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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:STAG1-ANKS1B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: STAG1-ANKS1B
FusionPDB ID: 87072
FusionGDB2.0 ID: 87072
HgeneTgene
Gene symbol

STAG1

ANKS1B

Gene ID

56937

56899

Gene nameprostate transmembrane protein, androgen induced 1ankyrin repeat and sterile alpha motif domain containing 1B
SynonymsSTAG1|TMEPAIAIDA|AIDA-1|ANKS2|EB-1|EB1|cajalin-2
Cytomap

20q13.31

12q23.1

Type of geneprotein-codingprotein-coding
Descriptionprotein TMEPAIsolid tumor-associated 1 proteintransmembrane, prostate androgen induced RNAankyrin repeat and sterile alpha motif domain-containing protein 1BE2a-Pbx1-associated proteinamyloid-beta precursor protein intracellular domain associated protein 1cajalin 2
Modification date2020031320200313
UniProtAcc.

Q7Z6G8

Ensembl transtripts involved in fusion geneENST idsENST00000236698, ENST00000383202, 
ENST00000434713, ENST00000480733, 
ENST00000536929, 		ENST00000547446, 
ENST00000549025, ENST00000549493, 
ENST00000332712, ENST00000333732, 
ENST00000341752, ENST00000546568, 
ENST00000546960, ENST00000549558, 
ENST00000550693, ENST00000550833, 
ENST00000329257, ENST00000547010, 
ENST00000547776, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 21 X 12=579627 X 22 X 9=5346
# samples 3328
** MAII scorelog2(33/5796*10)=-4.13451966531111
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/5346*10)=-4.25496110529811
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: STAG1 [Title/Abstract] AND ANKS1B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)STAG1(136183723)-ANKS1B(99548173), # samples:2
Anticipated loss of major functional domain due to fusion event.STAG1-ANKS1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STAG1-ANKS1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STAG1-ANKS1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
STAG1-ANKS1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
STAG1-ANKS1B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
STAG1-ANKS1B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
STAG1-ANKS1B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTAG1

GO:0010991

negative regulation of SMAD protein complex assembly

20129061

HgeneSTAG1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

24627487

HgeneSTAG1

GO:0060394

negative regulation of pathway-restricted SMAD protein phosphorylation

24627487


check buttonFusion gene breakpoints across STAG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANKS1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A23Y-01ASTAG1chr3

136183723

-ANKS1Bchr12

99548173

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000383202STAG1chr3136183723-ENST00000547776ANKS1Bchr1299548173-3036157014612897478
ENST00000383202STAG1chr3136183723-ENST00000329257ANKS1Bchr1299548173-2898157014612897478
ENST00000383202STAG1chr3136183723-ENST00000547010ANKS1Bchr1299548173-271815702181651477
ENST00000236698STAG1chr3136183723-ENST00000547776ANKS1Bchr1299548173-3046158014712907478
ENST00000236698STAG1chr3136183723-ENST00000329257ANKS1Bchr1299548173-2908158014712907479
ENST00000236698STAG1chr3136183723-ENST00000547010ANKS1Bchr1299548173-272815802281661477

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000383202ENST00000547776STAG1chr3136183723-ANKS1Bchr1299548173-0.0015867340.9984132
ENST00000383202ENST00000329257STAG1chr3136183723-ANKS1Bchr1299548173-0.0016975560.99830246
ENST00000383202ENST00000547010STAG1chr3136183723-ANKS1Bchr1299548173-0.0007997370.9992003
ENST00000236698ENST00000547776STAG1chr3136183723-ANKS1Bchr1299548173-0.0015263340.9984737
ENST00000236698ENST00000329257STAG1chr3136183723-ANKS1Bchr1299548173-0.0016268180.99837315
ENST00000236698ENST00000547010STAG1chr3136183723-ANKS1Bchr1299548173-0.0007710450.99922895

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87072_87072_1_STAG1-ANKS1B_STAG1_chr3_136183723_ENST00000236698_ANKS1B_chr12_99548173_ENST00000329257_length(amino acids)=479AA_BP=37
MEVKKLFPMKTVKMFTTWCTRHIALLLWQLESSFTKRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNS
GHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDD
PPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEAT
ASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRVMCVKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEI
RNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSI

--------------------------------------------------------------

>87072_87072_2_STAG1-ANKS1B_STAG1_chr3_136183723_ENST00000236698_ANKS1B_chr12_99548173_ENST00000547010_length(amino acids)=477AA_BP=451
MIILLHCERTSPAMITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIRGAGRGRANGHPQ
QNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMP
GPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNK
MIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVR
LKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHK

--------------------------------------------------------------

>87072_87072_3_STAG1-ANKS1B_STAG1_chr3_136183723_ENST00000236698_ANKS1B_chr12_99548173_ENST00000547776_length(amino acids)=478AA_BP=37
MEVKKLFPMKTVKMFTTWCTRHIALLLWQLESSFTKRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNS
GHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDD
PPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEAT
ASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEI
RNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSI

--------------------------------------------------------------

>87072_87072_4_STAG1-ANKS1B_STAG1_chr3_136183723_ENST00000383202_ANKS1B_chr12_99548173_ENST00000329257_length(amino acids)=478AA_BP=37
MEVKKLFPMKTVKMFTTWCTRHIALLLWQLESSFTKRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNS
GHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDD
PPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEAT
ASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRVMCVKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEI
RNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSI

--------------------------------------------------------------

>87072_87072_5_STAG1-ANKS1B_STAG1_chr3_136183723_ENST00000383202_ANKS1B_chr12_99548173_ENST00000547010_length(amino acids)=477AA_BP=451
MIILLHCERTSPAMITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIRGAGRGRANGHPQ
QNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMP
GPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNK
MIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVR
LKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHK

--------------------------------------------------------------

>87072_87072_6_STAG1-ANKS1B_STAG1_chr3_136183723_ENST00000383202_ANKS1B_chr12_99548173_ENST00000547776_length(amino acids)=478AA_BP=37
MEVKKLFPMKTVKMFTTWCTRHIALLLWQLESSFTKRPRCPVQTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNS
GHRQRILQAIQLLPKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLIGHRKRILASLGDRLHDD
PPQKPPRSITLREPSGNHTPPQLSPSLSQSTYTTGGSLDVPHIIMQGDARRRRNENYFDDIPRSKLERQMAQTGDWGEPSITLRPPNEAT
ASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKSTEQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEI
RNISCAAQDPEDLSTFAYITKDLKSNHHYCHVFTAFDVNLAYEIILTLGQAFEVAYQLALQARKGGHSSTLPESFENKPSKPIPKPRVSI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:136183723/chr12:99548173)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANKS1B

Q7Z6G8

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; FUNCTION: Isoform 3 can regulate global protein synthesis by altering nucleolar numbers. {ECO:0000250, ECO:0000269|PubMed:15347684, ECO:0000269|PubMed:15862129}.; FUNCTION: Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTAG1chr3:136183723chr12:99548173ENST00000383202-1334296_381437.66666666666671259.0DomainSCD
TgeneANKS1Bchr3:136183723chr12:99548173ENST000003417520101056_12130255.0DomainPID
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000341752010810_8760255.0DomainSAM 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000341752010884_9490255.0DomainSAM 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005465680111056_12130.0427.0DomainPID
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546568011810_8760.0427.0DomainSAM 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546568011884_9490.0427.0DomainSAM 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005469600121056_12130.0461.0DomainPID
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546960012810_8760.0461.0DomainSAM 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546960012884_9490.0461.0DomainSAM 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005470106181056_1213382.3333333333333765.0DomainPID
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547010618810_876382.3333333333333765.0DomainSAM 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547010618884_949382.3333333333333765.0DomainSAM 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005474460121056_12131.3333333333333333395.0DomainPID
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547446012810_8761.3333333333333333395.0DomainSAM 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547446012884_9491.3333333333333333395.0DomainSAM 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054777613261056_1213806.33333333333341249.0DomainPID
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005477761326810_876806.33333333333341249.0DomainSAM 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005477761326884_949806.33333333333341249.0DomainSAM 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005490250121056_12130358.0DomainPID
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549025012810_8760358.0DomainSAM 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549025012884_9490358.0DomainSAM 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005494930131056_12130511.0DomainPID
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549493013810_8760511.0DomainSAM 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549493013884_9490511.0DomainSAM 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005495580111056_12130415.0DomainPID
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549558011810_8760415.0DomainSAM 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549558011884_9490415.0DomainSAM 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005506930121056_12130451.0DomainPID
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000550693012810_8760451.0DomainSAM 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000550693012884_9490451.0DomainSAM 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000341752010935_9380255.0MotifNuclear localization signal
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546568011935_9380.0427.0MotifNuclear localization signal
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546960012935_9380.0461.0MotifNuclear localization signal
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547010618935_938382.3333333333333765.0MotifNuclear localization signal
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547446012935_9381.3333333333333333395.0MotifNuclear localization signal
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005477761326935_938806.33333333333341249.0MotifNuclear localization signal
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549025012935_9380358.0MotifNuclear localization signal
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549493013935_9380511.0MotifNuclear localization signal
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549558011935_9380415.0MotifNuclear localization signal
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000550693012935_9380451.0MotifNuclear localization signal
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000341752010127_1560255.0RepeatNote=ANK 4
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000341752010160_1890255.0RepeatNote=ANK 5
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000341752010193_2220255.0RepeatNote=ANK 6
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000341752010225_2540255.0RepeatNote=ANK 7
TgeneANKS1Bchr3:136183723chr12:99548173ENST000003417520102_310255.0RepeatNote=ANK 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000034175201058_870255.0RepeatNote=ANK 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000034175201091_1200255.0RepeatNote=ANK 3
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546568011127_1560.0427.0RepeatNote=ANK 4
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546568011160_1890.0427.0RepeatNote=ANK 5
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546568011193_2220.0427.0RepeatNote=ANK 6
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546568011225_2540.0427.0RepeatNote=ANK 7
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005465680112_310.0427.0RepeatNote=ANK 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054656801158_870.0427.0RepeatNote=ANK 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054656801191_1200.0427.0RepeatNote=ANK 3
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546960012127_1560.0461.0RepeatNote=ANK 4
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546960012160_1890.0461.0RepeatNote=ANK 5
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546960012193_2220.0461.0RepeatNote=ANK 6
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000546960012225_2540.0461.0RepeatNote=ANK 7
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005469600122_310.0461.0RepeatNote=ANK 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054696001258_870.0461.0RepeatNote=ANK 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054696001291_1200.0461.0RepeatNote=ANK 3
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547446012127_1561.3333333333333333395.0RepeatNote=ANK 4
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547446012160_1891.3333333333333333395.0RepeatNote=ANK 5
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547446012193_2221.3333333333333333395.0RepeatNote=ANK 6
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547446012225_2541.3333333333333333395.0RepeatNote=ANK 7
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005474460122_311.3333333333333333395.0RepeatNote=ANK 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054744601258_871.3333333333333333395.0RepeatNote=ANK 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054744601291_1201.3333333333333333395.0RepeatNote=ANK 3
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549025012127_1560358.0RepeatNote=ANK 4
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549025012160_1890358.0RepeatNote=ANK 5
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549025012193_2220358.0RepeatNote=ANK 6
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549025012225_2540358.0RepeatNote=ANK 7
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005490250122_310358.0RepeatNote=ANK 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054902501258_870358.0RepeatNote=ANK 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054902501291_1200358.0RepeatNote=ANK 3
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549493013127_1560511.0RepeatNote=ANK 4
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549493013160_1890511.0RepeatNote=ANK 5
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549493013193_2220511.0RepeatNote=ANK 6
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549493013225_2540511.0RepeatNote=ANK 7
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005494930132_310511.0RepeatNote=ANK 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054949301358_870511.0RepeatNote=ANK 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054949301391_1200511.0RepeatNote=ANK 3
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549558011127_1560415.0RepeatNote=ANK 4
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549558011160_1890415.0RepeatNote=ANK 5
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549558011193_2220415.0RepeatNote=ANK 6
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000549558011225_2540415.0RepeatNote=ANK 7
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005495580112_310415.0RepeatNote=ANK 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054955801158_870415.0RepeatNote=ANK 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054955801191_1200415.0RepeatNote=ANK 3
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000550693012127_1560451.0RepeatNote=ANK 4
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000550693012160_1890451.0RepeatNote=ANK 5
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000550693012193_2220451.0RepeatNote=ANK 6
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000550693012225_2540451.0RepeatNote=ANK 7
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005506930122_310451.0RepeatNote=ANK 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000055069301258_870451.0RepeatNote=ANK 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000055069301291_1200451.0RepeatNote=ANK 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTAG1chr3:136183723chr12:99548173ENST00000383202-13341065_1070437.66666666666671259.0Compositional biasNote=Poly-Ser
HgeneSTAG1chr3:136183723chr12:99548173ENST00000383202-1334684_687437.66666666666671259.0Compositional biasNote=Poly-Asp
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547010618127_156382.3333333333333765.0RepeatNote=ANK 4
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547010618160_189382.3333333333333765.0RepeatNote=ANK 5
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547010618193_222382.3333333333333765.0RepeatNote=ANK 6
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547010618225_254382.3333333333333765.0RepeatNote=ANK 7
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005470106182_31382.3333333333333765.0RepeatNote=ANK 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054701061858_87382.3333333333333765.0RepeatNote=ANK 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054701061891_120382.3333333333333765.0RepeatNote=ANK 3
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005477761326127_156806.33333333333341249.0RepeatNote=ANK 4
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005477761326160_189806.33333333333341249.0RepeatNote=ANK 5
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005477761326193_222806.33333333333341249.0RepeatNote=ANK 6
TgeneANKS1Bchr3:136183723chr12:99548173ENST000005477761326225_254806.33333333333341249.0RepeatNote=ANK 7
TgeneANKS1Bchr3:136183723chr12:99548173ENST0000054777613262_31806.33333333333341249.0RepeatNote=ANK 1
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547776132658_87806.33333333333341249.0RepeatNote=ANK 2
TgeneANKS1Bchr3:136183723chr12:99548173ENST00000547776132691_120806.33333333333341249.0RepeatNote=ANK 3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
STAG1
ANKS1B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to STAG1-ANKS1B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to STAG1-ANKS1B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource