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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SP100-ARID1B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SP100-ARID1B
FusionPDB ID: 85364
FusionGDB2.0 ID: 85364
HgeneTgene
Gene symbol

SP100

ARID1B

Gene ID

6672

57492

Gene nameSP100 nuclear antigenAT-rich interaction domain 1B
Synonymslysp100b6A3-5|BAF250B|BRIGHT|CSS1|DAN15|ELD/OSA1|MRD12|OSA2|P250R
Cytomap

2q37.1

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear autoantigen Sp-100SP100-HMG nuclear autoantigennuclear dot-associated Sp100 proteinspeckled 100 kDaAT-rich interactive domain-containing protein 1BARID domain-containing protein 1BAT rich interactive domain 1B (SWI1-like)BRG1-associated factor 250bBRG1-binding protein ELD/OSA1ELD (eyelid)/OSA protein
Modification date2020031320200320
UniProtAcc.

Q8NFD5

Ensembl transtripts involved in fusion geneENST idsENST00000264052, ENST00000340126, 
ENST00000341950, ENST00000409112, 
ENST00000409341, ENST00000409824, 
ENST00000409897, ENST00000427101, 
ENST00000478761, ENST00000275248, 
ENST00000346085, ENST00000350026, 
ENST00000367148, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 4 X 4=8010 X 12 X 6=720
# samples 512
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SP100 [Title/Abstract] AND ARID1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SP100(231375881)-ARID1B(157405796), # samples:1
Anticipated loss of major functional domain due to fusion event.SP100-ARID1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SP100-ARID1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SP100-ARID1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SP100-ARID1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSP100

GO:0000122

negative regulation of transcription by RNA polymerase II

15247905

HgeneSP100

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14647468

HgeneSP100

GO:0034340

response to type I interferon

9230084|15247905

HgeneSP100

GO:0034341

response to interferon-gamma

9230084

HgeneSP100

GO:0043392

negative regulation of DNA binding

15247905

HgeneSP100

GO:0043433

negative regulation of DNA-binding transcription factor activity

15247905

HgeneSP100

GO:0045185

maintenance of protein location

12470659


check buttonFusion gene breakpoints across SP100 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARID1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315487SP100chr2

231375881

+ARID1Bchr6

157405796

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000264052SP100chr2231375881+ENST00000350026ARID1Bchr6157405796+8421244935571612268
ENST00000264052SP100chr2231375881+ENST00000346085ARID1Bchr6157405796+10050244935571612268
ENST00000264052SP100chr2231375881+ENST00000367148ARID1Bchr6157405796+8697244935573202321
ENST00000264052SP100chr2231375881+ENST00000275248ARID1Bchr6157405796+8697244935573202321
ENST00000340126SP100chr2231375881+ENST00000350026ARID1Bchr6157405796+809721253168372268
ENST00000340126SP100chr2231375881+ENST00000346085ARID1Bchr6157405796+972621253168372268
ENST00000340126SP100chr2231375881+ENST00000367148ARID1Bchr6157405796+837321253169962321
ENST00000340126SP100chr2231375881+ENST00000275248ARID1Bchr6157405796+837321253169962321

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264052ENST00000350026SP100chr2231375881+ARID1Bchr6157405796+0.0025332480.9974668
ENST00000264052ENST00000346085SP100chr2231375881+ARID1Bchr6157405796+0.0009731040.9990269
ENST00000264052ENST00000367148SP100chr2231375881+ARID1Bchr6157405796+0.0023981650.9976018
ENST00000264052ENST00000275248SP100chr2231375881+ARID1Bchr6157405796+0.0023981650.9976018
ENST00000340126ENST00000350026SP100chr2231375881+ARID1Bchr6157405796+0.0018664060.9981336
ENST00000340126ENST00000346085SP100chr2231375881+ARID1Bchr6157405796+0.0006657730.99933416
ENST00000340126ENST00000367148SP100chr2231375881+ARID1Bchr6157405796+0.0017543930.9982456
ENST00000340126ENST00000275248SP100chr2231375881+ARID1Bchr6157405796+0.0017543930.9982456

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>85364_85364_1_SP100-ARID1B_SP100_chr2_231375881_ENST00000264052_ARID1B_chr6_157405796_ENST00000275248_length(amino acids)=2321AA_BP=698
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFE
DSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPC
DEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRF
SSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
SKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCI
QSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCDLSGSIDDLPTGTEATLSSAVS
ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERG
FMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSG
LMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGN
LPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPL
DLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPN
KDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSE
GPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWR
VMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLH
WQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKE
EDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHN

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>85364_85364_2_SP100-ARID1B_SP100_chr2_231375881_ENST00000264052_ARID1B_chr6_157405796_ENST00000346085_length(amino acids)=2268AA_BP=698
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFE
DSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPC
DEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRF
SSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
SKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCI
QSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCDLSGSIDDLPTGTEATLSSAVS
ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERG
FMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSG
LMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVY
ELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFA
FECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFS
DVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPY
GASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQG
QYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQ
WPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPP
IRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCL
IDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQA
SKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEK
SIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGN
DAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDG
LLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQG
DALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVL

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>85364_85364_3_SP100-ARID1B_SP100_chr2_231375881_ENST00000264052_ARID1B_chr6_157405796_ENST00000350026_length(amino acids)=2268AA_BP=698
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFE
DSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPC
DEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRF
SSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
SKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCI
QSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCDLSGSIDDLPTGTEATLSSAVS
ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERG
FMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSG
LMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVY
ELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFA
FECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFS
DVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPY
GASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQG
QYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQ
WPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPP
IRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCL
IDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQA
SKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEK
SIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGN
DAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDG
LLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQG
DALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVL

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>85364_85364_4_SP100-ARID1B_SP100_chr2_231375881_ENST00000264052_ARID1B_chr6_157405796_ENST00000367148_length(amino acids)=2321AA_BP=698
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFE
DSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPC
DEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRF
SSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
SKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCI
QSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCDLSGSIDDLPTGTEATLSSAVS
ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERG
FMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSG
LMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGN
LPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPL
DLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPN
KDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSE
GPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWR
VMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLH
WQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKE
EDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHN

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>85364_85364_5_SP100-ARID1B_SP100_chr2_231375881_ENST00000340126_ARID1B_chr6_157405796_ENST00000275248_length(amino acids)=2321AA_BP=698
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFE
DSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPC
DEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRF
SSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
SKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCI
QSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCDLSGSIDDLPTGTEATLSSAVS
ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERG
FMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSG
LMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGN
LPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPL
DLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPN
KDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSE
GPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWR
VMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLH
WQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKE
EDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHN

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>85364_85364_6_SP100-ARID1B_SP100_chr2_231375881_ENST00000340126_ARID1B_chr6_157405796_ENST00000346085_length(amino acids)=2268AA_BP=698
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFE
DSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPC
DEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRF
SSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
SKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCI
QSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCDLSGSIDDLPTGTEATLSSAVS
ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERG
FMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSG
LMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVY
ELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFA
FECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFS
DVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPY
GASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQG
QYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQ
WPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPP
IRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCL
IDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQA
SKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEK
SIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGN
DAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDG
LLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQG
DALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVL

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>85364_85364_7_SP100-ARID1B_SP100_chr2_231375881_ENST00000340126_ARID1B_chr6_157405796_ENST00000350026_length(amino acids)=2268AA_BP=698
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFE
DSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPC
DEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRF
SSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
SKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCI
QSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCDLSGSIDDLPTGTEATLSSAVS
ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERG
FMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSG
LMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKKSSSSTTTGEKITKVY
ELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPLDLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFA
FECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGSLQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFS
DVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPNKDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPY
GASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQQPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQG
QYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSEGPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQ
WPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPNHISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPP
IRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWRVMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCL
IDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDSGKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQA
SKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLHWQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEK
SIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQQAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGN
DAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKEEDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDG
LLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCKLSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQG
DALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHNLMHMQPPPLEPPSVDMMCRAAKALLAMARVDENRSEFLLHEGRLLDISISAVL

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>85364_85364_8_SP100-ARID1B_SP100_chr2_231375881_ENST00000340126_ARID1B_chr6_157405796_ENST00000367148_length(amino acids)=2321AA_BP=698
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFE
DSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENS
FRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPC
DEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPL
ESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRF
SSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHR
SKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCI
QSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCDLSGSIDDLPTGTEATLSSAVS
ASGSTSSQGDQSNPAQSPFSPHASPHLSSIPGGPSPSPVGSPVGSNQSRSGPISPASIPGSQMPPQPPGSQSESSSHPALSQSPMPQERG
FMAGTQRNPQMAQYGPQQTGPSMSPHPSPGGQMHAGISSFQQSNSSGTYGPQMSQYGPQGNYSRPPAYSGVPSASYSGPGPGMGISANNQ
MHGQGPSQPCGAVPLGRMPSAGMQNRPFPGNMSSMTPSSPGMSQQGGPGMGPPMPTVNRKAQEAAAAVMQAAANSAQSRQGSFPGMNQSG
LMASSSPYSQPMNNSSSLMNTQAPPYSMAPAMVNSSAASVGLADMMSPGESKLPLPLKADGKEEGTPQPESKSKDSYSSQGISQPPTPGN
LPVPSPMSPSSASISSFHGDESDSISSPGWPKTPSSPKSSSSTTTGEKITKVYELGNEPERKLWVDRYLTFMEERGSPVSSLPAVGKKPL
DLFRLYVCVKEIGGLAQVNKNKKWRELATNLNVGTSSSAASSLKKQYIQYLFAFECKIERGEEPPPEVFSTGDTKKQPKLQPPSPANSGS
LQGPQTPQSTGSNSMAEVPGDLKPPTPASTPHGQMTPMQGGRSSTISVHDPFSDVSDSSFPKRNSMTPNAPYQQGMSMPDVMGRMPYEPN
KDPFGGMRKVPGSSEPFMTQGQMPNSSMQDMYNQSPSGAMSNLGMGQRQQFPYGASYDRRHEPYGQQYPGQGPPSGQPPYGGHQPGLYPQ
QPNYKRHMDGMYGPPAKRHEGDMYNMQYSSQQQEMYNQYGGSYSGPDRRPIQGQYPYPYSRERMQGPGQIQTHGIPPQMMGGPLQSSSSE
GPQQNMWAARNDMPYPYQNRQGPGGPTQAPPYPGMNRTDDMMVPDQRINHESQWPSHVSQRQPYMSSSASMQPITRPPQPSYQTPPSLPN
HISRAPSPASFQRSLENRMSPSKSPFLPSMKMQKVMPTVPTSQVTGPPPQPPPIRREITFPPGSVEASQPVLKQRRKITSKDIVTPEAWR
VMMSLKSGLLAESTWALDTINILLYDDSTVATFNLSQLSGFLELLVEYFRKCLIDIFGILMEYEVGDPSQKALDHNAARKDDSQSLADDS
GKEEEDAECIDDDEEDEEDEEEDSEKTESDEKSSIALTAPDAAADPKEKPKQASKFDKLPIKIVKKNNLFVVDRSDKLGRVQEFNSGLLH
WQLGGGDTTEHIQTHFESKMEIPPRRRPPPPLSSAGRKKEQEGKGDSEEQQEKSIIATIDDVLSARPGALPEDANPGPQTESSKFPFGIQ
QAKSHRNIKLLEDEPRSRDETPLCTIAHWQDSLAKRCICVSNIVRSLSFVPGNDAEMSKHPGLVLILGKLILLHHEHPERKRAPQTYEKE
EDEDKGVACSKDEWWWDCLEVLRDNTLVTLANISGQLDLSAYTESICLPILDGLLHWMVCPSAEAQDPFPTVGPNSVLSPQRLVLETLCK
LSIQDNNVDLILATPPFSRQEKFYATLVRYVGDRKNPVCREMSMALLSNLAQGDALAARAIAVQKGSIGNLISFLEDGVTMAQYQQSQHN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:231375881/chr6:157405796)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ARID1B

Q8NFD5

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388). {ECO:0000250|UniProtKB:E9Q4N7, ECO:0000269|PubMed:14982958, ECO:0000269|PubMed:15170388, ECO:0000303|PubMed:12672490, ECO:0000303|PubMed:22952240, ECO:0000303|PubMed:26601204}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425156_164698.0880.0Compositional biasNote=Poly-Glu
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+24253_6698.0880.0Compositional biasNote=Poly-Gly
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429156_164698.0886.0Compositional biasNote=Poly-Glu
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+24293_6698.0886.0Compositional biasNote=Poly-Gly
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+242533_149698.0880.0DomainHSR
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425595_676698.0880.0DomainSAND
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+242933_149698.0886.0DomainHSR
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429595_676698.0886.0DomainSAND
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425165_168698.0880.0MotifNote=D-box%3B recognition signal for CDC20-mediated degradation
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425284_297698.0880.0MotifNote=PxVxL motif
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425536_553698.0880.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425568_592698.0880.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429165_168698.0886.0MotifNote=D-box%3B recognition signal for CDC20-mediated degradation
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429284_297698.0886.0MotifNote=PxVxL motif
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429536_553698.0886.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429568_592698.0886.0MotifNuclear localization signal
TgeneARID1Bchr2:231375881chr6:157405796ENST000003460854201034_1037679.02250.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr2:231375881chr6:157405796ENST000003460854201441_1444679.02250.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr2:231375881chr6:157405796ENST000003460854201459_1597679.02250.0Compositional biasNote=Pro-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST000003460854201833_1836679.02250.0Compositional biasNote=Poly-Pro
TgeneARID1Bchr2:231375881chr6:157405796ENST00000346085420684_771679.02250.0Compositional biasNote=Ser-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000346085420932_935679.02250.0Compositional biasNote=Poly-Ala
TgeneARID1Bchr2:231375881chr6:157405796ENST000003500263191034_1037666.02237.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr2:231375881chr6:157405796ENST000003500263191441_1444666.02237.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr2:231375881chr6:157405796ENST000003500263191459_1597666.02237.0Compositional biasNote=Pro-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST000003500263191833_1836666.02237.0Compositional biasNote=Poly-Pro
TgeneARID1Bchr2:231375881chr6:157405796ENST00000350026319684_771666.02237.0Compositional biasNote=Ser-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000350026319932_935666.02237.0Compositional biasNote=Poly-Ala
TgeneARID1Bchr2:231375881chr6:157405796ENST000003671483201034_1037666.02290.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr2:231375881chr6:157405796ENST000003671483201441_1444666.02290.0Compositional biasNote=Poly-Ser
TgeneARID1Bchr2:231375881chr6:157405796ENST000003671483201459_1597666.02290.0Compositional biasNote=Pro-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST000003671483201833_1836666.02290.0Compositional biasNote=Poly-Pro
TgeneARID1Bchr2:231375881chr6:157405796ENST00000367148320684_771666.02290.0Compositional biasNote=Ser-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000367148320932_935666.02290.0Compositional biasNote=Poly-Ala
TgeneARID1Bchr2:231375881chr6:157405796ENST000003460854201053_1144679.02250.0DomainARID
TgeneARID1Bchr2:231375881chr6:157405796ENST000003500263191053_1144666.02237.0DomainARID
TgeneARID1Bchr2:231375881chr6:157405796ENST000003671483201053_1144666.02290.0DomainARID
TgeneARID1Bchr2:231375881chr6:157405796ENST000003460854201358_1377679.02250.0MotifNuclear localization signal
TgeneARID1Bchr2:231375881chr6:157405796ENST000003460854202036_2040679.02250.0MotifNote=LXXLL
TgeneARID1Bchr2:231375881chr6:157405796ENST000003500263191358_1377666.02237.0MotifNuclear localization signal
TgeneARID1Bchr2:231375881chr6:157405796ENST000003500263192036_2040666.02237.0MotifNote=LXXLL
TgeneARID1Bchr2:231375881chr6:157405796ENST000003671483201358_1377666.02290.0MotifNuclear localization signal
TgeneARID1Bchr2:231375881chr6:157405796ENST000003671483202036_2040666.02290.0MotifNote=LXXLL

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425759_764698.0880.0Compositional biasNote=Poly-Lys
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425854_859698.0880.0Compositional biasNote=Poly-Lys
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425860_868698.0880.0Compositional biasNote=Poly-Glu
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429759_764698.0886.0Compositional biasNote=Poly-Lys
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429854_859698.0886.0Compositional biasNote=Poly-Lys
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429860_868698.0886.0Compositional biasNote=Poly-Glu
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115156_1640481.0Compositional biasNote=Poly-Glu
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+1153_60481.0Compositional biasNote=Poly-Gly
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115759_7640481.0Compositional biasNote=Poly-Lys
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115854_8590481.0Compositional biasNote=Poly-Lys
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115860_8680481.0Compositional biasNote=Poly-Glu
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116156_1640446.0Compositional biasNote=Poly-Glu
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+1163_60446.0Compositional biasNote=Poly-Gly
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116759_7640446.0Compositional biasNote=Poly-Lys
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116854_8590446.0Compositional biasNote=Poly-Lys
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116860_8680446.0Compositional biasNote=Poly-Glu
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114156_1640453.0Compositional biasNote=Poly-Glu
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+1143_60453.0Compositional biasNote=Poly-Gly
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114759_7640453.0Compositional biasNote=Poly-Lys
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114854_8590453.0Compositional biasNote=Poly-Lys
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114860_8680453.0Compositional biasNote=Poly-Glu
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425677_753698.0880.0DNA bindingHMG box 1
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425769_837698.0880.0DNA bindingHMG box 2
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429677_753698.0886.0DNA bindingHMG box 1
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429769_837698.0886.0DNA bindingHMG box 2
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115677_7530481.0DNA bindingHMG box 1
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115769_8370481.0DNA bindingHMG box 2
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116677_7530446.0DNA bindingHMG box 1
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116769_8370446.0DNA bindingHMG box 2
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114677_7530453.0DNA bindingHMG box 1
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114769_8370453.0DNA bindingHMG box 2
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+11533_1490481.0DomainHSR
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115595_6760481.0DomainSAND
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+11633_1490446.0DomainHSR
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116595_6760446.0DomainSAND
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+11433_1490453.0DomainHSR
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114595_6760453.0DomainSAND
HgeneSP100chr2:231375881chr6:157405796ENST00000264052+2425717_734698.0880.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000340126+2429717_734698.0886.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115165_1680481.0MotifNote=D-box%3B recognition signal for CDC20-mediated degradation
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115284_2970481.0MotifNote=PxVxL motif
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115536_5530481.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115568_5920481.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000409341+115717_7340481.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116165_1680446.0MotifNote=D-box%3B recognition signal for CDC20-mediated degradation
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116284_2970446.0MotifNote=PxVxL motif
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116536_5530446.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116568_5920446.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000409897+116717_7340446.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114165_1680453.0MotifNote=D-box%3B recognition signal for CDC20-mediated degradation
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114284_2970453.0MotifNote=PxVxL motif
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114536_5530453.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114568_5920453.0MotifNuclear localization signal
HgeneSP100chr2:231375881chr6:157405796ENST00000427101+114717_7340453.0MotifNuclear localization signal
TgeneARID1Bchr2:231375881chr6:157405796ENST00000346085420107_131679.02250.0Compositional biasNote=Gln-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000346085420114_131679.02250.0Compositional biasNote=Poly-Gln
TgeneARID1Bchr2:231375881chr6:157405796ENST00000346085420141_401679.02250.0Compositional biasNote=Gly-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST000003460854202_47679.02250.0Compositional biasNote=Ala-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000346085420329_493679.02250.0Compositional biasNote=Ala-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST0000034608542035_57679.02250.0Compositional biasNote=Ser-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000346085420574_633679.02250.0Compositional biasNote=Gln-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST0000034608542081_104679.02250.0Compositional biasNote=His-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000350026319107_131666.02237.0Compositional biasNote=Gln-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000350026319114_131666.02237.0Compositional biasNote=Poly-Gln
TgeneARID1Bchr2:231375881chr6:157405796ENST00000350026319141_401666.02237.0Compositional biasNote=Gly-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST000003500263192_47666.02237.0Compositional biasNote=Ala-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000350026319329_493666.02237.0Compositional biasNote=Ala-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST0000035002631935_57666.02237.0Compositional biasNote=Ser-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000350026319574_633666.02237.0Compositional biasNote=Gln-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST0000035002631981_104666.02237.0Compositional biasNote=His-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000367148320107_131666.02290.0Compositional biasNote=Gln-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000367148320114_131666.02290.0Compositional biasNote=Poly-Gln
TgeneARID1Bchr2:231375881chr6:157405796ENST00000367148320141_401666.02290.0Compositional biasNote=Gly-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST000003671483202_47666.02290.0Compositional biasNote=Ala-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000367148320329_493666.02290.0Compositional biasNote=Ala-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST0000036714832035_57666.02290.0Compositional biasNote=Ser-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000367148320574_633666.02290.0Compositional biasNote=Gln-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST0000036714832081_104666.02290.0Compositional biasNote=His-rich
TgeneARID1Bchr2:231375881chr6:157405796ENST00000346085420419_423679.02250.0MotifNote=LXXLL
TgeneARID1Bchr2:231375881chr6:157405796ENST00000350026319419_423666.02237.0MotifNote=LXXLL
TgeneARID1Bchr2:231375881chr6:157405796ENST00000367148320419_423666.02290.0MotifNote=LXXLL


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SP100
ARID1B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to SP100-ARID1B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SP100-ARID1B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource