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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SORT1-EIF4A2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SORT1-EIF4A2
FusionPDB ID: 85252
FusionGDB2.0 ID: 85252
HgeneTgene
Gene symbol

SORT1

EIF4A2

Gene ID

6272

1974

Gene namesortilin 1eukaryotic translation initiation factor 4A2
SynonymsGp95|LDLCQ6|NT3|NTR3BM-010|DDX2B|EIF4A|EIF4F|eIF-4A-II|eIF4A-II
Cytomap

1p13.3|1p21.3-p13.1

3q27.3

Type of geneprotein-codingprotein-coding
Descriptionsortilin100 kDa NT receptorglycoprotein 95neurotensin receptor 3eukaryotic initiation factor 4A-IIATP-dependent RNA helicase eIF4A-2
Modification date2020031320200322
UniProtAcc.

Q14240

Ensembl transtripts involved in fusion geneENST idsENST00000256637, ENST00000538502, 
ENST00000482236, 		ENST00000323963, 
ENST00000356531, ENST00000440191, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 8 X 4=25613 X 14 X 6=1092
# samples 816
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1092*10)=-2.77082904603249
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SORT1 [Title/Abstract] AND EIF4A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SORT1(109859471)-EIF4A2(186504915), # samples:1
Anticipated loss of major functional domain due to fusion event.SORT1-EIF4A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SORT1-EIF4A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SORT1-EIF4A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SORT1-EIF4A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSORT1

GO:0006895

Golgi to endosome transport

11331584

HgeneSORT1

GO:0006897

endocytosis

11331584|21092856

HgeneSORT1

GO:0007218

neuropeptide signaling pathway

9756851

HgeneSORT1

GO:0008333

endosome to lysosome transport

11331584

HgeneSORT1

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

14985763

HgeneSORT1

GO:0016050

vesicle organization

15992544

HgeneSORT1

GO:0032509

endosome transport via multivesicular body sorting pathway

11331584

HgeneSORT1

GO:0048227

plasma membrane to endosome transport

11331584

HgeneSORT1

GO:0051005

negative regulation of lipoprotein lipase activity

10085125

TgeneEIF4A2

GO:1900260

negative regulation of RNA-directed 5'-3' RNA polymerase activity

11922617


check buttonFusion gene breakpoints across SORT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EIF4A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-A7-A0D9-11ASORT1chr1

109859471

-EIF4A2chr3

186504915

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000256637SORT1chr1109859471-ENST00000323963EIF4A2chr3186504915+33932309592761900
ENST00000256637SORT1chr1109859471-ENST00000440191EIF4A2chr3186504915+33902309592761900
ENST00000256637SORT1chr1109859471-ENST00000356531EIF4A2chr3186504915+33872309592761900
ENST00000538502SORT1chr1109859471-ENST00000323963EIF4A2chr3186504915+335622723252724799
ENST00000538502SORT1chr1109859471-ENST00000440191EIF4A2chr3186504915+335322723252724799
ENST00000538502SORT1chr1109859471-ENST00000356531EIF4A2chr3186504915+335022723252724799

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000256637ENST00000323963SORT1chr1109859471-EIF4A2chr3186504915+0.000858450.9991416
ENST00000256637ENST00000440191SORT1chr1109859471-EIF4A2chr3186504915+0.0008673490.9991327
ENST00000256637ENST00000356531SORT1chr1109859471-EIF4A2chr3186504915+0.0009113490.99908864
ENST00000538502ENST00000323963SORT1chr1109859471-EIF4A2chr3186504915+0.0005462830.9994537
ENST00000538502ENST00000440191SORT1chr1109859471-EIF4A2chr3186504915+0.0005503440.9994497
ENST00000538502ENST00000356531SORT1chr1109859471-EIF4A2chr3186504915+0.0005671250.99943286

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>85252_85252_1_SORT1-EIF4A2_SORT1_chr1_109859471_ENST00000256637_EIF4A2_chr3_186504915_ENST00000323963_length(amino acids)=900AA_BP=749
MERPWGAADGLSRWPHGLGLLLLLQLLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWGLRAAAAGGAFPRGGRWRRSAPGEDEECGRVR
DFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSG
KVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFT
TYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDM
VFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDA
TAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHS
SRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDY
EDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPG
DKCQGGVNPVREVKDLKKKCTSNFLSPEKQEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMR
EFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI

--------------------------------------------------------------

>85252_85252_2_SORT1-EIF4A2_SORT1_chr1_109859471_ENST00000256637_EIF4A2_chr3_186504915_ENST00000356531_length(amino acids)=900AA_BP=749
MERPWGAADGLSRWPHGLGLLLLLQLLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWGLRAAAAGGAFPRGGRWRRSAPGEDEECGRVR
DFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSG
KVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFT
TYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDM
VFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDA
TAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHS
SRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDY
EDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPG
DKCQGGVNPVREVKDLKKKCTSNFLSPEKQEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMR
EFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI

--------------------------------------------------------------

>85252_85252_3_SORT1-EIF4A2_SORT1_chr1_109859471_ENST00000256637_EIF4A2_chr3_186504915_ENST00000440191_length(amino acids)=900AA_BP=749
MERPWGAADGLSRWPHGLGLLLLLQLLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWGLRAAAAGGAFPRGGRWRRSAPGEDEECGRVR
DFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSG
KVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFT
TYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDM
VFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDA
TAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHS
SRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDY
EDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPG
DKCQGGVNPVREVKDLKKKCTSNFLSPEKQEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMR
EFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI

--------------------------------------------------------------

>85252_85252_4_SORT1-EIF4A2_SORT1_chr1_109859471_ENST00000538502_EIF4A2_chr3_186504915_ENST00000323963_length(amino acids)=799AA_BP=648
MKHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSG
GSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCTDL
GALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDT
GFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLH
IHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFST
DEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQ
FLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVR
EVKDLKKKCTSNFLSPEKQEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLI

--------------------------------------------------------------

>85252_85252_5_SORT1-EIF4A2_SORT1_chr1_109859471_ENST00000538502_EIF4A2_chr3_186504915_ENST00000356531_length(amino acids)=799AA_BP=648
MKHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSG
GSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCTDL
GALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDT
GFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLH
IHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFST
DEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQ
FLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVR
EVKDLKKKCTSNFLSPEKQEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLI

--------------------------------------------------------------

>85252_85252_6_SORT1-EIF4A2_SORT1_chr1_109859471_ENST00000538502_EIF4A2_chr3_186504915_ENST00000440191_length(amino acids)=799AA_BP=648
MKHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSG
GSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCTDL
GALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDT
GFGTIFTSDDRGIVYSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLH
IHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFST
DEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQ
FLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVR
EVKDLKKKCTSNFLSPEKQEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLI

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:109859471/chr3:186504915)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF4A2

Q14240

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-172050_61750.0832.0RegionNote=Intrachain binding of the propeptide and the extracellular domain
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-172050_61613.0695.0RegionNote=Intrachain binding of the propeptide and the extracellular domain
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720145_156750.0832.0RepeatNote=BNR 1
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720198_209750.0832.0RepeatNote=BNR 2
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720240_251750.0832.0RepeatNote=BNR 3
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720287_298750.0832.0RepeatNote=BNR 4
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720328_339750.0832.0RepeatNote=BNR 5
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720377_388750.0832.0RepeatNote=BNR 6
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720428_439750.0832.0RepeatNote=BNR 7
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720506_517750.0832.0RepeatNote=BNR 8
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720548_559750.0832.0RepeatNote=BNR 9
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720145_156613.0695.0RepeatNote=BNR 1
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720198_209613.0695.0RepeatNote=BNR 2
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720240_251613.0695.0RepeatNote=BNR 3
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720287_298613.0695.0RepeatNote=BNR 4
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720328_339613.0695.0RepeatNote=BNR 5
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720377_388613.0695.0RepeatNote=BNR 6
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720428_439613.0695.0RepeatNote=BNR 7
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720506_517613.0695.0RepeatNote=BNR 8
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720548_559613.0695.0RepeatNote=BNR 9

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720787_792750.0832.0MotifEndocytosis signal
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720787_792613.0695.0MotifEndocytosis signal
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-172078_755750.0832.0Topological domainExtracellular
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-172078_755613.0695.0Topological domainExtracellular
HgeneSORT1chr1:109859471chr3:186504915ENST00000256637-1720756_778750.0832.0TransmembraneHelical
HgeneSORT1chr1:109859471chr3:186504915ENST00000538502-1720756_778613.0695.0TransmembraneHelical
TgeneEIF4A2chr1:109859471chr3:186504915ENST00000323963611246_407257.0408.0DomainHelicase C-terminal
TgeneEIF4A2chr1:109859471chr3:186504915ENST0000032396361164_235257.0408.0DomainHelicase ATP-binding
TgeneEIF4A2chr1:109859471chr3:186504915ENST00000440191611246_407258.0409.0DomainHelicase C-terminal
TgeneEIF4A2chr1:109859471chr3:186504915ENST0000044019161164_235258.0409.0DomainHelicase ATP-binding
TgeneEIF4A2chr1:109859471chr3:186504915ENST00000323963611183_186257.0408.0MotifNote=DEAD box
TgeneEIF4A2chr1:109859471chr3:186504915ENST0000032396361133_61257.0408.0MotifNote=Q motif
TgeneEIF4A2chr1:109859471chr3:186504915ENST00000440191611183_186258.0409.0MotifNote=DEAD box
TgeneEIF4A2chr1:109859471chr3:186504915ENST0000044019161133_61258.0409.0MotifNote=Q motif
TgeneEIF4A2chr1:109859471chr3:186504915ENST0000032396361177_84257.0408.0Nucleotide bindingATP
TgeneEIF4A2chr1:109859471chr3:186504915ENST0000044019161177_84258.0409.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SORT1
EIF4A2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SORT1-EIF4A2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SORT1-EIF4A2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource