UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:SPEN-CERS4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SPEN-CERS4
FusionPDB ID: 85713
FusionGDB2.0 ID: 85713
HgeneTgene
Gene symbol

SPEN

CERS4

Gene ID

64783

79603

Gene nameRNA binding motif protein 15ceramide synthase 4
SynonymsOTT|OTT1|SPENLASS4|Trh1
Cytomap

1p13.3

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein 15one twenty two proteinone twenty-twoone-twenty two protein 1putative RNA-binding protein 15ceramide synthase 4LAG1 homolog, ceramide synthase 4LAG1 longevity assurance homolog 4sphingosine N-acyltransferase CERS4
Modification date2020031320200320
UniProtAcc.

Q9HA82

Ensembl transtripts involved in fusion geneENST idsENST00000375759, ENST00000471538, 
ENST00000595722, ENST00000251363, 
ENST00000559336, ENST00000559450, 
ENST00000558331, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 12 X 15=360011 X 14 X 5=770
# samples 3115
** MAII scorelog2(31/3600*10)=-3.5376567859428
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/770*10)=-2.35989594508638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SPEN [Title/Abstract] AND CERS4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SPEN(16174645)-CERS4(8315960), # samples:3
Anticipated loss of major functional domain due to fusion event.SPEN-CERS4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPEN-CERS4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SPEN-CERS4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SPEN-CERS4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSPEN

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

26575292

HgeneSPEN

GO:0001510

RNA methylation

27602518

HgeneSPEN

GO:0009048

dosage compensation by inactivation of X chromosome

27602518

HgeneSPEN

GO:0045652

regulation of megakaryocyte differentiation

26575292

HgeneSPEN

GO:0045892

negative regulation of transcription, DNA-templated

16129689

TgeneCERS4

GO:0046513

ceramide biosynthetic process

17977534|29632068


check buttonFusion gene breakpoints across SPEN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CERS4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-38-4630-01ASPENchr1

16174644

+CERS4chr19

8315959

+
ChimerDB4LUADTCGA-38-4630-01ASPENchr1

16174644

+CERS4chr19

8319382

+
ChimerDB4LUADTCGA-38-4630-01ASPENchr1

16174645

+CERS4chr19

8312329

+
ChimerDB4LUADTCGA-38-4630-01ASPENchr1

16174645

-CERS4chr19

8315960

+
ChimerDB4LUADTCGA-38-4630-01ASPENchr1

16174645

+CERS4chr19

8315960

+
ChimerDB4LUADTCGA-38-4630-01ASPENchr1

16174645

+CERS4chr19

8319383

+
ChimerDB4LUADTCGA-38-4630SPENchr1

16174645

+CERS4chr19

8315959

+
ChimerDB4LUADTCGA-38-4630SPENchr1

16174645

+CERS4chr19

8319382

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000375759SPENchr116174645+ENST00000558331CERS4chr198319382+1600287271298423
ENST00000375759SPENchr116174645+ENST00000251363CERS4chr198319382+1583287271298423
ENST00000375759SPENchr116174645+ENST00000559450CERS4chr198319382+1331287271298423
ENST00000375759SPENchr116174645+ENST00000559336CERS4chr198319382+1347287271034335
ENST00000375759SPENchr116174645+ENST00000558331CERS4chr198319383+1600287271298423
ENST00000375759SPENchr116174645+ENST00000251363CERS4chr198319383+1583287271298423
ENST00000375759SPENchr116174645+ENST00000559450CERS4chr198319383+1331287271298423
ENST00000375759SPENchr116174645+ENST00000559336CERS4chr198319383+1347287271034335
ENST00000375759SPENchr116174644+ENST00000558331CERS4chr198319382+1600287271298423
ENST00000375759SPENchr116174644+ENST00000251363CERS4chr198319382+1583287271298423
ENST00000375759SPENchr116174644+ENST00000559450CERS4chr198319382+1331287271298423
ENST00000375759SPENchr116174644+ENST00000559336CERS4chr198319382+1347287271034335

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000375759ENST00000558331SPENchr116174645+CERS4chr198319382+0.0339236780.9660763
ENST00000375759ENST00000251363SPENchr116174645+CERS4chr198319382+0.0356734950.9643265
ENST00000375759ENST00000559450SPENchr116174645+CERS4chr198319382+0.0296215140.9703785
ENST00000375759ENST00000559336SPENchr116174645+CERS4chr198319382+0.0680587440.9319412
ENST00000375759ENST00000558331SPENchr116174645+CERS4chr198319383+0.0339236780.9660763
ENST00000375759ENST00000251363SPENchr116174645+CERS4chr198319383+0.0356734950.9643265
ENST00000375759ENST00000559450SPENchr116174645+CERS4chr198319383+0.0296215140.9703785
ENST00000375759ENST00000559336SPENchr116174645+CERS4chr198319383+0.0680587440.9319412
ENST00000375759ENST00000558331SPENchr116174644+CERS4chr198319382+0.0339236780.9660763
ENST00000375759ENST00000251363SPENchr116174644+CERS4chr198319382+0.0356734950.9643265
ENST00000375759ENST00000559450SPENchr116174644+CERS4chr198319382+0.0296215140.9703785
ENST00000375759ENST00000559336SPENchr116174644+CERS4chr198319382+0.0680587440.9319412

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>85713_85713_1_SPEN-CERS4_SPEN_chr1_16174644_ENST00000375759_CERS4_chr19_8319382_ENST00000251363_length(amino acids)=423AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS
SDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFM

--------------------------------------------------------------

>85713_85713_2_SPEN-CERS4_SPEN_chr1_16174644_ENST00000375759_CERS4_chr19_8319382_ENST00000558331_length(amino acids)=423AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS
SDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFM

--------------------------------------------------------------

>85713_85713_3_SPEN-CERS4_SPEN_chr1_16174644_ENST00000375759_CERS4_chr19_8319382_ENST00000559336_length(amino acids)=335AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS

--------------------------------------------------------------

>85713_85713_4_SPEN-CERS4_SPEN_chr1_16174644_ENST00000375759_CERS4_chr19_8319382_ENST00000559450_length(amino acids)=423AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS
SDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFM

--------------------------------------------------------------

>85713_85713_5_SPEN-CERS4_SPEN_chr1_16174645_ENST00000375759_CERS4_chr19_8319382_ENST00000251363_length(amino acids)=423AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS
SDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFM

--------------------------------------------------------------

>85713_85713_6_SPEN-CERS4_SPEN_chr1_16174645_ENST00000375759_CERS4_chr19_8319382_ENST00000558331_length(amino acids)=423AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS
SDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFM

--------------------------------------------------------------

>85713_85713_7_SPEN-CERS4_SPEN_chr1_16174645_ENST00000375759_CERS4_chr19_8319382_ENST00000559336_length(amino acids)=335AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS

--------------------------------------------------------------

>85713_85713_8_SPEN-CERS4_SPEN_chr1_16174645_ENST00000375759_CERS4_chr19_8319382_ENST00000559450_length(amino acids)=423AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS
SDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFM

--------------------------------------------------------------

>85713_85713_9_SPEN-CERS4_SPEN_chr1_16174645_ENST00000375759_CERS4_chr19_8319383_ENST00000251363_length(amino acids)=423AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS
SDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFM

--------------------------------------------------------------

>85713_85713_10_SPEN-CERS4_SPEN_chr1_16174645_ENST00000375759_CERS4_chr19_8319383_ENST00000558331_length(amino acids)=423AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS
SDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFM

--------------------------------------------------------------

>85713_85713_11_SPEN-CERS4_SPEN_chr1_16174645_ENST00000375759_CERS4_chr19_8319383_ENST00000559336_length(amino acids)=335AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS

--------------------------------------------------------------

>85713_85713_12_SPEN-CERS4_SPEN_chr1_16174645_ENST00000375759_CERS4_chr19_8319383_ENST00000559450_length(amino acids)=423AA_BP=86
MGERDGLCTGGSRRSRRRCRRHRRSRRRRRPGTRLPALTVSYEAGEGEPAAAVAGTPPSMVRETRHLWVGNLPENVREEKIIEHFKRFIG
LPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGL
SVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDS
SDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFM

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:16174645/chr19:8315960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CERS4

Q9HA82

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCERS4chr1:16174644chr19:8319382ENST00000251363212131_33257.666666666666664395.0DomainTLC
TgeneCERS4chr1:16174644chr19:8319382ENST00000559450111131_33257.666666666666664395.0DomainTLC
TgeneCERS4chr1:16174645chr19:8319382ENST00000251363212131_33257.666666666666664395.0DomainTLC
TgeneCERS4chr1:16174645chr19:8319382ENST00000559450111131_33257.666666666666664395.0DomainTLC
TgeneCERS4chr1:16174645chr19:8319383ENST00000251363212131_33257.666666666666664395.0DomainTLC
TgeneCERS4chr1:16174645chr19:8319383ENST00000559450111131_33257.666666666666664395.0DomainTLC
TgeneCERS4chr1:16174644chr19:8319382ENST00000251363212291_30157.666666666666664395.0MotifLast loop motif
TgeneCERS4chr1:16174644chr19:8319382ENST00000559450111291_30157.666666666666664395.0MotifLast loop motif
TgeneCERS4chr1:16174645chr19:8319382ENST00000251363212291_30157.666666666666664395.0MotifLast loop motif
TgeneCERS4chr1:16174645chr19:8319382ENST00000559450111291_30157.666666666666664395.0MotifLast loop motif
TgeneCERS4chr1:16174645chr19:8319383ENST00000251363212291_30157.666666666666664395.0MotifLast loop motif
TgeneCERS4chr1:16174645chr19:8319383ENST00000559450111291_30157.666666666666664395.0MotifLast loop motif
TgeneCERS4chr1:16174644chr19:8319382ENST0000025136321267_12857.666666666666664395.0RegionHomeobox-like
TgeneCERS4chr1:16174644chr19:8319382ENST0000055945011167_12857.666666666666664395.0RegionHomeobox-like
TgeneCERS4chr1:16174645chr19:8319382ENST0000025136321267_12857.666666666666664395.0RegionHomeobox-like
TgeneCERS4chr1:16174645chr19:8319382ENST0000055945011167_12857.666666666666664395.0RegionHomeobox-like
TgeneCERS4chr1:16174645chr19:8319383ENST0000025136321267_12857.666666666666664395.0RegionHomeobox-like
TgeneCERS4chr1:16174645chr19:8319383ENST0000055945011167_12857.666666666666664395.0RegionHomeobox-like
TgeneCERS4chr1:16174644chr19:8319382ENST00000251363212325_39457.666666666666664395.0Topological domainCytoplasmic
TgeneCERS4chr1:16174644chr19:8319382ENST00000559450111325_39457.666666666666664395.0Topological domainCytoplasmic
TgeneCERS4chr1:16174645chr19:8319382ENST00000251363212325_39457.666666666666664395.0Topological domainCytoplasmic
TgeneCERS4chr1:16174645chr19:8319382ENST00000559450111325_39457.666666666666664395.0Topological domainCytoplasmic
TgeneCERS4chr1:16174645chr19:8319383ENST00000251363212325_39457.666666666666664395.0Topological domainCytoplasmic
TgeneCERS4chr1:16174645chr19:8319383ENST00000559450111325_39457.666666666666664395.0Topological domainCytoplasmic
TgeneCERS4chr1:16174644chr19:8319382ENST00000251363212140_16057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174644chr19:8319382ENST00000251363212179_19957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174644chr19:8319382ENST00000251363212209_22957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174644chr19:8319382ENST00000251363212260_28057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174644chr19:8319382ENST00000251363212304_32457.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174644chr19:8319382ENST00000559450111140_16057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174644chr19:8319382ENST00000559450111179_19957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174644chr19:8319382ENST00000559450111209_22957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174644chr19:8319382ENST00000559450111260_28057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174644chr19:8319382ENST00000559450111304_32457.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST00000251363212140_16057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST00000251363212179_19957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST00000251363212209_22957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST00000251363212260_28057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST00000251363212304_32457.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST00000559450111140_16057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST00000559450111179_19957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST00000559450111209_22957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST00000559450111260_28057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST00000559450111304_32457.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST00000251363212140_16057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST00000251363212179_19957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST00000251363212209_22957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST00000251363212260_28057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST00000251363212304_32457.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST00000559450111140_16057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST00000559450111179_19957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST00000559450111209_22957.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST00000559450111260_28057.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST00000559450111304_32457.666666666666664395.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1151170_119127.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1151408_142827.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1151496_152927.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1151592_161227.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1151928_194427.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+115688_71527.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+115977_100427.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1151170_119127.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1151408_142827.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1151496_152927.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1151592_161227.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1151928_194427.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+115688_71527.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+115977_100427.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1151170_119127.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1151408_142827.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1151496_152927.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1151592_161227.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1151928_194427.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+115688_71527.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+115977_100427.6666666666666683665.0Coiled coilOntology_term=ECO:0000255
