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Fusion Protein:SS18-SSX4 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: SS18-SSX4 | FusionPDB ID: 86685 | FusionGDB2.0 ID: 86685 | Hgene | Tgene | Gene symbol | SS18 | SSX4 | Gene ID | 6760 | 6759 |
Gene name | SS18 subunit of BAF chromatin remodeling complex | SSX family member 4 | |
Synonyms | SSXT|SYT | CT5.4 | |
Cytomap | 18q11.2 | Xp11.23 | |
Type of gene | protein-coding | protein-coding | |
Description | protein SSXTSS18, nBAF chromatin remodeling complex subunitsynovial sarcoma translocated to X chromosome proteinsynovial sarcoma translocation, chromosome 18synovial sarcoma, translocated to X chromosome | protein SSX4cancer/testis antigen 5.4synovial sarcoma, X breakpoint 4 | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | O75177 | O60224 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000269137, ENST00000415083, ENST00000539849, ENST00000542420, ENST00000542743, ENST00000545952, ENST00000585241, | ENST00000375517, ENST00000376886, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 24 X 33 X 8=6336 | 1 X 4 X 2=8 |
# samples | 38 | 2 | |
** MAII score | log2(38/6336*10)=-4.05950101174866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: SS18 [Title/Abstract] AND SSX4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | SS18(23612363)-SSX4(48248786), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | SS18-SSX4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SS18-SSX4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SS18-SSX4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SS18-SSX4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SS18-SSX4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. SS18-SSX4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | SS18 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 15919756 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerKB3 | . | . | SS18 | chr18 | 23596216 | - | SSX4 | chrX | 48244002 | + |
ChimerKB3 | . | . | SS18 | chr18 | 23596216 | - | SSX4 | chrX | 48248787 | + |
ChimerKB3 | . | . | SS18 | chr18 | 23596216 | - | SSX4 | chrX | 48251310 | + |
ChimerKB3 | . | . | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48244002 | + |
ChimerKB3 | . | . | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48248787 | + |
ChimerKB3 | . | . | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48251310 | + |
ChiTaRS5.0 | N/A | AF114234 | SS18 | chr18 | 23612363 | - | SSX4 | chrX | 48248786 | + |
ChiTaRS5.0 | N/A | AF257500 | SS18 | chr18 | 23612363 | - | SSX4 | chrX | 48248786 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000415083 | SS18 | chr18 | 23612362 | - | ENST00000376886 | SSX4 | chrX | 48244002 | + | 2376 | 1286 | 56 | 1783 | 575 |
ENST00000415083 | SS18 | chr18 | 23612362 | - | ENST00000375517 | SSX4 | chrX | 48244002 | + | 1745 | 1286 | 56 | 1678 | 540 |
ENST00000269137 | SS18 | chr18 | 23612362 | - | ENST00000376886 | SSX4 | chrX | 48244002 | + | 2559 | 1469 | 161 | 1966 | 601 |
ENST00000269137 | SS18 | chr18 | 23612362 | - | ENST00000375517 | SSX4 | chrX | 48244002 | + | 1928 | 1469 | 161 | 1861 | 566 |
ENST00000545952 | SS18 | chr18 | 23612362 | - | ENST00000376886 | SSX4 | chrX | 48244002 | + | 2374 | 1284 | 303 | 1781 | 492 |
ENST00000545952 | SS18 | chr18 | 23612362 | - | ENST00000375517 | SSX4 | chrX | 48244002 | + | 1743 | 1284 | 303 | 1676 | 457 |
ENST00000415083 | SS18 | chr18 | 23612362 | - | ENST00000376886 | SSX4 | chrX | 48248787 | + | 2115 | 1286 | 56 | 1522 | 488 |
ENST00000269137 | SS18 | chr18 | 23612362 | - | ENST00000376886 | SSX4 | chrX | 48248787 | + | 2298 | 1469 | 161 | 1705 | 514 |
ENST00000545952 | SS18 | chr18 | 23612362 | - | ENST00000376886 | SSX4 | chrX | 48248787 | + | 2113 | 1284 | 303 | 1520 | 405 |
ENST00000415083 | SS18 | chr18 | 23612362 | - | ENST00000375517 | SSX4 | chrX | 48251310 | + | 1484 | 1286 | 56 | 1417 | 453 |
ENST00000542743 | SS18 | chr18 | 23612362 | - | ENST00000376886 | SSX4 | chrX | 48251310 | + | 2024 | 1331 | 350 | 1462 | 370 |
ENST00000269137 | SS18 | chr18 | 23612362 | - | ENST00000375517 | SSX4 | chrX | 48251310 | + | 1667 | 1469 | 161 | 1600 | 479 |
ENST00000545952 | SS18 | chr18 | 23612362 | - | ENST00000375517 | SSX4 | chrX | 48251310 | + | 1482 | 1284 | 303 | 1415 | 370 |
ENST00000415083 | SS18 | chr18 | 23612363 | - | ENST00000376886 | SSX4 | chrX | 48248786 | + | 2115 | 1286 | 56 | 1522 | 488 |
ENST00000269137 | SS18 | chr18 | 23612363 | - | ENST00000376886 | SSX4 | chrX | 48248786 | + | 2298 | 1469 | 161 | 1705 | 514 |
