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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:SSBP2-MSH3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SSBP2-MSH3
FusionPDB ID: 86714
FusionGDB2.0 ID: 86714
HgeneTgene
Gene symbol

SSBP2

MSH3

Gene ID

23635

4437

Gene namesingle stranded DNA binding protein 2mutS homolog 3
SynonymsHSPC116|SOSS-B2DUP|FAP4|MRP1
Cytomap

5q14.1

5q14.1

Type of geneprotein-codingprotein-coding
Descriptionsingle-stranded DNA-binding protein 2sequence-specific single-stranded-DNA-binding protein 2DNA mismatch repair protein Msh3divergent upstream proteinepididymis secretory sperm binding proteinhMSH3mismatch repair protein 1
Modification date2020031320200327
UniProtAcc

P81877

P20585

Ensembl transtripts involved in fusion geneENST idsENST00000320672, ENST00000505980, 
ENST00000509053, ENST00000514493, 
ENST00000515395, ENST00000510060, 
ENST00000512258, ENST00000265081, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 13 X 6=9366 X 7 X 2=84
# samples 147
** MAII scorelog2(14/936*10)=-2.74108170263844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/84*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: SSBP2 [Title/Abstract] AND MSH3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SSBP2(80733249)-MSH3(79974746), # samples:1
Anticipated loss of major functional domain due to fusion event.SSBP2-MSH3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SSBP2-MSH3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
SSBP2-MSH3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SSBP2-MSH3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMSH3

GO:0006281

DNA repair

8942985

TgeneMSH3

GO:0045910

negative regulation of DNA recombination

17715146

TgeneMSH3

GO:0051096

positive regulation of helicase activity

17715146


check buttonFusion gene breakpoints across SSBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MSH3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5717-01ASSBP2chr5

80733249

-MSH3chr5

79974746

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000320672SSBP2chr580733249-ENST00000265081MSH3chr579974746+4007116821134081065
ENST00000509053SSBP2chr580733249-ENST00000265081MSH3chr579974746+3712873631131035
ENST00000514493SSBP2chr580733249-ENST00000265081MSH3chr579974746+3914107520833151035
ENST00000505980SSBP2chr580733249-ENST00000265081MSH3chr579974746+3741902531421045
ENST00000515395SSBP2chr580733249-ENST00000265081MSH3chr579974746+37859465531861043

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000320672ENST00000265081SSBP2chr580733249-MSH3chr579974746+0.0003470860.99965286
ENST00000509053ENST00000265081SSBP2chr580733249-MSH3chr579974746+0.0003175230.99968255
ENST00000514493ENST00000265081SSBP2chr580733249-MSH3chr579974746+0.0003601730.99963987
ENST00000505980ENST00000265081SSBP2chr580733249-MSH3chr579974746+0.0004353050.9995647
ENST00000515395ENST00000265081SSBP2chr580733249-MSH3chr579974746+0.0002533030.99974674

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>86714_86714_1_SSBP2-MSH3_SSBP2_chr5_80733249_ENST00000320672_MSH3_chr5_79974746_ENST00000265081_length(amino acids)=1065AA_BP=319
MYGKGKSNSSAVPSDSQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRETCEHSSEAKA
FHDYSAAAAPSPVLGNIPPGDGMPVGPVPPGFFQPFMSPRYPGGPRPPLRIPNQALGGVPGSQPLLPSGMDPTRQQGHPNMGGPMQRMTP
PRGMVPLGPQNYGGAMRPPLNALGGPGMPGMNMGPGGGRPWPNPTNANSIPYSSASPGNYVGPPGGGGPPGTPIMPSPADSTNSGDNMYT
LMNAVPPGPNRPNFPMGPGSDGPMGGLGGMESHHMNGSLGSGDMDSISKGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSAL
SEQTEALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKDTVDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKP
ENFKQLSSKMEFMTINGTTLRNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIE
NHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTEL
FKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHL
NQLREQLVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNT
DLSEDSERVMIITGPNMGGKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTAEIIRKATSQSLV
ILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRG

--------------------------------------------------------------

>86714_86714_2_SSBP2-MSH3_SSBP2_chr5_80733249_ENST00000505980_MSH3_chr5_79974746_ENST00000265081_length(amino acids)=1045AA_BP=299
MYGKGKSNSSAVPSDSQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRETCEHSSEAKA
FHDYSAAAAPSPVLGNIPPGDGMPVGPVPPGFFQALGGVPGSQPLLPSGMDPTRQQGHPNMGGPMQRMTPPRGMVPLGPQNYGGAMRPPL
NALGGPGMPGMNMGPGGGRPWPNPTNANSIPYSSASPGNYVGPPGGGGPPGTPIMPSPADSTNSGDNMYTLMNAVPPGPNRPNFPMGPGS
DGPMGGLGGMESHHMNGSLGSGDMDSISKGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRATSVSVQDDR
IRVERMDNIYFEYSHAFQAVTEFYAKDTVDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTL
RNLEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKK
CSTQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGV
IDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSAEWLDFLE
KFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGK
SSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYA
TLEYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEI

--------------------------------------------------------------

>86714_86714_3_SSBP2-MSH3_SSBP2_chr5_80733249_ENST00000509053_MSH3_chr5_79974746_ENST00000265081_length(amino acids)=1035AA_BP=289
MYGKGKSNSSAVPSDSQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRETCEHSSEAKA
FHDYPFMSPRYPGGPRPPLRIPNQALGGVPGSQPLLPSGMDPTRQQGHPNMGGPMQRMTPPRGMVPLGPQNYGGAMRPPLNALGGPGMPG
MNMGPGGGRPWPNPTNANSIPYSSASPGNYVGPPGGGGPPGTPIMPSPADSTNSGDNMYTLMNAVPPGPNRPNFPMGPGSDGPMGGLGGM
ESHHMNGSLGSGDMDSISKGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRATSVSVQDDRIRVERMDNIY
FEYSHAFQAVTEFYAKDTVDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQNQT
DMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIV
KTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQE
IRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSLC
KAVHHLATVDCIFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSYIKQVALI
TIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVK
SLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKE

--------------------------------------------------------------

>86714_86714_4_SSBP2-MSH3_SSBP2_chr5_80733249_ENST00000514493_MSH3_chr5_79974746_ENST00000265081_length(amino acids)=1035AA_BP=289
MYGKGKSNSSAVPSDSQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRETCEHSSEAKA
FHDYPFMSPRYPGGPRPPLRIPNQALGGVPGSQPLLPSGMDPTRQQGHPNMGGPMQRMTPPRGMVPLGPQNYGGAMRPPLNALGGPGMPG
MNMGPGGGRPWPNPTNANSIPYSSASPGNYVGPPGGGGPPGTPIMPSPADSTNSGDNMYTLMNAVPPGPNRPNFPMGPGSDGPMGGLGGM
ESHHMNGSLGSGDMDSISKGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRATSVSVQDDRIRVERMDNIY
FEYSHAFQAVTEFYAKDTVDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQNQT
DMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIV
KTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQE
IRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSAEWLDFLEKFSEHYHSLC
KAVHHLATVDCIFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSYIKQVALI
TIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVK
SLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILKKAAHKSKE

--------------------------------------------------------------

>86714_86714_5_SSBP2-MSH3_SSBP2_chr5_80733249_ENST00000515395_MSH3_chr5_79974746_ENST00000265081_length(amino acids)=1043AA_BP=297
MYGKGKSNSSAVPSDSQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRETCEHSSEAKA
FHDYPFMSPRYPGGPRPPLRIPNQALGGVPGSQPLLPSGMDPTRQQGHPNMGGPMQRMTPPRGMVPLGPQSDPWLSLQNYGGAMRPPLNA
LGGPGMPGMNMGPGGGRPWPNPTNANSIPYSSASPGNYVGPPGGGGPPGTPIMPSPADSTNSGDNMYTLMNAVPPGPNRPNFPMGPGSDG
PMGGLGGMESHHMNGSLGSGDMDSISKGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRATSVSVQDDRIR
VERMDNIYFEYSHAFQAVTEFYAKDTVDIKGSQIISGIVNLEKPVICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRN
LEILQNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKCS
TQEFFLIVKTLYHLKSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKDLSDFPLIKKRKDEIQGVID
EIRMHLQEIRKILKNPSAQYVTVSGQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSAEWLDFLEKF
SEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSS
YIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAADNIYKGQSTFMEELTDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYATL
EYFIRDVKSLTLFVTHYPPVCELEKNYSHQVGNYHMGFLVSEDESKLDPGAAEQVPDFVTFLYQITRGIAARSYGLNVAKLADVPGEILK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:80733249/chr5:79974746)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SSBP2

P81877

MSH3

P20585

FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSSBP2chr5:80733249chr5:79974746ENST00000320672-1517100_293319.0362.0Compositional biasNote=Pro-rich
HgeneSSBP2chr5:80733249chr5:79974746ENST00000320672-1517147_312319.0362.0Compositional biasNote=Gly-rich
HgeneSSBP2chr5:80733249chr5:79974746ENST00000505980-1416100_293299.0342.0Compositional biasNote=Pro-rich
HgeneSSBP2chr5:80733249chr5:79974746ENST00000515395-1416100_293297.0340.0Compositional biasNote=Pro-rich
HgeneSSBP2chr5:80733249chr5:79974746ENST00000320672-151718_50319.0362.0DomainLisH
HgeneSSBP2chr5:80733249chr5:79974746ENST00000505980-141618_50299.0342.0DomainLisH
HgeneSSBP2chr5:80733249chr5:79974746ENST00000509053-141518_50289.0299.0DomainLisH
HgeneSSBP2chr5:80733249chr5:79974746ENST00000514493-141618_50289.0332.0DomainLisH
HgeneSSBP2chr5:80733249chr5:79974746ENST00000515395-141618_50297.0340.0DomainLisH
TgeneMSH3chr5:80733249chr5:79974746ENST00000265081624896_903391.01138.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSSBP2chr5:80733249chr5:79974746ENST00000505980-1416147_312299.0342.0Compositional biasNote=Gly-rich
HgeneSSBP2chr5:80733249chr5:79974746ENST00000509053-1415100_293289.0299.0Compositional biasNote=Pro-rich
HgeneSSBP2chr5:80733249chr5:79974746ENST00000509053-1415147_312289.0299.0Compositional biasNote=Gly-rich
HgeneSSBP2chr5:80733249chr5:79974746ENST00000514493-1416100_293289.0332.0Compositional biasNote=Pro-rich
HgeneSSBP2chr5:80733249chr5:79974746ENST00000514493-1416147_312289.0332.0Compositional biasNote=Gly-rich
HgeneSSBP2chr5:80733249chr5:79974746ENST00000515395-1416147_312297.0340.0Compositional biasNote=Gly-rich
TgeneMSH3chr5:80733249chr5:79974746ENST0000026508162451_62391.01138.0Compositional biasNote=Poly-Ala


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
SSBP2EWSR1, LDB1, IL36RN, TAL1, LMO2, TRIM33, DYRK2, CDK6, BAG3, TOM1, LDB2, LMX1B, IDI2, ISL2, ISL1, SSBP4, SSBP3, CLEC18A, LMO4, LHX4, LHX6, PIN1, ARHGAP22, ARHGEF10, CAMK2A, FPR1, RRD1, CBFA2T3, NABP1, INTS3, MYH9, ACACA, PC, MCCC2, MCCC1, EP300, PYGO1, BCL9, ORC6, BCL9L, LHX3, MFAP4, LMO1, LMO3, PICK1, VIM, S100A7A, HLA-DRB1, HMOX1, NDRG2, LCP1, IGHG1, IGHG2, TYMP, HIST1H2AG, HLA-DRA, PPL, IL36G, HIST1H1B, NDRG1, IVL, TREX2, IL1RN, GLUL, EVPL, SERPINA1, MNDA, TF, TRIM29, SERPINB3, SERPINB4, SERPINB2, C3, HLA-DQB1, HLA-DPB1, LGALS7B, FGB, SERPINB7, CBR1, ALOX15, IGKC, STAT3, SULT2B1, CALML3, PYCARD, CALML5, IGLL5, H2AFY, T, GATA2, LHX1, LHX2, LHX8, TEAD1, TLX1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
SSBP2all structure
MSH3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneMSH3chr5:80733249chr5:79974746ENST0000026508162475_297391.01138.0EXO1


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Related Drugs to SSBP2-MSH3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SSBP2-MSH3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSSBP2C0005586Bipolar Disorder1CTD_human
HgeneSSBP2C0005587Depression, Bipolar1CTD_human
HgeneSSBP2C0024713Manic Disorder1CTD_human
HgeneSSBP2C0033578Prostatic Neoplasms1CTD_human
HgeneSSBP2C0338831Manic1CTD_human
HgeneSSBP2C0376358Malignant neoplasm of prostate1CTD_human