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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SQSTM1-CDKN1C

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SQSTM1-CDKN1C
FusionPDB ID: 86201
FusionGDB2.0 ID: 86201
HgeneTgene
Gene symbol

SQSTM1

CDKN1C

Gene ID

8878

1028

Gene namesequestosome 1cyclin dependent kinase inhibitor 1C
SynonymsA170|DMRV|FTDALS3|NADGP|OSIL|PDB3|ZIP3|p60|p62|p62BBWCR|BWS|KIP2|WBS|p57|p57Kip2
Cytomap

5q35.3

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionsequestosome-1EBI3-associated protein of 60 kDaEBI3-associated protein p60EBIAPautophagy receptor p62oxidative stress induced likephosphotyrosine independent ligand for the Lck SH2 domain p62phosphotyrosine-independent ligand for the Lck SH2 domaincyclin-dependent kinase inhibitor 1Ccyclin-dependent kinase inhibitor 1C (p57, Kip2)cyclin-dependent kinase inhibitor p57
Modification date2020032720200315
UniProtAcc

Q13501

P49918

Ensembl transtripts involved in fusion geneENST idsENST00000360718, ENST00000376929, 
ENST00000389805, ENST00000402874, 
ENST00000510187, ENST00000506690, 
ENST00000380725, ENST00000313407, 
ENST00000414822, ENST00000430149, 
ENST00000440480, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score29 X 23 X 12=80043 X 3 X 3=27
# samples 333
** MAII scorelog2(33/8004*10)=-4.60018323765993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SQSTM1 [Title/Abstract] AND CDKN1C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SQSTM1(179251323)-CDKN1C(2905364), # samples:1
Anticipated loss of major functional domain due to fusion event.SQSTM1-CDKN1C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SQSTM1-CDKN1C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SQSTM1-CDKN1C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SQSTM1-CDKN1C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SQSTM1-CDKN1C seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSQSTM1

GO:0006914

autophagy

20452972

HgeneSQSTM1

GO:0007032

endosome organization

27368102

HgeneSQSTM1

GO:0031397

negative regulation of protein ubiquitination

20452972

HgeneSQSTM1

GO:0061635

regulation of protein complex stability

25127057

HgeneSQSTM1

GO:1905719

protein localization to perinuclear region of cytoplasm

27368102

TgeneCDKN1C

GO:0033673

negative regulation of kinase activity

19170105

TgeneCDKN1C

GO:0042326

negative regulation of phosphorylation

19170105

TgeneCDKN1C

GO:0045892

negative regulation of transcription, DNA-templated

19170105


check buttonFusion gene breakpoints across SQSTM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDKN1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A8NISQSTM1chr5

179251323

+CDKN1Cchr11

2905364

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376929SQSTM1chr5179251323+ENST00000414822CDKN1Cchr112905364-16207811032403209
ENST00000376929SQSTM1chr5179251323+ENST00000440480CDKN1Cchr112905364-16157811032403209
ENST00000376929SQSTM1chr5179251323+ENST00000313407CDKN1Cchr112905364-1597781303911202
ENST00000376929SQSTM1chr5179251323+ENST00000430149CDKN1Cchr112905364-1249781303911202
ENST00000389805SQSTM1chr5179251323+ENST00000414822CDKN1Cchr112905364-1690851178981267
ENST00000389805SQSTM1chr5179251323+ENST00000440480CDKN1Cchr112905364-1685851178981267
ENST00000389805SQSTM1chr5179251323+ENST00000313407CDKN1Cchr112905364-1667851178981267
ENST00000389805SQSTM1chr5179251323+ENST00000430149CDKN1Cchr112905364-1319851178981267
ENST00000402874SQSTM1chr5179251323+ENST00000414822CDKN1Cchr112905364-153069118821267
ENST00000402874SQSTM1chr5179251323+ENST00000440480CDKN1Cchr112905364-152569118821267
ENST00000402874SQSTM1chr5179251323+ENST00000313407CDKN1Cchr112905364-150769118821267
ENST00000402874SQSTM1chr5179251323+ENST00000430149CDKN1Cchr112905364-115969118821267
ENST00000510187SQSTM1chr5179251323+ENST00000414822CDKN1Cchr112905364-152868916819267
ENST00000510187SQSTM1chr5179251323+ENST00000440480CDKN1Cchr112905364-152368916819267
ENST00000510187SQSTM1chr5179251323+ENST00000313407CDKN1Cchr112905364-150568916819267
ENST00000510187SQSTM1chr5179251323+ENST00000430149CDKN1Cchr112905364-115768916819267
ENST00000360718SQSTM1chr5179251323+ENST00000414822CDKN1Cchr112905364-17809413341071245
ENST00000360718SQSTM1chr5179251323+ENST00000440480CDKN1Cchr112905364-17759413341071245
ENST00000360718SQSTM1chr5179251323+ENST00000313407CDKN1Cchr112905364-17579413341071245
ENST00000360718SQSTM1chr5179251323+ENST00000430149CDKN1Cchr112905364-14099413341071245

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376929ENST00000414822SQSTM1chr5179251323+CDKN1Cchr112905364-0.25429930.7457007
ENST00000376929ENST00000440480SQSTM1chr5179251323+CDKN1Cchr112905364-0.26055910.7394409
ENST00000376929ENST00000313407SQSTM1chr5179251323+CDKN1Cchr112905364-0.261151370.7388486
ENST00000376929ENST00000430149SQSTM1chr5179251323+CDKN1Cchr112905364-0.384475530.61552453
ENST00000389805ENST00000414822SQSTM1chr5179251323+CDKN1Cchr112905364-0.0707003550.9292997
ENST00000389805ENST00000440480SQSTM1chr5179251323+CDKN1Cchr112905364-0.0688380450.93116194
ENST00000389805ENST00000313407SQSTM1chr5179251323+CDKN1Cchr112905364-0.063002920.9369971
ENST00000389805ENST00000430149SQSTM1chr5179251323+CDKN1Cchr112905364-0.154652910.84534717
ENST00000402874ENST00000414822SQSTM1chr5179251323+CDKN1Cchr112905364-0.078980940.92101914
ENST00000402874ENST00000440480SQSTM1chr5179251323+CDKN1Cchr112905364-0.076801250.9231987
ENST00000402874ENST00000313407SQSTM1chr5179251323+CDKN1Cchr112905364-0.068976930.93102306
ENST00000402874ENST00000430149SQSTM1chr5179251323+CDKN1Cchr112905364-0.178414080.8215859
ENST00000510187ENST00000414822SQSTM1chr5179251323+CDKN1Cchr112905364-0.076866270.9231338
ENST00000510187ENST00000440480SQSTM1chr5179251323+CDKN1Cchr112905364-0.073998330.9260016
ENST00000510187ENST00000313407SQSTM1chr5179251323+CDKN1Cchr112905364-0.067273270.9327267
ENST00000510187ENST00000430149SQSTM1chr5179251323+CDKN1Cchr112905364-0.178082030.82191795
ENST00000360718ENST00000414822SQSTM1chr5179251323+CDKN1Cchr112905364-0.351249580.6487504
ENST00000360718ENST00000440480SQSTM1chr5179251323+CDKN1Cchr112905364-0.352478740.64752126
ENST00000360718ENST00000313407SQSTM1chr5179251323+CDKN1Cchr112905364-0.3279760.672024
ENST00000360718ENST00000430149SQSTM1chr5179251323+CDKN1Cchr112905364-0.402946770.59705323

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86201_86201_1_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000360718_CDKN1C_chr11_2905364_ENST00000313407_length(amino acids)=245AA_BP=202
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP

--------------------------------------------------------------

>86201_86201_2_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000360718_CDKN1C_chr11_2905364_ENST00000414822_length(amino acids)=245AA_BP=202
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP

--------------------------------------------------------------

>86201_86201_3_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000360718_CDKN1C_chr11_2905364_ENST00000430149_length(amino acids)=245AA_BP=202
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP

--------------------------------------------------------------

>86201_86201_4_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000360718_CDKN1C_chr11_2905364_ENST00000440480_length(amino acids)=245AA_BP=202
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP

--------------------------------------------------------------

>86201_86201_5_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000376929_CDKN1C_chr11_2905364_ENST00000313407_length(amino acids)=202AA_BP=159
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESDFFAKRKRSAPEKSSGDVPAP

--------------------------------------------------------------

>86201_86201_6_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000376929_CDKN1C_chr11_2905364_ENST00000414822_length(amino acids)=209AA_BP=1
MLCGSRRRLLLHERSQPRPSALPTSAAPAGSLGALWALNWLTAASCAGSAPPSPRQGRRLERDTARGHRPTTSQALISCAWRRNLILPWG
QGGPPLHEEDVGSSFLVDPFPILATRSVRVSPSGASGCARSPQTGARRGWGMRAWCAPGASPFPRRRYTSRSLGRRCTCSGFLPQAHCSH

--------------------------------------------------------------

>86201_86201_7_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000376929_CDKN1C_chr11_2905364_ENST00000430149_length(amino acids)=202AA_BP=159
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESDFFAKRKRSAPEKSSGDVPAP

--------------------------------------------------------------

>86201_86201_8_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000376929_CDKN1C_chr11_2905364_ENST00000440480_length(amino acids)=209AA_BP=1
MLCGSRRRLLLHERSQPRPSALPTSAAPAGSLGALWALNWLTAASCAGSAPPSPRQGRRLERDTARGHRPTTSQALISCAWRRNLILPWG
QGGPPLHEEDVGSSFLVDPFPILATRSVRVSPSGASGCARSPQTGARRGWGMRAWCAPGASPFPRRRYTSRSLGRRCTCSGFLPQAHCSH

--------------------------------------------------------------

>86201_86201_9_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000389805_CDKN1C_chr11_2905364_ENST00000313407_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_10_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000389805_CDKN1C_chr11_2905364_ENST00000414822_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_11_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000389805_CDKN1C_chr11_2905364_ENST00000430149_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_12_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000389805_CDKN1C_chr11_2905364_ENST00000440480_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_13_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000402874_CDKN1C_chr11_2905364_ENST00000313407_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_14_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000402874_CDKN1C_chr11_2905364_ENST00000414822_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_15_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000402874_CDKN1C_chr11_2905364_ENST00000430149_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_16_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000402874_CDKN1C_chr11_2905364_ENST00000440480_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_17_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000510187_CDKN1C_chr11_2905364_ENST00000313407_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_18_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000510187_CDKN1C_chr11_2905364_ENST00000414822_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_19_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000510187_CDKN1C_chr11_2905364_ENST00000430149_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

--------------------------------------------------------------

>86201_86201_20_SQSTM1-CDKN1C_SQSTM1_chr5_179251323_ENST00000510187_CDKN1C_chr11_2905364_ENST00000440480_length(amino acids)=267AA_BP=224
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179251323/chr11:2905364)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SQSTM1

Q13501

CDKN1C

P49918

FUNCTION: Autophagy receptor required for selective macroautophagy (aggrephagy). Functions as a bridge between polyubiquitinated cargo and autophagosomes. Interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family (PubMed:16286508, PubMed:20168092, PubMed:24128730, PubMed:28404643, PubMed:22622177). Along with WDFY3, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with WDFY3, required to recruit ubiquitinated proteins to PML bodies in the nucleus (PubMed:24128730, PubMed:20168092). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Involved in endosome organization by retaining vesicles in the perinuclear cloud: following ubiquitination by RNF26, attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102). Promotes relocalization of 'Lys-63'-linked ubiquitinated STING1 to autophagosomes (PubMed:29496741). Acts as an activator of the NFE2L2/NRF2 pathway via interaction with KEAP1: interaction inactivates the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2 and subsequent expression of cytoprotective genes (PubMed:20452972, PubMed:28380357, PubMed:33393215). {ECO:0000250|UniProtKB:O08623, ECO:0000250|UniProtKB:Q64337, ECO:0000269|PubMed:10356400, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11244088, ECO:0000269|PubMed:12471037, ECO:0000269|PubMed:15340068, ECO:0000269|PubMed:15802564, ECO:0000269|PubMed:15911346, ECO:0000269|PubMed:15953362, ECO:0000269|PubMed:16079148, ECO:0000269|PubMed:16286508, ECO:0000269|PubMed:19931284, ECO:0000269|PubMed:20168092, ECO:0000269|PubMed:20452972, ECO:0000269|PubMed:22622177, ECO:0000269|PubMed:24128730, ECO:0000269|PubMed:27368102, ECO:0000269|PubMed:28380357, ECO:0000269|PubMed:28404643, ECO:0000269|PubMed:29496741, ECO:0000269|PubMed:33393215}.FUNCTION: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+373_102140.33333333333334357.0DomainPB1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+593_102140.33333333333334357.0DomainPB1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000389805+483_102224.33333333333334441.0DomainPB1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+483_102140.33333333333334357.0DomainPB1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000389805+48170_220224.33333333333334441.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000389805+48122_167224.33333333333334441.0Zinc fingerZZ-type
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000031340714278_281262.3333333333333268.3333333333333MotifNuclear localization signal
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000041482203278_281273.3333333333333147.33333333333334MotifNuclear localization signal
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000043014903278_281273.333333333333360.333333333333336MotifNuclear localization signal
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000044048014278_281262.3333333333333258.3333333333333MotifNuclear localization signal

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+37272_294140.33333333333334357.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+59272_294140.33333333333334357.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000389805+48272_294224.33333333333334441.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+48272_294140.33333333333334357.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+37389_434140.33333333333334357.0DomainUBA
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+59389_434140.33333333333334357.0DomainUBA
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000389805+48389_434224.33333333333334441.0DomainUBA
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+48389_434140.33333333333334357.0DomainUBA
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+37228_233140.33333333333334357.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+37336_341140.33333333333334357.0MotifNote=LIR
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+59228_233140.33333333333334357.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+59336_341140.33333333333334357.0MotifNote=LIR
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000389805+48228_233224.33333333333334441.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000389805+48336_341224.33333333333334441.0MotifNote=LIR
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+48228_233140.33333333333334357.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+48336_341140.33333333333334357.0MotifNote=LIR
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+37170_220140.33333333333334357.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+37321_342140.33333333333334357.0RegionMAP1LC3B-binding
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+59170_220140.33333333333334357.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+59321_342140.33333333333334357.0RegionMAP1LC3B-binding
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000389805+48321_342224.33333333333334441.0RegionMAP1LC3B-binding
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+48170_220140.33333333333334357.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+48321_342140.33333333333334357.0RegionMAP1LC3B-binding
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+37122_167140.33333333333334357.0Zinc fingerZZ-type
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+59122_167140.33333333333334357.0Zinc fingerZZ-type
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+48122_167140.33333333333334357.0Zinc fingerZZ-type
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000031340714156_213262.3333333333333268.3333333333333RegionNote=9 X 4 AA repeats of P-A-P-A
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000041482203156_213273.3333333333333147.33333333333334RegionNote=9 X 4 AA repeats of P-A-P-A
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000043014903156_213273.333333333333360.333333333333336RegionNote=9 X 4 AA repeats of P-A-P-A
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000044048014156_213262.3333333333333258.3333333333333RegionNote=9 X 4 AA repeats of P-A-P-A
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000031340714156_159262.3333333333333268.3333333333333RepeatNote=1
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000031340714160_163262.3333333333333268.3333333333333RepeatNote=2
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000031340714180_183262.3333333333333268.3333333333333RepeatNote=3
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000031340714184_187262.3333333333333268.3333333333333RepeatNote=4
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000031340714188_191262.3333333333333268.3333333333333RepeatNote=5
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000031340714198_201262.3333333333333268.3333333333333RepeatNote=6
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000031340714202_205262.3333333333333268.3333333333333RepeatNote=7
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000031340714210_213262.3333333333333268.3333333333333RepeatNote=9
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000041482203156_159273.3333333333333147.33333333333334RepeatNote=1
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000041482203160_163273.3333333333333147.33333333333334RepeatNote=2
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000041482203180_183273.3333333333333147.33333333333334RepeatNote=3
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000041482203184_187273.3333333333333147.33333333333334RepeatNote=4
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000041482203188_191273.3333333333333147.33333333333334RepeatNote=5
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000041482203198_201273.3333333333333147.33333333333334RepeatNote=6
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000041482203202_205273.3333333333333147.33333333333334RepeatNote=7
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000041482203210_213273.3333333333333147.33333333333334RepeatNote=9
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000043014903156_159273.333333333333360.333333333333336RepeatNote=1
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000043014903160_163273.333333333333360.333333333333336RepeatNote=2
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000043014903180_183273.333333333333360.333333333333336RepeatNote=3
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000043014903184_187273.333333333333360.333333333333336RepeatNote=4
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000043014903188_191273.333333333333360.333333333333336RepeatNote=5
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000043014903198_201273.333333333333360.333333333333336RepeatNote=6
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000043014903202_205273.333333333333360.333333333333336RepeatNote=7
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000043014903210_213273.333333333333360.333333333333336RepeatNote=9
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000044048014156_159262.3333333333333258.3333333333333RepeatNote=1
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000044048014160_163262.3333333333333258.3333333333333RepeatNote=2
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000044048014180_183262.3333333333333258.3333333333333RepeatNote=3
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000044048014184_187262.3333333333333258.3333333333333RepeatNote=4
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000044048014188_191262.3333333333333258.3333333333333RepeatNote=5
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000044048014198_201262.3333333333333258.3333333333333RepeatNote=6
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000044048014202_205262.3333333333333258.3333333333333RepeatNote=7
TgeneCDKN1Cchr5:179251323chr11:2905364ENST0000044048014210_213262.3333333333333258.3333333333333RepeatNote=9


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SQSTM1GABARAPL2, RAD23A, GABARAPL1, SQSTM1, LINC00341, MAP1LC3B, TRAF6, PRKCZ, IRAK1, PRKCI, NTRK1, RIPK1, NTRK2, NTRK3, LCK, MAP1LC3A, Shank1, Dlg4, Grin2a, Gria1, Chrna7, KEAP1, GABARAP, C10orf2, ABHD10, CEP78, DIP2B, BLOC1S5, EMILIN3, NSUN4, OSBPL8, INA, NIPSNAP1, GBAS, LLGL1, HADHA, GPC4, HADHB, CTNND1, ASPH, ENPP1, TRMT61B, GLG1, MRPL38, NEFM, GTF3C3, SRRM2, MYD88, MYC, MAP3K3, MAP2K5, IRF8, TRIM21, CYLD, Cep78, Poc1b, CALM1, BNIP1, NFE2L2, CUL3, PIK3CA, PPHLN1, BPTF, UBC, DAZAP2, CDC37, TRIM13, CASP8, PCK1, STAT5A, PDE4A, MAPT, ATG4B, CHMP2B, TARDBP, CUL1, CUL2, HDAC6, ATG7, FUS, CSNK2A1, ZFAND5, TUBA1A, WDFY3, ATG8, BAG3, NBR1, SNCA, TRIM63, TRIM55, TTN, RARA, PSMC2, PSMD4, MAP1LC3C, TRIM50, ARHGEF28, TGM2, PAWR, RPTOR, MTOR, AKT1S1, MLST8, RPS6KB1, RRAGC, RRAGB, CDK9, tat, SPRED2, TRIM5, AJUBA, LIMD1, MAPK14, PARP10, vif, nef, TNFRSF10A, HTT, HNRNPA2B1, SDHA, CAV1, BID, FAS, SESN2, SESN1, MALT1, IKBKG, FHOD3, NOD2, SYNPO2, PYCARD, MLH1, PARK2, BCL2, PAN2, NPM1, MBP, YWHAZ, STXBP1, FKBP4, MEIS2, TKT, HSPA4, RELN, CAMK2A, ULK2, NCOR1, NGFR, env, HIV2gp7, CALCOCO2, Prkci, CDK1, CCNB1, PRKCD, MAPK1, SMAD3, EEF1D, RPL37, GEMIN4, DVL2, CHAF1A, TP53, CASP9, HIF1A, PSMD12, PSMD3, FLNB, PSMD10, TXNL1, TNK2, LGALS3, EDEM1, CFTR, CSNK2A2, DCP2, EGLN3, EPAS1, ULK1, TOLLIP, OPTN, ATXN3, STUB1, ISG15, MOV10, NXF1, CUL7, PIK3R1, PIK3R2, AGAP1, INSR, Ubc, TBK1, CRHBP, SCCPDH, DNAI1, DNAI2, TP53INP1, LLGL2, HSPB1, Ripk3, Nr2f2, IFI16, KIAA0753, MED4, CEP135, CNTRL, SASS6, TMEM17, XPO1, CD44, KIF5B, PML, Mgp, Poc1a, Fgfr1op, ENC1, SKI, TRIB3, RBM45, MAPK13, CHDH, EPDR1, GAS6, NDUFS2, NDUFS3, GFM2, NDUFA5, CD48, LDHA, RCN2, TRAF1, GBP2, KLHL3, EPM2A, RAD54L2, HSPA5, GRIA1, UBXN1, PEX5, BCL10, ATG5, CSNK1A1, VANGL2, SERPINA1, RNF168, LRRK2, VHL, TCEB2, TCEB1, RNF166, NOTCH1, RETN, KERA, INSL5, TMX1, VWCE, CD96, HTR3A, RNF26, INO80B, DLST, TRIM25, PLIN1, TES, WDR81, PSMA6, TRIM23, PGI1, UBE2D2, UBE2D3, ID1, ID2, TAX1BP1, Map1lc3b, UBD, RMND5A, RIPK4, MAPK6, TMPO, AIM2, TRIM11, TNFAIP3, VDR, NEDD4, CNOT2, WDR77, KRAS, RXRA, TGFB1, TRIP4, C19orf80, CCNF, VIM, FLNA, RAD51, NR4A1, RAD18, REL, RELA, RNF4, RNF31, PARK7, MYO6, XIAP, DDX5, CCND1, BPLF1, ESR2, BBC3, CDC6, BRCA1, CRYAB, DNAJC10, PADI1, CALCR, USP14, DDX58, Gabarapl1, MB21D1, SMN1, CRBN, FBL, ELAVL1, KIAA1429, AMBRA1, VCP, LAMP2, ATG16L1, LRRK1, PHB, BECN1, SOX2, PARP1, USP10, MTDH, FUNDC1, GBF1, MECOM, DCAF15, asp, SHMT2, CCT7, SLIRP, SND1, FADD, BIRC2, DYRK1A, PINK1, RB1CC1, IFITM3, P2RY6, GCH1, NUB1, PPP1CA, Casp8, FBXW7, BIRC3, LMBR1L, IGF2BP1, SERPINE2, MYO5A, FN1, CTHRC1, CD59, ITIH5, TNC, SNTB1, ROBO1, TUBB2A, GDF15, CNP, RAI14, ACSL3, CEP170, TAOK2, CNST, SSR3, SLC25A11, SPATA20, FARP1, UTRN, DHX33, CHCHD3, HS2ST1, PTRH2, SOD3, BCKDK, CCDC77, IQGAP1, FKBP11, CEP350, SCO1, SNTB2, MTX2, MYO1B, PWP1, SRPR, ATAD3A, ACTR1A, SLC25A1, MOGS, GOLGA2, SMG8, DYNC1LI2, UQCRH, SRPK2, CAPZA2, POLRMT, SMARCD1, GNB1, HSD17B12, DYNC1LI1, AIFM1, DARS2, GNAI2, TUBA1C, TUBA1B, MRPS28, CEP131, WDR82, PAFAH1B1, TUBB, MRPS34, ATP5A1, NOL9, ZC3H4, ATP5B, MRPS26, MRPS18B, ERAL1, PNKP, MIB1, SRP14, SLC25A3, MRPS22, CEP250, CCDC61, CKAP4, RPS16, BICD1, RPS15, ATP5H, AP2B1, NFIX, CDK5RAP2, RRBP1, SLC25A4, RPS5, TPX2, AP2A2, IK, PPP2R1A, GOLGB1, MPRIP, AHNAK, PCNT, RPS24, CETN2, HNRNPUL1, PRRC2A, DAP3, PIBF1, TJP1, RFC4, NOL8, CEP290, MAGI1, ZNF384, IQSEC1, TAOK1, PGAM5, SMG1, GAPVD1, MRPS9, ATAD3B, CSTF3, FRYL, EPRS, ARHGEF18, SNAP23, PRPF38A, RBM12B, SLC25A10, UTP23, FGFR1OP, SMU1, RAPGEF2, OFD1, PARD3, S100A9, EIF4B, EIF5B, IGF2BP3, ATXN1, HCVgp1, IKBKB, SKP2, PHB2, PLN, MAVS, APAF1, ECSIT, G3BP1, G3BP2, BNIP3, BNIP3L, CALR, DAXX, LINC01554, HMOX1, KAT5, PDPK1, PXN, RAF1, SH3BGRL, ORF7a, E, nsp6, ORF6, ORF8, ESR1, TRIM32, RQCD1, CIT, ANLN, AURKB, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, PDCD4, BRD1, FIS1, MARCH5, MFN2, OCIAD1, ABL1, Rnf183, AGR2, HULC, NLRP3, NUPR1, USP8, GSK3B, UCHL5, FAM20C, GJA1, CCDC88C, PRDM9, PPIA, USP20, USP19, OTUD7B, JOSD1, IRF3, STK17A, OGT, BAG5, PSMB2, PSMD14, TRIM37, AR, MCL1, AMOT, B3GAT1, GJD3, GOLGA1, IMPDH2, KRT8, PXMP2, AMER1, ARHGAP32, BCR, C1orf198, CC2D1A, CCDC85C, CDC27, CENPB, CEP85, CNOT1, CNOT10, CSTF2T, DNAJA2, EDRF1, FAM193A, FARSA, FLJ44635, GGA3, HGS, HIST1H2BD, HIST1H3F, HSPA1B, IARS2, IFT172, IFT74, IQGAP2, JADE3, KIF7, KPNA3, LZTS2, MAGED1, NAE1, NAV1, NUDT19, OCRL, PAPD7, PDLIM7, PEBP1, PIK3C2B, PJA2, PPP1R13B, PPP2R3B, PPP2R5D, RC3H1, RIPK2, SCYL2, SEC16A, SIRT2, SMG7, SNRPE, SYNJ1, TNIP1, TNRC6A, TNRC6B, TP53BP2, TRIM26, TRIP6, TTK, UBB, VWA8, ZCCHC14, ZCCHC2, ZFP36L2, ABLIM1, KIAA1244, ASNS, CEP152, DIAPH3, DNAAF2, DRG1, DVL3, EXOC4, KIAA1671, LPP, NELFCD, NRBF2, PAK4, PDLIM3, PDLIM5, RPAP2, SDCCAG3, SIPA1L3, SLAIN2, SYNJ2, TAB2, TANC1, TTC28, TTF2, UCHL1, WRAP73, YEATS2, SYNE3, VASP, JUN, UBQLN2, CCDC50, IFIH1, VDAC1, MOAP1, CHRNB4, ZCCHC10, PRR27, IL7R, IL17F, BAGE2, HFE, CST8, POGLUT1, EDDM3B, LY6G5C, ST14, TNFSF18, GREM2, C1QTNF1, CST11, HLA-DPB1, FIBIN, ADAMTS12, GLIPR1L2, FAM46C, BTF3, ZRANB1, UXT, WBP4, IFITM1, KDR, NEDD8, KDM1A, AARS, ACLY, ACTB, ARF4, ATG9A, ATP2A2, BZW1, CACYBP, CAD, CALCOCO1, CCAR2, CCPG1, CCT2, CCT3, CCT4, CCT5, CCT6A, CEP112, CKB, CLTC, CTPS1, DDX3X, DNM1L, DYNC1H1, EEF2, EIF2S3, EIF3A, EIF4A1, ERLIN1, FASN, FASTKD2, FTL, GART, GPC1, HEXB, HIST1H2BN, HMGB1, HSP90AA1, HSP90AB1, HSPA8, HSPH1, IPO5, IPO7, KLHL8, KPNA2, KPNA4, KPNB1, LPL, LRRC59, MAT2A, MFF, MTHFD1, MTMR4, NCOA4, NPR3, NUP155, PABPC1, PAICS, PAIP1, PDCD6, PFKM, PFKP, PGD, PHGDH, PRKACA, PRKAR1A, PSMC1, PSMC3, PSMC4, PSMC5, PSMC6, PSMD2, RAB18, RAB1A, RAB21, RAB2A, RAB5C, RAB7A, RAB8A, RHEB, RPS17, RRM1, RTN4, S100A6, SAR1B, SDC2, SDC4, SDCBP, SEPT7, SMC4, SPG20, ST13P5, STIP1, SYNGR2, TAGLN2, TBC1D15, TCP1, TFRC, TM9SF2, TMEM59, TNPO1, TPP1, TRAF2, TRAF3, TRIP13, TUBB4B, VAPA, VAPB, YBX1, YWHAB, YWHAE, TRIO, HECTD1, WNK1, SPATA5L1, CTNNB1, LUZP1, MTCL1, STAM, TMEM160, POLR2B, TNKS1BP1, PPP6R3, KIF11, RTN3, ADAR, RACGAP1, BUB3, CORO1B, PABPC4, MAP7, DCXR, TSR1, DNMT1, ZC3HAV1, RPS27A, RAB6A, ADRM1, DHX9, UBA1, GSTP1, ACTG1, CISD2, DNAJA4, SETX, KIAA0101, TYSND1, STARD7, RNF114, ALKBH5, LGALS1, ARPC1A, TPM2, MRPS11, NT5C2, ACOT1, MRPS21, ARHGEF1, UBAP2L, SLC38A2, RPP38, MAP7D3, BAG1, MMS19, EARS2, SPATS2L, LGALS3BP, OXSR1, ARHGEF40, IGF2R, TUBG1, NUP188, TNPO3, PTRF, TDRD3, MORF4L2, NIF3L1, NIPBL, FTH1, CHEK2, FBXO3, RPL37A, METAP2, MRPS23, RPS19, SART1, APRT, WBSCR22, HMGB2, RPL12, PSIP1, RPS7, STRBP, ZC3H15, MAGT1, DHX37, RFC1, SRP72, PRPF31, SEMA3C, HNRNPA0, SCAMP3, SRPK1, UPF3B, ZFR, SYNCRIP, ILF2, SLK, AP3D1, ARPC4-TTLL3, RPS26, SSBP1, HNRNPAB, TMEM192, SCAP, CNR2, KLF15, SAMM50, IMMT, MTX1, MAP1LC3B2, VPS29, TOMM40, PSMB4, TRIM44,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SQSTM1all structure
CDKN1C


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+37122_224140.33333333333334357.0GABRR3
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+59122_224140.33333333333334357.0GABRR3
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+48122_224140.33333333333334357.0GABRR3
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+37347_352140.33333333333334357.0KEAP1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+59347_352140.33333333333334357.0KEAP1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000389805+48347_352224.33333333333334441.0KEAP1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+48347_352140.33333333333334357.0KEAP1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000360718+37269_440140.33333333333334357.0NTRK1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000376929+59269_440140.33333333333334357.0NTRK1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000389805+48269_440224.33333333333334441.0NTRK1
HgeneSQSTM1chr5:179251323chr11:2905364ENST00000402874+48269_440140.33333333333334357.0NTRK1


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Related Drugs to SQSTM1-CDKN1C


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SQSTM1-CDKN1C


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSQSTM1C4085252PAGET DISEASE OF BONE 39GENOMICS_ENGLAND;UNIPROT
HgeneSQSTM1C0002736Amyotrophic Lateral Sclerosis5CTD_human;ORPHANET
HgeneSQSTM1C4225326FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 34CTD_human;UNIPROT
HgeneSQSTM1C0029463Osteosarcoma2GENOMICS_ENGLAND
HgeneSQSTM1C0221054Welander Distal Myopathy1ORPHANET
HgeneSQSTM1C0242383Age related macular degeneration1CTD_human
HgeneSQSTM1C0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
HgeneSQSTM1C0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
HgeneSQSTM1C1853926NONAKA MYOPATHY1CTD_human;GENOMICS_ENGLAND
HgeneSQSTM1C2931290Welander distal myopathy, Swedish type1ORPHANET
HgeneSQSTM1C3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET
HgeneSQSTM1C4011788Behavioral variant of frontotemporal dementia1ORPHANET