ENST00000545952 | SS18 | chr18 | 23612363 | - | ENST00000376886 | SSX4 | chrX | 48248786 | + | 2113 | 1284 | 303 | 1520 | 405 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000415083 | ENST00000376886 | SS18 | chr18 | 23612363 | - | SSX4 | chrX | 48248786 | + | 0.002362867 | 0.99763715 |
ENST00000269137 | ENST00000376886 | SS18 | chr18 | 23612363 | - | SSX4 | chrX | 48248786 | + | 0.002784379 | 0.9972156 |
ENST00000545952 | ENST00000376886 | SS18 | chr18 | 23612363 | - | SSX4 | chrX | 48248786 | + | 0.001066881 | 0.99893314 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >86685_86685_1_SS18-SSX4_SS18_chr18_23612362_ENST00000269137_SSX4_chrX_48244002_ENST00000375517_length(amino acids)=566AA_BP=436 MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFDDIAKYFSKKEW EKMKSSEKIVYVYMKLNYEVMTKLGFKVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKDPKGGNMPGPTDCVRES -------------------------------------------------------------- >86685_86685_2_SS18-SSX4_SS18_chr18_23612362_ENST00000269137_SSX4_chrX_48244002_ENST00000376886_length(amino acids)=601AA_BP=435 MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFDDIAKYFSKKEW EKMKSSEKIVYVYMKLNYEVMTKLGFKVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKIMPKKPAEEENGLKEVP -------------------------------------------------------------- >86685_86685_3_SS18-SSX4_SS18_chr18_23612362_ENST00000269137_SSX4_chrX_48248787_ENST00000376886_length(amino acids)=514AA_BP=436 MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEEENGLK -------------------------------------------------------------- >86685_86685_4_SS18-SSX4_SS18_chr18_23612362_ENST00000269137_SSX4_chrX_48251310_ENST00000375517_length(amino acids)=479AA_BP=436 MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCV -------------------------------------------------------------- >86685_86685_5_SS18-SSX4_SS18_chr18_23612362_ENST00000415083_SSX4_chrX_48244002_ENST00000375517_length(amino acids)=540AA_BP=410 MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFDDIAKYFSKKEWEKMKSSEKIVYVYMKLNYEVMTKLGF KVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKDPKGGNMPGPTDCVRESSWWFMKRSATLRKMTSNSPRGYDTCP -------------------------------------------------------------- >86685_86685_6_SS18-SSX4_SS18_chr18_23612362_ENST00000415083_SSX4_chrX_48244002_ENST00000376886_length(amino acids)=575AA_BP=409 MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFDDIAKYFSKKEWEKMKSSEKIVYVYMKLNYEVMTKLGF KVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKIMPKKPAEEENGLKEVPEASGPQNDGKQLCPPGNPSTLEKINK -------------------------------------------------------------- >86685_86685_7_SS18-SSX4_SS18_chr18_23612362_ENST00000415083_SSX4_chrX_48248787_ENST00000376886_length(amino acids)=488AA_BP=410 MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEEENGLKEVPEASGPQNDGKQLCPPGNPSTLEK -------------------------------------------------------------- >86685_86685_8_SS18-SSX4_SS18_chr18_23612362_ENST00000415083_SSX4_chrX_48251310_ENST00000375517_length(amino acids)=453AA_BP=410 MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCVRESSWWFMKRSATLRKMTSNSPRGYD -------------------------------------------------------------- >86685_86685_9_SS18-SSX4_SS18_chr18_23612362_ENST00000542743_SSX4_chrX_48251310_ENST00000376886_length(amino acids)=370AA_BP=327 MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCVRESSWWFMKRSATLRKMTS -------------------------------------------------------------- >86685_86685_10_SS18-SSX4_SS18_chr18_23612362_ENST00000545952_SSX4_chrX_48244002_ENST00000375517_length(amino acids)=457AA_BP=327 MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFDDIAKYFSKKEWEKMKSSEKIVYVYMKLNYE VMTKLGFKVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKDPKGGNMPGPTDCVRESSWWFMKRSATLRKMTSNSP -------------------------------------------------------------- >86685_86685_11_SS18-SSX4_SS18_chr18_23612362_ENST00000545952_SSX4_chrX_48244002_ENST00000376886_length(amino acids)=492AA_BP=326 MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFDDIAKYFSKKEWEKMKSSEKIVYVYMKLNYE VMTKLGFKVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKIMPKKPAEEENGLKEVPEASGPQNDGKQLCPPGNPS -------------------------------------------------------------- >86685_86685_12_SS18-SSX4_SS18_chr18_23612362_ENST00000545952_SSX4_chrX_48248787_ENST00000376886_length(amino acids)=405AA_BP=327 MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEEENGLKEVPEASGPQNDGKQLCPPG -------------------------------------------------------------- >86685_86685_13_SS18-SSX4_SS18_chr18_23612362_ENST00000545952_SSX4_chrX_48251310_ENST00000375517_length(amino acids)=370AA_BP=327 MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCVRESSWWFMKRSATLRKMTS -------------------------------------------------------------- >86685_86685_14_SS18-SSX4_SS18_chr18_23612363_ENST00000269137_SSX4_chrX_48248786_ENST00000376886_length(amino acids)=514AA_BP=436 MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEEENGLK -------------------------------------------------------------- >86685_86685_15_SS18-SSX4_SS18_chr18_23612363_ENST00000415083_SSX4_chrX_48248786_ENST00000376886_length(amino acids)=488AA_BP=410 MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEEENGLKEVPEASGPQNDGKQLCPPGNPSTLEK -------------------------------------------------------------- >86685_86685_16_SS18-SSX4_SS18_chr18_23612363_ENST00000545952_SSX4_chrX_48248786_ENST00000376886_length(amino acids)=405AA_BP=327 MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEEENGLKEVPEASGPQNDGKQLCPPG -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:23612363/chrX:48248786) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
SS18 | SSX4 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Could act as a modulator of transcription. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000269137 | - | 9 | 10 | 95_99 | 379.0 | 388.0 | Compositional bias | Note=Poly-Pro |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000415083 | - | 10 | 11 | 95_99 | 410.0 | 419.0 | Compositional bias | Note=Poly-Pro |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000269137 | - | 9 | 10 | 374_377 | 379.0 | 388.0 | Motif | SH2-binding |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000269137 | - | 9 | 10 | 50_53 | 379.0 | 388.0 | Motif | SH2-binding |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000415083 | - | 10 | 11 | 374_377 | 410.0 | 419.0 | Motif | SH2-binding |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000415083 | - | 10 | 11 | 392_401 | 410.0 | 419.0 | Motif | SH3-binding |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000415083 | - | 10 | 11 | 50_53 | 410.0 | 419.0 | Motif | SH2-binding |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000269137 | - | 9 | 10 | 2_186 | 379.0 | 388.0 | Region | Note=Transcriptional activation |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000269137 | - | 9 | 10 | 344_369 | 379.0 | 388.0 | Region | Note=2 X 13 AA imperfect tandem repeats |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000415083 | - | 10 | 11 | 2_186 | 410.0 | 419.0 | Region | Note=Transcriptional activation |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000415083 | - | 10 | 11 | 344_369 | 410.0 | 419.0 | Region | Note=2 X 13 AA imperfect tandem repeats |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000269137 | - | 9 | 10 | 344_356 | 379.0 | 388.0 | Repeat | Note=1 |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000269137 | - | 9 | 10 | 357_369 | 379.0 | 388.0 | Repeat | Note=2 |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000415083 | - | 10 | 11 | 344_356 | 410.0 | 419.0 | Repeat | Note=1 |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000415083 | - | 10 | 11 | 357_369 | 410.0 | 419.0 | Repeat | Note=2 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000269137 | - | 9 | 10 | 175_418 | 379.0 | 388.0 | Compositional bias | Note=Gln-rich |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000415083 | - | 10 | 11 | 175_418 | 410.0 | 419.0 | Compositional bias | Note=Gln-rich |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000269137 | - | 9 | 10 | 392_401 | 379.0 | 388.0 | Motif | SH3-binding |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000269137 | - | 9 | 10 | 413_416 | 379.0 | 388.0 | Motif | SH2-binding |
Hgene | SS18 | chr18:23612363 | chrX:48248786 | ENST00000415083 | - | 10 | 11 | 413_416 | 410.0 | 419.0 | Motif | SH2-binding |
Tgene | SSX4 | chr18:23612363 | chrX:48248786 | ENST00000376886 | 4 | 8 | 20_83 | 110.0 | 337.3333333333333 | Domain | KRAB-related |
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Fusion Protein Structures |
![]() * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
PDB file (123) >>>123.pdbFusion protein BP residue: 327 CIF file (123) >>>123.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48251310 | + | MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSH NMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNM PSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQ GPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPP YRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQ DAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQ GQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCVRESSWWFMK | 370 |
3D view using mol* of 123 (AA BP:327) | ||||||||||
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PDB file (168) >>>168.pdbFusion protein BP residue: 327 CIF file (168) >>>168.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48248787 | + | MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSH NMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNM PSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQ GPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPP YRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQ DAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQ GQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEEENGLKEVPEASGPQ NDGKQLCPPGNPSTLEKINKTSGPKRGKHAWTHRLRERKQLVVYEEISDP | 405 |
3D view using mol* of 168 (AA BP:327) | ||||||||||
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PDB file (223) >>>223.pdbFusion protein BP residue: 410 CIF file (223) >>>223.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48251310 | + | MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQY QQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPR SHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSM NMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQP NQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQI PPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGY QQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQ QYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQP PQQRPYGYDQDPKGGNMPGPTDCVRESSWWFMKRSATLRKMTSNSPRGYD | 453 |
3D view using mol* of 223 (AA BP:410) | ||||||||||
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PDB file (229) >>>229.pdbFusion protein BP residue: 327 CIF file (229) >>>229.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48244002 | + | MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSH NMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNM PSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQ GPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPP YRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQ DAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQ GQQYGGYRPTQPGPPQPPQQRPYGYDQAFDDIAKYFSKKEWEKMKSSEKI VYVYMKLNYEVMTKLGFKVTLPPFMRSKRAADFHGNDFGNDRNHRNQVER PQMTFGSLQRIFPKDPKGGNMPGPTDCVRESSWWFMKRSATLRKMTSNSP | 457 |
3D view using mol* of 229 (AA BP:327) | ||||||||||
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PDB file (262) >>>262.pdbFusion protein BP residue: 436 CIF file (262) >>>262.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48251310 | + | MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLA DSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGK TSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQS GPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQL NMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPR PNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNH MMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPD GNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGP QYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCV | 479 |
3D view using mol* of 262 (AA BP:436) | ||||||||||
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PDB file (281) >>>281.pdbFusion protein BP residue: 410 CIF file (281) >>>281.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48248787 | + | MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQY QQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPR SHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSM NMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQP NQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQI PPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGY QQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQ QYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQP PQQRPYGYDQIMPKKPAEEENGLKEVPEASGPQNDGKQLCPPGNPSTLEK | 488 |
3D view using mol* of 281 (AA BP:410) | ||||||||||
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PDB file (285) >>>285.pdbFusion protein BP residue: 326 CIF file (285) >>>285.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48244002 | + | MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSH NMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNM PSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQ GPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPP YRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQ DAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQ GQQYGGYRPTQPGPPQPPQQRPYGYDQAFDDIAKYFSKKEWEKMKSSEKI VYVYMKLNYEVMTKLGFKVTLPPFMRSKRAADFHGNDFGNDRNHRNQVER PQMTFGSLQRIFPKIMPKKPAEEENGLKEVPEASGPQNDGKQLCPPGNPS | 492 |
3D view using mol* of 285 (AA BP:326) | ||||||||||
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PDB file (325) >>>325.pdbFusion protein BP residue: 436 CIF file (325) >>>325.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48248787 | + | MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLA DSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGK TSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQS GPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQL NMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPR PNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNH MMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPD GNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGP QYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQIMPKKPAEEENGLK EVPEASGPQNDGKQLCPPGNPSTLEKINKTSGPKRGKHAWTHRLRERKQL | 514 |
3D view using mol* of 325 (AA BP:436) | ||||||||||
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PDB file (374) >>>374.pdbFusion protein BP residue: 410 CIF file (374) >>>374.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48244002 | + | MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQY QQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPR SHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSM NMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQP NQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQI PPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGY QQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQ QYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQP PQQRPYGYDQAFDDIAKYFSKKEWEKMKSSEKIVYVYMKLNYEVMTKLGF KVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKDPK | 540 |
3D view using mol* of 374 (AA BP:410) | ||||||||||
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PDB file (416) >>>416.pdbFusion protein BP residue: 436 CIF file (416) >>>416.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48244002 | + | MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLA DSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGK TSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQS GPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQL NMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPR PNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNH MMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPD GNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGP QYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFDDIAKYFSKKEW EKMKSSEKIVYVYMKLNYEVMTKLGFKVTLPPFMRSKRAADFHGNDFGND RNHRNQVERPQMTFGSLQRIFPKDPKGGNMPGPTDCVRESSWWFMKRSAT | 566 |
3D view using mol* of 416 (AA BP:436) | ||||||||||
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PDB file (437) >>>437.pdbFusion protein BP residue: 409 CIF file (437) >>>437.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48244002 | + | MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQY QQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPR SHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSM NMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQP NQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQI PPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGY QQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQ QYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQP PQQRPYGYDQAFDDIAKYFSKKEWEKMKSSEKIVYVYMKLNYEVMTKLGF KVTLPPFMRSKRAADFHGNDFGNDRNHRNQVERPQMTFGSLQRIFPKIMP KKPAEEENGLKEVPEASGPQNDGKQLCPPGNPSTLEKINKTSGPKRGKHA | 575 |
3D view using mol* of 437 (AA BP:409) | ||||||||||
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PDB file (475) >>>475.pdbFusion protein BP residue: 435 CIF file (475) >>>475.cif | SS18 | chr18 | 23612362 | - | SSX4 | chrX | 48244002 | + | MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLA DSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGK TSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQS GPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQL NMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPR PNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNH MMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPD GNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGP QYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFDDIAKYFSKKEW EKMKSSEKIVYVYMKLNYEVMTKLGFKVTLPPFMRSKRAADFHGNDFGND RNHRNQVERPQMTFGSLQRIFPKIMPKKPAEEENGLKEVPEASGPQNDGK QLCPPGNPSTLEKINKTSGPKRGKHAWTHRLRERKQLVVYEEISDPEEDD | 601 |
3D view using mol* of 475 (AA BP:435) | ||||||||||
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pLDDT score distribution |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
SS18_pLDDT.png![]() |
SSX4_pLDDT.png![]() |
![]() * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
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Potential Active Site Information |
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Fusion AA seq ID in FusionPDB | Site score | Size | D score | Volume | Exposure | Enclosure | Contact | Phobic | Philic | Balance | Don/Acc | Residues |
123 | 0.338 | 9 | 0.279 | 0.343 | 0.857 | 0.381 | 0.562 | 0.378 | 0.711 | 0.532 | 1.15 | Chain A: 141,142,143,144 |
168 | 0.321 | 8 | 0.215 | 3.087 | 0.837 | 0.457 | 0.787 | 0.093 | 0.996 | 0.093 | 0.637 | Chain A: 33,34,35,36,37,38 |
223 | 0.999 | 88 | 1.011 | 200.998 | 0.519 | 0.744 | 1.065 | 1.025 | 0.974 | 1.052 | 0.696 | Chain A: 22,25,26,28,29,32,33,35,36,39,51,54,58,61 ,424,427,428,429,431,432,435,438,439 |
229 | 1.082 | 342 | 1.151 | 990.241 | 0.524 | 0.711 | 0.952 | 1.4 | 0.663 | 2.113 | 1.527 | Chain A: 1,2,3,6,7,9,10,12,13,14,16,17,19,20,320,3 21,322,323,325,328,329,331,350,353,354,356,357,358 ,360,361,364,365,416,417,418,419,421,422,424,425,4 26,427,428,429,430,431,432,434,435,436,450,452,453 ,455,456,457 |
262 | 0.954 | 76 | 0.985 | 222.95 | 0.648 | 0.691 | 0.991 | 1.056 | 0.764 | 1.383 | 0.858 | Chain A: 82,85,86,89,92,93,96,99,101,104,108,111,1 15,447,450,453,454,455,457,458,461,465 |
281 | 1.018 | 138 | 1.096 | 480.543 | 0.678 | 0.612 | 0.816 | 1.035 | 0.648 | 1.597 | 1.183 | Chain A: 5,6,7,8,9,11,12,13,14,15,16,17,20,21,23,2 4,27,49,51,52,53,54,55,56,57,58,59,60,63,64,464,46 7,468 |
285 | 1.155 | 181 | 1.238 | 551.887 | 0.45 | 0.779 | 1.044 | 2.477 | 0.518 | 4.785 | 0.719 | Chain A: 1,2,4,5,6,8,9,322,323,325,328,329,331,332 ,350,351,353,354,355,356,357,360,361,364,405,408,4 09,411,412,413,414,415 |
325 | 0.835 | 59 | 0.857 | 218.491 | 0.72 | 0.611 | 0.792 | 0.746 | 0.71 | 1.051 | 1.03 | Chain A: 65,66,68,69,71,72,73,77,78,109,112,113,11 6,117,120,121 |
374 | 0.9345 | 4855 | 1.0503 | 2545.06 | 0.6632 | 0.4322 | 0.4022 | 0.3533 | 0.4573 | 0.7725 | 0.9652 | Chain A: 3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18, 20,21,22,23,24,25,27,28,29,30,31,32,33,34,35,36,37 ,38,39,40,41,42,43,44,46,47,48,49,50,51,52,53,54,5 5,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71, 72,73,74,75,76,77,78,400,401,402,403,404,405,406,4 07,408,409,410,411,412,413,414,416,417,418,419,420 ,421,422,423,424,426,427,428,429,430,431,432,433,4 34,435,436,437,438,439,440,441,442,443,444,445,446 ,447,448,450,451,452,453,454,455,456,457,458,459,4 60,461,462,465,466,480,481,482,483,484,485,486,487 ,488,489,490,491,492,493,494,495,496,497,498,499,5 00,501,502,503,504,505,506,507,508,509,510,511,512 ,513,514,515,516,517,518,519,520,521,522,523,524,5 25,526,527,528,529,530,531,532,533,534,535,536,537 ,538,539,540 |
416 | 0.963 | 44 | 0.932 | 61.74 | 0.38 | 0.936 | 1.399 | 2.929 | 0.776 | 3.777 | 0.628 | Chain A: 460,463,464,467,468,471,481,512,514,517,5 36,539,540,543,544 |
437 | 1.056 | 129 | 1.121 | 366.667 | 0.564 | 0.687 | 0.914 | 1.391 | 0.71 | 1.958 | 0.793 | Chain A: 35,39,44,47,48,51,54,55,58,430,433,434,43 7,488,491,492,495,496,497,498,499,500,501 |
475 | 1.0925 | 113 | 1.1832 | 227.066 | 0.5654 | 0.6851 | 0.8799 | 1.8905 | 0.5149 | 3.6714 | 0.7784 | Chain A: 434,456,459,460,462,463,514,517,518,521,5 22,523,524,525,526,527,528 |
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Potentially Interacting Small Molecules through Virtual Screening |
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Fusion AA seq ID in FusionPDB | ZINC ID | DrugBank ID | Drug name | Docking score | Glide gscore |
223 | ZINC000000057255 | DB00310 | Chlorthalidone | -6.63185 | -6.63325 |
223 | ZINC000000020253 | DB00310 | Chlorthalidone | -6.46611 | -6.46751 |
223 | ZINC000000509440 | DB00842 | Oxazepam | -6.45659 | -6.45659 |
223 | ZINC000000006157 | DB00751 | Epinastine | -4.76565 | -6.40975 |
223 | ZINC000001547851 | DB11868 | Etiracetam | -6.40559 | -6.40559 |
223 | ZINC000008143864 | DB09134 | Ioversol | -6.37744 | -6.37744 |
223 | ZINC000000896634 | DB00231 | Temazepam | -6.37103 | -6.37103 |
223 | ZINC000000085733 | DB00181 | Baclofen | -6.29964 | -6.29964 |
223 | ZINC000000007782 | DB06201 | Rufinamide | -6.26332 | -6.26332 |
223 | ZINC000000020220 | DB00537 | Ciprofloxacin | -6.12308 | -6.22288 |
223 | ZINC000000121541 | DB00643 | Mebendazole | -5.53118 | -6.21388 |
223 | ZINC000028973446 | DB00628 | Clorazepic acid | -6.20329 | -6.20329 |
223 | ZINC000000006427 | DB00829 | Diazepam | -6.18983 | -6.18983 |
223 | ZINC000000896731 | DB00744 | Zileuton | -6.15026 | -6.16886 |
223 | ZINC000019632917 | DB00475 | Chlordiazepoxide | -6.11138 | -6.15928 |
223 | ZINC000001482184 | DB00853 | Temozolomide | -6.15248 | -6.15408 |
223 | ZINC000000001899 | DB00299 | Penciclovir | -6.11976 | -6.11976 |
223 | ZINC000084441937 | DB00759 | Tetracycline | -5.97564 | -6.11524 |
223 | ZINC000001999441 | DB04861 | Nebivolol | -6.0585 | -6.0783 |
223 | ZINC000008035395 | DB09134 | Ioversol | -6.07282 | -6.07282 |
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ZINC ID | DrugBank ID | Drug name | Drug type | SMILES | Drug group |
ZINC000000057255 | DB00310 | Chlorthalidone | Small molecule | NS(=O)(=O)C1=C(Cl)C=CC(=C1)C1(O)NC(=O)C2=CC=CC=C12 | Approved |
ZINC000008143864 | DB09134 | Ioversol | Small molecule | OCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I | Approved |
ZINC000000085733 | DB00181 | Baclofen | Small molecule | NCC(CC(O)=O)C1=CC=C(Cl)C=C1 | Approved |
ZINC000000007782 | DB06201 | Rufinamide | Small molecule | NC(=O)C1=CN(CC2=C(F)C=CC=C2F)N=N1 | Approved |
ZINC000000020220 | DB00537 | Ciprofloxacin | Small molecule | OC(=O)C1=CN(C2CC2)C2=CC(N3CCNCC3)=C(F)C=C2C1=O | Approved|Investigational |
ZINC000000121541 | DB00643 | Mebendazole | Small molecule | COC(=O)NC1=NC2=C(N1)C=C(C=C2)C(=O)C1=CC=CC=C1 | Approved|Vet_approved |
ZINC000028973446 | DB00628 | Clorazepic acid | Small molecule | OC(=O)C1N=C(C2=CC=CC=C2)C2=C(NC1=O)C=CC(Cl)=C2 | Approved|Illicit |
ZINC000000006427 | DB00829 | Diazepam | Small molecule | CN1C2=C(C=C(Cl)C=C2)C(=NCC1=O)C1=CC=CC=C1 | Approved|Illicit|Investigational|Vet_approved |
ZINC000000896731 | DB00744 | Zileuton | Small molecule | CC(N(O)C(N)=O)C1=CC2=CC=CC=C2S1 | Approved|Investigational|Withdrawn |
ZINC000019632917 | DB00475 | Chlordiazepoxide | Small molecule | CNC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2)=[N+]([O-])C1 | Approved|Illicit|Investigational |
ZINC000001482184 | DB00853 | Temozolomide | Small molecule | CN1N=NC2=C(N=CN2C1=O)C(N)=O | Approved|Investigational |
ZINC000000001899 | DB00299 | Penciclovir | Small molecule | NC1=NC(=O)C2=C(N1)N(CCC(CO)CO)C=N2 | Approved |
ZINC000084441937 | DB00759 | Tetracycline | Small molecule | [H][C@@]12C[C@@]3([H])C(=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C)C(=O)C1=C(O)C=CC=C1[C@@]3(C)O | Approved|Vet_approved |
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Biochemical Features of Small Molecules |
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ZINC ID | mol_MW | dipole | SASA | FOSA | FISA | PISA | WPSA | volume | donorHB | accptHB | IP | Human Oral Absorption | Percent Human Oral Absorption | Rule Of Five | Rule Of Three |
ZINC000000057255 | 338.765 | 9.032 | 531.758 | 0.001 | 243.761 | 234.495 | 53.501 | 911.032 | 4 | 7.75 | 10.165 | 2 | 59.138 | 0 | 0 |
ZINC000000020253 | 338.765 | 5.817 | 531.475 | 0 | 243.204 | 234.864 | 53.406 | 910.356 | 4 | 7.75 | 10.189 | 2 | 59.233 | 0 | 0 |
ZINC000000509440 | 286.717 | 3.437 | 510.923 | 24.832 | 130.585 | 284.062 | 71.444 | 859.771 | 2 | 5.2 | 9.187 | 3 | 89.415 | 0 | 0 |
ZINC000000006157 | 249.315 | 4.842 | 470.726 | 92.019 | 78.033 | 300.675 | 0 | 820.853 | 2 | 2 | 8.106 | 3 | 100 | 0 | 0 |
ZINC000000006157 | 249.315 | 3.771 | 466.453 | 87.17 | 78.72 | 300.564 | 0 | 823.493 | 2 | 2 | 8.486 | 3 | 100 | 0 | 0 |
ZINC000001547851 | 170.211 | 3.554 | 386.861 | 254.133 | 132.728 | 0 | 0 | 627.872 | 2 | 5.5 | 9.606 | 2 | 59.075 | 0 | 0 |
ZINC000008143864 | 807.116 | 5.478 | 759.618 | 304.239 | 335.909 | 6.136 | 113.333 | 1427.748 | 8 | 18.2 | 9.211 | 1 | 0 | 3 | 1 |
ZINC000000896634 | 300.744 | 3.437 | 532.53 | 97.287 | 98.824 | 265.015 | 71.404 | 911.443 | 1 | 5.7 | 9.157 | 3 | 96.46 | 0 | 0 |
ZINC000000085733 | 213.663 | 3.613 | 420.91 | 80.54 | 149.736 | 119.128 | 71.506 | 697.141 | 3 | 3 | 9.549 | 2 | 48.776 | 0 | 0 |
ZINC000000007782 | 238.196 | 4.498 | 437.538 | 39.302 | 165.455 | 174.301 | 58.479 | 721.091 | 2 | 5 | 9.71 | 3 | 76.028 | 0 | 0 |
ZINC000000020220 | 331.346 | 8.67 | 578.412 | 299.833 | 178.539 | 68.487 | 31.553 | 1017.371 | 1 | 6 | 8.925 | 2 | 48.33 | 0 | 1 |
ZINC000000020220 | 331.346 | 8.111 | 575.511 | 298.04 | 176.667 | 69.246 | 31.558 | 1012.813 | 1 | 6 | 8.79 | 2 | 48.648 | 0 | 1 |
ZINC000000121541 | 295.297 | 6.562 | 576.161 | 98.468 | 169.387 | 308.306 | 0 | 957.18 | 1 | 5 | 8.911 | 3 | 83.641 | 0 | 0 |
ZINC000000121541 | 295.297 | 2.873 | 577.033 | 96.773 | 172.83 | 307.43 | 0 | 959.022 | 0 | 3 | 8.668 | 3 | 88.187 | 0 | 0 |
ZINC000000121541 | 295.297 | 10.919 | 575.199 | 98.469 | 170.072 | 306.658 | 0 | 956.419 | 1 | 5 | 8.861 | 3 | 83.461 | 0 | 0 |
ZINC000028973446 | 314.727 | 9.396 | 534.849 | 1.861 | 174.43 | 287.106 | 71.453 | 912.795 | 0 | 3.5 | 9.55 | 3 | 78.063 | 0 | 0 |
ZINC000000006427 | 284.744 | 4.728 | 520.923 | 120.031 | 61.526 | 267.939 | 71.426 | 890.968 | 0 | 4 | 9.194 | 3 | 100 | 0 | 0 |
ZINC000000896731 | 236.288 | 3.773 | 444.598 | 84.301 | 131.134 | 195.105 | 34.058 | 746.481 | 3 | 3.7 | 8.644 | 3 | 78.18 | 0 | 0 |
ZINC000000896731 | 236.288 | 5.297 | 450.816 | 85.528 | 135.414 | 201.881 | 27.993 | 746.812 | 3 | 3.7 | 8.57 | 3 | 76.556 | 0 | 0 |
ZINC000019632917 | 299.759 | 4.645 | 553.04 | 137.022 | 64.707 | 279.788 | 71.524 | 941.819 | 1 | 3 | 8.565 | 3 | 100 | 0 | 0 |
ZINC000019632917 | 299.759 | 5.502 | 549.003 | 118.965 | 74.766 | 283.82 | 71.453 | 935.577 | 1 | 3 | 8.408 | 3 | 100 | 0 | 0 |
ZINC000001482184 | 194.152 | 3.411 | 379.128 | 87.887 | 235.051 | 56.19 | 0 | 597.216 | 2 | 7 | 9.649 | 2 | 51.425 | 0 | 0 |
ZINC000000001899 | 253.26 | 10.065 | 488.204 | 144.44 | 279.885 | 63.878 | 0 | 807.088 | 5 | 8.9 | 8.591 | 2 | 42.536 | 0 | 1 |
ZINC000084441937 | 444.44 | 7.923 | 627.272 | 219.71 | 287.581 | 119.981 | 0 | 1207.685 | 3 | 8.25 | 9.493 | 1 | 21.617 | 1 | 2 |
ZINC000084441937 | 444.44 | 4.721 | 623.745 | 218.485 | 285.56 | 119.699 | 0 | 1199.75 | 3 | 8.25 | 9.391 | 1 | 21.788 | 1 | 2 |
ZINC000084441937 | 444.44 | 8.559 | 624.636 | 216.229 | 288.829 | 119.577 | 0 | 1207.755 | 3 | 8.25 | 9.339 | 1 | 21.381 | 1 | 2 |
ZINC000084441937 | 444.44 | 7.965 | 648.626 | 222.257 | 306.467 | 119.902 | 0 | 1232.212 | 3 | 8.25 | 9.32 | 1 | 18.389 | 1 | 2 |
ZINC000001999441 | 405.441 | 4.722 | 712.226 | 273.488 | 84.211 | 260.774 | 93.753 | 1256.147 | 3 | 6.4 | 9.229 | 3 | 95.143 | 0 | 0 |
ZINC000001999441 | 405.441 | 0.513 | 723.645 | 269.655 | 91.189 | 269.032 | 93.768 | 1265.844 | 3 | 6.4 | 9.27 | 3 | 94.039 | 0 | 0 |
ZINC000008035395 | 807.116 | 12.861 | 789.663 | 274.386 | 383.301 | 10.854 | 121.123 | 1453.819 | 8 | 18.2 | 9.427 | 1 | 0 | 3 | 1 |
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Drug Toxicity Information |
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ZINC ID | Smile | Surface Accessibility | Toxicity |
ZINC000000057255 | NS(=O)(=O)c1cc([C@@]2(O)NC(=O)c3ccccc32)ccc1Cl | 0.128141978 | 0.345401829 |
ZINC000000020253 | NS(=O)(=O)c1cc([C@]2(O)NC(=O)c3ccccc32)ccc1Cl | 0.128141978 | 0.345401829 |
ZINC000000509440 | O=C1Nc2ccc(Cl)cc2C(c2ccccc2)=N[C@@H]1O | 0.183501241 | 0.419564566 |
ZINC000000006157 | NC1=NC[C@@H]2c3ccccc3Cc3ccccc3N12 | 0.149488501 | 0.300300567 |
ZINC000001547851 | CC[C@@H](C(N)=O)N1CCCC1=O | 0.157335861 | 0.410047131 |
ZINC000008143864 | O=C(NC[C@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(N(CCO)C(=O)CO)c1I | 0.051780669 | 0.23149478 |
ZINC000000896634 | CN1C(=O)[C@@H](O)N=C(c2ccccc2)c2cc(Cl)ccc21 | 0.181356348 | 0.322163665 |
ZINC000000085733 | NC[C@@H](CC(=O)O)c1ccc(Cl)cc1 | 0.251203336 | 0.372196692 |
ZINC000000007782 | NC(=O)c1cn(Cc2c(F)cccc2F)nn1 | 0.277145156 | 0.235759804 |
ZINC000000020220 | O=C(O)c1cn(C2CC2)c2cc(N3CCNCC3)c(F)cc2c1=O | 0.231031629 | 0.323908212 |
ZINC000000121541 | COC(=O)/N=c1[nH]c2ccc(C(=O)c3ccccc3)cc2[nH]1 | 0.209696342 | 0.592445172 |
ZINC000028973446 | O=C(O)[C@H]1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O | 0.168191138 | 0.395189961 |
ZINC000000006427 | CN1C(=O)CN=C(c2ccccc2)c2cc(Cl)ccc21 | 0.326070618 | 0.290159579 |
ZINC000000896731 | C[C@H](c1cc2ccccc2s1)N(O)C(N)=O | 0.136335882 | 0.223511692 |
ZINC000019632917 | CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C1 | 0.147320673 | 0.447326601 |
ZINC000001482184 | Cn1nnc2c(C(N)=O)ncn2c1=O | 0.160886409 | 0.261932701 |
ZINC000000001899 | Nc1nc2c(ncn2CCC(CO)CO)c(=O)[nH]1 | 0.14943774 | 0.469025203 |
ZINC000084441937 | CN(C)[C@@H]1C(O)=C(C(N)=O)C(=O)[C@@]2(O)C(O)=C3C(=O)c4c(O)cccc4[C@@](C)(O)[C@H]3C[C@@H]12 | 0.031126136 | 0.341399693 |
ZINC000001999441 | O[C@@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]1CCc2cc(F)ccc2O1 | 0.055550082 | 0.198725964 |
ZINC000008035395 | O=C(NC[C@@H](O)CO)c1c(I)c(C(=O)NC[C@@H](O)CO)c(I)c(N(CCO)C(=O)CO)c1I | 0.051780669 | 0.23149478 |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
SS18 | SMARCA2, SMARCB1, EP300, MLLT10, GRB2, Bcl7b, SMARCD1, RBM14, YWHAG, ELAVL1, CUL3, CST11, ATF2, TLE1, SMARCA5, HDAC1, HDAC2, EED, SUZ12, EZH2, SS18, NFKBID, DPF3, DPF2, SMARCE1, ARID1B, ARID1A, PHF10, SMARCC2, SMARCC1, GLTSCR1, SMARCD3, SMARCD2, SMARCA4, ARID2, DPF1, ACTL6A, ACTL6B, BCL7A, BCL7C, BCL7B, BRD9, CDKN1A, NEFM, RAB5C, SYNCRIP, Wash, FUS, DDIT3, FLI1, nsp13ab, BRD3, NR3C1, SS18L1, BRD7, PBRM1, ACTC1, STK11IP, DDX58, UBQLN2, PTPRR, T, ELF5, ERG, ETV4, FOS, GATA2, GCM1, HNF4A, IRF1, IRF4, KLF3, KLF5, LHX2, MYOD1, PAX7, SOX17, SOX2, SP7, |
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Gene | STRING network |
SS18 | ![]() |
SSX4 | ![]() |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to SS18-SSX4 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to SS18-SSX4 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
SS18 | SSX4 | Pancreatic Adenocarcinoma | MyCancerGenome | |
SS18 | SSX4 | Breast Invasive Ductal Carcinoma | MyCancerGenome | |
SS18 | SSX4 | Esophagogastric Carcinoma | MyCancerGenome | |
SS18 | SSX4 | Invasive Breast Carcinoma | MyCancerGenome | |
SS18 | SSX4 | Papillary Renal Cell Carcinoma | MyCancerGenome |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SS18 | C0039101 | synovial sarcoma | 2 | CTD_human;ORPHANET |