UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SOS2-POLN

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SOS2-POLN
	FusionPDB ID: 85277
	FusionGDB2.0 ID: 85277
		Hgene	Tgene
	Gene symbol	SOS2	POLN
	Gene ID	6655	353497
	Gene name	SOS Ras/Rho guanine nucleotide exchange factor 2	DNA polymerase nu
	Synonyms	NS9\|SOS-2	POL4P
	Cytomap	14q21.3	4p16.3
	Type of gene	protein-coding	protein-coding
	Description	son of sevenless homolog 2guanine nucleotide releasing factor	DNA polymerase nuDNA polymerase NDNA polymerase POL4Ppolymerase (DNA directed) nupolymerase (DNA) nu
	Modification date	20200327	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000216373, ENST00000543680, ENST00000555794,	ENST00000515357, ENST00000382865, ENST00000511885,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 11 X 6=792	17 X 13 X 10=2210
	# samples	15	21
	** MAII score	log2(15/792*10)=-2.40053792958373 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/2210*10)=-3.39558513661267 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SOS2 [Title/Abstract] AND POLN [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SOS2(50697915)-POLN(2176478), # samples:3
Anticipated loss of major functional domain due to fusion event.	SOS2-POLN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SOS2-POLN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	POLN	GO:0019985	translesion synthesis	20102227

Fusion gene breakpoints across SOS2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across POLN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-NA-A5I1-01A	SOS2	chr14	50697915	-	POLN	chr4	2176478	-
ChimerDB4	UCS	TCGA-NA-A5I1	SOS2	chr14	50697915	-	POLN	chr4	2176478	-
ChimerDB4	UCS	TCGA-NA-A5I1	SOS2	chr14	50697915	-	POLN	chr4	2178061	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000216373	SOS2	chr14	50697915	-	ENST00000382865	POLN	chr4	2176478	-	2013	362	209	1816	535
ENST00000216373	SOS2	chr14	50697915	-	ENST00000511885	POLN	chr4	2176478	-	2013	362	209	1816	535
ENST00000543680	SOS2	chr14	50697915	-	ENST00000382865	POLN	chr4	2176478	-	1764	113	26	1567	513
ENST00000543680	SOS2	chr14	50697915	-	ENST00000511885	POLN	chr4	2176478	-	1764	113	26	1567	513
ENST00000216373	SOS2	chr14	50697915	-	ENST00000382865	POLN	chr4	2178061	-	2082	362	209	1885	558
ENST00000216373	SOS2	chr14	50697915	-	ENST00000511885	POLN	chr4	2178061	-	2082	362	209	1885	558
ENST00000543680	SOS2	chr14	50697915	-	ENST00000382865	POLN	chr4	2178061	-	1833	113	26	1636	536
ENST00000543680	SOS2	chr14	50697915	-	ENST00000511885	POLN	chr4	2178061	-	1833	113	26	1636	536

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000216373	ENST00000382865	SOS2	chr14	50697915	-	POLN	chr4	2176478	-	0.016177967	0.98382205
ENST00000216373	ENST00000511885	SOS2	chr14	50697915	-	POLN	chr4	2176478	-	0.016177967	0.98382205
ENST00000543680	ENST00000382865	SOS2	chr14	50697915	-	POLN	chr4	2176478	-	0.01859118	0.9814089
ENST00000543680	ENST00000511885	SOS2	chr14	50697915	-	POLN	chr4	2176478	-	0.01859118	0.9814089
ENST00000216373	ENST00000382865	SOS2	chr14	50697915	-	POLN	chr4	2178061	-	0.019461151	0.98053885
ENST00000216373	ENST00000511885	SOS2	chr14	50697915	-	POLN	chr4	2178061	-	0.019461151	0.98053885
ENST00000543680	ENST00000382865	SOS2	chr14	50697915	-	POLN	chr4	2178061	-	0.024139266	0.9758607
ENST00000543680	ENST00000511885	SOS2	chr14	50697915	-	POLN	chr4	2178061	-	0.024139266	0.9758607

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>85277_85277_1_SOS2-POLN_SOS2_chr14_50697915_ENST00000216373_POLN_chr4_2176478_ENST00000382865_length(amino acids)=535AA_BP=51
MPVRPPARPAGCPRCGGAVAGAMQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSA
LLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTF
VDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHL
SGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA
IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP

--------------------------------------------------------------

>85277_85277_2_SOS2-POLN_SOS2_chr14_50697915_ENST00000216373_POLN_chr4_2176478_ENST00000511885_length(amino acids)=535AA_BP=51
MPVRPPARPAGCPRCGGAVAGAMQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSA
LLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTF
VDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHL
SGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA
IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP

--------------------------------------------------------------

>85277_85277_3_SOS2-POLN_SOS2_chr14_50697915_ENST00000216373_POLN_chr4_2178061_ENST00000382865_length(amino acids)=558AA_BP=47
MPVRPPARPAGCPRCGGAVAGAMQQAPQPYEFFSEENSPKWRGLLVSALRKNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLI
PILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNAL
RDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFV
SSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQ
EAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHT
LTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPG

--------------------------------------------------------------

>85277_85277_4_SOS2-POLN_SOS2_chr14_50697915_ENST00000216373_POLN_chr4_2178061_ENST00000511885_length(amino acids)=558AA_BP=47
MPVRPPARPAGCPRCGGAVAGAMQQAPQPYEFFSEENSPKWRGLLVSALRKNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLI
PILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNAL
RDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFV
SSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQ
EAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHT
LTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQLQVPLKVSLSAGRSWGHLVPLQEAWGPPPGPCRTESPSNSLAAPG

--------------------------------------------------------------

>85277_85277_5_SOS2-POLN_SOS2_chr14_50697915_ENST00000543680_POLN_chr4_2176478_ENST00000382865_length(amino acids)=513AA_BP=29
MQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFL
ITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTL
TSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPR
IHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQ

--------------------------------------------------------------

>85277_85277_6_SOS2-POLN_SOS2_chr14_50697915_ENST00000543680_POLN_chr4_2176478_ENST00000511885_length(amino acids)=513AA_BP=29
MQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSALLGARLKELEQEAHFVAGERFL
ITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTFVDGLLACMKKGSISSTWNQTGT
VTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHLSGDPELLKLFQESERDDVFSTL
TSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAAIAQCHQTGCVVSIMGRRRPLPR
IHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIPECAALVRRTMESLEQVQALELQ

--------------------------------------------------------------

>85277_85277_7_SOS2-POLN_SOS2_chr14_50697915_ENST00000543680_POLN_chr4_2178061_ENST00000382865_length(amino acids)=536AA_BP=25
MQQAPQPYEFFSEENSPKWRGLLVSALRKNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTS
ALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKST
FVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTH
LSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARA
AIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQI

--------------------------------------------------------------

>85277_85277_8_SOS2-POLN_SOS2_chr14_50697915_ENST00000543680_POLN_chr4_2178061_ENST00000511885_length(amino acids)=536AA_BP=25
MQQAPQPYEFFSEENSPKWRGLLVSALRKNQNVRENLKTLYRLTMDLCSKLKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTS
ALLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKST
FVDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTH
LSGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARA
AIAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQI

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:50697915/chr4:2176478)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SOS2

chr14:50697915

chr4:2176478

ENST00000216373

1180_1183

29.0

1333.0

Compositional bias

Note=Poly-Pro

Hgene

SOS2

chr14:50697915

chr4:2176478

ENST00000216373

1203_1208

29.0

1333.0

Compositional bias

Note=Poly-Pro

Hgene

SOS2

chr14:50697915

chr4:2176478

ENST00000216373

755_758

29.0

1333.0

Compositional bias

Note=Poly-Pro

Hgene

SOS2

chr14:50697915

chr4:2178061

ENST00000216373

1180_1183

29.0

1333.0

Compositional bias

Note=Poly-Pro

Hgene

SOS2

chr14:50697915

chr4:2178061

ENST00000216373

1203_1208

29.0

1333.0

Compositional bias

Note=Poly-Pro

Hgene

SOS2

chr14:50697915

chr4:2178061

ENST00000216373

755_758

29.0

1333.0

Compositional bias

Note=Poly-Pro

Hgene

SOS2

chr14:50697915

chr4:2176478

ENST00000216373

198_388

29.0

1333.0

Domain

Hgene

SOS2

chr14:50697915

chr4:2176478

ENST00000216373

442_546

29.0

1333.0

Domain

Hgene

SOS2

chr14:50697915

chr4:2176478

ENST00000216373

595_739

29.0

1333.0

Domain

N-terminal Ras-GEF

Hgene

SOS2

chr14:50697915

chr4:2176478

ENST00000216373

778_1017

29.0

1333.0

Domain

Ras-GEF

Hgene

SOS2

chr14:50697915

chr4:2178061

ENST00000216373

198_388

29.0

1333.0

Domain

Hgene

SOS2

chr14:50697915

chr4:2178061

ENST00000216373

442_546

29.0

1333.0

Domain

Hgene

SOS2

chr14:50697915

chr4:2178061

ENST00000216373

595_739

29.0

1333.0

Domain

N-terminal Ras-GEF

Hgene

SOS2

chr14:50697915

chr4:2178061

ENST00000216373

778_1017

29.0

1333.0

Domain

Ras-GEF

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1144_SOS2_50697915_POLN_2176478_1144_SOS2_50697915_POLN_2176478_ranked_0.pdb	SOS2	50697915	50697915	ENST00000511885	POLN	chr4	2176478	-	MPVRPPARPAGCPRCGGAVAGAMQQAPQPYEFFSEENSPKWRGLLVSALRKDYGLWQLFRTLELPLIPILAVMESHAIQVNKEEMEKTSA LLGARLKELEQEAHFVAGERFLITSNNQLREILFGKLKLHLLSQRNSLPRTGLQKYPSTSEAVLNALRDLHPLPKIILEYRQVHKIKSTF VDGLLACMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIQITTPKNFKGKEDKILTISPRAMFVSSKGHTFLAADFSQIELRILTHL SGDPELLKLFQESERDDVFSTLTSQWKDVPVEQVTHADREQTKKVVYAVVYGAGKERLAACLGVPIQEAAQFLESFLQKYKKIKDFARAA IAQCHQTGCVVSIMGRRRPLPRIHAHDQQLRAQAERQAVNFVVQGSAADLCKLAMIHVFTAVAASHTLTARLVAQIHDELLFEVEDPQIP	535

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SOS2_pLDDT.png

POLN_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SOS2
POLN

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to SOS2-POLN

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to SOS2-POLN

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source