	-	ENST00000318607	PABPC1	chr8	101725017	-	2747	1129	40	2301	753
ENST00000311812	SNX31	chr8	101608867	-	ENST00000519004	PABPC1	chr8	101725017	-	2564	1129	40	2301	753
ENST00000311812	SNX31	chr8	101608867	-	ENST00000522387	PABPC1	chr8	101725017	-	2502	1129	40	2301	753
ENST00000428383	SNX31	chr8	101608867	-	ENST00000318607	PABPC1	chr8	101725017	-	2338	720	39	1892	617
ENST00000428383	SNX31	chr8	101608867	-	ENST00000519004	PABPC1	chr8	101725017	-	2155	720	39	1892	617
ENST00000428383	SNX31	chr8	101608867	-	ENST00000522387	PABPC1	chr8	101725017	-	2093	720	39	1892	617
ENST00000311812	SNX31	chr8	101608867	-	ENST00000318607	PABPC1	chr8	101724685	-	2609	1129	40	2163	707
ENST00000311812	SNX31	chr8	101608867	-	ENST00000519004	PABPC1	chr8	101724685	-	2426	1129	40	2163	707
ENST00000311812	SNX31	chr8	101608867	-	ENST00000522387	PABPC1	chr8	101724685	-	2364	1129	40	2163	707
ENST00000428383	SNX31	chr8	101608867	-	ENST00000318607	PABPC1	chr8	101724685	-	2200	720	39	1754	571
ENST00000428383	SNX31	chr8	101608867	-	ENST00000519004	PABPC1	chr8	101724685	-	2017	720	39	1754	571
ENST00000428383	SNX31	chr8	101608867	-	ENST00000522387	PABPC1	chr8	101724685	-	1955	720	39	1754	571

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000311812	ENST00000318607	SNX31	chr8	101608867	-	PABPC1	chr8	101725017	-	0.000769579	0.9992304
ENST00000311812	ENST00000519004	SNX31	chr8	101608867	-	PABPC1	chr8	101725017	-	0.00128856	0.99871147
ENST00000311812	ENST00000522387	SNX31	chr8	101608867	-	PABPC1	chr8	101725017	-	0.001858575	0.9981414
ENST00000428383	ENST00000318607	SNX31	chr8	101608867	-	PABPC1	chr8	101725017	-	0.000925846	0.9990741
ENST00000428383	ENST00000519004	SNX31	chr8	101608867	-	PABPC1	chr8	101725017	-	0.001481518	0.9985185
ENST00000428383	ENST00000522387	SNX31	chr8	101608867	-	PABPC1	chr8	101725017	-	0.001977471	0.99802256
ENST00000311812	ENST00000318607	SNX31	chr8	101608867	-	PABPC1	chr8	101724685	-	0.000747024	0.999253
ENST00000311812	ENST00000519004	SNX31	chr8	101608867	-	PABPC1	chr8	101724685	-	0.001264302	0.9987357
ENST00000311812	ENST00000522387	SNX31	chr8	101608867	-	PABPC1	chr8	101724685	-	0.001849309	0.99815065
ENST00000428383	ENST00000318607	SNX31	chr8	101608867	-	PABPC1	chr8	101724685	-	0.00060412	0.99939585
ENST00000428383	ENST00000519004	SNX31	chr8	101608867	-	PABPC1	chr8	101724685	-	0.000949149	0.9990508
ENST00000428383	ENST00000522387	SNX31	chr8	101608867	-	PABPC1	chr8	101724685	-	0.001376641	0.9986234

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>84990_84990_1_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000311812_PABPC1_chr8_101724685_ENST00000318607_length(amino acids)=707AA_BP=361
MSRVAGRAASTAAEFRAAHRPPPQVGFPALLPRHRSAMKMHFCIPVSQQRSDALGGRYVLYSVHLDGFLFCRVRYSQLHGWNEQLRRVFG
NCLPPFPPKYYLAMTTAMADERRDQLEQYLQNVTMDPNVLRSDVFVEFLKLAQLNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVL
EVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSLGSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIE
KGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTCDYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQV
TFLGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLT
NQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPA
SSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQK

--------------------------------------------------------------

>84990_84990_2_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000311812_PABPC1_chr8_101724685_ENST00000519004_length(amino acids)=707AA_BP=361
MSRVAGRAASTAAEFRAAHRPPPQVGFPALLPRHRSAMKMHFCIPVSQQRSDALGGRYVLYSVHLDGFLFCRVRYSQLHGWNEQLRRVFG
NCLPPFPPKYYLAMTTAMADERRDQLEQYLQNVTMDPNVLRSDVFVEFLKLAQLNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVL
EVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSLGSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIE
KGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTCDYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQV
TFLGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLT
NQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPA
SSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQK

--------------------------------------------------------------

>84990_84990_3_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000311812_PABPC1_chr8_101724685_ENST00000522387_length(amino acids)=707AA_BP=361
MSRVAGRAASTAAEFRAAHRPPPQVGFPALLPRHRSAMKMHFCIPVSQQRSDALGGRYVLYSVHLDGFLFCRVRYSQLHGWNEQLRRVFG
NCLPPFPPKYYLAMTTAMADERRDQLEQYLQNVTMDPNVLRSDVFVEFLKLAQLNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVL
EVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSLGSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIE
KGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTCDYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQV
TFLGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLT
NQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPA
SSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQK

--------------------------------------------------------------

>84990_84990_4_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000311812_PABPC1_chr8_101725017_ENST00000318607_length(amino acids)=753AA_BP=363
MSRVAGRAASTAAEFRAAHRPPPQVGFPALLPRHRSAMKMHFCIPVSQQRSDALGGRYVLYSVHLDGFLFCRVRYSQLHGWNEQLRRVFG
NCLPPFPPKYYLAMTTAMADERRDQLEQYLQNVTMDPNVLRSDVFVEFLKLAQLNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVL
EVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSLGSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIE
KGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTCDYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQV
TFLAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSK
GFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYY
PPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKY
AAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESL

--------------------------------------------------------------

>84990_84990_5_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000311812_PABPC1_chr8_101725017_ENST00000519004_length(amino acids)=753AA_BP=363
MSRVAGRAASTAAEFRAAHRPPPQVGFPALLPRHRSAMKMHFCIPVSQQRSDALGGRYVLYSVHLDGFLFCRVRYSQLHGWNEQLRRVFG
NCLPPFPPKYYLAMTTAMADERRDQLEQYLQNVTMDPNVLRSDVFVEFLKLAQLNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVL
EVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSLGSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIE
KGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTCDYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQV
TFLAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSK
GFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYY
PPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKY
AAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESL

--------------------------------------------------------------

>84990_84990_6_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000311812_PABPC1_chr8_101725017_ENST00000522387_length(amino acids)=753AA_BP=363
MSRVAGRAASTAAEFRAAHRPPPQVGFPALLPRHRSAMKMHFCIPVSQQRSDALGGRYVLYSVHLDGFLFCRVRYSQLHGWNEQLRRVFG
NCLPPFPPKYYLAMTTAMADERRDQLEQYLQNVTMDPNVLRSDVFVEFLKLAQLNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVL
EVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSLGSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIE
KGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTCDYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQV
TFLAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSK
GFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYY
PPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKY
AAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESL

--------------------------------------------------------------

>84990_84990_7_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000428383_PABPC1_chr8_101724685_ENST00000318607_length(amino acids)=571AA_BP=225
MLGNTENWNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVLEVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSL
GSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIEKGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTC
DYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQVTFLGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGF
GFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPP
SQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAA
GVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRS

--------------------------------------------------------------

>84990_84990_8_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000428383_PABPC1_chr8_101724685_ENST00000519004_length(amino acids)=571AA_BP=225
MLGNTENWNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVLEVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSL
GSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIEKGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTC
DYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQVTFLGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGF
GFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPP
SQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAA
GVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRS

--------------------------------------------------------------

>84990_84990_9_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000428383_PABPC1_chr8_101724685_ENST00000522387_length(amino acids)=571AA_BP=225
MLGNTENWNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVLEVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSL
GSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIEKGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTC
DYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQVTFLGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGF
GFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPP
SQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAA
GVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRS

--------------------------------------------------------------

>84990_84990_10_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000428383_PABPC1_chr8_101725017_ENST00000318607_length(amino acids)=617AA_BP=227
MLGNTENWNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVLEVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSL
GSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIEKGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTC
DYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQVTFLAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRIT
RYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLT
NQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPA
SSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQK

--------------------------------------------------------------

>84990_84990_11_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000428383_PABPC1_chr8_101725017_ENST00000519004_length(amino acids)=617AA_BP=227
MLGNTENWNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVLEVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSL
GSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIEKGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTC
DYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQVTFLAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRIT
RYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLT
NQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPA
SSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQK

--------------------------------------------------------------

>84990_84990_12_SNX31-PABPC1_SNX31_chr8_101608867_ENST00000428383_PABPC1_chr8_101725017_ENST00000522387_length(amino acids)=617AA_BP=227
MLGNTENWNTFDIATKKAYLDIFLPNEQSIRIEIITSDTAERVLEVVSHKIGLCRELLGYFGLFLIRFGKEGKLSVVKKLADFELPYVSL
GSSEVENCKVGLRKWYMAPSLDSVLMDCRVAVDLLYMQAIQDIEKGWAKPTQAQRQKLEAFQKEDSQTKFLELAREVRHYGYLQLDPCTC
DYPESGSGAVLSVGNNEISCCITLPDSQTQDIVFQMSRVKCWQVTFLAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRIT
RYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLT
NQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPA
SSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQK

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:101608867/chr8:101725017)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SNX31

chr8:101608867

chr8:101724685

ENST00000311812

1_109

326.0

441.0

Domain

Hgene

SNX31

chr8:101608867

chr8:101724685

ENST00000428383

1_109

227.0

342.0

Domain

Hgene

SNX31

chr8:101608867

chr8:101725017

ENST00000311812

1_109

326.0

441.0

Domain

Hgene

SNX31

chr8:101608867

chr8:101725017

ENST00000428383

1_109

227.0

342.0

Domain

Tgene

PABPC1

chr8:101608867

chr8:101724685

ENST00000318607

495_501

292.0

311.0

Compositional bias

Note=Poly-Ala

Tgene

PABPC1

chr8:101608867

chr8:101725017

ENST00000318607

495_501

246.0

311.0

Compositional bias

Note=Poly-Ala

Tgene

PABPC1

chr8:101608867

chr8:101724685

ENST00000318607

294_370

292.0

311.0

Domain

RRM 4

Tgene

PABPC1

chr8:101608867

chr8:101724685

ENST00000318607

542_619

292.0

311.0

Domain

PABC

Tgene

PABPC1

chr8:101608867

chr8:101725017

ENST00000318607

294_370

246.0

311.0

Domain

RRM 4

Tgene

PABPC1

chr8:101608867

chr8:101725017

ENST00000318607

542_619

246.0

311.0

Domain

PABC

Tgene

PABPC1

chr8:101608867

chr8:101724685

ENST00000318607

541_636

292.0

311.0

Region

(Microbial infection) Binding to HRSV M2-1 protein

Tgene

PABPC1

chr8:101608867

chr8:101725017

ENST00000318607

541_636

246.0

311.0

Region

(Microbial infection) Binding to HRSV M2-1 protein

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PABPC1

chr8:101608867

chr8:101724685

ENST00000318607

11_89

292.0

311.0

Domain

RRM 1

Tgene

PABPC1

chr8:101608867

chr8:101724685

ENST00000318607

191_268

292.0

311.0

Domain

RRM 3

Tgene

PABPC1

chr8:101608867

chr8:101724685

ENST00000318607

99_175

292.0

311.0

Domain

RRM 2

Tgene

PABPC1

chr8:101608867

chr8:101725017

ENST00000318607

11_89

246.0

311.0

Domain

RRM 1

Tgene

PABPC1

chr8:101608867

chr8:101725017

ENST00000318607

191_268

246.0

311.0

Domain

RRM 3

Tgene

PABPC1

chr8:101608867

chr8:101725017

ENST00000318607

99_175

246.0

311.0

Domain

RRM 2

Tgene

PABPC1

chr8:101608867

chr8:101724685

ENST00000318607

166_289

292.0

311.0

Region

Note=CSDE1-binding

Tgene

PABPC1

chr8:101608867

chr8:101725017

ENST00000318607

166_289

246.0

311.0

Region

Note=CSDE1-binding

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SNX31
PABPC1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to SNX31-PABPC1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SNX31-PABPC1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source