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+115125_27727.6666666666666683665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+115240_32527.6666666666666683665.0Compositional biasNote=Ser-rich
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1152428_252027.6666666666666683665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1153220_348227.6666666666666683665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+115616_81027.6666666666666683665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+115624_69727.6666666666666683665.0Compositional biasNote=Tyr-rich
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+115125_27727.6666666666666683665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+115240_32527.6666666666666683665.0Compositional biasNote=Ser-rich
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1152428_252027.6666666666666683665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1153220_348227.6666666666666683665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+115616_81027.6666666666666683665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+115624_69727.6666666666666683665.0Compositional biasNote=Tyr-rich
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+115125_27727.6666666666666683665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+115240_32527.6666666666666683665.0Compositional biasNote=Ser-rich
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1152428_252027.6666666666666683665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1153220_348227.6666666666666683665.0Compositional biasNote=Pro-rich
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+115616_81027.6666666666666683665.0Compositional biasNote=Arg-rich
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+115624_69727.6666666666666683665.0Compositional biasNote=Tyr-rich
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1151_57327.6666666666666683665.0DNA bindingOntology_term=ECO:0000250
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1151_57327.6666666666666683665.0DNA bindingOntology_term=ECO:0000250
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1151_57327.6666666666666683665.0DNA bindingOntology_term=ECO:0000250
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1152201_270727.6666666666666683665.0DomainNote=RID
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+115335_41527.6666666666666683665.0DomainRRM 2
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1153498_366427.6666666666666683665.0DomainSPOC
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+115438_51327.6666666666666683665.0DomainRRM 3
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+115517_58927.6666666666666683665.0DomainRRM 4
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1156_8127.6666666666666683665.0DomainRRM 1
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1152201_270727.6666666666666683665.0DomainNote=RID
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+115335_41527.6666666666666683665.0DomainRRM 2
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1153498_366427.6666666666666683665.0DomainSPOC
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+115438_51327.6666666666666683665.0DomainRRM 3
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+115517_58927.6666666666666683665.0DomainRRM 4
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1156_8127.6666666666666683665.0DomainRRM 1
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1152201_270727.6666666666666683665.0DomainNote=RID
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+115335_41527.6666666666666683665.0DomainRRM 2
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1153498_366427.6666666666666683665.0DomainSPOC
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+115438_51327.6666666666666683665.0DomainRRM 3
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+115517_58927.6666666666666683665.0DomainRRM 4
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1156_8127.6666666666666683665.0DomainRRM 1
TgeneCERS4chr1:16174644chr19:8319382ENST000002513632121_3157.666666666666664395.0Topological domainLumenal
TgeneCERS4chr1:16174644chr19:8319382ENST000005594501111_3157.666666666666664395.0Topological domainLumenal
TgeneCERS4chr1:16174645chr19:8319382ENST000002513632121_3157.666666666666664395.0Topological domainLumenal
TgeneCERS4chr1:16174645chr19:8319382ENST000005594501111_3157.666666666666664395.0Topological domainLumenal
TgeneCERS4chr1:16174645chr19:8319383ENST000002513632121_3157.666666666666664395.0Topological domainLumenal
TgeneCERS4chr1:16174645chr19:8319383ENST000005594501111_3157.666666666666664395.0Topological domainLumenal
TgeneCERS4chr1:16174644chr19:8319382ENST0000025136321232_5257.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174644chr19:8319382ENST0000055945011132_5257.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST0000025136321232_5257.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319382ENST0000055945011132_5257.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST0000025136321232_5257.666666666666664395.0TransmembraneHelical
TgeneCERS4chr1:16174645chr19:8319383ENST0000055945011132_5257.666666666666664395.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SPEN
CERS4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1152130_246427.6666666666666683665.0MSX2
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1152130_246427.6666666666666683665.0MSX2
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1152130_246427.6666666666666683665.0MSX2
HgeneSPENchr1:16174644chr19:8319382ENST00000375759+1152709_287027.6666666666666683665.0RBPSUH
HgeneSPENchr1:16174645chr19:8319382ENST00000375759+1152709_287027.6666666666666683665.0RBPSUH
HgeneSPENchr1:16174645chr19:8319383ENST00000375759+1152709_287027.6666666666666683665.0RBPSUH


Top

Related Drugs to SPEN-CERS4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to SPEN-CERS4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource