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Fusion Protein:STK10-SH3PXD2B |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: STK10-SH3PXD2B | FusionPDB ID: 87438 | FusionGDB2.0 ID: 87438 | Hgene | Tgene | Gene symbol | STK10 | SH3PXD2B | Gene ID | 6793 | 285590 |
Gene name | serine/threonine kinase 10 | SH3 and PX domains 2B | |
Synonyms | LOK|PRO2729 | FAD49|FTHS|HOFI|KIAA1295|TKS4|TSK4 | |
Cytomap | 5q35.1 | 5q35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase 10lymphocyte-oriented kinase | SH3 and PX domain-containing protein 2Badapter protein HOFIadaptor protein HOFIfactor for adipocyte differentiation 49tyrosine kinase substrate with four SH3 domains | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000176763, ENST00000517775, | ENST00000523651, ENST00000311601, ENST00000519643, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 9 X 11 X 6=594 | 5 X 5 X 4=100 |
# samples | 13 | 6 | |
** MAII score | log2(13/594*10)=-2.19195130777231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: STK10 [Title/Abstract] AND SH3PXD2B [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | STK10(171583628)-SH3PXD2B(171849500), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | STK10-SH3PXD2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STK10-SH3PXD2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STK10-SH3PXD2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. STK10-SH3PXD2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | STK10 | GO:0046777 | protein autophosphorylation | 12639966|18239682 |
Tgene | SH3PXD2B | GO:0006801 | superoxide metabolic process | 19755710 |
Tgene | SH3PXD2B | GO:0072657 | protein localization to membrane | 19755710 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-BH-A18T-01A | STK10 | chr5 | 171583628 | - | SH3PXD2B | chr5 | 171849500 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000176763 | STK10 | chr5 | 171583628 | - | ENST00000519643 | SH3PXD2B | chr5 | 171849500 | - | 1978 | 665 | 26 | 1882 | 618 |
ENST00000176763 | STK10 | chr5 | 171583628 | - | ENST00000311601 | SH3PXD2B | chr5 | 171849500 | - | 8196 | 665 | 26 | 3325 | 1099 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000176763 | ENST00000519643 | STK10 | chr5 | 171583628 | - | SH3PXD2B | chr5 | 171849500 | - | 0.002213562 | 0.9977864 |
ENST00000176763 | ENST00000311601 | STK10 | chr5 | 171583628 | - | SH3PXD2B | chr5 | 171849500 | - | 0.000656842 | 0.9993431 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >87438_87438_1_STK10-SH3PXD2B_STK10_chr5_171583628_ENST00000176763_SH3PXD2B_chr5_171849500_ENST00000311601_length(amino acids)=1099AA_BP=213 MERVRGSRRQGWAGQELRGRHKGGGPGDLTGRGRGRARRRLRGSGCSRRGAAQGTLDRGRAAGKGGSGENPERRGVLQLLLLLLAAAEAT ARARARARAGATAPPAMAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEE LEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILF RRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEIS LSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIR YQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDM TIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPH EVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKS EGELLERERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDL PEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDR TGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPP KAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVL -------------------------------------------------------------- >87438_87438_2_STK10-SH3PXD2B_STK10_chr5_171583628_ENST00000176763_SH3PXD2B_chr5_171849500_ENST00000519643_length(amino acids)=618AA_BP=213 MERVRGSRRQGWAGQELRGRHKGGGPGDLTGRGRGRARRRLRGSGCSRRGAAQGTLDRGRAAGKGGSGENPERRGVLQLLLLLLAAAEAT ARARARARAGATAPPAMAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEE LEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILF RRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEIS LSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIR YQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDM -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:171583628/chr5:171849500) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
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FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. | FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | STK10 | chr5:171583628 | chr5:171849500 | ENST00000176763 | - | 2 | 19 | 42_50 | 107.0 | 969.0 | Nucleotide binding | ATP |
Tgene | SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | 0 | 13 | 729_806 | 25.0 | 912.0 | Compositional bias | Note=Pro-rich | |
Tgene | SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | 0 | 13 | 152_211 | 25.0 | 912.0 | Domain | SH3 1 | |
Tgene | SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | 0 | 13 | 221_280 | 25.0 | 912.0 | Domain | SH3 2 | |
Tgene | SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | 0 | 13 | 368_427 | 25.0 | 912.0 | Domain | SH3 3 | |
Tgene | SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | 0 | 13 | 850_911 | 25.0 | 912.0 | Domain | SH3 4 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | STK10 | chr5:171583628 | chr5:171849500 | ENST00000176763 | - | 2 | 19 | 573_947 | 107.0 | 969.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | STK10 | chr5:171583628 | chr5:171849500 | ENST00000176763 | - | 2 | 19 | 750_884 | 107.0 | 969.0 | Compositional bias | Note=Gln-rich |
Hgene | STK10 | chr5:171583628 | chr5:171849500 | ENST00000176763 | - | 2 | 19 | 36_294 | 107.0 | 969.0 | Domain | Protein kinase |
Hgene | STK10 | chr5:171583628 | chr5:171849500 | ENST00000176763 | - | 2 | 19 | 175_224 | 107.0 | 969.0 | Region | Note=Activation segment |
Tgene | SH3PXD2B | chr5:171583628 | chr5:171849500 | ENST00000311601 | 0 | 13 | 5_129 | 25.0 | 912.0 | Domain | PX |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
STK10 | |
SH3PXD2B |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to STK10-SH3PXD2B |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to STK10-SH3PXD2B |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |