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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:STK11-HMHA1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: STK11-HMHA1
	FusionPDB ID: 87450
	FusionGDB2.0 ID: 87450
		Hgene	Tgene
	Gene symbol	STK11	HMHA1
	Gene ID	6794	23526
	Gene name	serine/threonine kinase 11	Rho GTPase activating protein 45
	Synonyms	LKB1\|PJS\|hLKB1	HA-1\|HLA-HA1\|HMHA1
	Cytomap	19p13.3	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase STK11liver kinase B1polarization-related protein LKB1renal carcinoma antigen NY-REN-19serine/threonine-protein kinase 11serine/threonine-protein kinase LKB1	rho GTPase-activating protein 45histocompatibility (minor) HA-1minor histocompatibility antigen HA-1minor histocompatibility protein HA-1
	Modification date	20200329	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000326873, ENST00000585748,	ENST00000590577, ENST00000591169, ENST00000592335, ENST00000313093, ENST00000536472, ENST00000539243, ENST00000543365, ENST00000586866, ENST00000590214,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 3 X 8=312	5 X 8 X 6=240
	# samples	17	9
	** MAII score	log2(17/312*10)=-0.876011282724546 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/240*10)=-1.41503749927884 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: STK11 [Title/Abstract] AND HMHA1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HMHA1(1066162)-STK11(1218416), # samples:1 STK11(1222005)-HMHA1(1080254), # samples:2
Anticipated loss of major functional domain due to fusion event.	STK11-HMHA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STK11-HMHA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. STK11-HMHA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. STK11-HMHA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STK11	GO:0006468	protein phosphorylation	12805220\|25329316
Hgene	STK11	GO:0007050	cell cycle arrest	12805220\|17216128
Hgene	STK11	GO:0046777	protein autophosphorylation	11430832
Hgene	STK11	GO:0071493	cellular response to UV-B	25329316
Hgene	STK11	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	11430832

Fusion gene breakpoints across STK11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HMHA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-NJ-A4YF-01A	STK11	chr19	1222005	-	HMHA1	chr19	1080254	+
ChimerDB4	LUAD	TCGA-NJ-A4YF-01A	STK11	chr19	1222005	+	HMHA1	chr19	1080254	+
ChimerDB4	LUAD	TCGA-NJ-A4YF	STK11	chr19	1222005	+	HMHA1	chr19	1080253	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000326873	STK11	chr19	1222005	+	ENST00000539243	HMHA1	chr19	1080253	+	4061	2093	1011	3800	929
ENST00000326873	STK11	chr19	1222005	+	ENST00000313093	HMHA1	chr19	1080253	+	4423	2093	1011	3800	929
ENST00000326873	STK11	chr19	1222005	+	ENST00000536472	HMHA1	chr19	1080253	+	3971	2093	1011	3884	957
ENST00000326873	STK11	chr19	1222005	+	ENST00000590214	HMHA1	chr19	1080253	+	4421	2093	1011	3800	929
ENST00000326873	STK11	chr19	1222005	+	ENST00000586866	HMHA1	chr19	1080253	+	4423	2093	1011	3800	929
ENST00000326873	STK11	chr19	1222005	+	ENST00000543365	HMHA1	chr19	1080253	+	4423	2093	1011	3800	929
ENST00000326873	STK11	chr19	1222005	+	ENST00000539243	HMHA1	chr19	1080254	+	4061	2093	1011	3800	929
ENST00000326873	STK11	chr19	1222005	+	ENST00000313093	HMHA1	chr19	1080254	+	4423	2093	1011	3800	929
ENST00000326873	STK11	chr19	1222005	+	ENST00000536472	HMHA1	chr19	1080254	+	3971	2093	1011	3884	957
ENST00000326873	STK11	chr19	1222005	+	ENST00000590214	HMHA1	chr19	1080254	+	4421	2093	1011	3800	929
ENST00000326873	STK11	chr19	1222005	+	ENST00000586866	HMHA1	chr19	1080254	+	4423	2093	1011	3800	929
ENST00000326873	STK11	chr19	1222005	+	ENST00000543365	HMHA1	chr19	1080254	+	4423	2093	1011	3800	929

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000326873	ENST00000539243	STK11	chr19	1222005	+	HMHA1	chr19	1080253	+	0.005945915	0.99405414
ENST00000326873	ENST00000313093	STK11	chr19	1222005	+	HMHA1	chr19	1080253	+	0.004719691	0.9952803
ENST00000326873	ENST00000536472	STK11	chr19	1222005	+	HMHA1	chr19	1080253	+	0.005659892	0.9943401
ENST00000326873	ENST00000590214	STK11	chr19	1222005	+	HMHA1	chr19	1080253	+	0.004752926	0.99524707
ENST00000326873	ENST00000586866	STK11	chr19	1222005	+	HMHA1	chr19	1080253	+	0.004719691	0.9952803
ENST00000326873	ENST00000543365	STK11	chr19	1222005	+	HMHA1	chr19	1080253	+	0.004719691	0.9952803
ENST00000326873	ENST00000539243	STK11	chr19	1222005	+	HMHA1	chr19	1080254	+	0.005945915	0.99405414
ENST00000326873	ENST00000313093	STK11	chr19	1222005	+	HMHA1	chr19	1080254	+	0.004719691	0.9952803
ENST00000326873	ENST00000536472	STK11	chr19	1222005	+	HMHA1	chr19	1080254	+	0.005659892	0.9943401
ENST00000326873	ENST00000590214	STK11	chr19	1222005	+	HMHA1	chr19	1080254	+	0.004752926	0.99524707
ENST00000326873	ENST00000586866	STK11	chr19	1222005	+	HMHA1	chr19	1080254	+	0.004719691	0.9952803
ENST00000326873	ENST00000543365	STK11	chr19	1222005	+	HMHA1	chr19	1080254	+	0.004719691	0.9952803

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>87450_87450_1_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080253_ENST00000313093_length(amino acids)=929AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEE
LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQC
GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYL
RQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP
GNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA
DGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNN

--------------------------------------------------------------

>87450_87450_2_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080253_ENST00000536472_length(amino acids)=957AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRGECPAGPRGGRWLPATHPGPSPETPLSPAGRGHQVHKSWPLSISDSDS
GLDPGPGAGDFKKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNS
YVYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLC
QAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLP
PENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESS
NQRAEVVVQVPYLEAGEAVVYPLQEAAADGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLE

--------------------------------------------------------------

>87450_87450_3_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080253_ENST00000539243_length(amino acids)=929AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEE
LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQC
GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYL
RQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP
GNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA
DGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNN

--------------------------------------------------------------

>87450_87450_4_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080253_ENST00000543365_length(amino acids)=929AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEE
LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQC
GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYL
RQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP
GNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA
DGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNN

--------------------------------------------------------------

>87450_87450_5_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080253_ENST00000586866_length(amino acids)=929AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEE
LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQC
GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYL
RQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP
GNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA
DGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNN

--------------------------------------------------------------

>87450_87450_6_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080253_ENST00000590214_length(amino acids)=929AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEE
LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQC
GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYL
RQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP
GNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA
DGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNN

--------------------------------------------------------------

>87450_87450_7_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080254_ENST00000313093_length(amino acids)=929AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEE
LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQC
GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYL
RQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP
GNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA
DGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNN

--------------------------------------------------------------

>87450_87450_8_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080254_ENST00000536472_length(amino acids)=957AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRGECPAGPRGGRWLPATHPGPSPETPLSPAGRGHQVHKSWPLSISDSDS
GLDPGPGAGDFKKFERTSSSGTMSSTEELVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNS
YVYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLC
QAFENGKELVELSQASPHDISNVLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLP
PENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESS
NQRAEVVVQVPYLEAGEAVVYPLQEAAADGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLE

--------------------------------------------------------------

>87450_87450_9_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080254_ENST00000539243_length(amino acids)=929AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEE
LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQC
GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYL
RQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP
GNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA
DGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNN

--------------------------------------------------------------

>87450_87450_10_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080254_ENST00000543365_length(amino acids)=929AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEE
LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQC
GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYL
RQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP
GNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA
DGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNN

--------------------------------------------------------------

>87450_87450_11_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080254_ENST00000586866_length(amino acids)=929AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEE
LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQC
GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYL
RQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP
GNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA
DGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNN

--------------------------------------------------------------

>87450_87450_12_STK11-HMHA1_STK11_chr19_1222005_ENST00000326873_HMHA1_chr19_1080254_ENST00000590214_length(amino acids)=929AA_BP=360
MLEEGFFPSFWGFCCLFFFFFLCKILEKGSRNTRKDRSPADSGLAAGLQDPGSSMEVVDPQQLGMFTEGELMSVGMDTFIHRIDSTEVIY
QPRRKRAKLIGKYLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHKNVIQLVDVLYNEEKQKMY
MVMEYCVCGMQEMLDSVPEKRFPVCQAHGYFCQLIDGLEYLHSQGIVHKDIKPGNLLLTTGGTLKISDLGVAEALHPFAADDTCRTSQGS
PAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGSYAIPGDCGPPLSDLLKGMLEYEPAKRFSIRQIRQH
RSPVMRARKSSFNVSDVARPEAAGSPPEEGGCTEGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEE
LVDPDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSYVYFQGAECEECCLACHKKCLETLAIQC
GHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYL
RQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTP
GNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAA
DGCRESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEATAREDGDGDEDGPAQQLSGFNTNQSNN

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:1066162/chr19:1218416)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STK11

chr19:1222005

chr19:1080253

ENST00000326873

49_309

306.6666666666667

225.33333333333334

Domain

Protein kinase

Hgene

STK11

chr19:1222005

chr19:1080254

ENST00000326873

49_309

306.6666666666667

225.33333333333334

Domain

Protein kinase

Hgene

STK11

chr19:1222005

chr19:1080253

ENST00000326873

55_63

306.6666666666667

225.33333333333334

Nucleotide binding

ATP

Hgene

STK11

chr19:1222005

chr19:1080254

ENST00000326873

55_63

306.6666666666667

225.33333333333334

Nucleotide binding

ATP

Tgene

HMHA1

chr19:1222005

chr19:1080253

ENST00000313093

761_974

567.6666666666666

1137.0

Domain

Rho-GAP

Tgene

HMHA1

chr19:1222005

chr19:1080253

ENST00000539243

761_974

583.6666666666666

1153.0

Domain

Rho-GAP

Tgene

HMHA1

chr19:1222005

chr19:1080254

ENST00000313093

761_974

567.6666666666666

1137.0

Domain

Rho-GAP

Tgene

HMHA1

chr19:1222005

chr19:1080254

ENST00000539243

761_974

583.6666666666666

1153.0

Domain

Rho-GAP

Tgene

HMHA1

chr19:1222005

chr19:1080253

ENST00000313093

702_747

567.6666666666666

1137.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

HMHA1

chr19:1222005

chr19:1080253

ENST00000539243

702_747

583.6666666666666

1153.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

HMHA1

chr19:1222005

chr19:1080254

ENST00000313093

702_747

567.6666666666666

1137.0

Zinc finger

Phorbol-ester/DAG-type

Tgene

HMHA1

chr19:1222005

chr19:1080254

ENST00000539243

702_747

583.6666666666666

1153.0

Zinc finger

Phorbol-ester/DAG-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

HMHA1

chr19:1222005

chr19:1080253

ENST00000313093

376_412

567.6666666666666

1137.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HMHA1

chr19:1222005

chr19:1080253

ENST00000313093

440_499

567.6666666666666

1137.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HMHA1

chr19:1222005

chr19:1080253

ENST00000539243

376_412

583.6666666666666

1153.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HMHA1

chr19:1222005

chr19:1080253

ENST00000539243

440_499

583.6666666666666

1153.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HMHA1

chr19:1222005

chr19:1080254

ENST00000313093

376_412

567.6666666666666

1137.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HMHA1

chr19:1222005

chr19:1080254

ENST00000313093

440_499

567.6666666666666

1137.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HMHA1

chr19:1222005

chr19:1080254

ENST00000539243

376_412

583.6666666666666

1153.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HMHA1

chr19:1222005

chr19:1080254

ENST00000539243

440_499

583.6666666666666

1153.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HMHA1

chr19:1222005

chr19:1080253

ENST00000313093

269_539

567.6666666666666

1137.0

Domain

F-BAR

Tgene

HMHA1

chr19:1222005

chr19:1080253

ENST00000539243

269_539

583.6666666666666

1153.0

Domain

F-BAR

Tgene

HMHA1

chr19:1222005

chr19:1080254

ENST00000313093

269_539

567.6666666666666

1137.0

Domain

F-BAR

Tgene

HMHA1

chr19:1222005

chr19:1080254

ENST00000539243

269_539

583.6666666666666

1153.0

Domain

F-BAR

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
STK11
HMHA1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to STK11-HMHA1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to STK11-HMHA1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source