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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SOX7-HGSNAT

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SOX7-HGSNAT
FusionPDB ID: 85357
FusionGDB2.0 ID: 85357
HgeneTgene
Gene symbol

SOX7

HGSNAT

Gene ID

83595

138050

Gene nameSRY-box transcription factor 7heparan-alpha-glucosaminide N-acetyltransferase
Synonyms-HGNAT|MPS3C|RP73|TMEM76
Cytomap

8p23.1

8p11.21-p11.1

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor SOX-7SRY (sex determining region Y)-box 7SRY-box 7heparan-alpha-glucosaminide N-acetyltransferasetransmembrane protein 76
Modification date2020031320200313
UniProtAcc.

Q68CP4

Ensembl transtripts involved in fusion geneENST idsENST00000553390, ENST00000554914, 
ENST00000304501, 
ENST00000297798, 
ENST00000379644, ENST00000458501, 
ENST00000521576, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 7 X 3=12612 X 13 X 4=624
# samples 713
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(13/624*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SOX7 [Title/Abstract] AND HGSNAT [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SOX7(10683662)-HGSNAT(43037288), # samples:2
Anticipated loss of major functional domain due to fusion event.SOX7-HGSNAT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SOX7-HGSNAT seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SOX7-HGSNAT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SOX7-HGSNAT seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSOX7

GO:0001706

endoderm formation

18682240

HgeneSOX7

GO:0008285

negative regulation of cell proliferation

19108950

HgeneSOX7

GO:0043280

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

19108950

HgeneSOX7

GO:0045892

negative regulation of transcription, DNA-templated

19108950

HgeneSOX7

GO:0060828

regulation of canonical Wnt signaling pathway

19108950

TgeneHGSNAT

GO:0007041

lysosomal transport

20650889

TgeneHGSNAT

GO:0051259

protein complex oligomerization

20650889


check buttonFusion gene breakpoints across SOX7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HGSNAT (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-7717-01ASOX7chr8

10683662

-HGSNATchr8

43037288

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000554914SOX7chr810683662-ENST00000458501HGSNATchr843037288+4638485101380456
ENST00000554914SOX7chr810683662-ENST00000379644HGSNATchr843037288+4667485101380456
ENST00000554914SOX7chr810683662-ENST00000297798HGSNATchr843037288+2359485101380456
ENST00000554914SOX7chr810683662-ENST00000521576HGSNATchr843037288+2367485101380456
ENST00000553390SOX7chr810683662-ENST00000458501HGSNATchr843037288+4638485101380456
ENST00000553390SOX7chr810683662-ENST00000379644HGSNATchr843037288+4667485101380456
ENST00000553390SOX7chr810683662-ENST00000297798HGSNATchr843037288+2359485101380456
ENST00000553390SOX7chr810683662-ENST00000521576HGSNATchr843037288+2367485101380456

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000554914ENST00000458501SOX7chr810683662-HGSNATchr843037288+0.001161270.9988387
ENST00000554914ENST00000379644SOX7chr810683662-HGSNATchr843037288+0.0011587330.99884135
ENST00000554914ENST00000297798SOX7chr810683662-HGSNATchr843037288+0.0010382480.9989617
ENST00000554914ENST00000521576SOX7chr810683662-HGSNATchr843037288+0.0010318410.9989681
ENST00000553390ENST00000458501SOX7chr810683662-HGSNATchr843037288+0.001161270.9988387
ENST00000553390ENST00000379644SOX7chr810683662-HGSNATchr843037288+0.0011587330.99884135
ENST00000553390ENST00000297798SOX7chr810683662-HGSNATchr843037288+0.0010382480.9989617
ENST00000553390ENST00000521576SOX7chr810683662-HGSNATchr843037288+0.0010318410.9989681

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>85357_85357_1_SOX7-HGSNAT_SOX7_chr8_10683662_ENST00000553390_HGSNAT_chr8_43037288_ENST00000297798_length(amino acids)=456AA_BP=158
MILLESPARPVAAVTQVQRRRYHRLSDMSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNN
HLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKVSWDKVRIPGVLQRLGVTYFVV
AVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGD
DHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWS
LSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRK

--------------------------------------------------------------

>85357_85357_2_SOX7-HGSNAT_SOX7_chr8_10683662_ENST00000553390_HGSNAT_chr8_43037288_ENST00000379644_length(amino acids)=456AA_BP=158
MILLESPARPVAAVTQVQRRRYHRLSDMSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNN
HLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKVSWDKVRIPGVLQRLGVTYFVV
AVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGD
DHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWS
LSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRK

--------------------------------------------------------------

>85357_85357_3_SOX7-HGSNAT_SOX7_chr8_10683662_ENST00000553390_HGSNAT_chr8_43037288_ENST00000458501_length(amino acids)=456AA_BP=158
MILLESPARPVAAVTQVQRRRYHRLSDMSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNN
HLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKVSWDKVRIPGVLQRLGVTYFVV
AVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGD
DHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWS
LSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRK

--------------------------------------------------------------

>85357_85357_4_SOX7-HGSNAT_SOX7_chr8_10683662_ENST00000553390_HGSNAT_chr8_43037288_ENST00000521576_length(amino acids)=456AA_BP=158
MILLESPARPVAAVTQVQRRRYHRLSDMSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNN
HLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKVSWDKVRIPGVLQRLGVTYFVV
AVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGD
DHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWS
LSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRK

--------------------------------------------------------------

>85357_85357_5_SOX7-HGSNAT_SOX7_chr8_10683662_ENST00000554914_HGSNAT_chr8_43037288_ENST00000297798_length(amino acids)=456AA_BP=158
MILLESPARPVAAVTQVQRRRYHRLSDMSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNN
HLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKVSWDKVRIPGVLQRLGVTYFVV
AVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGD
DHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWS
LSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRK

--------------------------------------------------------------

>85357_85357_6_SOX7-HGSNAT_SOX7_chr8_10683662_ENST00000554914_HGSNAT_chr8_43037288_ENST00000379644_length(amino acids)=456AA_BP=158
MILLESPARPVAAVTQVQRRRYHRLSDMSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNN
HLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKVSWDKVRIPGVLQRLGVTYFVV
AVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGD
DHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWS
LSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRK

--------------------------------------------------------------

>85357_85357_7_SOX7-HGSNAT_SOX7_chr8_10683662_ENST00000554914_HGSNAT_chr8_43037288_ENST00000458501_length(amino acids)=456AA_BP=158
MILLESPARPVAAVTQVQRRRYHRLSDMSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNN
HLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKVSWDKVRIPGVLQRLGVTYFVV
AVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGD
DHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWS
LSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRK

--------------------------------------------------------------

>85357_85357_8_SOX7-HGSNAT_SOX7_chr8_10683662_ENST00000554914_HGSNAT_chr8_43037288_ENST00000521576_length(amino acids)=456AA_BP=158
MILLESPARPVAAVTQVQRRRYHRLSDMSMLAERRRKQKWAVDPQNTAWSNDDSKFGQRMLEKMGWSKGKGLGAQEQGATDHIKVQVKNN
HLGLGATINNEDNWIAHQDDFNQLLAELNTCHGQETTDSSDKKEKKSFSLEEKSKISKNRVHYMKFTKVSWDKVRIPGVLQRLGVTYFVV
AVLELLFAKPVPEHCASERSCLSLRDITSSWPQWLLILVLEGLWLGLTFLLPVPGCPTGYLGPGGIGDFGKYPNCTGGAAGYIDRLLLGD
DHLYQHPSSAVLYHTEVAYDPEGILGTINSIVMAFLGVQAGKILLYYKARTKDILIRFTAWCCILGLISVALTKVSENEGFIPVNKNLWS
LSYVTTLSSFAFFILLVLYPVVDVKGLWTGTPFFYPGMNSILVYVGHEVFENYFPFQWKLKDNQSHKEHLTQNIVATALWVLIAYILYRK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:10683662/chr8:43037288)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HGSNAT

Q68CP4

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. {ECO:0000269|PubMed:16960811, ECO:0000269|PubMed:17033958, ECO:0000269|PubMed:19823584, ECO:0000269|PubMed:20650889}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918624_635337.3333333333333636.0RegionNote=Lysosomal targeting region
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918624_635365.3333333333333664.0RegionNote=Lysosomal targeting region
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918367_374337.3333333333333636.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918396_420337.3333333333333636.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918442_500337.3333333333333636.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918522_529337.3333333333333636.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918551_564337.3333333333333636.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918586_592337.3333333333333636.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918614_634337.3333333333333636.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918656_663337.3333333333333636.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918367_374365.3333333333333664.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918396_420365.3333333333333664.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918442_500365.3333333333333664.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918522_529365.3333333333333664.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918551_564365.3333333333333664.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918586_592365.3333333333333664.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918614_634365.3333333333333664.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918656_663365.3333333333333664.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918346_366337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918375_395337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918421_441337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918501_521337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918530_550337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918565_585337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918593_613337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918635_655337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918375_395365.3333333333333664.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918421_441365.3333333333333664.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918501_521365.3333333333333664.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918530_550365.3333333333333664.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918565_585365.3333333333333664.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918593_613365.3333333333333664.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918635_655365.3333333333333664.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSOX7chr8:10683662chr8:43037288ENST00000304501-1245_1130389.0DNA bindingHMG box
HgeneSOX7chr8:10683662chr8:43037288ENST00000304501-12268_3880389.0DomainSox C-terminal
TgeneHGSNATchr8:10683662chr8:43037288ENST000003796449184_64337.3333333333333636.0Compositional biasNote=Ala-rich
TgeneHGSNATchr8:10683662chr8:43037288ENST000004585019184_64365.3333333333333664.0Compositional biasNote=Ala-rich
TgeneHGSNATchr8:10683662chr8:43037288ENST000003796449181_190337.3333333333333636.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918212_275337.3333333333333636.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918297_302337.3333333333333636.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918324_345337.3333333333333636.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST000004585019181_190365.3333333333333664.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918212_275365.3333333333333664.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918297_302365.3333333333333664.0Topological domainLumenal%2C vesicle
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918324_345365.3333333333333664.0Topological domainCytoplasmic
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918191_211337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918276_296337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000379644918303_323337.3333333333333636.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918191_211365.3333333333333664.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918276_296365.3333333333333664.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918303_323365.3333333333333664.0TransmembraneHelical
TgeneHGSNATchr8:10683662chr8:43037288ENST00000458501918346_366365.3333333333333664.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SOX7
HGSNAT


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SOX7-HGSNAT


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SOX7-HGSNAT


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource