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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:STARD3-ACLY

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: STARD3-ACLY
FusionPDB ID: 87169
FusionGDB2.0 ID: 87169
HgeneTgene
Gene symbol

STARD3

ACLY

Gene ID

10948

47

Gene nameStAR related lipid transfer domain containing 3ATP citrate lyase
SynonymsCAB1|MLN64|es64ACL|ATPCL|CLATP
Cytomap

17q12

17q21.2

Type of geneprotein-codingprotein-coding
DescriptionstAR-related lipid transfer protein 3MLN 64START domain-containing protein 3StAR-related lipid transfer (START) domain containing 3metastatic lymph node gene 64 proteinmetastatic lymph node protein 64steroidogenic acute regulatory protein relatedATP-citrate synthaseATP-citrate (pro-S-)-lyasecitrate cleavage enzyme
Modification date2020031320200313
UniProtAcc

STARD3NL

P53396

Ensembl transtripts involved in fusion geneENST idsENST00000336308, ENST00000394250, 
ENST00000544210, ENST00000580611, 
ENST00000578232, 		ENST00000588779, 
ENST00000352035, ENST00000353196, 
ENST00000393896, ENST00000537919, 
ENST00000590151, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score25 X 11 X 9=247513 X 13 X 6=1014
# samples 3515
** MAII scorelog2(35/2475*10)=-2.82200169802201
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1014*10)=-2.75702324650746
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: STARD3 [Title/Abstract] AND ACLY [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)STARD3(37818597)-ACLY(40054092), # samples:3
Anticipated loss of major functional domain due to fusion event.STARD3-ACLY seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STARD3-ACLY seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
STARD3-ACLY seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
STARD3-ACLY seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
STARD3-ACLY seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTARD3

GO:0030301

cholesterol transport

28377464

HgeneSTARD3

GO:0099044

vesicle tethering to endoplasmic reticulum

24105263|28377464

TgeneACLY

GO:0006085

acetyl-CoA biosynthetic process

1371749

TgeneACLY

GO:0006101

citrate metabolic process

1371749

TgeneACLY

GO:0006107

oxaloacetate metabolic process

1371749

TgeneACLY

GO:0008610

lipid biosynthetic process

23932781


check buttonFusion gene breakpoints across STARD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ACLY (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A91X-01ASTARD3chr17

37818597

+ACLYchr17

40054092

-
ChimerDB4STADTCGA-VQ-A91XSTARD3chr17

37818597

+ACLYchr17

40054092

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336308STARD3chr1737818597+ENST00000352035ACLYchr1740054092-4321145119734181073
ENST00000336308STARD3chr1737818597+ENST00000590151ACLYchr1740054092-4312145119734181073
ENST00000336308STARD3chr1737818597+ENST00000353196ACLYchr1740054092-4268145119733881063
ENST00000336308STARD3chr1737818597+ENST00000537919ACLYchr1740054092-3743145119733881063
ENST00000336308STARD3chr1737818597+ENST00000393896ACLYchr1740054092-3625145119733881063
ENST00000544210STARD3chr1737818597+ENST00000352035ACLYchr1740054092-4245137512133421073
ENST00000544210STARD3chr1737818597+ENST00000590151ACLYchr1740054092-4236137512133421073
ENST00000544210STARD3chr1737818597+ENST00000353196ACLYchr1740054092-4192137512133121063
ENST00000544210STARD3chr1737818597+ENST00000537919ACLYchr1740054092-3667137512133121063
ENST00000544210STARD3chr1737818597+ENST00000393896ACLYchr1740054092-3549137512133121063
ENST00000394250STARD3chr1737818597+ENST00000352035ACLYchr1740054092-4188131811832851055
ENST00000394250STARD3chr1737818597+ENST00000590151ACLYchr1740054092-4179131811832851055
ENST00000394250STARD3chr1737818597+ENST00000353196ACLYchr1740054092-4135131811832551045
ENST00000394250STARD3chr1737818597+ENST00000537919ACLYchr1740054092-3610131811832551045
ENST00000394250STARD3chr1737818597+ENST00000393896ACLYchr1740054092-3492131811832551045

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336308ENST00000352035STARD3chr1737818597+ACLYchr1740054092-0.0013409740.998659
ENST00000336308ENST00000590151STARD3chr1737818597+ACLYchr1740054092-0.0013341310.9986659
ENST00000336308ENST00000353196STARD3chr1737818597+ACLYchr1740054092-0.0012846780.9987153
ENST00000336308ENST00000537919STARD3chr1737818597+ACLYchr1740054092-0.0027691910.9972308
ENST00000336308ENST00000393896STARD3chr1737818597+ACLYchr1740054092-0.0030935460.99690646
ENST00000544210ENST00000352035STARD3chr1737818597+ACLYchr1740054092-0.0011836350.9988164
ENST00000544210ENST00000590151STARD3chr1737818597+ACLYchr1740054092-0.0011752730.99882466
ENST00000544210ENST00000353196STARD3chr1737818597+ACLYchr1740054092-0.0007829580.99921703
ENST00000544210ENST00000537919STARD3chr1737818597+ACLYchr1740054092-0.0019553560.9980446
ENST00000544210ENST00000393896STARD3chr1737818597+ACLYchr1740054092-0.002254770.9977452
ENST00000394250ENST00000352035STARD3chr1737818597+ACLYchr1740054092-0.0007107420.9992893
ENST00000394250ENST00000590151STARD3chr1737818597+ACLYchr1740054092-0.0007096060.99929035
ENST00000394250ENST00000353196STARD3chr1737818597+ACLYchr1740054092-0.0008402260.9991598
ENST00000394250ENST00000537919STARD3chr1737818597+ACLYchr1740054092-0.0020337990.9979662
ENST00000394250ENST00000393896STARD3chr1737818597+ACLYchr1740054092-0.0023452210.9976548

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87169_87169_1_STARD3-ACLY_STARD3_chr17_37818597_ENST00000336308_ACLY_chr17_40054092_ENST00000352035_length(amino acids)=1073AA_BP=418
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKV
LPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQDS
VPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDV
LINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVA
YVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTC
ATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPA
SFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGL
LTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKK

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>87169_87169_2_STARD3-ACLY_STARD3_chr17_37818597_ENST00000336308_ACLY_chr17_40054092_ENST00000353196_length(amino acids)=1063AA_BP=418
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKV
LPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQGK
STTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSA
YDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSN
ELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQF
GHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDER
GQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGA
LDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGL

--------------------------------------------------------------

>87169_87169_3_STARD3-ACLY_STARD3_chr17_37818597_ENST00000336308_ACLY_chr17_40054092_ENST00000393896_length(amino acids)=1063AA_BP=418
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKV
LPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQGK
STTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSA
YDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSN
ELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQF
GHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDER
GQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGA
LDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGL

--------------------------------------------------------------

>87169_87169_4_STARD3-ACLY_STARD3_chr17_37818597_ENST00000336308_ACLY_chr17_40054092_ENST00000537919_length(amino acids)=1063AA_BP=418
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKV
LPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQGK
STTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSA
YDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSN
ELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQF
GHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDER
GQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGA
LDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGL

--------------------------------------------------------------

>87169_87169_5_STARD3-ACLY_STARD3_chr17_37818597_ENST00000336308_ACLY_chr17_40054092_ENST00000590151_length(amino acids)=1073AA_BP=418
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKV
LPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQDS
VPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDV
LINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVA
YVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTC
ATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPA
SFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGL
LTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKK

--------------------------------------------------------------

>87169_87169_6_STARD3-ACLY_STARD3_chr17_37818597_ENST00000394250_ACLY_chr17_40054092_ENST00000352035_length(amino acids)=1055AA_BP=400
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIALLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAV
ARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGK
TFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSA
KPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRH
TKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETM
NYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISR
TTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACAN
QASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAG
MPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMF
SKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDM

--------------------------------------------------------------

>87169_87169_7_STARD3-ACLY_STARD3_chr17_37818597_ENST00000394250_ACLY_chr17_40054092_ENST00000353196_length(amino acids)=1045AA_BP=400
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIALLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAV
ARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGK
TFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSA
KPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQT
RAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAI
IAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVA
IGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKN
QALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEE
MGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIP
MEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTRE

--------------------------------------------------------------

>87169_87169_8_STARD3-ACLY_STARD3_chr17_37818597_ENST00000394250_ACLY_chr17_40054092_ENST00000393896_length(amino acids)=1045AA_BP=400
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIALLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAV
ARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGK
TFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSA
KPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQT
RAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAI
IAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVA
IGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKN
QALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEE
MGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIP
MEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTRE

--------------------------------------------------------------

>87169_87169_9_STARD3-ACLY_STARD3_chr17_37818597_ENST00000394250_ACLY_chr17_40054092_ENST00000537919_length(amino acids)=1045AA_BP=400
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIALLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAV
ARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGK
TFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSA
KPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQT
RAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAI
IAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVA
IGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKN
QALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEE
MGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIP
MEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTRE

--------------------------------------------------------------

>87169_87169_10_STARD3-ACLY_STARD3_chr17_37818597_ENST00000394250_ACLY_chr17_40054092_ENST00000590151_length(amino acids)=1055AA_BP=400
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIALLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAV
ARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGK
TFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSA
KPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQDSVPSPRSLQGKSTTLFSRH
TKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETM
NYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISR
TTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACAN
QASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAG
MPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMF
SKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDM

--------------------------------------------------------------

>87169_87169_11_STARD3-ACLY_STARD3_chr17_37818597_ENST00000544210_ACLY_chr17_40054092_ENST00000352035_length(amino acids)=1073AA_BP=418
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWSRRWCPVHSSLSRSSSLSCSAKGHLATCSPSSLLSSPGWRPGSLTSKSYPRK
LKRSDSAPPGYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQDS
VPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDV
LINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVA
YVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTC
ATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPA
SFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGL
LTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKK

--------------------------------------------------------------

>87169_87169_12_STARD3-ACLY_STARD3_chr17_37818597_ENST00000544210_ACLY_chr17_40054092_ENST00000353196_length(amino acids)=1063AA_BP=418
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWSRRWCPVHSSLSRSSSLSCSAKGHLATCSPSSLLSSPGWRPGSLTSKSYPRK
LKRSDSAPPGYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQGK
STTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSA
YDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSN
ELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQF
GHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDER
GQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGA
LDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGL

--------------------------------------------------------------

>87169_87169_13_STARD3-ACLY_STARD3_chr17_37818597_ENST00000544210_ACLY_chr17_40054092_ENST00000393896_length(amino acids)=1063AA_BP=418
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWSRRWCPVHSSLSRSSSLSCSAKGHLATCSPSSLLSSPGWRPGSLTSKSYPRK
LKRSDSAPPGYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQGK
STTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSA
YDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSN
ELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQF
GHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDER
GQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGA
LDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGL

--------------------------------------------------------------

>87169_87169_14_STARD3-ACLY_STARD3_chr17_37818597_ENST00000544210_ACLY_chr17_40054092_ENST00000537919_length(amino acids)=1063AA_BP=418
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWSRRWCPVHSSLSRSSSLSCSAKGHLATCSPSSLLSSPGWRPGSLTSKSYPRK
LKRSDSAPPGYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQGK
STTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSA
YDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSN
ELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQF
GHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDER
GQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGA
LDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGL

--------------------------------------------------------------

>87169_87169_15_STARD3-ACLY_STARD3_chr17_37818597_ENST00000544210_ACLY_chr17_40054092_ENST00000590151_length(amino acids)=1073AA_BP=418
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWSRRWCPVHSSLSRSSSLSCSAKGHLATCSPSSLLSSPGWRPGSLTSKSYPRK
LKRSDSAPPGYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQDS
VPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDV
LINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVA
YVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTC
ATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPA
SFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGL
LTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:37818597/chr17:40054092)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STARD3

STARD3NL

ACLY

P53396

234FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis. {ECO:0000269|PubMed:10653665, ECO:0000269|PubMed:1371749, ECO:0000269|PubMed:19286649, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:9116495}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+141546_217411.0446.0DomainMENTAL
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+131446_217393.0428.0DomainMENTAL
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+141546_217411.0446.0DomainMENTAL
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+1415207_212411.0446.0MotifFFAT
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+1314207_212393.0428.0MotifFFAT
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+1415207_212411.0446.0MotifFFAT
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+1415116_120411.0446.0Topological domainCytoplasmic
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+1415142_148411.0446.0Topological domainExtracellular
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+14151_51411.0446.0Topological domainCytoplasmic
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+141573_94411.0446.0Topological domainExtracellular
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+1314116_120393.0428.0Topological domainCytoplasmic
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+1314142_148393.0428.0Topological domainExtracellular
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+13141_51393.0428.0Topological domainCytoplasmic
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+131473_94393.0428.0Topological domainExtracellular
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+1415116_120411.0446.0Topological domainCytoplasmic
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+1415142_148411.0446.0Topological domainExtracellular
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+14151_51411.0446.0Topological domainCytoplasmic
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+141573_94411.0446.0Topological domainExtracellular
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+1415121_141411.0446.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+1415149_169411.0446.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+141552_72411.0446.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+141595_115411.0446.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+1314121_141393.0428.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+1314149_169393.0428.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+131452_72393.0428.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+131495_115393.0428.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+1415121_141411.0446.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+1415149_169411.0446.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+141552_72411.0446.0TransmembraneHelical
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+141595_115411.0446.0TransmembraneHelical
TgeneACLYchr17:37818597chr17:40054092ENST000003520351129701_721446.01102.0Nucleotide bindingATP
TgeneACLYchr17:37818597chr17:40054092ENST000003520351129752_778446.01102.0Nucleotide bindingATP
TgeneACLYchr17:37818597chr17:40054092ENST000003531961128701_721446.01092.0Nucleotide bindingATP
TgeneACLYchr17:37818597chr17:40054092ENST000003531961128752_778446.01092.0Nucleotide bindingATP
TgeneACLYchr17:37818597chr17:40054092ENST000003938961128701_721446.01092.0Nucleotide bindingATP
TgeneACLYchr17:37818597chr17:40054092ENST000003938961128752_778446.01092.0Nucleotide bindingATP
TgeneACLYchr17:37818597chr17:40054092ENST000005901511129701_721446.01102.0Nucleotide bindingATP
TgeneACLYchr17:37818597chr17:40054092ENST000005901511129752_778446.01102.0Nucleotide bindingATP
TgeneACLYchr17:37818597chr17:40054092ENST000003520351129779_789446.01102.0RegionCoA-binding
TgeneACLYchr17:37818597chr17:40054092ENST000003531961128779_789446.01092.0RegionCoA-binding
TgeneACLYchr17:37818597chr17:40054092ENST000003938961128779_789446.01092.0RegionCoA-binding
TgeneACLYchr17:37818597chr17:40054092ENST000005901511129779_789446.01102.0RegionCoA-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+1415230_443411.0446.0DomainSTART
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+1314230_443393.0428.0DomainSTART
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+1415230_443411.0446.0DomainSTART
HgeneSTARD3chr17:37818597chr17:40054092ENST00000336308+1415170_445411.0446.0Topological domainCytoplasmic
HgeneSTARD3chr17:37818597chr17:40054092ENST00000394250+1314170_445393.0428.0Topological domainCytoplasmic
HgeneSTARD3chr17:37818597chr17:40054092ENST00000544210+1415170_445411.0446.0Topological domainCytoplasmic
TgeneACLYchr17:37818597chr17:40054092ENST0000035203511294_265446.01102.0DomainNote=ATP-grasp
TgeneACLYchr17:37818597chr17:40054092ENST0000035319611284_265446.01092.0DomainNote=ATP-grasp
TgeneACLYchr17:37818597chr17:40054092ENST0000039389611284_265446.01092.0DomainNote=ATP-grasp
TgeneACLYchr17:37818597chr17:40054092ENST0000059015111294_265446.01102.0DomainNote=ATP-grasp
TgeneACLYchr17:37818597chr17:40054092ENST000003520351129109_111446.01102.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37818597chr17:40054092ENST00000352035112966_67446.01102.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37818597chr17:40054092ENST000003531961128109_111446.01092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37818597chr17:40054092ENST00000353196112866_67446.01092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37818597chr17:40054092ENST000003938961128109_111446.01092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37818597chr17:40054092ENST00000393896112866_67446.01092.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37818597chr17:40054092ENST000005901511129109_111446.01102.0Nucleotide bindingNote=ATP
TgeneACLYchr17:37818597chr17:40054092ENST00000590151112966_67446.01102.0Nucleotide bindingNote=ATP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1846_STARD3_37818597_ACLY_40054092_ranked_0.pdbSTARD33781859737818597ENST00000393896ACLYchr1740054092-
MRWGPTRMSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFDLLFISLLWIIELNTNTGIRKNLE
QEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKV
LPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEK
NNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRI
ERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKTPAPSRTASFSESRADEVAPAKKAKPAMPQDS
VPSPRSLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDV
LINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVA
YVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTC
ATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPA
SFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGL
LTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKK
1073


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
STARD3_pLDDT.png
all structure
all structure
ACLY_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
STARD3
ACLY


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to STARD3-ACLY


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to STARD3-ACLY


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource